Hub : Genes

SPATA2L

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.0810	0.0380	0.0054	0.005	NA	0.053	NA	0.028	1.7e-01	NA	6.6e-04	NA	1.1e-02
2	GTEx	Uterus	0.5290	0.1490	0.0049	-0.010	NA	-0.008	NA	0.011	5.6e-01	NA	5.1e-01	NA	1.9e-01
3	YFS	Blood	0.1130	0.0281	0.0000	0.068	0.119	0.110	0.12	0.111	2.7e-21	7.6e-37	6.4e-34	5.5e-37	3.3e-34
4	TCGA	Bladder Urothelial Carcinoma	0.0940	0.0480	0.0069	-0.003	-0.002	0.005	NA	-0.002	8.0e-01	6.2e-01	1.1e-01	NA	5.0e-01
5	TCGA	Lung Squamous Cell Carcinoma	0.0327	0.0190	0.0065	0.014	0.007	0.005	NA	0.011	8.9e-03	4.9e-02	7.7e-02	NA	1.9e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	4.6	7.2	12.4	-3.5	-1.4	-3.5	0.0	-3.1
Bipolar Disorder or Schizophrenia	4.7	11.5	18.2	-4.2	-2.3	-4.3	0.0	-4.0
Depressed Affect (Nagel 2018)	0.4	0.8	2.3	1.5	-0.1	0.2	0.0	-1.2
Depression (Nagel 2018)	1.1	1.6	3.6	1.9	1.5	1.2	-0.3	-0.7
Intelligence (Savage-Jansen 2018)	0.7	2.3	6.4	2.0	-0.3	2.5	0.1	0.8
Neuroticism (Nagel 2018)	1.2	2.7	9.4	3.1	0.6	1.1	1.6	-0.6
Schizophrenia (2018)	2.4	4.9	7.3	-2.6	-2.0	-2.7	0.0	-2.7
Schizophrenia vs Biploar Disorder	0.7	0.9	3.2	0.6	1.0	0.0	0.0	1.8
Worry (Nagel 2018)	0.8	1.7	6.1	2.5	0.4	0.3	1.2	-0.9
Alzheimer’s Disease (in mother)	3.2	3.7	9.2	-3.0	-0.7	-1.4	-2.7	-0.3
Alzheimer’s Disease (in father)	1.0	1.1	2.6	-0.9	1.6	-0.7	-0.2	-1.3
Alzheimer’s Disease (including proxy)	2.7	3.9	8.7	-3.0	0.3	-1.7	-2.4	-1.5
Crohns Disease (2017)	0.8	1.7	4.7	2.2	-0.4	-0.0	1.7	-0.9
Irritable Bowel Disease (IBD)	0.4	1.0	2.2	1.3	-0.2	-0.1	1.5	-1.1
Ulcerative Colitis (UC)	0.3	0.5	1.6	-0.3	0.4	-0.0	1.3	-0.8
Major Depression (MDD)	0.2	0.3	0.5	0.7	0.7	-0.5	0.0	0.0
Reaction Time	0.6	1.2	4.4	0.4	1.0	0.2	2.1	-0.7
Verbal and Numeric Reasoning (VNR)	1.9	4.6	10.6	2.6	1.6	3.3	0.6	1.7
Breast Cancer	1.2	2.8	11.0	-1.4	-0.5	0.4	-0.8	-3.3
Ovarian Cancer	0.4	0.5	1.8	-0.6	-0.4	-0.1	0.0	-1.4
Prostate Cancer	0.4	0.5	2.4	0.1	1.6	0.3	0.1	-0.4
Age at First Birth	1.6	2.3	7.2	2.7	0.4	1.6	1.1	-0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.5	2.0	0.5	0.1	-0.3	1.4	0.1
Coronary Artery Disease (CAD)	0.6	0.8	1.2	-1.1	-1.0	-0.9	0.0	-0.9
Crohns Disease (2012)	0.4	0.7	1.5	1.2	1.1	0.9	0.0	-0.0
Mean Putamen Volume	0.6	0.7	1.3	0.9	0.3	-0.5	1.0	-1.1
Fasting Glucose	0.3	0.3	0.9	-0.3	0.4	-0.9	-0.4	0.6
HbA1C	3.6	4.0	7.4	-1.5	-0.5	-2.5	-2.7	-1.9
HDL Cholesterol	0.8	1.4	2.0	1.4	-1.4	1.0	-1.4	-0.6
LDL Cholesterol	0.7	1.1	1.9	-1.3	-0.3	-0.9	-0.9	1.4
Lupus	0.6	1.0	2.7	-1.2	-0.8	-1.6	-0.1	0.0
Neuroticism (2016)	1.3	1.9	4.2	2.0	0.8	0.8	1.7	1.0
Primary Biliary Cirrhosis	0.7	0.9	1.4	-1.0	0.1	-1.1	1.1	1.2
Rheumatoid Arthritis	0.7	1.0	2.9	-0.4	1.7	-1.4	0.0	-0.1
Schizophrenia (2014)	4.1	9.1	21.9	-3.9	-1.9	-4.7	0.0	-2.3
Triglycerides	1.8	3.0	10.5	-1.7	0.3	-3.2	0.2	1.2
Type 2 Diabetes (T2D) (2012)	1.6	1.8	3.7	-1.4	0.2	-1.9	-1.1	1.4
Ulcerative Colitis	0.3	0.4	0.9	-0.4	0.6	1.0	0.0	-0.9
