TWAS hub - ZNF774

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1970	0.0430	7.3e-14	0.080	0.136	0.119	NA	0.138	5.6e-10	3.4e-16	2.6e-14	NA	1.8e-16
2	GTEx	Adipose Subcutaneous	0.0960	0.0370	4.8e-04	0.013	NA	0.007	NA	0.017	2.6e-02	NA	7.4e-02	NA	1.3e-02
3	GTEx	Artery Aorta	0.2170	0.0590	4.2e-09	0.236	NA	0.229	NA	0.022	3.1e-13	NA	7.6e-13	NA	2.1e-02
4	GTEx	Artery Tibial	0.1199	0.0406	1.3e-04	0.024	NA	0.063	NA	0.061	4.8e-03	NA	1.1e-05	NA	1.6e-05
5	GTEx	Colon Transverse	0.2390	0.0820	7.0e-04	0.095	NA	0.050	NA	0.078	2.9e-05	NA	2.0e-03	NA	1.5e-04
6	GTEx	Esophagus Gastroesophageal Junction	0.1630	0.0720	3.1e-03	0.155	NA	0.040	NA	0.112	3.0e-06	NA	1.4e-02	NA	7.8e-05
7	GTEx	Esophagus Mucosa	0.2660	0.0570	1.4e-12	0.137	NA	0.218	NA	0.176	1.9e-09	NA	1.3e-14	NA	6.8e-12
8	GTEx	Esophagus Muscularis	0.1770	0.0510	7.1e-08	0.194	NA	0.137	NA	0.180	6.1e-12	NA	1.1e-08	NA	4.1e-11
9	GTEx	Lung	0.0609	0.0294	2.8e-03	0.091	NA	0.032	NA	0.010	2.0e-07	NA	1.5e-03	NA	5.6e-02
10	GTEx	Nerve Tibial	0.1974	0.0606	8.8e-08	0.066	NA	0.136	NA	0.113	1.8e-05	NA	7.6e-10	NA	2.2e-08
11	GTEx	Testis	0.1300	0.0510	3.7e-03	0.089	NA	0.055	NA	0.084	9.4e-05	NA	1.9e-03	NA	1.5e-04
12	GTEx	Thyroid	0.0910	0.0400	1.3e-03	0.060	NA	0.054	NA	-0.003	2.3e-05	NA	6.0e-05	NA	7.1e-01
13	TCGA	Head and Neck Squamous Cell Carcinoma	0.0400	0.0221	4.9e-04	0.018	0.023	0.022	NA	0.015	3.3e-03	1.2e-03	1.4e-03	NA	7.2e-03
14	TCGA	Kidney Renal Clear Cell Carcinoma	0.0362	0.0221	2.3e-03	0.000	0.006	0.007	NA	0.002	3.3e-01	6.8e-02	5.1e-02	NA	1.6e-01
15	TCGA	Brain Lower Grade Glioma	0.0551	0.0327	4.6e-05	0.055	0.038	0.039	NA	0.043	6.6e-07	3.2e-05	2.6e-05	NA	1.2e-05
16	TCGA	Lung Squamous Cell Carcinoma	0.0399	0.0251	4.7e-03	0.028	0.016	0.019	NA	0.016	3.3e-04	5.7e-03	2.7e-03	NA	5.5e-03
17	TCGA	Prostate Adenocarcinoma	0.1730	0.0619	1.5e-13	0.136	0.143	0.135	NA	0.131	5.0e-14	9.2e-15	5.6e-14	NA	1.3e-13

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17
Allergy or Eczema	13.1	34.6	85.6	4.3	-5.5	-7.8	-1.0	-5.6	-8.0	2.9	7.4	-6.2	-4.7	9.3	-6.8	5.1	-6.0	8.0	0.5	-0.3
Hayfever, allergic rhinitis or eczema	13.0	28.3	75.2	3.5	-5.4	-7.1	-1.1	-5.4	-7.2	2.3	6.5	-5.5	-4.5	8.7	-6.0	4.4	-5.2	7.2	0.2	-0.4
Heel T-Score	12.9	102.7	176.9	11.5	-7.4	-11.3	-2.0	-1.9	-13.3	9.8	11.8	-13.0	-8.4	9.2	-11.8	11.5	-10.9	12.9	8.5	7.7
Heel bone mineral density (BMD) T-score, automated (left)	9.7	22.1	37.1	5.0	-3.4	-5.8	0.9	-0.9	-6.1	4.3	5.7	-5.4	-3.9	5.2	-5.0	5.4	-5.9	6.0	3.6	2.4
Hair/balding pattern: Pattern 4	8.6	20.9	41.0	3.6	-3.3	-5.6	-0.1	-3.5	-6.4	2.7	5.6	-5.4	-4.0	5.7	-5.9	4.7	-5.4	6.0	2.6	1.6
Heel bone mineral density (BMD) T-score, automated (right)	8.3	19.1	32.1	4.7	-3.2	-5.3	0.4	-0.8	-5.7	4.2	5.3	-5.1	-3.3	4.4	-5.2	5.0	-5.3	5.5	3.3	2.4
Hayfever/allergic rhinitis (self-reported)	7.1	9.4	22.4	2.4	-2.9	-4.0	0.3	-2.5	-4.0	2.1	3.8	-3.0	-3.2	4.7	-2.6	3.2	-3.5	4.0	1.4	0.4
Allergy	6.3	14.4	43.8	-2.8	4.7	5.0	1.8	4.0	5.0	-1.6	-4.2	3.7	3.1	-6.6	3.6	-2.8	3.3	-5.1	0.1	0.2
Mouth/teeth dental problems: Mouth ulcers	5.2	8.2	13.5	3.6	-3.5	-3.1	-1.1	-0.2	-2.9	3.5	3.0	-2.8	-3.7	2.6	-1.5	3.4	-2.5	3.1	2.7	2.9
Supplements: Calcium	5.2	5.8	12.2	-2.5	1.2	3.2	-0.1	1.9	2.9	-1.3	-3.0	2.6	2.0	-2.5	2.6	-2.7	3.5	-2.8	-2.4	-1.1
Financial situation satisfaction	4.1	5.0	9.0	-2.9	3.0	1.7	2.3	0.7	2.0	-2.6	-2.0	2.3	2.3	-1.3	1.7	-2.6	1.7	-2.3	-2.6	-2.9
Falls in the last year	4.0	5.4	11.8	3.4	-2.2	-3.1	-0.6	0.3	-2.1	3.0	2.9	-1.8	-1.9	2.0	-3.4	2.9	-1.6	2.2	1.5	1.8
Birth weight of first child	3.9	7.0	16.2	1.5	-1.4	-3.6	0.1	-2.5	-4.0	0.9	3.4	-3.7	-3.0	3.3	-3.6	2.3	-1.5	3.7	-0.0	0.3
Comparative height size at age 10	3.9	21.7	42.8	-5.2	2.7	5.5	0.6	1.0	6.5	-4.2	-5.2	5.8	4.4	-5.8	3.4	-5.3	5.5	-6.3	-3.6	-2.9
Ever had hysterectomy (womb removed)	3.3	3.7	9.9	-1.2	0.7	3.1	-0.3	0.3	2.5	-1.4	-3.0	2.2	1.5	-1.8	3.0	-1.6	2.2	-2.5	-0.4	-0.2
Pack years of smoking	3.0	4.4	7.9	-2.2	0.7	2.1	0.5	0.3	2.5	-2.2	-2.7	2.5	0.3	-1.5	2.3	-2.7	2.8	-2.6	-2.5	-1.8
Rheumatoid Arthritis	2.9	4.0	9.4	-2.2	2.1	2.0	1.1	-0.4	1.7	-2.4	-1.9	1.5	3.1	-2.1	1.1	-2.5	2.0	-1.9	-2.2	-2.0
Supplements: Zinc	2.9	3.2	6.7	-2.2	1.5	2.4	-0.2	-0.3	2.0	-1.7	-2.2	2.1	1.5	-0.9	2.6	-2.0	1.8	-1.9	-1.6	-1.4
Number of incorrect matches in round	2.9	4.8	10.2	-2.9	1.4	2.1	0.6	-0.8	1.8	-3.2	-2.0	2.1	0.9	-0.5	1.8	-3.1	2.5	-2.0	-3.2	-3.2
Pain all over the body in last month	2.8	3.0	7.3	0.9	-0.1	-2.5	-0.9	-2.2	-2.7	0.1	2.0	-2.7	-2.1	2.0	-1.5	0.9	-1.2	2.6	-0.3	-0.4
Birth weight	2.8	6.2	12.0	3.0	-3.5	-2.4	-1.6	-1.2	-2.4	2.4	1.8	-2.3	-1.8	2.5	-2.4	3.3	-1.9	2.7	2.7	3.1
Pulse wave reflection index	2.7	3.3	9.2	2.0	-1.7	-2.0	-1.2	1.4	-1.1	2.1	1.6	-1.2	-1.4	0.2	-3.0	2.1	-2.4	1.4	2.3	2.0
Osteoporosis (self-reported)	2.7	3.3	9.4	-2.6	2.0	1.7	0.2	-0.8	1.3	-2.2	-1.5	1.4	0.3	-0.5	0.9	-2.5	2.2	-1.5	-3.1	-2.6
Verbal and Numeric Reasoning (VNR)	2.6	6.2	11.5	2.2	-1.5	-3.2	-1.3	-0.6	-3.1	2.6	3.4	-3.1	-1.9	2.4	-3.1	2.8	-2.6	3.1	1.7	1.4
Bilateral oophorectomy (both ovaries removed)	2.6	3.0	7.7	-1.9	0.6	2.3	-0.2	0.7	1.8	-1.5	-2.3	1.8	1.2	-1.5	2.8	-2.1	1.9	-1.9	-1.7	-1.1
Exposure to tobacco smoke at home	2.6	2.9	7.0	-1.7	1.1	1.0	1.5	-1.0	1.4	-2.1	-1.0	2.1	1.4	-0.6	2.7	-1.9	1.0	-1.4	-2.5	-2.6
Had major operations	2.6	3.1	6.6	-2.0	1.9	1.3	1.0	-1.1	1.8	-2.6	-1.2	1.4	0.6	-1.8	0.9	-2.3	1.9	-1.8	-2.3	-2.4
Gout (self-reported)	2.5	3.4	7.7	2.8	-1.5	-2.0	-0.6	-1.4	-2.0	2.4	2.0	-2.0	-1.1	1.8	-2.1	2.0	-1.9	2.0	1.5	1.2
