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chr15:90,208,219-91,744,509

Best TWAS P=4.28e-15 · Best GWAS P=9.47e-13 conditioned to 0.268

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
19	The Cancer Genome Atlas	Prostate Adenocarcinoma	IQGAP1	0.11	0.03	enet	8	0.06	1.4e-06	6.2	7.8	4.3e-15	0.83	0.01	0.98	TRUE
10	METSIM	Adipose	IQGAP1	0.11	0.08	enet	32	0.12	3.9e-17	5.3	7.6	4.2e-14	0.86	0.08	0.92	FALSE
11	YFS	Blood	IQGAP1	0.18	0.17	enet	46	0.20	5.8e-65	7.1	7.5	8.2e-14	0.91	0.00	1.00	FALSE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	IQGAP1	0.03	0.02	blup	94	0.02	6.5e-05	6.9	7.4	1.8e-13	0.92	0.01	0.99	FALSE
18	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IQGAP1	0.02	0.02	blup	94	0.02	6.2e-03	6.9	7.0	3.4e-12	0.92	0.02	0.87	FALSE
3	GTEx	Cells Transformed fibroblasts	IQGAP1	0.13	0.06	enet	19	0.11	9.2e-09	2.6	6.9	3.8e-12	0.55	0.39	0.44	FALSE
17	The Cancer Genome Atlas	Brain Lower Grade Glioma	IQGAP1	0.05	0.04	enet	12	0.03	1.1e-04	4.6	6.9	5.2e-12	0.54	0.50	0.28	FALSE
8	GTEx	Testis	ZNF774	0.13	0.09	lasso	4	0.08	1.5e-04	6.8	-6.6	3.7e-11	-0.99	0.00	0.99	FALSE
9	GTEx	Vagina	IQGAP1	0.32	0.11	lasso	6	0.17	1.3e-04	6.8	6.5	6.6e-11	0.85	0.02	0.93	FALSE
1	CommonMind	Brain Pre-frontal Cortex	IQGAP1	0.19	0.21	lasso	5	0.20	1.7e-24	6.2	6.3	3.0e-10	0.94	0.01	0.99	FALSE
14	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IQGAP1	0.15	0.05	enet	10	0.08	2.5e-09	6.2	6.3	3.1e-10	0.88	0.01	0.99	FALSE
4	GTEx	Esophagus Mucosa	IQGAP1	0.26	0.19	enet	39	0.21	2.3e-14	6.8	6.3	3.5e-10	0.73	0.02	0.98	FALSE
21	The Cancer Genome Atlas	Thyroid Carcinoma	IQGAP1	0.06	0.04	blup	95	0.08	3.0e-08	6.8	6.2	4.9e-10	0.85	0.04	0.96	FALSE
7	GTEx	Stomach	IQGAP1	0.21	0.14	enet	17	0.18	8.3e-09	6.8	5.9	4.9e-09	0.86	0.04	0.96	FALSE
13	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	IQGAP1	0.15	0.09	lasso	4	0.12	1.9e-06	5.2	5.7	1.4e-08	0.81	0.12	0.86	FALSE
2	GTEx	Artery Aorta	IQGAP1	0.44	0.51	enet	27	0.51	5.3e-32	4.7	5.5	3.9e-08	0.69	1.00	0.00	FALSE
6	GTEx	Pituitary	IQGAP1	0.60	0.45	enet	26	0.52	3.7e-15	4.7	5.4	6.0e-08	0.67	0.95	0.05	FALSE
5	GTEx	Esophagus Muscularis	IQGAP1	0.24	0.14	enet	18	0.14	5.7e-09	4.7	5.3	9.1e-08	0.69	0.40	0.60	FALSE
16	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	IQGAP1	0.06	0.05	blup	94	0.04	2.6e-03	4.5	5.3	1.4e-07	0.71	0.12	0.56	FALSE
20	The Cancer Genome Atlas	Stomach Adenocarcinoma	IQGAP1	0.12	0.07	lasso	4	0.07	1.4e-05	5.3	5.3	1.4e-07	0.77	0.47	0.50	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IQGAP1	0.07	0.06	blup	94	0.07	9.5e-09	5.3	5.2	1.5e-07	0.70	0.96	0.04	FALSE