Blood Eosinophil Count	0.1	0.5	2.0	0.6	1.4	0.3	-0.2	0.5
Blood Platelet Count	0.8	9.2	14.7	2.8	3.7	3.8	2.7	1.6
Blood Red Count	0.4	3.9	7.9	-2.8	-2.1	-0.8	-2.5	-0.2
Blood White Count	0.5	3.4	13.8	-3.7	0.0	-1.4	-1.1	0.1
Heel T-Score	0.9	7.2	28.3	0.3	-2.1	1.7	-0.0	5.3
BMI	0.7	4.2	14.8	-1.1	-2.1	-3.9	0.0	0.5
Height	0.5	9.0	27.6	-3.0	0.3	1.4	-2.6	5.2
Waist Hip Ratio (WHR)	0.1	0.5	1.0	-0.7	0.6	-1.0	-0.2	-0.7
Systolic Blood Pressure	1.0	4.8	11.4	3.4	1.7	1.2	2.9	-0.1
Smoking Status	1.0	2.4	6.2	-2.5	0.6	-1.1	-1.8	-1.1
Allergy or Eczema	0.2	0.5	1.3	-0.3	0.2	-0.4	-1.0	-1.1
Cardiovascular Disease	4.1	13.5	28.1	5.3	0.8	3.5	3.3	4.0
Hypothyroidism (self reported)	0.5	1.2	2.0	-1.4	-1.3	-1.4	-0.8	-0.0
Respiratory disease	0.5	1.0	2.3	-1.1	1.5	-0.7	-0.0	-1.1
Type 2 Diabetes (T2D) (2018)	1.4	2.6	5.2	-2.3	-1.5	-2.3	-0.6	-0.2
Lung FEV1/FVC ratio	0.3	1.3	4.0	-0.9	0.0	-1.1	0.8	2.0
Lung FVC	0.6	3.2	7.8	0.4	0.9	2.8	0.8	2.6
Neuroticism	1.1	2.7	7.2	2.7	-0.5	-0.1	1.8	-1.7
Chronotype (morning person)	0.2	0.4	0.8	0.6	0.7	0.4	0.9	-0.2
Hair Pigment	191.9	5472.3	17689.0	133.0	13.4	38.9	73.2	-51.2
Tanning	169.4	2067.6	6674.9	-81.7	-4.7	-35.3	-48.6	5.7
Hand grip strength (left)	1.6	4.1	9.1	1.0	-0.2	2.6	-1.9	3.0
Number of treatments/medications taken	0.5	0.9	2.2	1.5	-0.6	-0.0	0.5	-1.4
Average weekly spirits intake	1.6	2.0	6.0	2.4	-0.7	1.3	1.3	0.2
Sensitivity / hurt feelings	0.7	1.3	3.7	1.5	0.1	0.0	1.9	0.5
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.5	1.2	1.1	0.1	-0.2	0.1
Hearing difficulty/problems: Yes	0.2	0.3	0.6	0.6	0.6	0.3	-0.0	0.8
Relative age of first facial hair	3.2	6.7	14.0	3.7	0.2	1.3	2.3	-3.5
Other serious medical condition/disability diagnosed by doctor	5.8	7.5	12.5	-3.5	-2.0	-3.5	-1.2	-2.7
Ever used hormone-replacement therapy (HRT)	0.7	0.9	3.0	0.9	0.3	0.6	0.4	-1.7
Ever had hysterectomy (womb removed)	0.7	0.8	2.0	-0.3	1.1	0.0	-0.8	-1.4
Systolic blood pressure, automated reading	0.8	2.4	6.2	2.5	1.2	0.1	1.2	-1.7
Eye problems/disorders: Diabetes related eye disease	2.5	2.8	6.6	-1.7	-1.8	-1.1	-2.6	0.2
Angina	0.6	0.7	1.4	-0.7	-1.2	-0.7	0.7	-0.9
Medication for hormone replacement therapy	0.5	0.6	2.1	1.5	0.2	0.4	0.7	0.5
Vitamin and mineral supplements	1.5	2.0	3.2	1.3	-1.6	1.8	-0.7	1.3
Supplements: Zinc	0.9	1.0	2.0	-1.1	-0.2	-1.4	-1.3	-0.3
Medication: Co-codamol	0.6	0.7	2.1	-1.4	-0.2	0.0	-0.4	-1.1
Medication: Metformin	1.0	1.4	3.2	-0.0	-1.7	-0.2	1.1	1.8
Diabetes (father)	2.5	3.1	6.8	-2.6	-2.1	-1.8	-0.9	0.5
Diabetes (mother)	2.2	2.8	6.6	-2.2	-1.6	-2.6	0.4	-0.4
Severe depression (siblings)	4.7	5.2	8.8	-2.7	-1.0	-2.4	-3.0	-1.8
Pack years adult smoking proportion	1.0	1.6	4.2	-2.0	-0.6	-1.7	-0.4	0.7
Impedance of leg (right)	0.4	2.0	2.8	-1.5	1.0	1.4	-1.7	1.5
Leg fat-free mass (left)	0.2	1.0	2.8	-0.7	-0.5	-1.1	0.0	1.7
Trunk fat percentage	1.5	6.0	14.4	-3.8	-1.2	-2.9	-0.4	2.3
