TWAS hub - SART1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.0820	0.0410	0.00980	-0.003	NA	0.003	NA	-0.005	5.6e-01	NA	2.1e-01	NA	7.3e-01
2	METSIM	Adipose	0.0834	0.0284	0.00001	0.045	0.045	0.047	0.046	0.044	2.1e-07	2.2e-07	1.1e-07	1.7e-07	3.2e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood Eosinophil Count	13.8	106.5	130.0	11.4	9.1
Allergy or Eczema	9.2	24.2	32.2	5.7	4.0
Hayfever, allergic rhinitis or eczema	8.3	18.1	24.5	4.9	3.4
Hayfever/allergic rhinitis (self-reported)	8.3	11.0	13.4	3.7	2.9
Waist Hip Ratio (WHR)	8.0	36.1	46.5	5.1	6.8
Allergy	7.5	17.3	26.7	-5.2	-2.8
Illness, injury, bereavement, stress in last 2 years	6.7	8.2	11.4	-2.3	-3.4
Hypothyroidism (self reported)	6.1	14.1	15.4	3.6	3.9
Gout (self-reported)	5.6	7.7	12.2	1.8	3.5
Hypothyroidism/myxoedema (self-reported)	5.6	11.0	13.3	2.9	3.6
Medication: Levothyroxine sodium	5.3	8.9	9.1	3.0	3.0
Alcohol intake versus 10 years previously	5.3	7.9	15.3	0.6	3.9
Comparative body size at age 10	5.3	14.8	17.0	-3.5	-4.1
Blood White Count	4.9	36.1	42.0	6.5	5.5
Medication: Allopurinol	4.9	6.6	10.3	1.7	3.2
Heel T-Score	4.2	33.4	61.6	2.3	7.8
Heel bone mineral density (BMD) T-score, automated (left)	4.0	9.2	15.5	1.7	3.9
Breast Cancer	3.8	9.2	14.2	3.8	2.1
Asthma	3.8	7.5	15.1	3.9	0.2
Mineral and other dietary supplements	3.8	5.2	7.5	-1.7	-2.7
Medication: Blood pressure	3.8	7.2	14.3	0.3	3.8
Medication: Bendroflumethiazide	3.8	5.8	11.1	-3.3	-0.7
Respiratory disease	3.7	8.2	16.2	4.0	0.5
Ever taken oral contraceptive pill	3.7	4.1	4.5	2.1	2.0
Lupus	3.6	5.5	8.8	1.5	3.0
Heel bone mineral density (BMD) T-score, automated (right)	3.5	8.0	12.9	1.8	3.6
Asthma (self-reported)	3.5	6.9	13.8	3.7	-0.1
Commuting to job workplace: Cycle	3.5	4.3	7.6	-1.0	-2.8
Hand grip strength (left)	3.4	8.9	11.7	3.4	2.5
Ulcerative Colitis (UC)	3.2	5.9	7.0	-2.2	-2.7
Medication: Co-codamol	3.2	3.6	6.9	-2.6	-0.7
Alcohol drinker status: Never	3.2	3.8	6.0	-1.3	-2.4
Multivitamins +/- minerals	3.1	4.0	5.0	2.2	1.7
Number of full brothers	3.1	3.9	5.5	1.5	2.4
Forced vital capacity (FVC), Best measure	3.0	10.8	11.7	3.4	3.2
Heart disease (mother)	3.0	3.7	4.9	1.6	2.2
LDL Cholesterol	2.9	4.7	8.9	-0.6	-3.0
Forced vital capacity (FVC)	2.9	11.0	11.6	3.2	3.4
Glaucoma (self-reported)	2.9	3.4	6.8	2.6	0.2
Depression (self-reported)	2.8	3.4	6.2	0.8	2.5
Number of self-reported non-cancer illnesses	2.6	4.5	5.9	1.8	2.4
Risk taking	2.6	3.9	6.6	2.6	1.1
Irritable Bowel Disease (IBD)	2.5	6.0	6.3	-2.4	-2.5
Relative age of first facial hair	2.5	5.2	6.1	-2.1	-2.5
Financial difficulties in last 2 years	2.5	3.4	4.3	2.1	1.6
Standing height	2.5	24.5	38.3	3.3	6.2
Headache pain in last month	2.5	4.3	6.9	2.6	1.3
Average weekly beer plus cider intake	2.5	3.6	5.4	1.3	2.3
Major Depression (MDD)	2.4	2.9	5.6	0.4	2.4
Crohns Disease (2012)	2.4	3.8	4.0	-1.9	-2.0
Height	2.4	46.8	70.1	4.8	8.4
Type 2 Diabetes (T2D) (2018)	2.4	4.5	4.8	2.1	2.2
Comparative height size at age 10	2.4	13.0	23.3	1.6	4.8
