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chr17:46,258,510-47,718,188

Best TWAS P=5.63e-12 · Best GWAS P=2.41e-15 conditioned to 3.71e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
25	The Cancer Genome Atlas	Lung Adenocarcinoma	ZNF652	0.05	0.02	blup	55	0.02	2.5e-03	7.1	-6.9	5.6e-12	-0.79	0.04	0.86	TRUE
4	GTEx	Artery Aorta	AC091133.1	0.10	0.07	lasso	5	0.07	1.2e-04	-5.0	6.3	2.2e-10	0.02	0.53	0.06	TRUE
20	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HOXB9	0.05	0.00	enet	7	0.01	4.4e-02	-3.9	5.3	1.0e-07	-0.03	0.01	0.22	TRUE
8	GTEx	Cells Transformed fibroblasts	RP11-463M16.4	0.10	0.00	enet	21	0.01	2.8e-02	-5.7	6.5	9.8e-11	0.22	0.27	0.07	FALSE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF652	0.03	0.03	enet	5	0.03	2.6e-04	5.6	-6.3	3.4e-10	-0.80	0.14	0.67	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SNF8	0.08	0.07	lasso	5	0.08	9.3e-10	-5.1	6.1	8.9e-10	-0.09	1.00	0.00	FALSE
10	GTEx	Esophagus Muscularis	SNF8	0.08	0.03	lasso	3	0.01	5.7e-02	-5.9	6.1	9.5e-10	-0.06	0.12	0.04	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ATP5G1	0.07	0.05	lasso	3	0.06	4.7e-08	-6.0	6.0	1.9e-09	-0.01	0.99	0.00	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	UBE2Z	0.11	0.07	lasso	6	0.04	1.8e-03	-5.9	6.0	2.7e-09	-0.06	0.11	0.04	FALSE
11	GTEx	Heart Left Ventricle	ATP5G1	0.24	0.22	lasso	4	0.22	9.3e-12	-5.7	5.9	3.7e-09	-0.03	1.00	0.00	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	UBE2Z	0.16	0.01	enet	25	0.10	3.5e-04	-4.4	-5.8	8.5e-09	-0.09	0.28	0.04	FALSE
12	GTEx	Muscle Skeletal	UBE2Z	0.06	0.02	lasso	8	0.03	9.8e-04	-5.7	5.7	1.2e-08	-0.08	0.78	0.01	FALSE
14	GTEx	Ovary	ATP5G1	0.15	0.08	enet	13	0.09	2.8e-03	-4.3	5.6	1.7e-08	-0.06	0.22	0.04	FALSE
7	GTEx	Cells Transformed fibroblasts	SNF8	0.12	0.10	lasso	3	0.12	5.1e-09	-5.1	5.6	1.8e-08	-0.05	1.00	0.00	FALSE
26	The Cancer Genome Atlas	Prostate Adenocarcinoma	SNF8	0.05	0.06	blup	47	0.06	1.0e-06	-5.9	5.6	2.7e-08	-0.09	0.14	0.86	FALSE
16	GTEx	Skin Sun Exposed Lower leg	UBE2Z	0.14	0.11	lasso	9	0.14	6.3e-12	-4.8	5.5	2.9e-08	-0.04	1.00	0.00	FALSE
19	The Cancer Genome Atlas	Colon Adenocarcinoma	ZNF652	0.09	0.01	enet	12	0.05	5.5e-04	5.9	-5.5	2.9e-08	-0.60	0.01	0.58	FALSE
3	GTEx	Artery Aorta	SNF8	0.12	0.12	lasso	6	0.10	2.3e-06	-5.0	5.5	3.5e-08	-0.01	0.86	0.02	FALSE
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	TTLL6	0.03	0.00	blup	59	0.02	2.7e-03	-3.7	-5.5	4.5e-08	-0.01	0.02	0.82	FALSE
17	GTEx	Thyroid	SNF8	0.11	0.08	lasso	3	0.07	2.5e-06	-5.2	5.5	4.8e-08	-0.03	0.97	0.00	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	UBE2Z	0.13	0.09	lasso	4	0.12	2.7e-11	-5.1	5.4	5.9e-08	-0.05	0.06	0.94	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNF8	0.01	0.01	blup	47	0.01	9.1e-03	-4.4	5.4	6.4e-08	-0.10	0.06	0.22	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	SNF8	0.11	0.12	lasso	4	0.12	1.4e-13	-5.0	5.4	7.5e-08	-0.06	0.53	0.47	FALSE
13	GTEx	Nerve Tibial	UBE2Z	0.12	0.04	enet	16	0.05	1.5e-04	-5.0	5.3	1.0e-07	-0.02	0.90	0.00	FALSE
9	GTEx	Esophagus Muscularis	ATP5G1	0.09	0.06	lasso	5	0.05	4.5e-04	-5.2	5.2	1.7e-07	-0.03	0.33	0.03	FALSE
5	GTEx	Brain Cortex	ATP5G1	0.16	0.15	lasso	2	0.14	1.3e-04	-5.2	5.2	2.3e-07	-0.03	0.18	0.06	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF652	0.06	0.03	lasso	4	0.02	1.6e-03	5.5	-5.2	2.3e-07	-0.68	0.34	0.27	FALSE