Hand grip strength (right)	1.3	3.5	8.3	-0.1	-1.1	1.7	-2.2	2.9
Townsend deprivation index at recruitment	1.1	1.6	3.6	-0.5	-1.9	-1.6	-1.2	-0.5
Current tobacco smoking	0.8	1.4	4.4	-1.2	0.5	-0.2	-2.1	0.8
Average weekly fortified wine intake	0.7	0.9	1.8	1.1	1.3	0.9	0.1	-0.7
Maternal smoking around birth	1.0	1.5	3.5	-1.5	0.2	-1.2	-0.5	1.9
Fed-up feelings	0.2	0.4	0.9	-0.0	-0.1	-1.0	-0.1	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.8	0.6	1.4	0.4	0.3	-0.6
Relative age voice broke	2.6	4.0	11.5	2.4	0.8	0.2	1.3	-3.4
Taking other prescription medications	1.8	2.8	7.1	-1.1	-1.5	-2.7	0.5	-1.8
Age when periods started (menarche)	0.2	0.4	0.9	-0.5	0.9	-0.0	-0.4	0.7
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.7	0.9	-0.7	-0.2	-0.7	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	7.1	-1.4	-0.5	-0.7	-2.7	1.3
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	3.7	0.4	0.8	0.5	1.4	1.9
Qualifications: CSEs or equivalent	1.5	1.9	4.4	-0.2	2.1	-1.3	1.5	1.1
Serious illness, injury or assault to yourself	1.9	2.3	3.8	-1.6	-1.0	-0.0	-1.9	-2.0
High blood pressure	5.4	14.9	37.3	6.1	0.8	4.2	3.6	2.4
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.7	-0.4	0.1	-0.1	-0.6	-0.8
Multivitamins +/- minerals	1.1	1.4	4.5	-1.4	2.1	-0.5	0.6	-0.2
Stomach or abdominal pain in last month	3.4	4.2	10.0	-3.2	-2.2	-1.5	-1.2	-1.6
Supplements: Glucosamine	0.5	0.6	1.4	0.4	-0.4	-1.2	1.0	-0.7
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.5	-1.2	0.6	-0.7	-0.3	0.7
Medication: Atenolol	2.5	3.1	10.3	3.2	-0.5	2.0	0.4	-0.9
Medication: Levothyroxine sodium	1.3	2.2	3.4	-1.5	-1.7	-1.8	-1.5	-0.3
Sitting height	0.3	2.0	4.9	-2.2	0.5	-0.4	-2.0	0.9
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	-0.7	0.4	0.1	-0.5	-0.4
High blood pressure (mother)	2.8	3.9	7.2	2.0	0.5	2.7	1.3	2.5
Body mass index (BMI)	0.6	2.5	7.7	-1.7	-1.1	-2.8	0.5	0.4
Impedance of leg (left)	0.6	3.0	4.8	-1.8	0.9	2.0	-1.4	2.2
Leg predicted mass (left)	0.2	1.0	2.9	-0.9	-0.5	-1.1	-0.1	1.7
Trunk fat mass	1.2	5.1	11.2	-3.3	-1.1	-2.6	-0.6	2.5
Waist circumference	0.6	2.1	5.2	-1.5	-0.9	-2.3	0.1	1.5
Number of incorrect matches in round	1.0	1.6	5.8	0.0	1.0	-1.2	-0.1	-2.4
Past tobacco smoking	1.4	2.6	4.8	1.6	1.5	1.5	1.1	2.2
Alcohol usually taken with meals	0.1	0.1	0.4	0.3	-0.0	-0.3	-0.4	0.6
Nervous feelings	0.5	0.9	1.8	1.1	-0.9	-0.2	0.5	-1.4
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	5.3	-0.7	-0.8	-1.1	-2.0	-2.3
Hearing difficulty/problems with background noise	0.1	0.1	0.4	-0.6	0.4	-0.2	-0.2	-0.1
Hair/balding pattern: Pattern 2	0.3	0.4	0.5	0.6	-0.7	-0.6	0.4	-0.7
Had menopause	3.9	4.9	19.5	0.7	1.2	1.7	0.1	-4.4
Had other major operations	1.4	1.7	3.4	-1.1	1.1	-1.3	-1.8	0.9
Forced vital capacity (FVC)	1.3	4.9	18.3	0.3	0.6	2.2	-0.9	4.3
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	5.5	-1.0	-0.2	-0.1	-2.3	1.6
