Hub : Genes

REXO4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2940 0.0360 0.0e+00 0.268 0.297 0.321 0.313 0.330 1.4e-32 1.6e-36 6.4e-40 8.1e-39 2.6e-41
2 GTEx Brain Frontal Cortex BA9 0.3640 0.1004 3.8e-04 -0.007 NA 0.052 NA 0.005 5.4e-01 NA 1.7e-02 NA 2.3e-01
3 GTEx Cells Transformed fibroblasts 0.3120 0.0530 1.6e-11 0.128 NA 0.203 NA 0.126 7.6e-10 NA 3.3e-15 NA 1.2e-09
4 GTEx Esophagus Muscularis 0.1560 0.0560 3.4e-03 0.017 NA 0.027 NA 0.048 3.0e-02 NA 8.8e-03 NA 7.0e-04
5 GTEx Liver 0.3670 0.1280 7.7e-03 0.107 NA 0.075 NA 0.102 6.7e-04 NA 4.1e-03 NA 9.1e-04
6 GTEx Testis 0.2800 0.0760 4.9e-05 0.016 NA -0.004 NA 0.014 6.4e-02 NA 5.6e-01 NA 7.3e-02
7 METSIM Adipose 0.0997 0.0253 2.7e-07 0.060 0.043 0.055 0.064 0.050 2.5e-09 4.4e-07 1.0e-08 6.8e-10 4.8e-08
8 TCGA Breast Invasive Carcinoma 0.0261 0.0124 2.0e-06 0.008 0.023 0.014 NA 0.018 7.9e-03 1.1e-05 5.5e-04 NA 1.2e-04
9 TCGA Kidney Renal Clear Cell Carcinoma 0.0429 0.0298 1.7e-03 0.009 0.014 0.021 NA 0.022 2.9e-02 9.2e-03 1.8e-03 NA 1.4e-03
10 TCGA Brain Lower Grade Glioma 0.0850 0.0357 4.1e-11 0.066 0.108 0.096 NA 0.088 5.3e-08 3.0e-12 5.2e-11 NA 3.5e-10
11 TCGA Lung Squamous Cell Carcinoma 0.0318 0.0231 1.7e-03 0.028 0.021 0.008 NA 0.026 3.4e-04 1.5e-03 3.5e-02 NA 5.1e-04
12 TCGA Pheochromocytoma and Paraganglioma 0.1270 0.0680 2.3e-05 0.050 0.104 0.111 NA 0.083 4.6e-03 6.3e-05 3.6e-05 NA 3.4e-04
13 TCGA Prostate Adenocarcinoma 0.0392 0.0210 2.1e-05 0.035 0.039 0.025 NA 0.033 1.3e-04 5.1e-05 1.2e-03 NA 1.8e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bipolar Disorder (2018) 0.5 0.8 1.4 -1.0 0.0 0.2 -0.2 -0.3 1.0 -1.2 -1.0 -0.7 -0.9 -1.1 -1.1 -1.1
Bipolar Disorder or Schizophrenia 0.2 0.4 1.3 -0.5 0.2 -1.1 0.1 -0.4 -0.1 -1.0 -0.3 -0.8 -0.8 -0.2 -0.9 -0.7
Depressed Affect (Nagel 2018) 1.5 3.2 5.7 2.3 1.4 0.0 1.1 -0.8 -2.4 1.8 2.3 0.5 2.1 1.9 2.1 2.2
Depression (Nagel 2018) 3.9 5.9 10.6 3.0 1.3 -0.5 1.3 -0.4 -3.2 2.5 3.1 1.6 2.8 3.3 2.7 3.1
Intelligence (Savage-Jansen 2018) 0.3 0.9 4.0 0.8 -0.4 1.2 -0.3 2.0 -0.5 1.0 0.4 1.5 0.8 0.3 0.6 0.8
Neuroticism (Nagel 2018) 0.4 1.0 2.3 1.3 0.1 0.9 0.1 0.5 -1.5 0.9 1.2 0.5 1.1 1.1 1.1 1.3
Schizophrenia (2018) 0.2 0.4 2.7 0.2 0.3 -1.6 0.3 -0.2 -1.0 -0.3 0.4 -0.5 -0.2 0.7 -0.3 0.0
Schizophrenia vs Biploar Disorder 2.2 2.9 5.1 2.0 1.6 -1.8 1.5 -0.4 -2.3 1.5 2.1 1.0 1.8 1.9 1.8 1.8
Worry (Nagel 2018) 0.1 0.3 1.0 0.6 0.8 -0.5 0.8 -0.5 -1.0 -0.2 0.5 -0.2 0.2 0.0 0.6 0.3
Alzheimer’s Disease (in mother) 0.4 0.5 2.4 0.1 -0.8 0.9 -0.9 0.9 -0.4 0.3 0.3 -0.7 0.3 1.6 -0.3 0.4
Alzheimer’s Disease (in father) 0.6 0.7 1.8 0.9 0.1 0.5 -0.2 -0.6 -0.6 1.2 0.9 0.4 1.0 1.3 0.6 1.1
Alzheimer’s Disease (including proxy) 0.4 0.6 3.2 0.7 -0.3 0.5 -0.4 0.1 -0.7 0.6 0.8 -0.4 0.8 1.8 0.1 0.9
