TWAS
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High blood pressure
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chr17:44,788,310-45,597,098
Best TWAS P=1.28e-07 · Best GWAS P=2.85e-12 conditioned to 4.22e-12
44.8M
44.9M
45M
45.1M
45.2M
45.3M
45.4M
45.5M
45.6M
0
2
4
6
8
10
12
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Spleen
WNT3
0.23
0.07
lasso
8
0.13
3.6e-04
-3.6
-5.3
1.3e-07
-0.01
0.07
0.05
TRUE
2
The Cancer Genome Atlas
Soft Tissue Sarcoma
LRRC37A2
0.43
0.26
enet
22
0.37
3.8e-23
-3.8
-5.1
2.9e-07
-0.13
0.04
0.55
FALSE