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	2.6	-1.1	-0.3	-1.6	-0.6	-1.4
Qualifications: None of the above	0.3	0.7	1.6	-0.6	0.7	-0.2	1.1	-1.3
Financial difficulties in last 2 years	0.4	0.5	0.9	0.5	-0.8	-0.5	-1.0	-0.7
Mouth/teeth dental problems	0.7	1.1	2.5	1.6	-0.8	1.5	0.1	0.3
Heart attack	0.3	0.3	0.8	-0.0	-0.9	-0.5	-0.0	-0.7
Allergy	0.5	1.1	3.0	1.7	-0.8	0.8	1.0	-0.2
Pain all over the body in last month	1.2	1.3	2.8	-1.7	-1.0	-1.4	-0.1	0.9
Diabetes (self-reported)	1.8	2.8	6.0	-1.7	-2.5	-2.1	-0.6	0.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.0	0.9	0.8	-0.2	-1.0	-0.1
Medication: Ramipril	0.5	0.7	2.1	0.5	0.1	0.5	1.4	0.9
Medication: Simvastatin	0.4	0.5	1.1	-0.7	-1.0	-0.7	0.5	0.5
Fluid intelligence score	1.1	2.2	5.8	1.6	0.7	2.4	-0.5	1.4
Illnesses of siblings	0.7	0.9	2.3	-0.5	0.1	1.5	-0.7	1.3
Neuroticism score	0.5	1.1	2.9	1.7	-1.3	-0.8	0.4	-0.5
Weight	0.5	2.3	5.5	-1.8	-0.6	-1.6	-0.3	2.3
Impedance of arm (right)	0.4	2.1	4.7	-2.2	0.5	-1.2	-1.8	-1.0
Arm fat percentage (right)	1.1	4.3	13.9	-2.6	-0.7	-3.7	-0.1	0.3
Trunk fat-free mass	0.1	0.7	2.8	-0.0	0.8	0.3	-0.4	1.7
Hip circumference	0.4	1.6	5.4	-1.3	-0.4	-0.8	-0.4	2.3
Time employed in main current job	1.1	1.3	5.0	-1.0	-0.1	-0.4	0.0	-2.2
Alcohol intake versus 10 years previously	0.5	0.8	1.7	-1.3	-0.7	-0.8	-0.1	-1.1
Father’s age at death	1.0	1.4	2.2	-1.2	-0.9	-1.5	-1.2	0.9
Worrier / anxious feelings	0.2	0.3	1.1	-0.1	0.0	-0.5	-1.1	-0.0
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.8	7.8	-2.3	-0.4	-2.3	-2.8	-0.7
Falls in the last year	2.3	3.1	4.5	-2.1	-1.0	-2.1	-2.0	-1.4
Hair/balding pattern: Pattern 3	1.1	1.7	5.1	0.9	0.6	2.3	-0.1	1.5
Number of live births	3.5	5.0	11.1	-3.3	1.2	-0.9	-2.0	-2.7
Forced expiratory volume in 1-second (FEV1)	1.3	4.4	18.2	-0.2	0.5	1.9	-0.3	4.3
Pulse rate	1.1	1.9	7.5	-0.5	2.7	0.0	-1.2	-0.4
Happiness	1.1	1.3	3.9	-1.2	-0.6	-0.1	-0.9	-2.0
Noisy workplace	0.4	0.5	1.0	0.4	-0.9	-0.3	1.0	-0.7
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.7	1.3	-0.8	0.9	0.2	1.2
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	4.3	-1.5	-1.7	-0.2	-2.1	-0.5
Mouth/teeth dental problems: Dentures	0.6	1.0	2.1	-1.4	0.8	-1.4	-0.6	-0.4
Asthma	0.7	1.3	2.3	-1.5	1.4	-1.0	-0.5	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	1.2	0.1	-0.1	0.2	-1.1	0.0
Medication: Cholesterol lowering	0.3	0.4	0.8	-0.4	-0.9	0.4	0.9	0.5
Depression (self-reported)	1.3	1.6	6.2	-0.4	-0.9	-0.8	-0.4	-2.5
Medication: Lansoprazole	0.9	1.1	2.3	-1.2	0.0	-1.5	-0.5	-1.1
Prospective memory result	1.6	2.0	3.8	1.9	1.5	0.8	1.7	-0.4
Lung cancer (father)	0.7	0.8	2.6	-0.3	1.6	-0.0	-1.2	0.2
Illnesses of mother	1.3	1.5	2.4	-0.8	-0.9	-1.5	-1.6	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	13.2	0.7	0.5	1.8	0.0	3.6
Pulse wave Arterial Stiffness index	0.3	0.3	0.8	-0.7	0.9	-0.1	-0.3	-0.5
Impedance of arm (left)	0.2	1.1	3.7	-1.9	-0.1	0.0	-1.1	0.5