Medication: Allopurinol	2.4	3.2	6.6	2.6	-1.4	-1.9	0.1	-0.8	-1.9	2.1	2.2	-1.9	-1.0	1.6	-2.3	2.1	-2.0	2.1	1.6	1.1
Fractured/broken bones in last 5 years	2.4	3.1	5.7	-1.7	1.7	1.3	0.4	-0.5	2.3	-2.2	-1.2	1.9	1.5	-1.6	1.4	-2.2	2.4	-2.3	-2.0	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.9	10.7	-1.7	2.3	2.6	1.4	-0.5	3.0	-2.0	-2.3	2.7	3.3	-2.9	1.0	-1.9	2.2	-2.9	-1.2	-1.3
Pack years adult smoking proportion	2.2	3.4	6.2	-1.8	0.4	1.9	0.4	0.7	2.4	-1.7	-2.4	2.3	-0.0	-1.5	2.0	-2.2	2.5	-2.5	-2.1	-1.4
Medication: Lansoprazole	2.2	2.5	6.7	-1.3	2.4	1.1	1.1	-0.1	1.0	-1.6	-0.8	1.5	1.3	-0.9	1.6	-1.9	1.2	-1.4	-2.5	-2.6
Illnesses of siblings: Diabetes	2.2	2.7	6.6	-1.5	1.2	1.5	-1.1	-0.7	1.8	-2.1	-1.5	1.2	0.4	-0.8	1.4	-2.6	2.2	-1.8	-2.3	-2.2
Mouth/teeth dental problems: Loose teeth	2.1	2.5	5.3	1.5	-2.1	-1.5	0.4	1.1	-1.6	2.0	1.3	-1.2	-1.7	1.6	-1.3	2.3	-1.7	1.5	1.7	1.6
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	6.1	1.5	0.1	-2.1	0.2	-0.3	-1.8	1.0	2.1	-2.2	-1.2	1.0	-2.5	1.5	-1.2	1.8	0.6	0.7
Vitamin and mineral supplements	2.0	2.8	5.3	1.8	-0.9	-2.0	0.3	-1.5	-2.1	0.9	2.3	-2.2	-2.1	1.4	-2.0	1.6	-2.1	1.7	1.0	0.5
Multivitamins +/- minerals	2.0	2.6	5.2	-1.5	2.3	2.1	-0.1	-0.4	1.3	-1.7	-2.0	1.2	2.0	-1.3	1.5	-2.1	2.3	-1.4	-1.4	-1.0
Average weekly red wine intake	2.0	3.0	6.7	2.0	-1.9	-1.9	-0.4	0.4	-1.6	1.6	1.4	-1.9	-1.7	0.3	-0.3	2.5	-1.9	1.6	2.6	2.5
Systolic blood pressure, automated reading	1.9	5.4	10.8	-2.3	1.5	3.3	-0.5	1.1	2.9	-1.7	-3.2	2.1	0.4	-3.2	2.7	-2.8	3.3	-2.8	-1.2	-0.5
Diverticular disease/diverticulitis (self-reported)	1.9	2.3	5.4	1.9	-2.3	-1.0	-2.3	-0.5	-1.2	2.0	0.8	-1.5	-1.7	1.5	-0.9	1.4	-1.0	1.3	1.4	1.5
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	6.4	0.7	-1.1	-1.7	-1.6	-1.0	-2.1	0.8	1.9	-2.0	-1.5	2.5	-1.1	1.0	-1.3	2.1	-0.1	0.0
Osteoarthritis (self-reported)	1.9	2.4	11.3	-0.8	1.5	2.0	1.6	-0.9	1.5	-1.5	-1.8	1.8	3.4	-1.2	1.7	-1.1	0.7	-1.5	-0.5	-0.7
Neck or shoulder pain in last month	1.8	2.5	5.5	-1.8	0.8	1.6	1.4	2.0	1.8	-0.9	-2.3	2.4	1.4	-1.1	1.7	-1.5	1.6	-1.9	-1.0	-0.6
Medication: Co-codamol	1.7	1.9	3.3	-1.1	1.4	1.5	1.1	-0.2	1.4	-1.2	-0.8	1.5	1.6	-1.3	1.0	-1.8	1.5	-1.7	-1.7	-1.7
Mouth/teeth dental problems	1.7	2.6	6.2	-1.6	2.1	2.1	0.6	1.2	1.8	-1.3	-2.0	1.4	1.5	-2.5	1.6	-1.7	1.6	-1.9	-0.8	-0.5
Lung cancer (father)	1.7	2.0	3.7	1.3	-1.1	-1.5	0.3	-0.1	-1.9	1.5	1.1	-1.8	-1.9	1.3	-0.8	1.6	-1.7	1.9	1.5	1.3
Standing height	1.7	17.2	40.8	-4.7	1.5	4.9	0.2	1.5	6.4	-3.7	-5.0	5.8	3.5	-4.4	2.0	-4.3	4.8	-6.1	-3.0	-2.4
Emphysema/chronic bronchitis	1.7	1.9	7.8	0.1	0.0	1.5	0.3	1.2	1.9	-0.5	-1.7	1.5	1.4	-1.9	2.8	-0.9	1.4	-1.8	-0.2	0.4
Major Depression (MDD)	1.6	1.9	8.6	0.9	-0.1	0.9	-1.3	2.9	1.6	1.2	-1.1	0.3	0.5	-2.3	0.7	0.0	1.3	-1.2	1.3	1.9
Trunk fat-free mass	1.6	9.3	17.9	-3.3	3.0	3.6	0.6	1.4	4.2	-2.8	-3.6	3.8	3.0	-3.4	2.0	-3.1	3.2	-4.2	-2.1	-1.8
Trunk predicted mass	1.6	9.2	17.8	-3.3	3.0	3.6	0.5	1.4	4.1	-2.8	-3.6	3.7	3.0	-3.4	2.0	-3.1	3.3	-4.2	-2.1	-1.8
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.8	5.1	-1.3	0.4	-0.0	0.2	-1.9	1.3	-1.9	-0.4	1.9	1.4	0.4	1.3	-1.3	0.8	-1.2	-1.7	-2.3
Ulcerative Colitis (UC)	1.5	2.8	9.2	-1.5	3.0	2.0	1.7	-0.1	1.4	-2.2	-1.7	0.9	0.4	-2.5	1.9	-1.6	1.3	-1.9	-0.7	-1.1
Breast Cancer	1.5	3.6	7.0	1.7	-1.2	-2.6	-1.7	-1.5	-2.1	1.7	2.6	-2.3	-2.4	1.8	-2.0	1.8	-1.3	2.2	1.2	0.9
Blood White Count	1.5	11.2	25.8	-3.3	5.1	2.5	3.2	-0.7	3.0	-3.7	-2.1	2.3	3.4	-4.6	2.7	-3.9	3.8	-3.6	-3.6	-3.1
Had menopause	1.5	1.9	3.5	1.2	-1.1	-1.2	-0.2	0.4	-1.4	1.9	0.8	-1.7	-1.9	0.4	-0.2	1.7	-1.6	1.7	1.9	1.8
Tense / ‘highly strung’	1.5	2.4	7.5	-1.6	0.9	1.9	-1.7	-0.4	1.5	-1.4	-1.8	1.2	0.1	-1.1	1.1	-2.3	2.7	-1.6	-1.9	-1.2
Migraine (self-reported)	1.5	1.9	4.9	-1.2	0.6	1.6	0.8	1.1	2.1	-1.0	-1.3	2.2	0.7	-0.9	0.8	-1.5	1.5	-2.1	-1.3	-1.3
Height	1.4	27.3	61.2	-5.7	2.5	6.5	-0.3	2.0	7.8	-4.7	-6.5	7.0	3.9	-5.6	2.5	-5.7	6.3	-7.5	-3.8	-2.9
Forced vital capacity (FVC)	1.4	5.3	10.0	-3.2	1.6	2.5	0.5	-0.8	2.6	-2.7	-1.8	2.5	2.7	-2.2	1.0	-2.9	2.2	-2.6	-2.7	-2.6
Hair/balding pattern: Pattern 3	1.4	2.0	6.5	0.9	-1.3	-1.8	0.5	-0.6	-1.6	0.7	1.9	-0.6	-0.4	2.6	-1.5	1.7	-2.3	1.8	0.6	-0.3
Illnesses of mother	1.4	1.7	5.3	1.6	-0.7	-1.2	1.4	0.6	-0.9	1.6	1.2	-0.8	0.1	0.6	-1.1	1.9	-2.3	1.0	1.9	1.3
Family relationship satisfaction	1.4	1.7	5.9	-1.0	2.4	1.0	1.5	0.0	1.6	-1.5	-0.8	1.2	1.4	-1.4	0.8	-1.1	0.8	-1.8	-0.6	-1.5
Ever had bowel cancer screening	1.4	1.7	5.2	1.4	-0.9	-0.8	-2.3	1.4	-0.9	1.9	0.2	-1.6	-1.6	0.0	0.0	1.1	-0.4	1.0	1.5	1.9
Intelligence (Savage-Jansen 2018)	1.3	4.1	8.0	1.6	-0.9	-2.7	-0.4	0.1	-2.5	2.0	2.8	-2.5	-2.0	1.8	-2.5	2.3	-2.7	2.6	1.1	0.7
Diabetes (mother)	1.3	1.6	4.5	-1.1	0.8	0.8	-0.2	-2.1	1.0	-1.8	-0.8	0.9	0.5	-0.3	1.8	-1.5	1.7	-1.2	-1.4	-1.5
Hand grip strength (right)	1.3	3.5	11.0	-0.8	0.6	2.1	-0.8	3.3	2.9	0.3	-2.0	1.6	1.4	-3.1	1.6	-0.9	1.8	-2.7	0.6	1.2
Hip circumference	1.3	5.5	17.5	-2.2	4.2	2.1	2.3	1.6	2.5	-2.4	-2.2	2.2	2.4	-2.6	2.6	-2.0	1.4	-2.8	-1.0	-1.7
Chest pain or discomfort	1.3	1.9	6.4	1.2	-1.3	-2.5	0.0	0.6	-1.4	1.1	1.6	-1.2	-1.5	1.8	-1.9	1.6	-1.1	1.6	0.6	0.6
Whole body fat-free mass	1.3	7.5	14.1	-2.9	2.9	3.2	0.9	1.4	3.7	-2.5	-3.2	3.3	2.7	-3.2	2.0	-2.8	2.8	-3.8	-1.8	-1.7
Whole body water mass	1.3	7.5	13.9	-3.0	2.9	3.1	0.9	1.2	3.7	-2.5	-3.2	3.3	2.7	-3.1	2.0	-2.8	2.9	-3.7	-1.8	-1.7
Basal metabolic rate	1.3	7.0	12.7	-2.8	3.1	3.0	1.2	1.3	3.5	-2.4	-3.0	3.2	2.7	-2.9	2.1	-2.6	2.6	-3.6	-1.7	-1.7
