Best TWAS P=3.59e-09 · Best GWAS P=1.29e-08 conditioned to 0.231
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | LMAN2 | 0.13 | 0.10 | lasso | 6 | 0.06 | 1.9e-04 | -5.6 | -5.5 | 4.1e-08 | 0.98 | 0.01 | 0.98 | FALSE |
2 | GTEx | Pancreas | RGS14 | 0.25 | 0.12 | lasso | 13 | 0.12 | 1.5e-05 | -5.6 | 5.4 | 6.9e-08 | -0.93 | 0.01 | 0.99 | FALSE |
3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RGS14 | 0.08 | 0.10 | lasso | 2 | 0.12 | 1.5e-23 | -5.2 | 5.2 | 1.9e-07 | -0.74 | 0.06 | 0.94 | FALSE |
4 | The Cancer Genome Atlas | Glioblastoma Multiforme | RGS14 | 0.22 | 0.24 | blup | 39 | 0.27 | 6.9e-09 | -4.6 | 5.9 | 3.6e-09 | -0.86 | 0.04 | 0.96 | TRUE |
5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RGS14 | 0.03 | 0.02 | blup | 39 | 0.03 | 8.1e-05 | -5.1 | 5.3 | 1.3e-07 | -0.91 | 0.02 | 0.98 | FALSE |
6 | The Cancer Genome Atlas | Thyroid Carcinoma | RGS14 | 0.26 | 0.18 | lasso | 5 | 0.19 | 4.5e-18 | -5.2 | 5.3 | 1.1e-07 | -0.73 | 0.06 | 0.94 | FALSE |