Arm fat mass (right)	0.8	3.3	9.5	-2.4	-0.5	-3.1	-0.2	1.0
Trunk predicted mass	0.1	0.7	2.3	-0.0	0.8	0.3	-0.7	1.5
Standing height	0.6	5.9	18.1	-1.1	1.3	2.2	-1.9	4.3
Length of working week for main job	0.3	0.3	0.7	-0.3	-0.7	-0.3	-0.6	0.8
Exposure to tobacco smoke at home	0.1	0.1	0.3	-0.5	-0.0	-0.4	-0.1	-0.1
Breastfed as a baby	1.0	1.3	4.0	0.7	-0.5	-0.8	-0.9	-2.0
Tense / ‘highly strung’	0.3	0.5	0.9	0.9	-0.0	-0.7	0.6	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.4	6.0	-1.1	-2.4	-2.5	-1.9	-0.2
Hair/balding pattern: Pattern 4	2.4	5.8	15.7	4.0	-0.9	2.4	1.8	1.9
Birth weight of first child	0.3	0.6	1.3	-0.3	1.1	0.7	0.9	0.3
Peak expiratory flow (PEF)	2.2	5.0	18.7	1.0	1.2	1.9	-0.5	4.3
Pulse wave reflection index	0.3	0.4	1.5	-0.0	0.2	0.5	1.2	-0.3
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.5	0.5	0.2	-0.7	0.5	-0.6
Loud music exposure frequency	0.7	0.8	1.7	-0.9	0.2	-0.4	-1.1	-1.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.5	0.4	0.7	-0.3	0.2	0.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.3	1.2	0.3	0.3	0.9	0.3
Blood clot in the leg (DVT)	1.7	2.2	4.2	-1.7	1.8	0.5	-0.4	2.0
Medication: Paracetamol	0.2	0.4	0.6	-0.7	-0.7	0.1	0.6	-0.7
Headache pain in last month	0.8	1.3	2.6	-0.5	1.2	1.6	-0.0	-1.5
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.2	-1.1	1.1	-1.0	-1.5	-0.9
Glaucoma (self-reported)	0.4	0.5	0.9	-0.4	-0.5	-0.5	1.0	1.0
Gout (self-reported)	0.8	1.1	2.0	-1.1	-1.3	-0.8	0.1	1.4
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	3.4	-1.7	-0.9	-1.8	-1.3	0.0
Medication: Amlodipine	0.9	1.2	3.2	1.8	-0.2	1.7	0.2	0.1
Medication: Ventolin 100micrograms inhaler	0.6	0.7	2.8	-0.3	0.1	-0.8	-1.7	-0.1
Birth weight	0.7	1.5	4.5	-1.3	-0.2	-1.1	-0.4	-2.1
Chronic bronchitis/emphysema (mother)	1.9	2.2	6.1	-2.5	-0.9	-1.5	-1.3	0.3
High blood pressure (siblings)	0.2	0.3	0.5	0.7	-0.7	0.2	0.7	0.5
Forced vital capacity (FVC), Best measure	1.1	4.0	14.9	0.4	0.4	2.1	-0.9	3.9
Body fat percentage	1.2	4.7	10.9	-3.3	-0.9	-2.8	-0.4	1.9
Leg fat percentage (right)	0.7	2.5	5.9	-2.4	-0.5	-2.3	-0.6	0.7
Arm fat-free mass (right)	0.3	1.8	8.2	0.3	0.1	0.8	0.1	2.9
Exposure to tobacco smoke outside home	1.0	1.4	3.9	-1.1	-0.2	-2.0	-1.1	0.9
Comparative body size at age 10	0.9	2.6	7.0	1.4	0.2	-2.1	0.2	-2.6
Number of full brothers	0.7	0.9	2.1	-1.1	-0.8	-0.1	-1.4	-0.8
Worry too long after embarrassment	2.5	4.2	13.8	3.7	1.1	0.2	2.3	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	2.0	2.9	-1.7	-1.4	-1.4	-1.4	-1.1
Wheeze or whistling in the chest in last year	1.8	3.1	10.0	-3.2	0.6	-1.6	-0.5	-1.6
Number of children fathered	0.9	1.0	1.6	-1.2	-1.1	-0.7	-0.7	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.7	-0.7	0.8	-1.4	-0.4	-1.6
Age at first live birth	0.4	0.8	1.6	0.4	-1.3	0.3	-1.2	-0.7
Pulse wave peak to peak time	0.3	0.3	0.7	0.6	-0.8	0.2	0.1	0.8