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.4	-0.9	1.6	1.0	1.2	1.3	1.7	-0.8	-1.2	1.4	1.9	-1.5	0.9	-0.8	1.0	-1.6	-0.3	-0.2
Body Mass Index (BMI) (2010)	1.2	1.6	5.0	-1.9	0.8	0.4	0.2	0.3	1.1	-1.6	-0.7	1.3	0.8	-0.0	1.1	-1.8	1.2	-1.0	-2.2	-2.1
Chronotype (morning person)	1.2	2.7	6.8	1.2	-1.4	-1.9	1.2	0.7	-2.1	1.4	1.7	-1.2	-0.6	1.9	-2.6	1.7	-2.6	2.0	1.2	0.7
Hearing difficulty/problems: Yes	1.2	1.8	3.3	-1.6	1.7	1.0	1.2	0.1	1.1	-1.8	-0.8	0.7	0.6	-1.3	1.5	-1.6	1.3	-1.3	-1.8	-1.8
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	5.0	-0.3	-1.8	-1.2	-0.8	2.0	-1.1	0.9	0.4	-0.5	0.0	2.2	-1.0	0.8	-0.8	1.5	0.3	0.3
Stomach or abdominal pain in last month	1.2	1.5	3.5	-1.1	1.7	1.1	0.7	-0.0	1.2	-1.4	-0.7	1.4	1.9	-0.5	1.2	-1.3	0.9	-1.3	-1.1	-1.6
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	4.8	-0.8	1.7	-0.2	2.1	-1.6	-0.5	-1.7	0.4	0.0	1.6	0.1	-0.6	-0.9	0.5	-0.0	-1.8	-2.2
Forced expiratory volume in 1-second (FEV1)	1.2	3.9	7.7	-2.8	1.3	2.2	-0.2	-0.5	2.2	-2.2	-1.4	2.0	2.4	-1.9	0.6	-2.5	2.1	-2.1	-2.4	-2.3
Peak expiratory flow (PEF)	1.2	2.7	4.9	-2.0	1.1	1.8	-0.3	0.6	2.2	-1.4	-1.1	1.7	2.0	-2.0	0.5	-1.9	2.2	-2.0	-1.7	-1.4
Shortness of breath walking on level ground	1.2	1.4	3.6	-0.4	1.1	1.1	-0.7	1.0	1.6	-0.7	-1.7	1.3	0.2	-1.0	1.9	-1.2	1.9	-1.6	-0.4	0.3
Eye problems/disorders: Cataract	1.2	1.4	5.8	-0.8	1.9	1.3	0.6	-0.5	0.7	-1.5	-1.0	0.7	2.4	-1.3	0.4	-1.4	1.1	-0.8	-0.9	-0.7
Mineral and other dietary supplements	1.2	1.6	3.7	0.9	-0.4	-1.4	0.7	-1.7	-1.8	0.1	1.9	-1.9	-1.4	1.3	-1.4	0.4	-0.9	1.5	-0.8	-0.7
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.9	-1.0	0.6	1.2	0.0	-0.0	1.7	-1.4	-1.0	1.3	0.7	-0.8	1.3	-1.4	1.6	-1.6	-1.4	-1.4
Alcohol drinker status: Never	1.2	1.5	3.4	1.0	-1.8	-0.9	-1.8	1.0	-1.1	1.8	0.6	-1.3	-0.9	1.2	-0.5	1.2	-1.3	1.2	1.2	1.0
Arm fat-free mass (left)	1.2	6.0	12.0	-2.5	2.4	3.0	0.3	1.1	3.5	-2.2	-3.0	3.0	2.4	-2.6	2.0	-2.5	2.6	-3.4	-1.4	-1.4
Number of operations (self-reported)	1.2	1.8	5.6	-0.9	1.5	1.0	-1.8	-0.1	1.3	-0.9	-1.6	0.2	-0.9	-1.7	2.4	-1.5	1.8	-1.2	-0.9	-0.5
Commuting to job workplace: Cycle	1.2	1.4	5.0	-1.0	2.2	-0.1	2.0	-1.2	-0.1	-1.6	0.2	0.3	2.2	0.0	-0.2	-0.8	-0.3	-0.1	-1.3	-1.7
Type 2 Diabetes (T2D) (2012)	1.1	1.3	2.5	-1.3	0.6	1.1	-0.2	0.4	1.3	-1.4	-1.5	0.9	0.7	-0.8	1.4	-1.6	1.3	-1.2	-1.1	-1.2
Ulcerative Colitis	1.1	1.6	5.1	-1.0	1.6	1.7	0.5	-0.3	1.4	-1.2	-1.8	0.7	0.2	-2.2	1.8	-1.0	0.9	-1.7	0.4	0.1
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.3	-1.2	1.4	1.5	0.2	-0.3	1.4	-1.3	-1.8	1.6	1.0	-0.8	1.7	-1.2	0.7	-1.4	-0.2	-0.7
Leg fat-free mass (left)	1.1	6.0	10.4	-2.6	2.9	2.7	1.6	1.2	3.2	-2.2	-2.7	3.0	2.6	-2.6	2.1	-2.3	2.2	-3.2	-1.6	-1.7
Leg predicted mass (left)	1.1	6.1	10.6	-2.6	2.8	2.7	1.5	1.2	3.2	-2.2	-2.8	3.1	2.6	-2.6	2.1	-2.4	2.2	-3.3	-1.6	-1.7
Qualifications: College or University degree	1.1	3.5	7.3	1.1	-1.7	-2.5	-0.6	-0.9	-2.4	1.4	2.7	-2.1	-0.8	2.4	-2.6	2.0	-2.1	2.5	0.8	0.4
Arm predicted mass (right)	1.1	5.8	12.0	-2.4	2.2	2.9	0.4	2.0	3.5	-1.6	-3.0	2.9	2.4	-3.0	2.0	-2.2	2.3	-3.5	-1.0	-0.9
Leg fat-free mass (right)	1.1	5.9	9.6	-2.6	2.8	2.6	1.6	1.2	3.0	-2.1	-2.6	2.9	2.6	-2.7	2.1	-2.4	2.2	-3.1	-1.8	-1.8
Mood swings	1.1	1.9	4.6	-1.6	1.2	1.3	-1.0	0.8	1.4	-1.3	-1.6	1.4	-0.2	-0.4	1.0	-1.9	1.8	-1.4	-2.1	-1.8
Leg predicted mass (right)	1.1	5.8	9.5	-2.6	2.8	2.5	1.7	1.2	3.0	-2.1	-2.6	2.9	2.7	-2.7	2.0	-2.4	2.2	-3.1	-1.8	-1.8
Arm predicted mass (left)	1.1	5.7	11.6	-2.3	2.5	2.9	0.3	1.3	3.4	-1.9	-3.0	2.8	2.2	-2.8	2.0	-2.3	2.5	-3.4	-1.2	-1.1
Systolic Blood Pressure	1.0	4.9	16.3	-1.8	2.3	3.2	-0.7	1.1	2.6	-1.0	-2.7	1.5	-0.2	-4.0	1.9	-2.5	3.4	-2.7	-1.0	-0.0
Hand grip strength (left)	1.0	2.7	7.7	-0.6	0.3	2.0	-0.7	2.1	2.7	0.1	-1.4	1.7	1.9	-2.8	1.1	-0.8	1.7	-2.6	0.5	0.9
Hearing difficulty/problems with background noise	1.0	1.5	5.3	-1.7	1.1	0.5	-0.0	0.9	1.0	-1.0	-0.4	0.6	0.2	-1.5	1.1	-1.7	1.6	-1.2	-2.3	-1.8
Fluid intelligence score	1.0	2.1	6.1	1.1	-0.6	-1.8	-0.3	-0.5	-1.9	1.6	2.5	-2.0	-0.9	1.0	-1.5	1.6	-1.5	1.7	1.1	0.9
Pulse rate	1.0	1.6	4.3	-1.1	0.8	1.9	-0.8	-0.1	1.5	-1.1	-1.4	0.9	0.2	-1.2	1.8	-1.5	2.1	-1.7	-0.8	-0.4
Prospective memory result	1.0	1.2	5.1	0.9	-0.5	-0.8	-1.1	1.3	-1.4	1.0	0.4	-2.3	-1.5	-0.1	-1.3	0.5	0.4	1.4	-0.1	1.0
Cholesterol lowering medication	1.0	1.5	4.0	-1.5	0.7	1.3	-1.2	2.0	1.0	-0.7	-1.2	1.3	-0.2	0.3	1.8	-1.3	0.7	-1.0	-1.6	-1.5
Alzheimer’s Disease (in mother)	0.9	1.1	4.9	-0.7	2.2	0.7	1.4	-1.3	0.1	-1.6	-0.4	0.6	1.2	-0.3	0.6	-0.8	0.4	-0.3	-0.9	-1.3
Prostate Cancer	0.9	1.3	4.5	1.8	-0.8	-0.8	0.5	-0.7	-0.5	1.5	0.9	-1.0	0.1	-0.2	-1.0	1.5	-0.8	0.6	2.1	2.1
Medication for hormone replacement therapy	0.9	1.0	2.9	-1.3	1.3	1.0	1.3	1.7	0.7	-0.5	-1.3	0.8	0.7	-1.1	0.2	-0.9	0.6	-0.7	-0.9	-0.8
Supplements: Glucosamine	0.9	1.2	4.7	1.1	-1.1	-0.4	-1.2	0.8	-0.0	1.6	-0.4	0.1	0.7	0.2	-0.3	1.5	-0.7	0.2	2.2	2.1
Had other major operations	0.9	1.1	4.2	-0.4	1.2	1.1	-1.6	-0.7	0.8	-0.9	-1.1	0.2	-0.2	-0.5	2.0	-1.2	1.3	-0.8	-0.8	-0.6
Time employed in main current job	0.9	1.0	4.8	-1.2	2.2	1.2	1.1	-0.7	0.6	-1.0	-0.8	0.5	1.1	-1.0	0.4	-0.8	0.7	-0.7	-0.8	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.5	0.7	-1.5	-1.4	-0.5	-0.3	-0.9	1.0	1.0	-0.8	-1.6	1.0	-1.5	1.0	-1.1	1.1	0.7	0.7
Mean time to correctly identify matches	0.9	1.7	4.8	1.2	-2.2	-0.8	-1.2	0.9	-0.9	1.5	0.0	-0.7	-1.8	1.9	-0.2	1.6	-1.2	1.2	1.5	1.4
