[Hub]/) : Traits : Blood clot in the leg (DVT) :

chr9:134,907,263-137,552,398

Best TWAS P=1.17e-69 · Best GWAS P=3.68e-65 conditioned to 0.00542

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Tibial CACFD1 0.10 0.03 lasso 4 0.03 1.7e-03 -2.23 7.8 7.1e-15 0.40 0.13 0.35 FALSE
2 GTEx Brain Cerebellar Hemisphere AK8 0.43 0.12 enet 24 0.08 3.8e-03 -0.78 5.2 1.6e-07 0.20 0.12 0.10 TRUE
3 GTEx Breast Mammary Tissue VAV2 0.38 0.11 lasso 10 0.18 1.2e-09 -0.82 7.0 2.7e-12 0.38 0.45 0.50 FALSE
4 GTEx Breast Mammary Tissue AL590710.1 0.31 0.11 lasso 7 0.12 1.3e-06 -1.45 7.7 1.0e-14 0.36 0.11 0.81 FALSE
5 GTEx Spleen SARDH 0.40 -0.01 enet 49 0.10 1.3e-03 1.54 5.8 5.3e-09 0.17 0.07 0.08 TRUE
6 GTEx Testis CACFD1 0.26 0.05 enet 25 0.10 5.3e-05 11.35 6.4 2.0e-10 0.23 0.30 0.14 FALSE
7 GTEx Uterus SURF1 0.40 0.05 enet 18 0.08 9.2e-03 8.80 -7.0 2.4e-12 -0.21 0.07 0.11 FALSE
8 METSIM Adipose C9orf96 0.07 0.01 blup 605 0.03 7.8e-05 -0.48 7.9 2.8e-15 0.38 0.09 0.29 FALSE
9 METSIM Adipose VAV2 0.09 0.03 bslmm 690 0.03 2.9e-05 -3.65 -5.1 2.7e-07 -0.07 0.18 0.03 TRUE
10 The Cancer Genome Atlas Bladder Urothelial Carcinoma ABO 0.08 0.01 blup 43 0.07 7.9e-07 16.29 12.6 2.4e-36 0.77 0.01 0.98 FALSE
11 The Cancer Genome Atlas Breast Invasive Carcinoma ABO 0.07 0.08 lasso 3 0.08 5.0e-16 16.29 16.3 1.1e-59 0.94 0.39 0.61 FALSE
12 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma ABO 0.11 0.05 blup 43 0.12 1.2e-06 -6.62 13.3 2.7e-40 0.77 0.02 0.97 FALSE
13 The Cancer Genome Atlas Colon Adenocarcinoma ABO 0.27 0.31 blup 43 0.33 2.1e-19 16.34 16.5 5.2e-61 0.87 0.01 0.99 FALSE
14 The Cancer Genome Atlas Esophageal Carcinoma ABO 0.27 0.13 lasso 2 0.11 1.8e-04 16.34 16.3 1.2e-59 0.93 0.02 0.96 FALSE
15 The Cancer Genome Atlas Glioblastoma Multiforme ABO 0.18 0.01 blup 42 0.07 3.0e-03 16.34 15.0 1.5e-50 0.84 0.00 0.74 FALSE
16 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ABO 0.11 0.08 blup 43 0.12 2.5e-13 16.34 15.0 1.3e-50 0.78 0.01 0.99 FALSE
17 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ABO 0.20 0.19 blup 43 0.33 3.0e-38 -6.59 12.2 3.7e-34 0.79 0.58 0.42 FALSE
18 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C9orf7 0.09 0.00 blup 21 0.03 2.2e-04 -2.39 6.1 8.2e-10 0.28 0.01 0.03 FALSE
19 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma REXO4 0.04 0.01 lasso 4 0.02 1.4e-03 -0.44 -6.5 6.9e-11 -0.30 0.01 0.84 FALSE
20 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma ABO 0.31 0.38 lasso 5 0.42 3.1e-26 16.98 16.3 8.4e-60 0.97 0.01 0.99 FALSE
21 The Cancer Genome Atlas Brain Lower Grade Glioma ABO 0.26 0.23 enet 10 0.26 6.0e-29 16.29 16.8 3.2e-63 0.88 0.95 0.05 FALSE
22 The Cancer Genome Atlas Liver Hepatocellular Carcinoma ABO 0.23 0.23 lasso 2 0.24 2.2e-11 16.98 17.0 6.7e-65 0.99 0.00 1.00 FALSE
23 The Cancer Genome Atlas Lung Adenocarcinoma ABO 0.21 0.25 lasso 5 0.25 2.1e-29 16.29 16.7 8.0e-63 0.97 0.02 0.98 FALSE
24 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ABO 0.08 0.06 blup 43 0.09 1.7e-10 16.29 13.9 9.0e-44 0.89 0.00 1.00 FALSE
25 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma ABO 0.28 0.22 lasso 8 0.22 1.2e-14 16.29 16.5 2.1e-61 0.94 0.01 0.99 FALSE
26 The Cancer Genome Atlas Pancreatic Adenocarcinoma ABO 0.23 0.21 lasso 5 0.20 6.7e-09 16.98 16.4 2.1e-60 0.95 0.00 1.00 FALSE
27 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma ABO 0.23 0.23 lasso 3 0.23 2.0e-09 16.34 16.2 1.1e-58 0.95 0.01 0.99 FALSE
28 The Cancer Genome Atlas Prostate Adenocarcinoma ABO 0.18 0.15 blup 43 0.21 3.4e-21 16.98 12.8 1.5e-37 0.84 0.00 1.00 FALSE
29 The Cancer Genome Atlas Rectum Adenocarcinoma ABO 0.48 0.23 enet 10 0.27 4.7e-07 17.05 17.6 1.2e-69 0.89 0.00 0.98 TRUE
30 The Cancer Genome Atlas Soft Tissue Sarcoma ABO 0.32 0.18 enet 10 0.20 2.3e-12 16.29 14.7 5.3e-49 0.85 0.01 0.99 FALSE
31 The Cancer Genome Atlas Skin Cutaneous Melanoma ABO 0.38 0.11 blup 43 0.15 9.6e-05 7.80 13.5 1.2e-41 0.76 0.02 0.86 FALSE
32 The Cancer Genome Atlas Stomach Adenocarcinoma ABO 0.20 0.10 blup 42 0.18 5.8e-13 16.29 15.8 2.4e-56 0.83 0.01 0.99 FALSE
33 The Cancer Genome Atlas Testicular Germ Cell Tumors ABO 0.41 0.17 enet 12 0.25 3.0e-09 -9.91 13.4 9.9e-41 0.87 0.10 0.89 FALSE
34 The Cancer Genome Atlas Thyroid Carcinoma ABO 0.44 0.57 enet 18 0.60 1.9e-73 16.29 16.3 7.8e-60 0.97 0.00 1.00 FALSE
35 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma ABO 0.23 0.07 blup 44 0.12 4.3e-04 16.98 10.1 6.0e-24 0.64 0.00 0.77 FALSE