Diabetes (father)	2.3	2.8	4.9	0.9	2.2
Hand grip strength (right)	2.3	6.2	6.2	2.5	2.5
Average weekly fortified wine intake	2.3	2.7	4.5	-1.0	-2.1
Relative age voice broke	2.3	3.5	4.0	-2.0	-1.7
Birth weight	2.3	5.0	7.2	-2.7	-1.7
Eye problems/disorders: Glaucoma	2.3	2.8	5.1	2.3	0.6
Exposure to tobacco smoke outside home	2.2	2.9	4.8	1.0	2.2
Impedance of leg (right)	2.1	10.2	12.8	3.6	2.8
Average weekly champagne plus white wine intake	2.1	2.9	3.1	1.8	1.6
Alzheimer’s Disease (including proxy)	2.0	2.8	2.9	1.7	1.7
Lung cancer (father)	2.0	2.4	2.4	-1.5	-1.5
Pack years adult smoking proportion	1.9	2.9	3.2	1.6	1.8
Loud music exposure frequency	1.9	2.1	2.3	1.5	1.4
Ulcerative Colitis	1.8	2.6	3.4	-1.3	-1.9
Lung FVC	1.8	9.2	12.9	3.6	2.4
Vitamin and mineral supplements	1.8	2.4	2.9	-1.7	-1.4
Osteoarthritis (self-reported)	1.8	2.4	4.5	0.4	2.1
Pulse rate	1.7	2.9	5.8	0.2	-2.4
Medication: Seretide 50 evohaler	1.7	1.9	2.9	1.7	1.0
Vascular/heart problems diagnosed by doctor	1.7	4.6	8.0	1.1	-2.8
Basal cell carcinoma (self-reported)	1.7	2.0	3.5	-0.7	-1.9
Pack years of smoking	1.7	2.5	3.6	1.1	1.9
Impedance of whole body	1.7	8.7	12.5	3.5	2.2
Chronotype (morning person)	1.6	3.7	7.2	2.7	-0.3
High blood pressure	1.6	4.3	6.4	-1.5	2.5
Supplements: Glucosamine	1.6	2.1	3.4	0.9	1.9
Impedance of arm (right)	1.6	7.3	13.3	3.6	1.1
Impedance of arm (left)	1.6	7.4	11.4	3.4	1.9
Hypertension (Self-reported)	1.6	4.5	8.0	-1.0	2.8
Back pain experienced in last month	1.6	2.4	4.3	0.7	2.1
Alzheimer’s Disease (in mother)	1.5	1.8	1.8	1.3	1.3
Ever had hysterectomy (womb removed)	1.5	1.7	2.3	-1.5	-1.0
Impedance of leg (left)	1.5	7.2	8.1	2.8	2.5
Prospective memory result	1.5	1.9	3.8	0.2	-1.9
Tense / ‘highly strung’	1.5	2.6	3.3	1.3	1.8
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	4.6	2.2	-0.5
High blood pressure (siblings)	1.5	2.1	3.4	-1.8	0.9
Loneliness, isolation	1.5	2.1	3.4	1.9	0.9
Diabetes diagnosed by doctor	1.5	2.4	2.9	1.4	1.7
Bipolar Disorder (2011)	1.4	1.4	2.7	-0.2	1.6
Mean Putamen Volume	1.4	1.6	2.0	-1.1	-1.4
Cardiovascular Disease	1.4	4.6	9.2	-0.3	3.0
Lung FEV1/FVC ratio	1.4	7.2	13.2	-3.6	-1.1
Townsend deprivation index at recruitment	1.4	1.9	3.5	0.6	1.9
Medication: Atenolol	1.4	1.8	3.5	0.3	1.9
Medication: Blood pressure	1.4	2.5	4.6	-2.1	0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	4.3	1.3	2.1
Friendships satisfaction	1.4	1.7	1.9	1.4	-1.2
Pain type(s) experienced in last month: Hip pain	1.4	1.7	3.4	-0.2	1.8
Medication: Lisinopril	1.4	1.8	2.1	-1.5	1.2
Supplements: Calcium	1.4	1.5	1.5	1.2	1.2
Crohns Disease (2017)	1.3	2.8	3.7	-1.9	-1.4
Systolic blood pressure, automated reading	1.3	3.8	6.1	-2.5	1.3
Taking other prescription medications	1.3	2.0	3.6	0.6	1.9
Waist circumference	1.3	4.6	9.1	0.3	3.0
Number of incorrect matches in round	1.3	2.2	2.8	-1.7	-1.3
Medication: Ventolin 100micrograms inhaler	1.3	1.7	3.0	1.7	0.6
Mouth/teeth dental problems: Loose teeth	1.3	1.6	3.0	1.7	0.4