Leg pain on walking	0.9	1.1	4.0	0.5	0.0	-1.6	-0.4	-1.1	-1.1	0.2	1.5	-1.0	-2.0	1.1	-1.7	0.7	-0.8	1.0	0.1	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	5.5	0.2	0.6	0.9	0.5	1.2	1.1	0.8	-1.4	1.0	0.0	-0.9	2.3	0.1	-0.1	-1.2	1.3	0.6
Medication: Bendroflumethiazide	0.9	1.4	3.0	-1.0	1.6	1.2	-0.0	0.5	1.2	-0.7	-0.9	1.0	-0.0	-1.4	1.5	-1.4	1.7	-1.3	-1.6	-1.2
Unable to work because of sickness or disability	0.9	1.1	4.3	-0.9	1.3	-0.2	0.9	-1.3	-0.2	-1.7	0.0	-0.3	0.1	-0.1	0.8	-1.3	0.8	-0.2	-2.1	-1.8
Bipolar Disorder (2018)	0.8	1.3	3.1	1.6	-0.4	-0.6	-0.6	0.9	-0.9	1.8	0.3	-1.5	-1.0	0.1	0.5	1.6	-1.0	1.0	1.6	1.7
Triglycerides	0.8	1.4	4.2	0.4	0.5	-1.5	0.5	0.0	-1.9	0.9	1.4	-2.0	-0.7	1.0	-1.3	1.0	-1.4	2.0	-0.3	-0.2
High blood pressure (mother)	0.8	1.2	5.0	-1.3	0.3	0.7	-1.8	0.8	0.8	-0.4	-0.8	0.1	-1.0	-1.4	0.4	-1.3	2.2	-0.9	-1.3	-0.2
Qualifications: None of the above	0.8	1.8	5.3	-1.0	0.5	1.4	-0.2	2.3	1.5	-0.3	-1.9	0.9	-0.3	-2.1	1.5	-1.6	1.8	-1.4	-1.0	-0.0
Medication: Ramipril	0.8	1.1	8.4	-0.7	2.9	0.9	1.5	-1.0	-0.2	-1.1	-0.7	-0.3	0.2	-0.9	0.3	-0.6	0.8	-0.3	-0.5	-0.8
Weight	0.8	4.0	8.6	-2.0	2.9	2.0	1.5	1.1	2.6	-2.0	-2.2	2.4	2.0	-1.8	1.9	-1.7	1.6	-2.7	-1.1	-1.5
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.6	1.1	-0.8	-1.1	-0.2	0.3	-0.6	0.8	0.5	-0.4	-1.6	0.5	-1.6	1.4	-0.9	0.7	1.4	1.5
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	2.9	0.6	-0.6	-1.6	0.4	-0.4	-1.7	1.2	1.2	-1.6	-0.2	1.2	-1.0	1.3	-1.1	1.7	0.4	0.5
Arm fat-free mass (right)	0.8	4.1	8.4	-2.1	2.0	2.4	0.2	1.5	2.9	-1.4	-2.5	2.4	2.0	-2.6	1.5	-1.9	2.1	-2.9	-1.0	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	3.0	-1.3	0.4	1.5	0.4	-0.4	0.5	-1.7	-0.9	0.5	0.6	-0.5	1.0	-1.3	0.8	-0.5	-1.2	-1.3
Pulse wave peak to peak time	0.8	0.9	4.4	-1.2	0.2	0.6	0.2	0.0	0.3	-1.0	-0.5	0.3	1.0	-0.2	1.2	-1.2	1.5	-0.3	-2.1	-1.3
Supplements: Vitamin C	0.8	1.0	2.6	-1.6	-0.1	0.3	-0.7	0.9	1.0	-0.8	-1.0	1.2	1.3	-0.9	1.1	-0.9	1.3	-0.8	-1.2	-0.4
Medication for cholesterol	0.8	1.2	2.1	1.4	-1.0	-1.2	0.2	-1.3	-1.1	0.8	1.4	-1.3	-0.3	0.5	-1.1	1.2	-0.7	1.1	1.4	1.3
Wears glasses or contact lenses	0.8	0.9	4.4	0.7	-1.0	-0.8	-1.5	-0.6	-0.7	0.5	0.2	-1.1	-2.1	1.0	-0.7	0.9	-0.1	1.0	0.7	0.8
Medication: Blood pressure	0.8	1.4	2.7	-1.3	1.4	1.3	-0.0	1.2	1.1	-0.6	-1.4	0.9	-0.1	-1.2	1.5	-1.5	1.6	-1.2	-1.6	-1.1
Supplements: Fish oil (including cod liver oil)	0.8	1.1	3.2	-1.1	0.8	1.4	-0.7	0.7	1.2	-0.6	-1.8	1.2	1.2	-1.3	1.2	-0.8	1.0	-1.1	0.6	0.4
Myopia	0.8	1.2	3.6	0.7	-0.8	-1.3	-1.0	-0.2	-1.1	0.7	0.8	-1.0	-1.1	1.5	-0.6	1.4	-1.9	1.1	1.3	0.6
Crohns Disease (2017)	0.7	1.5	7.7	1.0	-0.7	-0.8	0.1	0.1	-1.6	0.8	0.9	-1.8	-2.8	0.7	-1.5	1.2	-0.9	1.4	1.1	0.8
HDL Cholesterol	0.7	1.1	3.6	0.0	-0.2	1.4	-0.3	1.0	1.7	-0.0	-1.4	1.2	0.0	-1.9	0.6	-0.5	1.2	-1.8	0.5	0.9
Lupus	0.7	1.1	2.4	1.0	-0.9	-1.4	-1.1	-1.1	-1.2	1.2	0.8	-1.5	-1.3	0.2	-1.3	0.7	0.1	1.4	0.1	0.9
Respiratory disease	0.7	1.6	5.5	-1.0	0.9	1.1	0.2	-0.8	0.6	-1.7	-1.2	0.8	1.5	-0.3	0.4	-1.9	1.7	-0.8	-2.4	-1.7
Taking other prescription medications	0.7	1.0	3.9	-0.6	2.0	0.3	2.0	-0.4	0.4	-1.3	-0.1	0.7	0.1	0.2	1.2	-0.6	0.5	-0.7	-1.3	-1.6
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.5	-0.2	0.1	1.0	-0.3	-0.8	1.1	-1.2	-0.9	1.6	1.2	0.4	-0.0	-0.9	0.8	-1.2	-0.9	-1.2
Number of full brothers	0.7	0.9	2.9	0.8	-1.7	-0.3	-1.4	0.8	-1.0	1.2	0.2	-1.1	-0.5	1.2	-0.2	0.7	-0.2	1.2	0.4	1.1
Number of children fathered	0.7	0.8	2.3	1.1	-0.8	-0.6	-0.1	-0.8	-0.6	0.8	0.7	-0.6	0.6	0.5	-0.9	1.2	-1.1	0.8	1.5	1.1
Medication: Seretide 50 evohaler	0.7	0.8	3.8	-0.3	-0.8	0.5	-1.4	1.0	1.1	0.2	-0.7	0.3	-0.4	-1.2	0.3	-0.8	2.0	-0.9	-0.8	0.5
Suffer from ‘nerves’	0.7	1.0	2.6	0.6	-1.4	-1.0	-1.2	0.1	-1.5	1.1	1.0	-1.6	-1.0	0.6	-0.8	0.8	-0.4	1.6	0.2	0.7
Age at last live birth	0.7	1.0	3.4	-1.8	1.1	-0.3	1.5	-0.2	0.2	-1.5	-0.3	1.1	1.2	0.8	0.1	-0.7	-0.4	-0.3	-1.0	-1.6
Illnesses of father: Heart disease	0.7	1.0	3.4	0.2	-1.5	-1.3	-1.8	-1.4	-0.9	0.3	0.6	-1.0	-1.6	1.1	0.0	0.4	-0.1	1.0	0.1	0.3
Smoking status: Current	0.7	1.1	3.4	-0.6	1.4	0.6	0.6	-0.4	1.0	-1.5	-0.5	1.1	1.4	-0.2	0.7	-1.1	0.7	-1.2	-1.4	-1.9
Number of self-reported non-cancer illnesses	0.7	1.3	4.0	-1.0	1.2	0.1	0.6	-1.0	0.3	-1.8	-0.6	0.5	-0.4	0.6	1.4	-1.4	1.1	-0.4	-2.0	-1.9
Hearing aid user	0.7	0.8	3.3	-0.7	-0.1	0.8	-0.2	1.1	1.4	-0.1	-0.9	1.0	0.3	-1.8	1.0	-0.6	1.1	-1.3	-0.2	0.3
Mother’s age at death	0.7	0.9	4.4	0.3	-2.1	-0.8	-1.6	0.7	-0.3	0.8	-0.1	-0.3	-0.9	1.6	-0.2	0.8	-1.0	0.6	1.1	0.8
Commuting to job workplace: Public transport	0.7	0.9	6.8	1.1	-0.2	-0.5	-0.4	1.1	-0.5	1.0	0.6	-0.9	-2.6	0.3	-0.5	0.8	-0.3	0.5	0.6	0.8
Illnesses of father: High blood pressure	0.7	0.9	3.4	0.8	-0.5	-0.7	0.5	-0.4	-0.9	1.0	1.6	-1.0	-1.4	-0.1	-1.8	1.1	-0.7	0.5	0.4	0.4
Risk taking	0.7	1.1	4.3	-0.1	-0.1	-1.0	0.2	-2.1	-1.4	-0.0	1.6	-1.1	-0.5	1.6	-1.2	0.2	-0.7	1.2	-0.7	-0.9
Age started oral contraceptive pill	0.7	0.9	3.3	0.6	-1.0	-0.7	-1.7	0.7	-0.8	1.0	0.6	-0.6	-1.8	1.3	-0.9	0.6	-0.3	1.0	-0.1	0.3
Basal cell carcinoma (self-reported)	0.7	0.8	2.3	-0.4	0.6	0.5	0.0	1.0	1.1	-0.1	-0.8	1.0	0.1	-1.5	1.5	-1.0	1.5	-1.1	-0.6	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	5.2	-0.4	0.2	1.2	-0.4	0.0	1.2	-0.8	-1.2	1.3	0.0	-0.5	2.3	-1.0	0.7	-1.2	-0.3	-0.3
Alzheimer’s Disease (including proxy)	0.6	0.9	4.3	-0.4	2.1	0.3	1.8	-0.3	-0.5	-1.3	0.3	0.1	0.8	0.4	-0.5	-0.3	-0.7	0.3	-0.7	-1.5
Bipolar Disorder (2011)	0.6	0.6	1.8	0.3	-0.2	-0.7	-0.8	-0.6	-1.1	0.1	1.1	-1.1	-0.9	0.8	-1.4	0.2	0.0	0.9	-0.6	-0.3
Fasting Glucose	0.6	0.7	2.2	-1.1	1.4	0.9	-0.0	-0.4	0.5	-0.6	-1.2	0.8	1.5	0.3	1.5	-0.7	0.0	-0.4	-0.4	-0.6
