Hub : Traits :

Blood clot in the leg (DVT)

67 significantly associated models · 26 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	168375973	170514229	6	6	6.5e-17	1.1e-172	1.2e-88	49	ATP1B1 C1orf112 NME7 SLC19A2
2	4	154758667	156166231	3	1	4.4e-16	2.2e-17	8.8e-04	85	PLRG1
3	4	186328499	187829016	3	3	5.6e-15	1.8e-22	3.2e-09	63	CYP4V2 F11 FAM149A
4	9	134907263	137552398	10	4	1.2e-69	3.7e-65	5.4e-03	97	ABO AK8 SARDH VAV2
5	10	70516744	71966819	1	1	5.9e-11	6.0e-11	1.0e+00	100	TSPAN15
6	20	32898339	34562581	3	1	1.4e-08	1.4e-08	2.4e-02	84	EIF6

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Ulcerative Colitis (UC)	1.50	1	0	0.0	0.00	1.0e+00	EIF6
Reaction Time	1.30	1	0	0.0	0.00	1.0e+00	EIF6
Ovarian Cancer	2.56	1	0	0.0	0.00	1.0e+00	ABO
Coronary Artery Disease (CAD)	3.70	1	1	2.2	0.00	1.0e+00	ABO
LDL Cholesterol	3.73	1	1	2.2	0.00	1.0e+00	ABO
Primary Biliary Cirrhosis	1.80	1	0	0.0	0.00	1.0e+00	ATP1B1
Ulcerative Colitis	1.60	1	0	0.0	0.00	1.0e+00	EIF6
Blood Eosinophil Count	1.01	3	1	2.2	0.00	1.0e+00	ABO SARDH VAV2
Blood Platelet Count	0.73	4	1	2.2	-0.53	4.7e-01	AK8 ATP1B1 CYP4V2 TSPAN15
Blood Red Count	1.91	3	2	4.4	0.00	1.0e+00	ABO ATP1B1 SARDH
Blood White Count	2.21	3	2	4.4	0.00	1.0e+00	ABO AK8 SARDH
Heel T-Score	0.97	2	1	2.2	0.00	1.0e+00	ABO CYP4V2
BMI	0.45	1	0	0.0	0.00	1.0e+00	AK8
Height	2.34	4	1	2.2	-0.21	7.9e-01	ABO AK8 EIF6 PLRG1
Systolic Blood Pressure	1.34	3	1	2.2	0.00	1.0e+00	ABO ATP1B1 NME7
Allergy or Eczema	1.71	1	1	2.2	0.00	1.0e+00	ABO
Lung FEV1/FVC ratio	1.47	3	1	2.2	0.00	1.0e+00	ABO EIF6 NME7
Lung FVC	0.73	2	0	0.0	0.00	1.0e+00	ABO EIF6
Hair Pigment	0.42	1	1	2.2	0.00	1.0e+00	EIF6
Tanning	1.23	1	1	2.2	0.00	1.0e+00	EIF6
Hand grip strength (left)	1.74	2	1	2.2	0.00	1.0e+00	ABO EIF6
Ever used hormone-replacement therapy (HRT)	1.22	1	0	0.0	0.00	1.0e+00	C1orf112
Systolic blood pressure, automated reading	1.05	1	0	0.0	0.00	1.0e+00	ATP1B1
Angina	2.79	1	0	0.0	0.00	1.0e+00	NME7
Medication: Metformin	1.18	1	0	0.0	0.00	1.0e+00	ABO
Impedance of leg (right)	0.78	2	0	0.0	0.00	1.0e+00	AK8 EIF6
Leg fat-free mass (left)	1.67	1	1	2.2	0.00	1.0e+00	EIF6
Trunk fat percentage	0.93	2	1	2.2	0.00	1.0e+00	ABO AK8
Hand grip strength (right)	2.13	2	1	2.2	0.00	1.0e+00	ABO EIF6
Age when periods started (menarche)	0.90	1	0	0.0	0.00	1.0e+00	EIF6
Heel bone mineral density (BMD) T-score, automated (left)	0.75	1	0	0.0	0.00	1.0e+00	ABO
High blood pressure	1.56	1	1	2.2	0.00	1.0e+00	ABO
Hayfever, allergic rhinitis or eczema	1.37	1	0	0.0	0.00	1.0e+00	ABO
Sitting height	2.96	1	1	2.2	0.00	1.0e+00	EIF6
Body mass index (BMI)	0.61	1	0	0.0	0.00	1.0e+00	AK8
Impedance of leg (left)	0.88	2	0	0.0	0.00	1.0e+00	EIF6 SARDH
Leg predicted mass (left)	1.67	1	1	2.2	0.00	1.0e+00	EIF6
Trunk fat mass	0.63	2	0	0.0	0.00	1.0e+00	ABO AK8
Forced vital capacity (FVC)	0.85	2	0	0.0	0.00	1.0e+00	ABO EIF6
Heel bone mineral density (BMD) T-score, automated (right)	0.67	1	0	0.0	0.00	1.0e+00	ABO
Allergy	3.97	3	1	2.2	0.00	1.0e+00	ABO EIF6 SARDH
Medication: Simvastatin	1.47	1	0	0.0	0.00	1.0e+00	ABO
Fluid intelligence score	0.93	1	0	0.0	0.00	1.0e+00	AK8
Weight	0.86	1	1	2.2	0.00	1.0e+00	EIF6
Impedance of arm (right)	1.58	1	1	2.2	0.00	1.0e+00	ABO
Arm fat percentage (right)	1.37	2	1	2.2	0.00	1.0e+00	ABO AK8
Trunk fat-free mass	2.53	2	2	4.4	0.00	1.0e+00	ABO EIF6