Number of full sisters	1.3	1.6	2.6	0.8	1.6
Qualifications: nursing, teaching	1.3	2.0	3.6	1.9	0.5
Diabetes (self-reported)	1.2	1.9	2.2	1.2	1.5
Forced expiratory volume in 1-second (FEV1)	1.2	4.0	5.9	1.4	2.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.7	4.8	1.6	2.2
Ever highly irritable/argumentative for 2 days	1.2	1.4	2.3	-1.5	-0.7
Pulse rate, automated reading	1.2	4.0	7.8	0.5	-2.8
Average weekly red wine intake	1.2	1.7	3.4	1.8	-0.3
Miserableness	1.2	2.0	2.5	1.6	1.3
Medication: Atorvastatin	1.2	1.4	2.1	0.9	1.5
Blood Red Count	1.1	10.5	15.4	-2.4	-3.9
Hair/balding pattern: Pattern 2	1.1	1.5	2.7	0.4	-1.6
Illnesses of mother	1.1	1.3	2.7	-0.1	-1.6
Worry too long after embarrassment	1.1	1.8	3.5	-0.3	-1.9
Age started oral contraceptive pill	1.1	1.4	2.7	0.4	-1.6
Prostate Cancer	1.0	1.4	1.8	-1.4	-1.0
Angina	1.0	1.4	2.0	0.8	1.4
Diabetes (mother)	1.0	1.3	2.6	0.3	1.6
Illnesses of father: None of the above (group 1)	1.0	1.3	2.2	-0.6	-1.5
Diastolic blood pressure, automated reading	1.0	3.0	4.9	-1.1	2.2
Alcohol drinker status: Previous	1.0	1.2	1.8	0.7	1.3
Depressed Affect (Nagel 2018)	0.9	1.9	2.6	1.6	1.1
Rheumatoid Arthritis	0.9	1.2	1.7	0.8	1.3
Blood Platelet Count	0.9	10.9	20.6	4.5	-1.1
Systolic Blood Pressure	0.9	4.6	7.8	-2.8	1.2
Stomach or abdominal pain in last month	0.9	1.1	1.5	-0.8	-1.2
Mouth/teeth dental problems: Dentures	0.9	1.6	2.8	-1.7	0.6
Pulse wave reflection index	0.9	1.1	2.0	-1.4	0.3
Angina (self-reported)	0.9	1.2	1.7	0.8	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	1.1	-1.1	-1.0
Supplements: Vitamin C	0.9	1.1	1.2	1.1	1.0
Ever had bowel cancer screening	0.9	1.1	1.9	-1.4	-0.5
Medication for cholesterol	0.9	1.4	2.5	-0.5	-1.6
Hearing aid user	0.9	1.0	1.9	-1.4	-0.1
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	1.7	0.6	1.3
Serious illness, injury or assault to yourself	0.8	1.0	1.7	0.5	1.3
Mouth/teeth dental problems	0.8	1.2	1.4	1.0	-1.2
Wheeze or whistling in the chest in last year	0.8	1.4	2.8	1.7	-0.1
Illnesses of siblings: Diabetes	0.8	1.0	1.5	0.8	1.2
Eye problems/disorders: Cataract	0.8	0.9	1.8	0.1	1.3
Ever smoked	0.8	1.4	2.0	0.9	1.4
Ever had prostate specific antigen (PSA) test	0.8	0.9	0.9	-1.0	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.6	-0.5	1.3
Exposure to tobacco smoke at home	0.7	0.8	0.9	-1.0	-0.8
Breast cancer (self-reported)	0.7	0.8	1.6	-0.2	-1.3
Medication: Gliclazide	0.7	0.8	1.2	-1.1	-0.7
Illnesses of father: High blood pressure	0.7	0.9	1.4	1.2	0.6
Pain experienced in last month	0.7	1.2	2.1	-0.6	-1.5
Bipolar Disorder (2018)	0.6	0.9	1.1	-0.8	1.1
Neuroticism (Nagel 2018)	0.6	1.3	1.4	1.1	1.2
Ovarian Cancer	0.6	0.8	1.5	0.2	1.2
Age at First Birth	0.6	0.8	1.3	0.5	1.2
Triglycerides	0.6	1.0	1.7	1.3	0.5
Hearing difficulty/problems: Yes	0.6	0.9	1.2	-1.1	-0.8
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	0.8	0.9	0.7
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.2	-0.4	-1.1
