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chr16:10,325,245-12,138,068

Best TWAS P=8.18e-32 · Best GWAS P=1.82e-41 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Visceral Omentum	DEXI	0.17	0.02	enet	27	0.03	1.3e-02	10.84	7.5	9.1e-14	0.53	0.07	0.85	FALSE
2	GTEx	Adipose Visceral Omentum	RP11-876N24.5	0.11	0.08	lasso	2	0.10	6.0e-06	11.13	11.1	7.4e-29	0.68	0.06	0.92	FALSE
3	GTEx	Brain Putamen basal ganglia	RMI2	0.48	0.31	lasso	9	0.40	1.7e-10	2.97	6.2	5.7e-10	0.34	0.69	0.03	TRUE
4	GTEx	Breast Mammary Tissue	DEXI	0.12	0.07	enet	14	0.08	6.9e-05	10.23	9.8	7.7e-23	0.72	0.06	0.89	FALSE
5	GTEx	Breast Mammary Tissue	RP11-876N24.5	0.15	0.11	enet	19	0.12	1.4e-06	10.23	11.7	1.6e-31	0.73	0.28	0.70	TRUE
6	GTEx	Breast Mammary Tissue (Male)	DEXI	0.18	0.04	lasso	3	-0.01	4.9e-01	6.97	7.3	2.4e-13	0.63	0.03	0.64	FALSE
7	GTEx	Breast Mammary Tissue (Male)	RP11-876N24.5	0.16	0.24	lasso	2	0.21	1.5e-05	7.57	8.2	3.6e-16	0.36	0.07	0.22	FALSE
8	GTEx	Breast Mammary Tissue (Female)	DEXI	0.13	0.06	lasso	2	0.04	2.0e-02	11.31	11.3	1.6e-29	0.79	0.05	0.52	FALSE
9	GTEx	Breast Mammary Tissue (Female)	RP11-876N24.5	0.22	0.14	enet	11	0.13	1.0e-04	10.13	11.3	1.2e-29	0.77	0.14	0.75	TRUE
10	GTEx	Cells Transformed fibroblasts	DEXI	0.12	0.05	lasso	5	0.08	9.6e-07	6.57	9.1	1.2e-19	0.72	0.17	0.82	TRUE
11	GTEx	Cells Transformed fibroblasts	RP11-876N24.4	0.12	0.04	lasso	5	0.08	2.1e-06	6.57	9.1	8.4e-20	0.73	0.17	0.82	FALSE
12	GTEx	Nerve Tibial	DEXI	0.11	0.05	enet	7	0.07	1.7e-05	10.23	11.6	3.9e-31	0.81	0.64	0.28	FALSE
13	GTEx	Pancreas	DEXI	0.13	0.06	lasso	4	0.07	5.7e-04	8.71	8.9	3.9e-19	0.67	0.18	0.68	FALSE
14	GTEx	Pancreas	RP11-876N24.4	0.11	0.05	lasso	3	0.04	8.6e-03	8.71	8.9	3.6e-19	0.67	0.15	0.67	FALSE
15	GTEx	Skin Sun Exposed Lower leg	DEXI	0.05	0.06	lasso	2	0.03	7.8e-04	8.71	8.6	1.2e-17	0.65	0.70	0.21	FALSE
16	GTEx	Testis	CLEC16A	0.15	0.00	enet	20	0.01	1.2e-01	10.39	11.5	2.3e-30	0.71	0.02	0.92	FALSE
17	GTEx	Testis	DEXI	0.21	0.11	lasso	3	0.08	2.1e-04	11.24	9.9	5.1e-23	0.68	0.29	0.32	FALSE
18	GTEx	Testis	RP11-876N24.4	0.21	0.06	lasso	5	0.07	6.0e-04	11.24	10.6	3.1e-26	0.70	0.22	0.30	FALSE
19	GTEx	Thyroid	DEXI	0.08	0.00	enet	18	0.03	1.8e-03	8.71	7.5	7.6e-14	0.53	0.18	0.65	FALSE
20	GTEx	Thyroid	RP11-876N24.4	0.06	0.00	enet	17	0.02	1.5e-02	-2.56	6.2	5.7e-10	0.43	0.18	0.33	FALSE
21	GTEx	Thyroid	RP11-396B14.2	0.12	0.01	lasso	6	0.01	4.0e-02	11.16	-11.7	8.2e-32	-0.80	0.01	0.96	TRUE
22	ROSMAP	Brain Pre-frontal Cortex	DEXI	0.12	0.12	lasso	6	0.13	5.9e-16	8.26	9.3	2.1e-20	0.70	1.00	0.00	FALSE
23	YFS	Blood	CLEC16A	0.08	0.01	bslmm	627	0.03	1.2e-09	-0.94	-5.5	4.0e-08	-0.17	0.93	0.00	TRUE
24	YFS	Blood	DEXI	0.11	0.15	enet	29	0.16	2.6e-51	8.26	8.5	2.6e-17	0.66	1.00	0.00	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	DEXI	0.04	0.02	blup	49	0.04	8.6e-08	11.13	9.2	4.4e-20	0.66	0.03	0.97	TRUE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DEXI	0.05	0.02	lasso	4	0.03	1.7e-04	6.96	7.7	1.1e-14	0.64	0.02	0.84	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	DEXI	0.09	0.01	blup	49	0.07	8.8e-08	-2.30	5.9	4.8e-09	0.54	0.02	0.87	FALSE
28	The Cancer Genome Atlas	Thyroid Carcinoma	CLEC16A	0.14	0.06	lasso	4	0.09	6.8e-09	10.23	-8.0	1.8e-15	-0.63	0.22	0.78	FALSE