Father's age at death	2.66	2	0	0.0	0.00	1.0e+00	ABO NME7
Frequency of tiredness / lethargy in last 2 weeks	1.94	1	0	0.0	0.00	1.0e+00	NME7
Forced expiratory volume in 1-second (FEV1)	1.05	2	0	0.0	0.00	1.0e+00	ABO EIF6
Medication: Cholesterol lowering	1.63	1	0	0.0	0.00	1.0e+00	ABO
Prospective memory result	1.28	1	0	0.0	0.00	1.0e+00	AK8
Forced expiratory volume in 1-second (FEV1), Best measure	1.23	2	0	0.0	0.00	1.0e+00	ABO EIF6
Impedance of arm (left)	1.68	2	1	2.2	0.00	1.0e+00	ABO VAV2
Arm fat mass (right)	0.72	2	0	0.0	0.00	1.0e+00	ABO AK8
Trunk predicted mass	2.55	2	2	4.4	0.00	1.0e+00	ABO EIF6
Standing height	2.41	2	1	2.2	0.00	1.0e+00	EIF6 PLRG1
Peak expiratory flow (PEF)	2.20	2	1	2.2	0.00	1.0e+00	ABO EIF6
Mouth/teeth dental problems: Bleeding gums	1.08	1	0	0.0	0.00	1.0e+00	EIF6
Forced vital capacity (FVC), Best measure	0.94	1	0	0.0	0.00	1.0e+00	EIF6
Body fat percentage	0.87	2	0	0.0	0.00	1.0e+00	ABO AK8
Leg fat percentage (right)	0.67	1	0	0.0	0.00	1.0e+00	EIF6
Arm fat-free mass (right)	2.25	2	2	4.4	0.00	1.0e+00	ABO EIF6
Qualifications: College or University degree	1.19	1	0	0.0	0.00	1.0e+00	EIF6
Medication for pain relief, constipation, heartburn	1.58	1	0	0.0	0.00	1.0e+00	NME7
Heart disease (mother)	2.08	1	0	0.0	0.00	1.0e+00	ABO
Whole body fat mass	0.60	1	0	0.0	0.00	1.0e+00	AK8
Arm predicted mass (right)	2.27	2	2	4.4	0.00	1.0e+00	ABO EIF6
Pulse rate, automated reading	0.70	1	0	0.0	0.00	1.0e+00	ABO
Alcohol intake frequency.	1.24	1	0	0.0	0.00	1.0e+00	NME7
Comparative height size at age 10	1.28	1	1	2.2	0.00	1.0e+00	EIF6
Age at last live birth	1.37	1	0	0.0	0.00	1.0e+00	VAV2
Medication: Aspirin	3.51	2	0	0.0	0.00	1.0e+00	ABO NME7
Hypertension (Self-reported)	1.44	1	1	2.2	0.00	1.0e+00	ABO
Illnesses of father: Heart disease	1.90	1	0	0.0	0.00	1.0e+00	ABO
Forced expiratory volume in 1-second (FEV1), predicted	1.33	1	1	2.2	0.00	1.0e+00	EIF6
Whole body fat-free mass	2.11	1	1	2.2	0.00	1.0e+00	EIF6
Leg fat-free mass (right)	1.71	1	1	2.2	0.00	1.0e+00	EIF6
Arm fat percentage (left)	1.41	2	1	2.2	0.00	1.0e+00	ABO AK8
Ever had bowel cancer screening	1.71	1	0	0.0	0.00	1.0e+00	ABO
Medication: Aspirin	3.11	1	0	0.0	0.00	1.0e+00	NME7
Smoking status: Current	1.42	1	0	0.0	0.00	1.0e+00	SLC19A2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.68	1	0	0.0	0.00	1.0e+00	ABO
Whole body water mass	2.10	1	1	2.2	0.00	1.0e+00	EIF6
Leg predicted mass (right)	1.70	1	1	2.2	0.00	1.0e+00	EIF6
Arm fat mass (left)	0.73	2	0	0.0	0.00	1.0e+00	ABO AK8
Number of self-reported non-cancer illnesses	1.76	2	0	0.0	0.00	1.0e+00	ATP1B1 NME7
Mother's age at death	2.48	1	0	0.0	0.00	1.0e+00	ABO
Medication: Blood pressure	1.08	1	0	0.0	0.00	1.0e+00	ATP1B1
High cholesterol (Self-reported)	2.10	1	1	2.2	0.00	1.0e+00	ABO
Medication: Atorvastatin	2.23	1	0	0.0	0.00	1.0e+00	ABO
Basal metabolic rate	1.81	1	1	2.2	0.00	1.0e+00	EIF6
Leg fat percentage (left)	0.66	1	0	0.0	0.00	1.0e+00	EIF6
Arm fat-free mass (left)	2.18	2	2	4.4	0.00	1.0e+00	ABO EIF6
Diastolic blood pressure, automated reading	1.35	1	1	2.2	0.00	1.0e+00	ABO
Vascular/heart problems diagnosed by doctor	1.32	1	0	0.0	0.00	1.0e+00	ABO
Cholesterol lowering medication	2.21	1	1	2.2	0.00	1.0e+00	ABO
Deep venous thrombosis (DVT) (self-reported)	47.05	14	13	28.9	1.00	1.9e-23	ABO AK8 ATP1B1 C1orf112 CYP4V2 EIF6 F11 FAM149A NME7 PLRG1 SARDH SLC19A2 TSPAN15 VAV2