Had menopause	0.6	0.7	1.2	1.1	-0.5
Medication: Cholesterol lowering	0.6	1.0	1.2	-1.1	0.9
Medication: Paracetamol	0.6	1.0	1.7	0.6	1.3
Medication: Amlodipine	0.6	0.9	1.1	1.0	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.3	0.3	-1.1
Medication for pain relief, constipation, heartburn	0.6	1.0	1.9	-0.2	-1.4
Neck or shoulder pain in last month	0.6	0.9	1.0	-0.9	1.0
Arm predicted mass (right)	0.6	3.0	5.4	-0.8	2.3
Suffer from ‘nerves’	0.6	1.0	1.0	1.0	1.0
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.7	0.5	1.3
Osteoporosis (self-reported)	0.6	0.8	1.2	0.6	-1.1
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.3	0.4	1.1
Heart disease (siblings)	0.6	0.8	1.5	0.2	1.2
Schizophrenia vs Biploar Disorder	0.5	0.6	0.7	0.7	-0.9
Smoking Status	0.5	1.3	2.0	0.8	1.4
Sensitivity / hurt feelings	0.5	0.8	1.6	-0.1	-1.3
Medication for hormone replacement therapy	0.5	0.5	1.0	0.3	-1.0
Body mass index (BMI)	0.5	2.3	4.3	-2.1	-0.6
Trunk fat mass	0.5	2.1	4.2	-0.3	2.0
Nervous feelings	0.5	0.9	1.1	1.1	0.8
Medication: Simvastatin	0.5	0.7	0.8	-0.8	0.9
Illnesses of siblings	0.5	0.7	1.0	1.0	-0.7
Weight	0.5	2.6	4.7	-0.7	2.2
Medication: Lansoprazole	0.5	0.6	0.8	-0.9	-0.6
Arm fat-free mass (right)	0.5	2.6	4.9	-0.6	2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.3	0.1	1.1
Pulse wave peak to peak time	0.5	0.5	0.9	0.9	0.4
Eye problems/disorders: None of the above	0.5	0.6	0.7	-0.6	-0.9
Medication: Ibuprofen	0.5	0.6	0.9	-0.9	0.5
Alcohol intake frequency.	0.5	1.2	1.9	-0.6	1.4
Knee pain experienced in last month	0.5	0.7	0.7	-0.9	0.9
Mood swings	0.5	0.9	1.8	1.3	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.1	-0.0	-1.1
Wears glasses or contact lenses	0.5	0.6	0.6	-0.7	-0.8
Worry (Nagel 2018)	0.4	0.9	1.3	0.7	1.1
BMI	0.4	2.1	4.0	-2.0	-0.4
Number of treatments/medications taken	0.4	0.7	1.1	-0.5	1.1
Medication: Metformin	0.4	0.6	1.0	0.4	1.0
Trunk fat percentage	0.4	1.5	2.8	-0.3	1.7
High blood pressure (mother)	0.4	0.6	0.8	-0.6	0.9
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.9	-0.5	0.9
Pain all over the body in last month	0.4	0.5	0.9	-0.9	-0.2
Trunk fat-free mass	0.4	2.4	4.9	0.1	2.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	0.8	0.9	0.8
Number of live births	0.4	0.6	0.8	0.9	0.6
Trunk predicted mass	0.4	2.5	5.1	0.0	2.2
Birth weight of first child	0.4	0.7	1.3	0.2	1.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.1	-0.5	1.0
Blood clot in the leg (DVT)	0.4	0.5	0.6	0.6	-0.7
Qualifications: College or University degree	0.4	1.3	2.6	0.2	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.4	-0.6	0.7
Whole body fat mass	0.4	1.7	2.8	-0.7	1.7
Chest pain or discomfort	0.4	0.5	0.6	0.7	0.8
Illnesses of father: Heart disease	0.4	0.6	0.8	0.7	0.9
Whole body fat-free mass	0.4	2.0	3.8	-0.4	2.0
Whole body water mass	0.4	2.1	4.0	-0.4	2.0
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.6	-0.5	-0.8
Basal metabolic rate	0.4	2.2	4.1	-0.5	2.0
Arm fat-free mass (left)	0.4	1.8	3.5	-0.4	1.9