Health satisfaction	2.4	3.2	7.3	-2.3	-0.4	-2.7	-1.6	-0.9
Shortness of breath walking on level ground	1.4	1.7	5.7	-2.4	-0.6	-0.9	-0.9	0.9
Qualifications: College or University degree	0.5	1.7	2.8	1.0	-1.5	1.7	-1.3	0.9
Eye problems/disorders: None of the above	1.0	1.2	3.0	0.7	0.2	1.7	-0.8	-1.3
Mouth/teeth dental problems: Loose teeth	3.5	4.1	6.4	-2.1	-2.2	-2.5	-1.9	-1.0
Emphysema/chronic bronchitis	1.6	1.8	4.2	-2.1	-0.8	-0.5	-1.6	1.1
Medication for pain relief, constipation, heartburn	0.2	0.4	0.9	-0.8	-0.2	0.3	0.7	1.0
Neck or shoulder pain in last month	1.9	2.7	8.4	-2.9	-0.6	-1.6	-1.0	-0.9
Medication: Blood pressure	2.1	3.7	6.4	2.5	-1.1	1.8	2.0	2.0
Angina (self-reported)	0.4	0.5	1.1	-0.5	-0.8	-0.5	1.1	-0.6
Migraine (self-reported)	0.9	1.1	3.6	-1.9	-0.9	0.5	-0.7	-0.3
Medication: Ibuprofen	0.4	0.5	1.9	-0.8	-0.1	0.0	-1.4	-0.2
Medication: Allopurinol	1.0	1.3	4.6	-1.0	-2.1	-0.7	-0.3	0.5
Medication: Omeprazole	2.9	3.5	5.5	-1.9	-0.8	-1.5	-2.3	-2.3
Medication: Seretide 50 evohaler	0.2	0.2	0.7	-0.6	-0.8	0.0	-0.4	0.0
Mean time to correctly identify matches	0.9	1.8	3.5	0.2	1.9	0.8	1.7	-1.3
Heart disease (mother)	1.1	1.3	2.3	1.3	0.1	0.9	1.5	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.3	-0.2	-1.8	-1.3	-0.9	-0.3
Whole body fat mass	0.9	3.8	7.7	-2.8	-0.8	-2.4	-0.3	2.2
Leg fat mass (right)	0.6	2.4	4.3	-2.1	-0.8	-2.1	-0.4	1.6
Arm predicted mass (right)	0.3	1.5	6.9	-0.2	-0.1	0.7	-0.3	2.6
Pulse rate, automated reading	0.2	0.5	1.7	-0.1	1.3	-0.1	0.5	-0.7
Alcohol intake frequency.	1.1	2.5	4.3	-2.1	-1.2	-2.1	-0.3	-1.6
Comparative height size at age 10	0.6	3.5	6.7	0.5	1.3	2.0	-2.6	2.3
Number of full sisters	0.7	0.9	1.4	0.6	1.2	1.0	1.2	0.5
Suffer from ‘nerves’	0.6	0.9	1.7	1.1	-1.3	-0.0	0.7	-1.0
Overall health rating	1.4	3.1	6.8	-1.6	-0.8	-2.6	-1.7	-1.5
Chest pain or discomfort	1.0	1.5	2.4	-1.5	-1.6	-1.4	-0.4	0.9
Had major operations	1.2	1.4	3.0	-0.8	-1.6	-0.7	-1.7	0.6
Age at last live birth	2.9	4.1	17.4	-0.3	-0.9	-0.3	-4.2	-1.6
Family relationship satisfaction	0.3	0.4	1.5	1.2	-0.3	0.5	0.3	0.1
Leg pain on walking	1.6	2.0	4.0	-2.0	-1.1	-1.9	-0.9	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.3	-0.4	0.5	0.1	-0.3	0.5
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.4	-1.2	0.2	0.0	0.2	-0.3
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	4.3	-0.5	0.7	0.6	2.1	1.4
Medication: Aspirin	3.1	4.0	13.8	3.7	1.6	1.7	0.9	0.2
Supplements: Vitamin C	1.2	1.4	3.6	-1.5	1.1	-1.9	0.3	-0.3
Knee pain experienced in last month	2.9	4.5	10.6	-3.0	0.9	-3.3	-0.2	-1.4
Hypertension (Self-reported)	6.3	17.4	40.4	6.4	1.0	4.4	3.8	3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.8	4.2	-1.2	0.0	-1.8	0.6	-2.0
Illnesses of father: Heart disease	0.4	0.5	0.8	0.9	-0.4	0.9	0.8	-0.5
Illnesses of siblings: Diabetes	1.7	2.1	9.4	-0.6	0.3	-3.1	-0.6	0.2