Neuroticism (2016)	0.6	0.9	2.6	0.9	-0.9	-0.9	-0.0	-1.4	-1.6	0.2	1.0	-1.1	-0.6	1.3	-0.8	0.7	-0.4	1.6	0.1	0.2
Hypothyroidism (self reported)	0.6	1.4	3.5	1.4	0.5	-1.3	1.6	0.7	-1.1	0.8	1.9	-0.6	-0.2	1.1	-1.4	1.6	-1.8	1.0	0.8	0.2
Number of treatments/medications taken	0.6	1.1	3.3	-1.1	1.0	0.8	0.3	-0.4	0.5	-1.1	-0.8	0.7	0.4	0.1	1.7	-1.4	1.3	-0.8	-1.8	-1.6
Diabetes (father)	0.6	0.7	3.0	-0.3	0.3	-0.3	-0.1	-1.4	-0.6	-0.6	1.2	-0.5	0.5	0.4	-1.2	-0.6	-0.1	0.4	-1.6	-1.7
Waist circumference	0.6	2.4	5.3	-1.6	2.3	1.3	1.2	0.6	1.8	-1.9	-1.7	1.7	1.5	-0.8	1.8	-1.3	1.4	-1.8	-1.0	-1.3
Hair/balding pattern: Pattern 2	0.6	0.8	4.6	-0.3	-1.1	0.6	-1.5	2.1	0.9	0.7	-0.9	0.7	0.4	-0.5	0.3	-0.5	0.6	-0.6	-0.1	0.6
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.2	0.3	-0.5	-0.7	-1.0	-1.8	-0.9	-0.1	1.0	-1.0	-0.1	1.1	-1.4	-0.1	0.1	0.8	-0.8	-0.7
Blood clot in the leg (DVT)	0.6	0.7	5.1	-0.1	-0.2	1.0	-0.5	0.5	1.0	-0.2	-1.1	1.2	-0.2	-0.5	2.3	-0.6	0.5	-1.0	0.1	0.1
Comparative body size at age 10	0.6	1.6	3.7	1.1	1.5	-1.0	1.7	-1.4	-1.9	0.3	1.4	-1.5	-0.2	0.8	0.7	1.1	-1.9	1.4	1.2	0.1
Health satisfaction	0.6	0.7	2.3	-0.8	0.9	0.1	-1.1	-0.6	0.3	-1.0	-0.5	0.4	-0.4	0.7	0.7	-1.2	1.4	-0.4	-1.5	-1.1
Medication: Omeprazole	0.6	0.7	2.7	-0.3	0.2	1.2	-0.5	1.7	0.9	0.2	-1.0	0.4	0.8	-1.2	1.4	-0.4	1.1	-0.6	-0.0	0.6
Knee pain experienced in last month	0.6	1.0	3.5	-0.6	1.8	1.5	0.6	1.2	0.8	0.1	-1.4	0.5	0.9	-1.9	0.7	-0.8	0.6	-0.9	-0.3	0.1
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.8	1.3	-0.1	-0.5	-0.9	1.0	-0.6	1.1	0.7	-1.2	-0.6	0.3	-1.2	0.8	-0.8	0.5	1.0	1.0
Diastolic blood pressure, automated reading	0.6	1.8	4.0	-1.0	0.7	2.0	-1.4	0.3	1.8	-0.8	-1.7	1.0	-0.2	-1.9	1.7	-1.4	2.0	-1.7	-0.2	0.0
Schizophrenia (2018)	0.5	1.1	2.4	-0.9	0.0	1.2	0.1	0.9	1.5	-0.7	-1.1	1.3	-0.3	-0.3	1.0	-1.3	1.0	-1.4	-1.4	-1.4
Alzheimer’s Disease (in father)	0.5	0.5	1.9	-0.5	1.4	0.3	1.1	0.8	-0.3	-0.9	0.2	-0.2	0.3	0.2	-0.7	-0.4	-0.4	0.1	-0.9	-1.3
Reaction Time	0.5	1.0	4.0	0.8	-2.0	-0.1	-1.3	0.6	-0.7	1.1	-0.1	-0.3	-1.1	1.5	0.4	1.1	-0.9	0.8	1.1	1.2
Coronary Artery Disease (CAD)	0.5	0.6	2.3	-0.9	0.2	0.8	1.5	-1.3	0.4	-0.9	-0.6	0.7	0.4	-0.3	1.5	-0.3	-0.1	-0.7	0.1	-0.2
Mean Putamen Volume	0.5	0.5	2.1	0.7	-0.6	-0.4	-1.0	0.6	-0.4	1.1	1.0	-0.8	-1.4	-0.4	-0.6	0.5	0.5	0.4	-0.2	0.8
Current tobacco smoking	0.5	0.8	2.8	-0.5	1.1	0.5	0.5	-0.3	0.8	-1.2	-0.5	0.9	1.4	-0.0	0.6	-0.9	0.5	-1.0	-1.2	-1.7
Average weekly fortified wine intake	0.5	0.5	1.9	-0.6	0.4	0.7	0.9	-1.2	0.6	-0.7	-0.9	0.8	1.4	-0.8	0.2	-0.3	0.2	-0.6	0.6	0.5
Age when periods started (menarche)	0.5	1.1	11.8	-0.2	-0.9	0.2	-0.1	3.4	0.3	1.4	-0.5	-0.1	-0.4	-1.1	-0.5	0.2	-0.1	-0.0	0.8	1.3
Medication: Levothyroxine sodium	0.5	0.8	4.0	1.0	0.8	0.7	1.3	2.0	0.7	0.5	-0.2	0.6	0.3	-1.1	0.3	0.8	-0.4	-0.7	1.2	1.1
Trunk fat mass	0.5	2.2	5.8	-1.4	2.4	1.0	1.8	0.9	1.8	-1.6	-1.5	1.8	1.4	-0.9	1.8	-1.1	0.9	-1.8	-0.7	-1.3
Alcohol intake versus 10 years previously	0.5	0.8	3.7	1.0	-1.5	-1.0	-0.6	0.2	-0.6	0.7	0.8	-0.4	-0.0	1.9	-1.3	0.9	-0.6	0.9	0.3	0.1
Worrier / anxious feelings	0.5	1.0	2.3	0.6	-0.7	-1.0	-1.5	-0.9	-1.5	0.4	0.7	-1.2	-1.0	1.3	-1.3	0.9	-0.9	1.4	0.6	0.5
Depression (self-reported)	0.5	0.6	3.0	-0.6	1.7	0.8	1.0	0.7	0.4	-1.0	-0.6	0.4	0.5	-0.7	0.8	-0.6	0.4	-0.5	-0.6	-0.7
Pulse wave Arterial Stiffness index	0.5	0.6	3.5	0.8	-0.1	-0.2	-0.2	0.2	0.3	0.7	0.1	0.1	-0.8	-0.2	-1.1	0.9	-1.1	-0.2	1.9	1.2
Loud music exposure frequency	0.5	0.6	1.8	-0.3	0.0	1.4	-0.8	0.7	0.6	-0.3	-1.2	0.7	1.0	-0.6	1.0	-0.5	0.8	-0.7	0.0	0.1
Medication: Amlodipine	0.5	0.7	3.1	-0.5	-0.2	0.3	-0.0	-0.2	0.8	-0.4	-0.0	0.7	-0.6	-0.9	-0.3	-1.2	1.5	-0.8	-1.8	-1.0
High blood pressure (siblings)	0.5	0.7	4.7	0.3	0.7	-0.0	0.1	2.2	0.3	0.8	-0.1	-0.5	-1.8	-0.9	-0.1	0.2	0.6	-0.4	0.4	0.9
Forced vital capacity (FVC), Best measure	0.5	1.7	4.1	-2.0	1.2	1.3	1.0	-0.2	1.3	-1.4	-0.7	1.4	1.6	-1.3	0.1	-1.5	0.8	-1.4	-1.6	-1.9
Exposure to tobacco smoke outside home	0.5	0.6	3.9	-0.5	0.4	0.2	0.7	0.7	0.8	-0.2	-1.3	1.1	1.0	-0.2	2.0	-0.2	0.5	-0.7	-0.3	0.0
Worry too long after embarrassment	0.5	0.9	3.0	-1.4	1.7	0.1	0.5	-1.2	0.1	-1.1	-0.2	0.3	1.7	-0.6	0.4	-0.9	0.3	-0.3	-0.8	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.5	-0.6	1.2	0.8	-0.4	0.3	0.8	-1.0	-0.9	0.6	0.9	-1.0	1.1	-1.0	0.8	-1.0	-0.6	-0.5
Medication: Blood pressure	0.5	0.8	2.5	0.7	-0.5	-1.2	-0.9	-1.6	-1.2	0.3	1.2	-0.9	-1.1	0.9	-0.9	0.5	-0.1	1.1	-0.0	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.4	-0.4	1.5	0.7	0.1	-1.5	0.2	-1.2	0.2	-0.2	0.3	-0.9	0.1	-1.0	0.7	-0.4	-0.8	-1.0
Whole body fat mass	0.5	2.0	6.4	-1.2	2.5	1.0	1.8	0.8	1.7	-1.5	-1.4	1.7	1.5	-0.9	1.7	-1.0	0.7	-1.7	-0.5	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.7	2.5	-0.1	0.7	0.6	0.4	0.3	1.1	-0.7	-0.4	1.3	1.6	-0.6	0.8	-0.8	0.8	-1.2	-0.5	-0.6
Long-standing illness, disability or infirmity	0.5	0.7	4.5	-0.9	0.4	-0.2	0.6	0.9	0.1	-0.8	0.5	0.4	0.5	-0.3	-0.3	-0.8	1.0	-0.3	-2.1	-1.5
Friendships satisfaction	0.5	0.6	3.2	-0.6	1.4	0.5	-0.3	-1.8	0.4	-1.2	-0.4	0.1	1.1	-0.2	0.6	-0.6	0.2	-0.6	-0.2	-0.9
Eye problems/disorders: Glaucoma	0.5	0.6	1.7	-1.3	-0.2	-0.8	-0.3	-1.3	-0.5	-0.8	0.5	-0.1	-0.5	1.2	-0.2	-0.3	-0.2	0.6	-1.1	-1.0
High cholesterol (Self-reported)	0.5	0.9	2.9	-1.4	0.3	0.9	-0.6	0.9	1.1	-0.4	-1.0	1.3	0.2	-0.1	1.7	-1.1	0.7	-0.9	-1.0	-1.0
Depressed Affect (Nagel 2018)	0.4	0.8	2.9	-0.5	1.7	0.8	-0.5	-0.8	0.7	-1.3	-0.7	0.5	0.3	-0.7	0.2	-1.2	0.7	-1.0	-0.9	-1.1