Irritability	0.4	0.7	1.4	-0.0	1.2
Cholesterol lowering medication	0.4	0.6	0.7	0.9	0.7
Coronary Artery Disease (CAD)	0.3	0.3	0.6	0.3	0.7
Schizophrenia (2014)	0.3	0.6	0.8	0.6	0.9
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.6	-0.8	0.1
Hair Pigment	0.3	7.6	12.6	-1.6	-3.5
Severe depression (siblings)	0.3	0.3	0.6	-0.2	0.8
Leg fat-free mass (left)	0.3	1.6	2.8	-0.7	1.7
Maternal smoking around birth	0.3	0.4	0.8	0.9	0.1
Fed-up feelings	0.3	0.5	1.0	1.0	0.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	0.7	-0.8	0.2
Leg predicted mass (left)	0.3	1.6	2.7	-0.7	1.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.9	0.4	0.9
Medication: Ramipril	0.3	0.4	0.4	-0.6	0.7
Worrier / anxious feelings	0.3	0.5	0.9	1.0	0.3
Number of children fathered	0.3	0.3	0.6	0.3	0.8
Overall health rating	0.3	0.6	1.2	0.2	1.1
Medication: Aspirin	0.3	0.4	0.6	-0.3	0.8
Leg fat-free mass (right)	0.3	1.4	1.9	-1.0	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.7	0.8	0.4
Medication: Aspirin	0.3	0.3	0.4	-0.6	0.5
Leg predicted mass (right)	0.3	1.4	1.7	-1.0	1.3
Mother’s age at death	0.3	0.3	0.6	-0.3	-0.8
Leg fat percentage (left)	0.3	0.9	1.2	-1.1	0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.4	0.7	-0.6
Leg fat mass (left)	0.3	1.3	1.7	-1.3	0.9
Arm predicted mass (left)	0.3	1.5	2.9	-0.4	1.7
Depression (Nagel 2018)	0.2	0.3	0.6	0.2	0.8
Intelligence (Savage-Jansen 2018)	0.2	0.7	0.8	0.9	0.8
Alzheimer’s Disease (in father)	0.2	0.2	0.3	-0.5	0.2
Body Mass Index (BMI) (2010)	0.2	0.3	0.4	-0.6	-0.4
Fasting Glucose	0.2	0.2	0.4	0.3	0.6
HDL Cholesterol	0.2	0.3	0.5	0.7	-0.3
Neuroticism	0.2	0.4	0.6	0.8	0.6
Average weekly spirits intake	0.2	0.2	0.4	-0.6	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	0.3	0.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.3	-0.3	-0.5
Had other major operations	0.2	0.3	0.5	0.7	0.1
Heart attack	0.2	0.2	0.3	-0.5	-0.4
Hip circumference	0.2	1.0	1.8	-1.3	0.4
Hair/balding pattern: Pattern 3	0.2	0.3	0.5	-0.7	-0.3
Noisy workplace	0.2	0.2	0.2	-0.5	-0.4
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.8	-0.9	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	0.3	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.3	-0.6	0.4
Peak expiratory flow (PEF)	0.2	0.5	0.9	-0.3	1.0
Body fat percentage	0.2	1.0	1.4	-0.7	1.2
Leg fat percentage (right)	0.2	0.6	0.6	-0.7	0.8
Emphysema/chronic bronchitis	0.2	0.2	0.4	0.6	-0.0
Migraine (self-reported)	0.2	0.2	0.4	0.6	-0.3
Medication: Omeprazole	0.2	0.2	0.2	-0.5	-0.4
Leg fat mass (right)	0.2	0.9	1.2	-1.1	0.8
Had major operations	0.2	0.2	0.2	-0.4	0.4
Leg pain on walking	0.2	0.2	0.4	0.6	-0.1
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	-0.6	0.1
Smoking status: Previous	0.2	0.3	0.5	-0.7	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.6	-0.8	-0.1
Arm fat mass (left)	0.2	0.6	0.9	-0.9	0.6
Guilty feelings	0.2	0.2	0.4	0.3	0.6
Financial situation satisfaction	0.2	0.3	0.4	0.4	0.7