Smoking status: Previous	0.8	1.2	3.9	-0.6	-1.0	-0.8	0.0	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	7.2	-0.7	-0.9	0.3	-0.9	2.7
Whole body fat-free mass	0.1	0.7	3.2	-0.2	0.3	-0.0	-0.1	1.8
Leg fat-free mass (right)	0.2	1.0	3.3	-0.6	-0.6	-0.8	0.3	1.8
Arm fat percentage (left)	1.0	3.9	10.8	-2.7	-1.0	-3.3	0.1	0.8
Average weekly red wine intake	0.5	0.8	1.6	-1.0	0.7	-0.8	-1.3	0.3
Handedness (chirality/laterality): Left-handed	2.5	3.0	7.6	2.8	1.1	2.2	0.9	0.8
Mood swings	1.9	3.4	6.3	-2.0	-0.7	-2.2	-1.1	-2.5
Loneliness, isolation	0.5	0.7	2.8	1.7	-0.2	0.5	0.1	0.5
Long-standing illness, disability or infirmity	1.9	2.8	4.8	-1.9	-1.5	-2.2	-0.3	-1.8
Ever had bowel cancer screening	0.6	0.7	2.7	0.0	-0.3	-0.6	0.7	-1.6
Diabetes diagnosed by doctor	1.6	2.6	5.8	-2.4	-1.8	-1.7	-1.0	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.4	0.1	1.2	-0.5	0.5	0.5
Friendships satisfaction	0.3	0.4	0.7	0.9	-0.4	-0.2	0.5	-0.8
Qualifications: nursing, teaching	0.3	0.5	1.4	-0.2	0.5	0.6	0.6	1.2
Commuting to job workplace: Walk	0.2	0.2	0.4	0.7	0.6	0.5	-0.2	0.2
Eye problems/disorders: Cataract	0.5	0.5	1.8	0.1	0.8	0.1	1.3	0.4
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	4.6	-1.6	0.9	-1.0	0.7	-2.1
Medication for cholesterol	4.8	7.3	18.7	-4.3	-1.6	-3.4	-1.4	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.8	0.5	-0.1	-0.4	0.3	-0.9
Back pain experienced in last month	2.7	3.9	7.2	-2.7	-1.4	-2.1	-2.3	-0.8
Mineral and other dietary supplements	1.3	1.7	3.5	0.1	-1.0	1.6	1.2	1.9
Breast cancer (self-reported)	0.7	0.8	2.4	-0.5	1.0	0.5	-1.6	-0.5
Asthma (self-reported)	0.6	1.3	2.3	-1.5	1.3	-1.0	-0.5	-1.1
Osteoporosis (self-reported)	1.0	1.3	3.7	1.1	1.9	-0.3	0.8	-0.9
Osteoarthritis (self-reported)	2.6	3.4	9.3	-1.4	-1.0	-3.0	-1.7	-1.4
Medication: Aspirin	4.2	5.4	17.7	4.2	2.0	1.9	1.1	0.8
Medication: Gliclazide	0.1	0.1	0.3	-0.2	-0.1	-0.6	-0.2	0.5
Illnesses of father: None of the above (group 1)	0.6	0.7	1.5	-0.7	1.1	-1.2	-0.4	-0.1
Smoking status: Current	1.1	1.8	5.0	-1.9	0.3	-0.5	-2.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	4.4	0.3	-0.2	0.3	1.1	2.1
Whole body water mass	0.1	0.7	3.4	-0.2	0.3	-0.1	-0.1	1.8
Leg predicted mass (right)	0.2	1.0	3.7	-0.6	-0.5	-0.7	0.2	1.9
Arm fat mass (left)	0.9	3.6	8.5	-2.6	-0.9	-2.9	-0.3	1.4
Number of self-reported non-cancer illnesses	0.6	1.1	3.7	-0.8	-0.9	-1.9	0.5	0.1
Average weekly champagne plus white wine intake	1.2	1.6	3.6	1.9	1.2	1.5	-0.2	0.8
Miserableness	1.2	2.1	4.1	0.3	-1.9	-2.0	-1.7	0.4
Guilty feelings	0.4	0.6	1.4	1.0	-0.6	0.2	1.2	0.2
Wears glasses or contact lenses	0.9	1.0	2.9	1.7	0.1	0.8	0.1	-1.2
Ever taken oral contraceptive pill	0.5	0.5	1.8	0.7	-0.4	0.1	-1.3	0.2
Hearing aid user	0.3	0.3	0.7	-0.0	-0.7	0.4	-0.4	-0.9
Mother’s age at death	1.4	1.7	4.1	1.6	1.2	2.0	0.7	-0.0
Financial situation satisfaction	1.8	2.3	3.0	-1.4	-1.4	-1.6	-1.3	-1.7
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.5	1.3	1.6	-0.1	0.0	0.6