Neuroticism (Nagel 2018)	0.4	0.9	3.7	-0.9	1.9	1.3	-0.3	-0.7	0.7	-0.9	-0.8	0.4	0.5	-1.4	0.5	-1.0	0.8	-1.0	-0.4	-0.6
Schizophrenia vs Biploar Disorder	0.4	0.6	4.9	-0.2	1.3	0.2	-0.2	-2.2	-0.3	-1.0	0.1	-0.7	0.0	-0.0	-0.8	-0.5	-0.1	-0.0	0.1	-0.4
Age at First Birth	0.4	0.6	3.9	0.8	-0.5	0.3	0.5	0.5	0.4	1.0	-0.3	0.6	-0.2	0.0	0.1	1.0	-1.2	-0.2	2.0	1.2
Smoking Status	0.4	1.1	2.7	0.1	1.0	-1.0	0.7	-1.6	-0.8	-1.2	0.7	-0.4	1.4	1.4	-1.6	-0.1	-0.4	0.5	-1.0	-1.4
Maternal smoking around birth	0.4	0.6	3.1	1.1	-0.2	-0.8	0.5	-1.7	-0.6	-0.1	1.1	-0.9	-1.2	0.1	-0.7	0.5	0.1	0.6	0.1	0.1
Serious illness, injury or assault to yourself	0.4	0.4	2.1	-0.2	-0.5	-0.2	-0.5	0.4	0.7	0.2	-0.1	-0.1	0.7	-1.5	-1.2	0.2	1.0	-0.5	-0.0	0.9
Chronic bronchitis/emphysema (father)	0.4	0.5	1.7	0.3	0.3	0.9	-1.3	0.8	1.0	0.4	-0.7	0.5	0.0	-1.0	0.7	-0.7	0.9	-0.9	-0.1	0.3
Alcohol usually taken with meals	0.4	0.7	2.7	-0.4	0.9	0.4	0.0	1.4	0.7	0.2	-0.7	0.2	-0.2	-1.6	0.3	0.3	0.5	-0.8	1.2	1.5
Heart attack	0.4	0.6	4.4	-0.5	-0.8	-0.4	-2.1	1.4	0.4	-0.2	-0.6	0.5	-0.6	0.7	-0.2	-0.5	0.2	-0.2	-0.3	-0.2
Diabetes (self-reported)	0.4	0.6	1.7	-0.1	1.3	0.7	0.9	-0.9	0.5	-1.1	-0.5	0.2	0.9	-0.9	0.4	-0.6	0.6	-0.8	-0.6	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.1	-0.9	0.7	0.6	-0.6	-0.5	0.9	-0.7	-0.9	0.7	-0.3	-0.4	0.8	-1.0	1.5	-0.9	-1.2	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	3.1	-1.8	1.1	1.1	0.6	-0.2	1.1	-1.2	-0.4	1.0	1.6	-1.3	-0.3	-1.3	1.0	-1.1	-1.5	-1.7
Arm fat mass (right)	0.4	1.7	7.9	-1.0	2.8	0.7	1.9	0.4	1.2	-1.5	-1.0	1.2	1.4	-0.6	1.6	-0.8	0.5	-1.3	-0.5	-1.3
Medication: Ibuprofen	0.4	0.5	1.6	0.3	-1.3	-1.0	-0.3	0.1	-0.4	0.7	0.4	-0.2	-1.1	0.6	-0.8	0.7	-0.7	0.6	0.7	0.7
Alcohol intake frequency.	0.4	0.9	4.3	0.4	-1.6	-0.7	-2.1	0.6	-0.4	0.8	0.6	-0.6	-1.5	1.3	-0.6	0.3	-0.2	0.7	-0.4	-0.1
Commuting to job workplace: Walk	0.4	0.5	3.1	-0.4	0.9	0.3	0.9	0.6	0.3	-0.1	-0.4	0.4	1.8	-0.5	1.2	-0.2	-0.0	-0.4	-0.0	0.2
Medication: Gliclazide	0.4	0.5	1.2	1.0	0.6	-0.3	1.0	-1.0	-0.8	0.3	0.8	-1.1	0.1	-0.3	-0.6	0.7	-0.6	0.5	0.6	0.3
Illnesses of father: None of the above (group 1)	0.4	0.5	1.9	-0.9	0.3	0.6	-0.2	0.4	0.6	-0.7	-1.4	0.7	0.8	0.2	1.1	-0.9	0.6	-0.4	-0.4	-0.2
Medication: Atorvastatin	0.4	0.6	3.7	-0.1	0.1	0.4	-0.5	1.9	0.5	0.7	-0.5	0.2	-1.1	-0.9	0.1	-0.1	0.6	-0.5	0.6	1.1
Ever depressed for a whole week	0.4	0.5	1.7	0.6	-0.1	-1.2	0.2	-0.4	-1.3	0.2	1.0	-1.1	0.0	0.3	-1.3	0.5	-0.5	1.0	-0.1	0.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.5	0.2	0.0	1.0	-0.4	1.2	0.7	0.5	-0.7	0.4	1.1	-0.8	1.2	-0.1	0.4	-0.4	0.4	0.6
Heart attack/myocardial infarction (self-reported)	0.4	0.5	3.6	-0.5	-0.7	-0.3	-1.8	1.9	0.6	-0.1	-0.7	0.6	-0.4	0.3	-0.2	-0.4	0.2	-0.4	-0.1	-0.1
Ovarian Cancer	0.3	0.4	2.5	0.5	-0.1	0.2	-1.6	0.6	-0.2	0.7	-0.3	-0.7	-0.4	-0.9	0.2	0.1	0.7	0.3	0.3	1.1
HbA1C	0.3	0.3	1.0	0.7	-0.7	-0.3	-0.2	-0.2	-0.8	0.4	0.4	-0.7	0.4	-0.1	-1.0	0.4	-0.1	0.6	0.6	0.5
LDL Cholesterol	0.3	0.5	2.7	0.6	-0.1	0.3	0.1	0.7	-0.1	0.8	0.3	-0.3	1.1	-0.5	0.4	0.9	-0.7	0.2	1.7	1.3
Primary Biliary Cirrhosis	0.3	0.4	1.8	0.1	0.3	0.4	0.1	0.4	1.3	-0.1	-0.7	1.3	0.3	-0.6	0.7	-0.3	0.4	-1.2	0.0	0.0
Schizophrenia (2014)	0.3	0.6	1.7	-0.2	0.6	1.2	0.4	0.8	1.2	-0.2	-1.2	0.8	0.0	-0.9	0.8	-0.5	0.4	-1.3	-0.0	-0.2
Blood Eosinophil Count	0.3	2.4	16.2	-1.3	0.9	-0.9	1.5	-4.0	-0.8	-1.8	1.2	0.0	-1.1	1.5	-0.3	-0.6	-0.2	0.5	-1.7	-2.7
Waist Hip Ratio (WHR)	0.3	1.2	6.9	-0.5	-1.5	0.1	-1.9	-2.6	0.3	-0.9	-0.6	0.5	0.9	1.5	-0.3	-0.5	1.2	-0.1	-0.7	-0.3
Type 2 Diabetes (T2D) (2018)	0.3	0.6	3.9	0.7	0.9	0.0	0.7	-0.8	-0.4	0.0	0.3	-0.9	2.0	-0.8	-1.0	0.5	-0.5	0.2	0.8	0.5
Sensitivity / hurt feelings	0.3	0.5	1.3	-0.6	0.6	0.8	-0.7	-0.8	0.6	-0.9	-0.8	0.5	-0.6	-0.8	0.5	-0.7	1.1	-0.7	-0.6	-0.4
Angina	0.3	0.4	1.4	-0.0	0.6	-1.2	-0.4	-0.7	-0.6	-0.2	0.6	-0.4	-0.8	0.8	-0.6	-0.1	-0.3	0.4	-0.5	-0.8
Townsend deprivation index at recruitment	0.3	0.4	1.7	-0.8	0.7	0.5	1.3	-0.8	0.4	-1.0	-0.6	0.6	-0.2	-0.2	0.1	-0.6	0.0	-0.4	-0.7	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.8	0.9	-0.5	-0.8	-0.3	0.8	-0.0	0.6	0.3	-0.2	-1.3	0.0	-0.5	0.9	-0.5	0.1	0.9	0.8
Relative age voice broke	0.3	0.4	1.1	0.7	-0.6	-0.6	-0.5	0.8	-0.3	0.9	0.3	-0.4	-0.9	-0.5	-1.0	0.4	0.2	0.4	0.4	1.0
Sitting height	0.3	2.2	6.7	-1.9	-0.2	1.7	-0.1	0.9	2.6	-0.7	-1.4	2.1	0.3	-1.9	-0.2	-1.3	1.5	-2.3	-1.3	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	4.0	0.5	-1.0	-0.1	-2.0	0.6	0.1	0.9	-0.2	-0.2	-1.0	0.2	0.3	0.2	0.2	-0.0	0.6	1.0
Financial difficulties in last 2 years	0.3	0.3	1.4	-0.3	0.2	-0.2	1.2	-0.8	-0.4	-0.5	0.3	0.0	1.0	1.0	0.2	0.1	-0.5	0.3	-0.6	-0.7
Illnesses of siblings	0.3	0.4	1.2	0.2	-1.0	-0.6	0.0	-1.1	-0.9	0.2	0.5	-0.4	1.1	0.4	-0.2	0.6	-0.7	1.0	0.5	0.3
Neuroticism score	0.3	0.5	1.8	-0.5	1.0	0.5	-1.2	-1.4	0.2	-0.8	-0.5	-0.1	-0.8	-0.5	-0.4	-0.8	0.8	-0.4	-0.6	-0.7
Father’s age at death	0.3	0.3	1.3	0.4	-0.1	-0.6	0.4	0.4	-0.1	0.6	0.5	0.2	1.1	0.7	-1.1	0.6	-0.5	0.1	0.7	0.4
Happiness	0.3	0.4	2.2	-0.6	1.5	0.6	0.1	-0.8	0.2	-0.7	-0.6	0.0	1.0	-0.6	0.3	-0.5	0.4	-0.4	-0.1	-0.5
Asthma	0.3	0.5	3.1	0.3	-0.2	-0.7	-0.4	-1.7	-0.9	-0.3	0.2	-0.4	0.7	1.4	-0.8	-0.2	-0.2	0.7	-0.6	-0.6
Length of working week for main job	0.3	0.3	0.9	0.3	-0.2	-0.7	-0.7	-0.5	-0.9	0.1	0.5	-1.0	-0.7	0.8	-0.3	0.1	0.1	1.0	-0.3	0.0
Breastfed as a baby	0.3	0.3	2.4	-0.6	0.0	-0.5	0.2	-1.2	-0.1	-0.6	0.1	-0.0	-1.5	0.2	-0.1	-0.1	0.7	0.0	-0.6	-0.3
Wheeze or whistling in the chest in last year	0.3	0.5	1.9	-0.7	-0.0	0.1	0.2	-0.2	0.9	-1.0	-0.3	0.9	0.3	0.2	-0.4	-0.8	1.1	-0.8	-1.4	-1.1
