Best TWAS P=1.01e-10 · Best GWAS P=6.99e-18 conditioned to 0.155
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | MAP3K11 | 0.08 | 0.08 | lasso | 4 | 0.05 | 1.7e-03 | -5.3 | -5.2 | 2.5e-07 | -0.60 | 0.47 | 0.10 | FALSE |
| 2 | GTEx | Artery Aorta | SART1 | 0.08 | 0.00 | enet | 23 | 0.00 | 2.1e-01 | 3.9 | -5.2 | 2.3e-07 | -0.43 | 0.08 | 0.14 | FALSE |
| 3 | GTEx | Artery Tibial | EFEMP2 | 0.11 | 0.07 | lasso | 8 | 0.05 | 1.3e-04 | -6.1 | 6.0 | 2.5e-09 | 0.54 | 0.91 | 0.04 | FALSE |
| 4 | GTEx | Artery Tibial | BANF1 | 0.05 | 0.05 | lasso | 5 | 0.06 | 3.4e-05 | 5.3 | -5.4 | 8.1e-08 | -0.48 | 0.47 | 0.04 | FALSE |
| 5 | METSIM | Adipose | EFEMP2 | 0.07 | 0.05 | lasso | 8 | 0.04 | 4.2e-06 | 5.6 | 5.9 | 3.4e-09 | 0.51 | 1.00 | 0.00 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | EFEMP2 | 0.08 | 0.09 | enet | 13 | 0.09 | 6.8e-12 | -5.9 | 5.2 | 1.7e-07 | 0.49 | 1.00 | 0.00 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | OVOL1 | 0.16 | 0.24 | lasso | 2 | 0.24 | 1.3e-30 | -5.3 | -5.2 | 1.6e-07 | -0.64 | 1.00 | 0.00 | FALSE |
| 8 | YFS | Blood | EFEMP2 | 0.12 | 0.07 | bslmm | 348 | 0.13 | 4.3e-41 | 5.3 | 6.4 | 1.8e-10 | 0.40 | 1.00 | 0.00 | FALSE |
| 9 | YFS | Blood | MUS81 | 0.04 | 0.02 | blup | 348 | 0.04 | 6.3e-12 | 5.0 | -5.8 | 6.8e-09 | -0.47 | 1.00 | 0.00 | FALSE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DKFZp761E198 | 0.09 | 0.06 | lasso | 3 | 0.07 | 2.3e-08 | -4.3 | -5.4 | 6.4e-08 | -0.59 | 0.63 | 0.36 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | OVOL1 | 0.03 | 0.03 | blup | 36 | 0.02 | 8.3e-04 | -5.3 | -6.5 | 1.0e-10 | -0.75 | 0.02 | 0.86 | TRUE |
| 12 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RNASEH2C | 0.10 | 0.01 | blup | 32 | 0.05 | 7.9e-03 | 3.7 | 5.4 | 5.3e-08 | 0.58 | 0.01 | 0.19 | FALSE |
| 13 | The Cancer Genome Atlas | Thyroid Carcinoma | DKFZp761E198 | 0.06 | 0.05 | blup | 39 | 0.05 | 3.0e-05 | -4.3 | -5.8 | 6.1e-09 | -0.56 | 0.19 | 0.57 | TRUE |