Commuting to job workplace: Public transport	1.1	1.3	5.4	2.3	1.0	0.3	0.3	-0.4
Eye problems/disorders: Glaucoma	0.6	0.8	1.3	-0.5	0.7	-0.9	1.2	1.0
Medication: Blood pressure	9.0	17.0	33.2	5.8	2.3	5.4	3.2	2.7
Pain type(s) experienced in last month: Hip pain	1.4	1.8	4.4	-0.7	0.4	-1.8	-0.9	-2.1
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.2	-0.1	0.6	-0.9	-0.6	-1.1
High cholesterol (Self-reported)	0.4	0.7	1.1	-0.8	-1.0	0.3	1.0	0.7
Medication: Bendroflumethiazide	2.5	3.8	7.9	2.8	-0.7	2.0	1.7	2.0
Medication: Paracetamol	0.5	0.7	2.1	-1.5	-0.7	-0.3	0.5	-0.9
Medication: Lisinopril	3.5	4.5	9.9	2.5	1.2	1.8	3.1	1.1
Medication: Atorvastatin	0.2	0.3	0.8	0.2	0.5	0.2	-0.9	0.5
Illnesses of father: High blood pressure	4.0	5.0	10.9	3.3	-0.5	1.7	1.1	3.1
Alcohol drinker status: Never	1.8	2.1	4.9	0.4	1.9	1.4	2.2	-0.1
Ever smoked	0.4	0.7	1.4	-0.4	-1.0	0.2	-1.2	-1.0
Basal metabolic rate	0.2	1.1	4.8	-0.7	0.1	-0.5	-0.1	2.2
Leg fat percentage (left)	0.7	2.6	6.7	-2.6	-0.7	-2.0	-0.5	1.2
Arm fat-free mass (left)	0.2	1.0	5.0	-0.1	0.2	0.0	-0.3	2.2
Number of operations (self-reported)	1.0	1.5	3.6	-0.9	-0.4	-1.8	-1.9	-0.1
Average weekly beer plus cider intake	0.8	1.2	2.7	0.9	0.6	1.7	0.8	1.2
Irritability	0.4	0.6	1.1	0.6	-0.4	1.0	-0.7	-1.0
Risk taking	0.7	1.0	1.7	-1.1	0.2	-0.7	-1.3	-1.2
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.3	1.1	-0.7	0.9	0.6	0.2
Fractured/broken bones in last 5 years	2.0	2.6	7.1	-1.3	-1.2	-0.9	-2.7	-1.4
Age started oral contraceptive pill	1.9	2.3	8.9	3.0	1.0	1.2	0.2	-0.4
Diastolic blood pressure, automated reading	1.9	6.0	17.1	4.1	1.3	3.0	1.0	1.1
Ever depressed for a whole week	0.9	1.1	3.2	0.2	-1.8	-1.4	-0.0	-0.5
Unable to work because of sickness or disability	1.5	1.9	3.1	-1.6	-1.8	-0.8	-1.5	-0.9
Commuting to job workplace: Cycle	1.2	1.4	2.8	1.7	0.4	1.6	-0.1	1.2
Myopia	0.9	1.3	4.5	-0.5	0.3	0.9	-0.9	-2.1
Vascular/heart problems diagnosed by doctor	4.9	13.4	34.0	-5.8	0.3	-3.7	-3.6	-2.5
Cholesterol lowering medication	0.1	0.1	0.2	-0.3	0.3	-0.1	0.5	-0.5
Medication: Omeprazole (e.g. Zanprol)	2.2	2.7	3.9	-1.8	-0.8	-1.9	-1.3	-2.0
Pain experienced in last month	2.5	4.1	11.2	3.3	-0.3	2.3	1.4	1.3
Supplements: Calcium	3.2	3.5	8.5	-2.0	0.6	-2.9	-2.2	-0.2
Basal cell carcinoma (self-reported)	6.7	8.0	31.4	5.6	0.1	2.6	1.3	-0.0
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.2	0.1	-1.1	-0.5	-0.1	-0.2
Deep venous thrombosis (DVT) (self-reported)	1.7	2.1	4.2	-1.7	2.0	0.5	-0.4	1.8
Heart disease (siblings)	0.7	0.9	2.2	0.4	1.3	0.3	0.4	-1.5
Alcohol drinker status: Previous	3.7	4.2	8.9	-2.0	-0.2	-2.8	0.2	-3.0
Pack years of smoking	0.8	1.1	3.0	-1.7	-0.0	-1.5	0.0	0.6
Impedance of whole body	0.4	1.8	4.1	-2.0	0.4	0.7	-1.6	1.4
Leg fat mass (left)	0.6	2.5	4.5	-2.1	-0.8	-1.9	-0.3	1.9
Arm predicted mass (left)	0.3	1.3	5.9	-0.2	0.6	0.3	-0.1	2.4