Age at first live birth	0.3	0.6	3.2	-1.3	0.9	-0.2	1.3	-0.5	0.0	-0.9	-0.0	0.8	1.8	0.6	-0.2	-0.3	-0.4	-0.2	-0.2	-0.9
Angina (self-reported)	0.3	0.4	1.0	-0.2	0.6	-1.0	-0.5	-0.7	-0.5	-0.4	0.5	-0.3	-1.0	0.8	-0.5	-0.3	-0.2	0.3	-0.7	-0.9
Leg fat mass (right)	0.3	1.3	6.8	-0.9	2.6	0.6	1.7	0.8	1.0	-1.2	-0.7	1.0	1.3	-0.4	1.2	-0.6	0.1	-1.1	-0.4	-1.2
Number of full sisters	0.3	0.4	1.6	-0.3	1.0	-0.0	1.1	-0.6	-0.4	-0.4	0.2	-0.5	0.3	-0.3	0.0	-0.6	0.9	0.3	-1.3	-0.5
Loneliness, isolation	0.3	0.4	1.1	0.2	-0.0	-0.6	-0.1	-1.1	-0.9	-0.4	0.2	-0.7	-0.4	0.8	-0.9	-0.0	-0.5	0.7	-0.7	-0.8
Medication: Aspirin	0.3	0.4	1.2	-1.1	1.0	0.2	0.3	0.9	0.3	-0.4	-0.7	0.5	-0.1	-0.1	0.6	-0.8	-0.0	-0.5	-0.7	-0.9
Arm fat mass (left)	0.3	1.2	5.9	-0.9	2.4	0.5	1.8	0.4	0.9	-1.2	-0.8	1.0	1.0	-0.5	1.4	-0.6	0.4	-1.0	-0.4	-1.0
Ever taken oral contraceptive pill	0.3	0.3	2.8	0.1	0.7	-0.5	0.2	-1.7	-0.2	-0.5	0.6	-0.1	-0.2	0.4	-0.2	-0.1	0.2	0.0	-0.4	-0.4
Vascular/heart problems diagnosed by doctor	0.3	0.7	3.2	-0.7	0.1	1.3	0.3	0.8	1.1	-0.0	-1.1	1.0	1.8	-0.9	0.7	-0.4	0.1	-1.0	0.2	0.1
Leg fat mass (left)	0.3	1.3	6.5	-0.9	2.5	0.5	1.9	0.6	0.8	-1.3	-0.7	1.0	1.3	-0.2	1.2	-0.6	0.0	-1.0	-0.4	-1.3
Irritable Bowel Disease (IBD)	0.2	0.5	3.2	-0.2	1.4	0.7	0.7	0.1	-0.1	-0.7	-0.7	-0.6	-1.8	-1.1	0.3	-0.2	0.3	-0.3	0.5	0.2
Crohns Disease (2012)	0.2	0.3	1.5	0.1	1.2	0.6	0.5	0.4	-0.3	-0.1	-0.4	-0.8	-0.6	-0.9	-0.4	0.2	-0.4	-0.2	0.8	0.4
BMI	0.2	1.2	6.3	-1.0	2.5	0.3	2.1	0.8	-0.2	-1.0	-0.4	0.2	0.9	0.4	1.9	-0.6	-0.3	0.0	-0.6	-1.4
Lung FVC	0.2	0.8	2.0	0.9	0.1	-0.9	0.4	-0.3	-1.3	1.0	1.4	-1.4	-0.4	-0.5	-0.8	0.9	-1.0	1.0	0.7	0.7
Neuroticism	0.2	0.4	1.4	-0.4	1.1	0.4	-0.9	-1.2	0.2	-0.7	-0.7	-0.2	-0.5	-0.4	-0.2	-0.8	0.6	-0.3	-0.5	-0.5
Hair Pigment	0.2	6.3	16.3	1.7	-1.0	-2.8	-0.8	-1.4	-4.0	1.8	3.1	-4.0	-2.5	2.8	-3.2	2.0	-1.9	3.9	0.3	0.7
Tanning	0.2	2.0	6.6	-1.2	1.0	1.0	1.4	-1.5	1.6	-1.7	-0.7	2.4	1.6	0.1	0.1	-1.4	0.0	-1.7	-1.2	-2.6
Average weekly spirits intake	0.2	0.3	1.5	0.5	0.1	0.2	-0.9	0.5	0.4	-0.1	-0.5	0.2	1.0	-0.0	1.2	0.2	-0.2	-0.3	0.5	0.2
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.9	-0.2	0.6	0.5	-1.0	0.6	0.5	-0.3	-0.5	0.2	0.9	-0.5	0.5	-0.5	0.1	-0.5	0.1	-0.2
Relative age of first facial hair	0.2	0.5	3.7	0.1	1.0	0.4	0.5	1.1	0.4	0.3	-0.4	-0.2	-0.4	-1.9	0.5	-0.3	0.9	-0.6	0.0	0.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.4	0.5	0.5	-1.2	0.6	0.1	-0.4	0.3	0.6	-0.3	-0.8	0.3	-1.1	0.6	-0.1	0.3	-0.0	0.2
Medication: Metformin	0.2	0.3	1.0	0.2	0.8	0.6	0.5	-0.6	0.1	-0.2	-0.4	-0.2	1.0	-0.7	0.9	-0.2	0.4	-0.4	0.3	-0.0
Severe depression (siblings)	0.2	0.3	0.9	0.1	0.1	0.0	-0.9	-0.4	0.1	-0.3	0.5	-0.0	-0.9	0.3	-0.5	-0.4	0.0	-0.0	-1.0	-0.8
Trunk fat percentage	0.2	0.6	2.6	-0.5	1.6	-0.1	1.6	0.3	0.6	-0.9	-0.5	0.7	0.6	0.2	1.4	-0.2	0.0	-0.6	-0.1	-0.8
High blood pressure	0.2	0.5	3.3	0.6	-0.0	-0.8	-0.1	-1.0	-0.9	0.2	1.0	-0.8	-1.8	0.5	-0.2	0.3	0.2	0.8	-0.3	-0.1
Medication: Atenolol	0.2	0.3	1.8	-0.2	-0.3	-0.7	-0.2	-0.9	-0.6	-0.2	0.1	-0.1	-0.1	1.3	0.4	0.0	-0.3	0.6	-0.5	-0.8
Nervous feelings	0.2	0.4	1.6	-0.9	-0.3	0.7	-0.8	0.1	0.2	-0.3	-0.8	0.2	-0.7	-0.7	0.7	-0.8	1.3	-0.3	-0.5	0.2
Medication: Simvastatin	0.2	0.3	1.2	-0.8	0.8	0.4	-0.1	-0.3	-0.1	-0.5	-0.2	0.1	0.2	0.4	0.9	-0.4	-0.5	0.0	-0.6	-1.1
Impedance of arm (right)	0.2	0.8	2.7	-0.8	-0.6	0.0	0.9	-1.5	0.4	-1.4	0.0	0.9	0.3	0.6	-0.4	-0.8	0.7	-0.3	-1.6	-1.6
Arm fat percentage (right)	0.2	1.0	5.6	-0.4	2.4	-0.3	2.1	-0.1	0.1	-1.2	-0.1	0.5	0.5	0.6	1.3	-0.2	-0.3	-0.2	-0.4	-1.3
Number of live births	0.2	0.3	1.1	0.2	0.1	-0.7	-0.2	-0.1	-0.9	-0.1	0.3	-0.8	0.2	1.0	-0.7	0.1	-1.1	0.9	0.1	-0.1
Noisy workplace	0.2	0.3	0.8	-0.2	-0.1	0.7	0.3	0.8	0.6	-0.3	-0.9	0.6	-0.5	-0.4	0.2	-0.6	0.5	-0.6	-0.7	-0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.5	2.0	-0.2	-0.1	-0.8	-0.0	-1.4	-0.8	0.1	0.9	-0.7	0.5	1.0	-0.6	0.1	0.2	0.8	-1.0	-0.8
Mouth/teeth dental problems: Dentures	0.2	0.4	2.1	-0.3	0.5	-0.5	1.4	-0.6	-0.3	-0.6	0.2	0.4	-0.3	0.9	-0.7	-0.1	-0.5	0.2	-0.6	-1.0
Medication: Cholesterol lowering	0.2	0.3	0.6	0.2	0.0	-0.8	0.3	-0.7	-0.4	0.3	0.7	-0.4	0.5	0.0	-0.7	0.5	-0.6	0.4	0.7	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.1	-0.4	1.0	-0.2	0.8	-1.0	0.0	-0.9	0.1	0.3	-0.6	0.3	-0.1	-0.2	0.3	-0.3	-0.7	-0.8
Glaucoma (self-reported)	0.2	0.2	0.9	-0.9	-0.5	-0.3	-0.3	-0.6	-0.1	-0.6	-0.0	0.6	-0.2	0.7	0.6	0.2	-0.3	0.1	-0.1	-0.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	2.1	0.2	1.1	0.1	1.5	0.9	-0.1	-0.4	0.2	0.3	0.2	0.5	-0.3	0.3	-0.5	0.1	-0.1	-0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.0	-0.3	-0.0	-0.5	0.5	-0.7	-0.1	-0.7	0.3	0.2	0.5	1.0	-0.7	-0.2	-0.3	0.2	-0.8	-0.9
Body fat percentage	0.2	0.6	3.2	-0.4	1.8	-0.1	1.6	0.3	0.4	-1.0	-0.4	0.6	0.5	0.4	1.4	-0.2	-0.1	-0.5	-0.1	-0.9
Leg fat percentage (right)	0.2	0.6	4.5	-0.1	2.1	-0.1	1.5	0.4	-0.0	-0.8	0.1	0.1	0.6	0.5	0.8	0.1	-0.5	-0.2	0.1	-0.8
Eye problems/disorders: None of the above	0.2	0.2	0.9	0.5	-0.6	0.2	-0.3	0.8	0.1	0.9	-0.1	-0.1	-0.7	-0.2	-0.2	0.3	-0.4	-0.1	0.8	0.5
Overall health rating	0.2	0.4	1.4	0.3	-0.4	-0.6	-1.2	-0.6	0.1	-0.3	0.4	0.1	-0.5	0.3	0.4	-0.5	1.1	-0.1	-1.1	-0.7
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	2.2	0.4	0.9	0.2	1.5	0.3	0.1	0.1	-0.0	0.5	0.5	-0.3	0.1	0.2	-0.4	-0.2	0.5	-0.1
Arm fat percentage (left)	0.2	0.8	4.5	-0.1	2.1	-0.7	2.1	-0.0	-0.3	-0.7	0.2	0.1	0.4	0.7	1.0	0.2	-0.6	0.1	-0.1	-0.9