Ever depressed for a whole week	0.2	0.3	0.5	-0.7	0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.4	-0.6	-0.5
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	0.1	0.7
Schizophrenia (2018)	0.1	0.3	0.5	0.7	0.2
Neuroticism (2016)	0.1	0.2	0.3	-0.6	-0.2
Primary Biliary Cirrhosis	0.1	0.2	0.3	-0.6	-0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.1	0.3	0.3
Supplements: Zinc	0.1	0.1	0.1	0.3	-0.3
Current tobacco smoking	0.1	0.1	0.2	-0.1	0.4
Age when periods started (menarche)	0.1	0.2	0.3	0.3	-0.5
Qualifications: CSEs or equivalent	0.1	0.2	0.3	0.5	0.2
Sitting height	0.1	0.5	0.7	0.5	0.8
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.2	-0.4
Past tobacco smoking	0.1	0.2	0.5	-0.1	-0.7
Alcohol usually taken with meals	0.1	0.2	0.3	0.3	0.6
Hearing difficulty/problems with background noise	0.1	0.1	0.1	0.4	-0.3
Qualifications: None of the above	0.1	0.2	0.4	0.1	0.6
Fluid intelligence score	0.1	0.2	0.3	-0.6	0.4
Neuroticism score	0.1	0.2	0.2	0.5	0.3
Arm fat percentage (right)	0.1	0.4	0.8	-0.9	-0.3
Time employed in main current job	0.1	0.2	0.3	0.5	0.3
Father’s age at death	0.1	0.2	0.2	-0.4	-0.4
Happiness	0.1	0.2	0.3	0.1	0.6
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	-0.5	0.1
Arm fat mass (right)	0.1	0.5	0.7	-0.8	0.6
Breastfed as a baby	0.1	0.2	0.2	0.5	-0.3
Hair/balding pattern: Pattern 4	0.1	0.3	0.4	-0.7	0.3
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.3	-0.4
Age at first live birth	0.1	0.1	0.2	-0.5	-0.3
Arm fat percentage (left)	0.1	0.5	1.0	-1.0	0.0
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.3	-0.0	0.6
Long-standing illness, disability or infirmity	0.1	0.2	0.4	-0.2	0.6
Medication: Paracetamol	0.1	0.2	0.4	-0.3	0.6
Fractured/broken bones in last 5 years	0.1	0.1	0.2	0.5	0.1
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.4	0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.4	-0.1
Reaction Time	0.0	0.0	0.1	-0.1	0.3
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.1	-0.4	-0.3
HbA1C	0.0	0.0	0.0	-0.1	-0.1
Tanning	0.0	0.4	0.8	0.9	-0.1
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.1	-0.3	-0.2
Falls in the last year	0.0	0.1	0.1	0.2	-0.3
Length of working week for main job	0.0	0.0	0.0	0.2	0.2
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.0	0.1	0.2
Health satisfaction	0.0	0.0	0.1	0.2	0.2
Shortness of breath walking on level ground	0.0	0.0	0.0	0.2	-0.1
Mean time to correctly identify matches	0.0	0.1	0.1	-0.3	0.1
Age at last live birth	0.0	0.0	0.0	0.2	-0.1
Family relationship satisfaction	0.0	0.0	0.0	-0.1	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.0	-0.0	0.1
Commuting to job workplace: Walk	0.0	0.0	0.1	-0.1	-0.2
Smoking status: Current	0.0	0.0	0.1	0.3	-0.0
Commuting to job workplace: Public transport	0.0	0.0	0.1	0.0	0.2
High cholesterol (Self-reported)	0.0	0.0	0.0	0.1	0.1
Number of operations (self-reported)	0.0	0.0	0.1	-0.1	-0.3
Myopia	0.0	0.0	0.0	0.1	-0.1

Hub : Genes

SART1

Models

Trait associations