Best TWAS P=3.6e-28 · Best GWAS P=9.17e-35 conditioned to 5.1e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | SMAD3 | 0.22 | 0.12 | enet | 12 | 0.11 | 5.2e-11 | -10.2 | 11.0 | 3.6e-28 | -0.88 | 0.01 | 0.99 | TRUE |
| 1 | CommonMind | Brain Pre-frontal Cortex | AAGAB | 0.06 | 0.05 | enet | 11 | 0.05 | 3.2e-07 | 5.6 | 5.6 | 2.8e-08 | -0.04 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Thyroid | SMAD3 | 0.19 | 0.02 | enet | 3 | 0.03 | 2.3e-03 | -12.3 | 9.0 | 3.2e-19 | -0.75 | 0.00 | 0.97 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | IQCH | 0.13 | 0.11 | bslmm | 597 | 0.10 | 5.9e-12 | 7.1 | -5.5 | 3.4e-08 | 0.06 | 1.00 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | IQCH | 0.08 | 0.02 | blup | 111 | 0.05 | 4.2e-04 | 3.1 | -5.5 | 4.5e-08 | 0.00 | 0.05 | 0.88 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IQCH | 0.06 | 0.05 | blup | 112 | 0.06 | 5.2e-12 | 7.1 | -5.3 | 1.0e-07 | -0.01 | 0.02 | 0.98 | FALSE |