Best TWAS P=3.42e-42 · Best GWAS P=3.21e-67 conditioned to 2.06e-17
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | C11orf30 | 0.07 | 0.06 | lasso | 6 | 0.06 | 2.1e-07 | -6.9 | 6.8 | 1.4e-11 | -0.50 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | LRRC32 | 0.21 | 0.00 | enet | 15 | 0.01 | 1.5e-01 | -15.3 | -13.6 | 3.4e-42 | 0.62 | 0.00 | 0.96 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | RP11-111M22.3 | 0.14 | 0.07 | lasso | 2 | 0.04 | 2.7e-04 | -5.3 | 5.2 | 1.7e-07 | -0.34 | 0.42 | 0.13 | TRUE |
| 4 | GTEx | Prostate | CAPN5 | 0.27 | 0.04 | lasso | 3 | 0.10 | 2.1e-03 | 6.2 | 5.4 | 8.2e-08 | -0.12 | 0.07 | 0.08 | FALSE |
| 5 | GTEx | Whole Blood | WNT11 | 0.10 | 0.01 | enet | 8 | 0.03 | 7.3e-04 | 4.8 | 5.8 | 7.0e-09 | -0.16 | 0.16 | 0.03 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | RP11-111M22.3 | 0.21 | 0.05 | enet | 16 | 0.12 | 1.3e-14 | -5.3 | 6.3 | 3.5e-10 | -0.36 | 0.99 | 0.00 | TRUE |
| 7 | YFS | Blood | LRRC32 | 0.02 | 0.00 | bslmm | 481 | 0.00 | 9.1e-02 | -7.1 | 7.9 | 2.9e-15 | -0.55 | 0.17 | 0.41 | FALSE |