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.3	-0.5	-0.7	-0.7	-1.1	-0.3	-0.2	0.1	0.4	-0.0	-1.1	0.7	-0.4	-0.0	-0.2	0.2	-0.5	-0.3
Qualifications: nursing, teaching	0.2	0.3	1.3	-0.8	1.1	-0.2	-0.0	0.1	-0.3	-0.3	0.4	-0.5	0.2	-0.2	-0.1	-0.6	0.9	0.0	-1.1	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	1.2	0.3	-0.4	-0.8	-0.4	-0.0	-0.8	0.3	0.5	-0.8	-0.1	1.1	0.2	0.4	-0.2	0.9	-0.2	-0.1
Back pain experienced in last month	0.2	0.3	1.3	-0.1	0.3	0.2	0.7	0.7	0.4	0.1	0.1	0.4	0.7	-0.9	-1.1	-0.2	0.3	-0.3	-0.5	-0.0
Asthma (self-reported)	0.2	0.5	2.4	-0.1	0.1	-0.3	-0.2	-1.5	-0.7	-0.7	-0.1	-0.2	1.0	1.1	-0.7	-0.5	0.0	0.5	-0.9	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.9	0.6	-0.4	-0.7	-0.7	-1.1	-0.8	0.4	1.4	-0.9	0.2	0.0	-1.0	0.6	-0.5	0.8	0.3	0.1
Average weekly champagne plus white wine intake	0.2	0.2	1.8	-0.3	0.6	-0.7	0.3	0.0	-0.5	-0.1	0.5	-0.4	1.4	0.1	-0.6	0.1	0.1	0.5	-0.0	0.2
Miserableness	0.2	0.4	1.2	-0.5	1.0	1.1	-0.8	-0.1	0.6	-0.4	-0.4	0.4	-0.4	-0.8	-0.0	-0.7	0.8	-0.8	-0.6	-0.3
Ever smoked	0.2	0.3	1.4	0.3	0.3	-0.5	-0.2	-1.2	-0.2	-0.7	-0.3	-0.2	0.8	1.0	-0.7	0.1	0.4	0.2	-0.3	-0.2
Leg fat percentage (left)	0.2	0.6	4.2	-0.1	2.1	-0.3	1.6	0.0	-0.3	-0.9	0.2	-0.1	0.6	0.6	0.7	0.1	-0.6	0.1	0.0	-0.9
Irritability	0.2	0.3	2.3	-0.0	1.5	0.2	-0.1	-0.2	0.3	0.4	-0.2	0.1	-1.0	-0.3	0.5	0.2	-0.2	-0.4	0.5	-0.2
Heart disease (siblings)	0.2	0.3	1.1	-0.6	0.6	0.4	0.1	0.6	0.2	-0.5	-0.2	0.3	-0.5	0.5	-0.2	-0.5	0.2	-0.3	-1.0	-1.1
Alcohol drinker status: Previous	0.2	0.2	1.0	-0.2	0.9	1.0	0.1	0.2	0.0	-0.7	-0.7	-0.1	0.9	-0.3	-0.4	-0.3	0.4	-0.0	-0.2	-0.2
Bipolar Disorder or Schizophrenia	0.1	0.3	1.5	0.3	-0.2	0.7	-0.4	1.2	0.6	0.6	-0.7	0.1	-0.9	-0.2	1.1	0.0	0.1	-0.5	-0.1	-0.0
Depression (Nagel 2018)	0.1	0.2	0.7	0.2	0.8	-0.1	0.2	0.6	0.2	-0.2	0.4	-0.2	-0.1	-0.7	0.1	0.2	-0.5	-0.2	0.8	0.3
Worry (Nagel 2018)	0.1	0.3	2.0	0.2	-0.3	0.1	-1.4	-0.6	-0.2	0.4	-0.2	-0.5	-0.3	-0.6	-0.2	0.2	0.2	0.2	0.8	1.0
Blood Platelet Count	0.1	0.8	7.1	0.2	0.5	-0.2	2.7	-1.0	-0.3	-0.8	0.4	0.7	0.1	1.3	-0.3	0.8	-1.4	0.3	0.2	-0.6
Blood Red Count	0.1	1.4	9.9	0.9	-1.1	-0.1	-3.1	-0.7	-0.9	1.0	0.4	-1.7	-1.4	-0.2	-0.2	0.7	0.2	0.9	1.1	1.5
Cardiovascular Disease	0.1	0.5	1.8	-0.5	1.3	-0.1	0.8	-1.3	-0.3	-0.6	0.4	-0.3	-0.2	-0.1	0.5	-0.5	0.2	0.1	-0.9	-1.2
Impedance of leg (right)	0.1	0.3	2.2	0.1	-1.5	0.0	-1.0	-0.5	0.3	-0.2	0.3	0.1	-0.5	0.6	-0.9	0.1	0.3	-0.1	-0.1	0.0
Fed-up feelings	0.1	0.2	1.6	0.3	1.2	0.0	0.2	-1.1	-0.2	-0.7	0.2	-0.2	-0.1	-0.2	-0.5	-0.1	-0.2	0.0	-0.2	-0.5
Qualifications: CSEs or equivalent	0.1	0.1	0.4	-0.1	0.0	0.3	0.6	-0.3	0.4	-0.2	0.3	0.4	0.4	-0.7	0.7	0.1	-0.1	-0.2	-0.2	-0.3
Body mass index (BMI)	0.1	0.6	5.4	0.0	2.3	-0.2	1.5	0.5	-0.1	-0.4	-0.0	-0.0	0.4	0.1	1.1	0.1	-0.4	-0.1	0.3	-0.4
Impedance of leg (left)	0.1	0.5	2.9	0.3	-1.7	-0.5	-0.8	-0.9	-0.3	-0.0	0.7	-0.4	-0.4	1.0	-1.0	0.2	-0.2	0.5	-0.1	-0.1
Past tobacco smoking	0.1	0.2	0.5	-0.5	-0.6	0.4	-0.1	0.3	0.3	0.6	0.1	0.3	-0.5	-0.7	0.7	-0.1	-0.4	-0.2	0.2	0.1
Impedance of arm (left)	0.1	0.4	1.8	-0.4	-1.2	-0.4	0.3	-1.3	-0.0	-0.7	0.4	0.2	0.1	0.5	-0.6	-0.2	0.5	0.2	-1.0	-0.7
Medication: Paracetamol	0.1	0.2	0.8	-0.4	0.3	0.3	-0.2	-0.0	0.6	-0.2	-0.5	0.9	0.1	0.2	0.4	-0.3	0.3	-0.7	-0.3	-0.5
Headache pain in last month	0.1	0.2	0.6	-0.2	0.3	0.1	-0.3	-0.1	0.8	-0.5	-0.1	0.6	0.3	0.0	-0.3	-0.6	0.7	-0.6	-0.7	-0.5
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	1.6	-0.3	0.4	0.3	0.4	1.2	0.3	0.1	-0.2	0.2	0.3	-0.0	0.1	-0.3	-0.2	-0.2	-0.5	-0.5
Medication for pain relief, constipation, heartburn	0.1	0.2	1.2	0.6	-0.4	0.0	0.3	0.2	-0.2	0.3	0.2	-0.4	-0.3	-0.7	-0.7	0.5	-0.1	0.1	0.8	1.1
Heart disease (mother)	0.1	0.2	0.6	0.6	-0.1	-0.0	-0.4	0.2	-0.0	0.5	-0.4	-0.2	0.1	-0.5	0.8	0.1	0.3	0.1	0.3	0.8
Pulse rate, automated reading	0.1	0.4	3.2	0.4	-0.1	0.1	-0.4	-0.9	-0.0	-0.1	0.1	-0.4	-1.8	0.1	0.9	0.1	0.9	-0.2	0.1	0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.4	-0.0	-0.2	-0.3	-0.1	-0.1	-0.2	0.2	0.4	-0.1	-0.2	-0.3	-0.6	0.4	-0.5	0.2	0.5	0.3
Medication: Aspirin	0.1	0.1	0.4	-0.4	0.6	-0.5	0.3	0.6	-0.4	0.0	0.0	-0.2	-0.4	0.3	0.1	-0.2	-0.5	0.2	-0.3	-0.6
Hypertension (Self-reported)	0.1	0.3	2.2	0.5	-0.4	-0.7	-0.2	-0.4	-0.6	0.4	0.7	-0.5	-1.5	0.4	-0.1	0.2	0.3	0.6	-0.3	-0.0
Smoking status: Previous	0.1	0.2	0.7	0.5	0.3	-0.4	0.1	0.4	-0.5	0.2	0.0	-0.5	0.1	0.3	-0.8	0.5	0.0	0.4	0.5	0.6
Diabetes diagnosed by doctor	0.1	0.2	0.7	-0.0	0.8	-0.0	0.4	-0.8	-0.3	-0.6	0.3	-0.6	0.8	-0.3	-0.0	-0.2	0.3	0.1	-0.7	-0.7
Breast cancer (self-reported)	0.1	0.1	0.4	-0.2	-0.4	-0.0	-0.2	-0.6	0.6	0.1	-0.5	0.2	0.2	0.5	0.4	-0.3	0.1	-0.3	0.0	-0.4
Guilty feelings	0.1	0.1	1.3	-0.1	0.3	0.4	-0.3	-1.1	-0.1	-0.3	0.2	-0.2	-0.4	-0.3	0.1	-0.1	0.2	-0.1	-0.3	-0.4
Medication: Paracetamol	0.1	0.1	0.7	-0.1	-0.2	-0.0	-0.1	0.6	0.5	0.1	-0.1	0.8	0.2	0.1	0.3	0.0	0.1	-0.6	-0.2	-0.2
Medication: Lisinopril	0.1	0.2	0.9	-0.5	-0.1	0.5	0.1	0.5	0.2	0.0	-0.6	0.4	-0.7	0.0	0.9	-0.3	0.2	-0.1	-0.2	0.1
Average weekly beer plus cider intake	0.1	0.2	0.6	-0.1	0.6	0.1	0.8	-0.3	0.4	0.5	0.2	0.1	-0.7	-0.6	-0.2	-0.2	0.1	-0.3	0.2	-0.1
Pain experienced in last month	0.1	0.2	2.6	0.0	-0.3	-0.1	-0.3	-1.6	-0.3	-0.4	0.4	-0.4	-0.4	0.3	0.7	0.1	-0.0	0.1	0.1	-0.2
Impedance of whole body	0.1	0.5	4.2	0.3	-2.1	-0.6	-0.5	-1.1	-0.2	0.0	0.6	-0.2	-0.5	0.9	-0.8	0.3	0.1	0.5	-0.3	-0.0
Lung FEV1/FVC ratio	0.0	0.2	2.6	0.1	0.6	-0.1	-0.0	1.6	-0.1	-0.0	-0.1	-0.3	0.0	-0.2	0.1	0.2	0.2	0.2	0.2	0.1

Hub : Genes

ZNF774

Models

Trait associations