Alcohol drinker status: Previous	2.47	1	0	0.0	0.00	1.0e+00	NME7
Impedance of whole body	0.75	2	0	0.0	0.00	1.0e+00	ABO EIF6
Leg fat mass (left)	0.45	1	0	0.0	0.00	1.0e+00	AK8
Arm predicted mass (left)	2.20	2	2	4.4	0.00	1.0e+00	ABO EIF6

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	0	0.000	1.3
GTEx	Adipose Visceral Omentum	0	0.000	1.3
GTEx	Adrenal Gland	0	0.000	1.3
GTEx	Artery Aorta	1	0.034	1.3
GTEx	Artery Coronary	0	0.000	1.3
GTEx	Artery Tibial	2	0.053	1.3
GTEx	Brain Caudate basal ganglia	1	0.109	1.4
GTEx	Brain Cerebellar Hemisphere	1	0.067	1.2
GTEx	Brain Cerebellum	1	0.050	1.3
GTEx	Brain Cortex	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Brain Hippocampus	0	0.000	1.3
GTEx	Brain Hypothalamus	0	0.000	1.4
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue	2	0.101	1.4
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.1
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.3
GTEx	Cells Transformed fibroblasts	1	0.024	1.3
GTEx	Colon Sigmoid	0	0.000	1.2
GTEx	Colon Transverse	1	0.048	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Esophagus Mucosa	2	0.060	1.3
GTEx	Esophagus Muscularis	0	0.000	1.3
GTEx	Heart Atrial Appendage	1	0.063	1.3
GTEx	Heart Left Ventricle	0	0.000	1.2
GTEx	Liver	0	0.000	1.2
GTEx	Lung	1	0.035	1.3
GTEx	Muscle Skeletal	0	0.000	1.3
GTEx	Nerve Tibial	1	0.023	1.3
GTEx	Ovary	0	0.000	1.2
GTEx	Pancreas	0	0.000	1.4
GTEx	Pituitary	0	0.000	1.3
GTEx	Prostate	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	1	0.041	1.4
GTEx	Skin Sun Exposed Lower leg	1	0.027	1.3
GTEx	Small Intestine Terminal Ileum	0	0.000	1.4
GTEx	Spleen	2	0.142	1.3
GTEx	Stomach	1	0.069	1.3
GTEx	Testis	1	0.032	1.3
GTEx	Thyroid	1	0.025	1.3
GTEx	Uterus	1	0.176	1.4
GTEx	Vagina	1	0.157	1.3
GTEx	Whole Blood	1	0.050	1.3
METSIM	Adipose	4	0.087	1.3
NTR	Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	1	0.023	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	1	0.060	1.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	2	0.045	1.3
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	1	0.091	1.5
The Cancer Genome Atlas	Colon Adenocarcinoma	2	0.097	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	1	0.146	1.6
The Cancer Genome Atlas	Glioblastoma Multiforme	2	0.196	1.6
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	2	0.073	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	5	0.122	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	1	0.049	1.4
The Cancer Genome Atlas	Brain Lower Grade Glioma	2	0.046	1.3
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	1	0.090	1.5
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	4	0.160	1.3
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	1	0.063	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	1	0.060	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	1	0.075	1.4
The Cancer Genome Atlas	Prostate Adenocarcinoma	2	0.043	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	1	0.145	1.7
The Cancer Genome Atlas	Soft Tissue Sarcoma	1	0.094	1.5
The Cancer Genome Atlas	Skin Cutaneous Melanoma	1	0.187	1.6
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.059	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	1	0.078	1.4
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.019	1.3
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	1	0.197	1.3