Crohns Disease (2017) 1.1 2.3 7.6 -0.4 -2.6 2.5 -2.8 2.4 0.2 1.1 -0.9 0.4 -0.3 0.5 -0.8 0.1
Irritable Bowel Disease (IBD) 0.9 2.1 6.9 0.2 -2.2 2.5 -2.2 2.6 0.1 1.6 -0.4 0.7 0.3 0.5 -0.3 0.6
Ulcerative Colitis (UC) 0.5 0.9 3.4 0.7 -1.0 1.5 -0.9 1.9 -0.1 1.2 0.3 0.9 0.7 0.5 0.4 0.8
Major Depression (MDD) 0.6 0.8 2.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 -1.5 -0.8 -1.5 -0.8 -1.6 -1.4
Reaction Time 0.3 0.5 3.4 -0.2 1.1 -1.0 0.8 -1.8 -0.1 -0.5 0.1 -0.1 -0.3 -0.6 0.3 -0.1
Verbal and Numeric Reasoning (VNR) 0.4 1.0 4.8 0.6 -0.8 1.5 -0.6 2.2 -0.3 0.6 -0.1 2.1 0.2 -0.1 0.3 0.4
Breast Cancer 1.5 3.6 7.1 -2.1 -2.7 2.1 -2.4 0.8 1.9 -1.1 -2.3 0.7 -2.4 -1.5 -1.8 -1.7
Ovarian Cancer 1.2 1.6 13.2 1.0 -0.4 -0.0 -0.4 0.9 -0.8 1.1 0.7 3.6 0.4 1.1 1.0 1.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.2 0.3 1.6 0.2 -1.0 0.8 -0.9 1.2 -0.2 0.7 0.0 0.0 0.0 0.0 0.0 0.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.4 0.6 1.3 1.1 1.0 -1.2 0.9 -0.9 -1.1 0.9 0.0 0.0 0.0 0.0 0.0 0.0
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 1.5 2.5 6.7 -0.4 -2.6 2.5 -2.6 2.5 0.1 0.8 -0.9 2.1 -0.4 0.4 -0.4 -0.1
Mean Putamen Volume 0.4 0.4 1.0 -0.6 -0.5 1.0 -0.6 0.8 1.0 -0.3 -0.7 0.3 -0.6 -0.6 -0.5 -0.5
Fasting Glucose 1.4 1.7 3.1 -1.7 -1.3 1.0 -1.6 0.8 1.8 -1.1 -1.4 -0.8 -1.5 -0.4 -1.6 -1.3
HbA1C 0.4 0.5 1.6 -1.1 -0.4 1.3 -0.5 1.2 1.0 -0.8 0.0 0.0 0.0 0.0 0.0 0.0
HDL Cholesterol 0.5 0.9 4.0 -0.4 -1.9 2.0 -1.5 0.8 0.6 -0.1 0.0 0.0 0.0 0.0 0.0 0.0
LDL Cholesterol 0.7 1.1 3.2 -1.1 1.3 -1.5 1.2 -1.4 1.8 -1.2 0.0 0.0 0.0 0.0 0.0 0.0
Lupus 1.9 2.8 4.7 1.8 2.0 -1.3 2.0 -1.1 -2.0 1.1 2.0 0.6 1.8 1.1 2.2 1.8
Neuroticism (2016) 0.1 0.1 1.0 0.1 0.3 -0.1 0.3 0.1 -0.1 -0.4 0.1 -1.0 0.2 0.2 -0.3 -0.1
Primary Biliary Cirrhosis 0.5 0.8 1.3 1.0 0.3 -1.1 -0.1 0.4 -0.9 1.1 0.8 1.0 1.0 0.9 0.9 1.0
Rheumatoid Arthritis 0.4 0.6 2.1 -0.2 -1.0 1.4 -1.3 0.5 0.1 -0.1 -0.4 1.2 -0.3 0.8 -0.5 0.1
Schizophrenia (2014) 0.3 0.6 3.2 0.5 0.5 -1.8 0.6 0.1 -1.3 -0.1 0.7 -0.4 0.1 0.9 -0.2 0.3
Triglycerides 0.8 1.2 4.5 -0.0 1.9 -2.0 1.9 -2.1 0.3 -0.4 0.0 0.0 0.0 0.0 0.0 0.0
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.8 -0.2 0.3 -0.2 0.3 -0.5 0.9 -0.1 0.0 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.4 0.5 1.1 0.9 -0.1 -0.1 0.0 1.0 -0.6 0.8 0.7 1.1 0.8 0.6 0.8 0.8
Blood Eosinophil Count 0.9 6.9 26.2 -0.1 -3.4 4.2 -3.3 5.1 0.2 1.0 -0.8 4.6 -0.6 0.8 -0.2 0.5
Blood Platelet Count 1.5 17.8 58.7 3.7 6.6 -7.1 7.7 -3.4 -3.1 0.6 3.6 -1.7 3.4 -0.7 3.5 1.8
Blood Red Count 4.9 47.4 171.6 -1.1 -10.0 12.0 -10.3 7.3 1.1 3.2 -2.0 13.1 -2.3 4.1 -0.6 1.4
Blood White Count 0.7 5.5 45.0 1.1 -1.4 2.4 -1.7 2.4 -0.9 1.1 0.5 6.7 0.2 1.4 1.5 1.4
Heel T-Score 1.9 14.7 71.1 3.8 0.1 1.8 0.1 1.5 -3.5 4.3 3.4 8.4 3.1 3.7 4.2 4.1
BMI 0.2 1.2 5.1 0.6 2.0 -1.6 2.3 -1.1 -0.6 -0.2 0.8 -0.8 0.4 -0.2 0.5 0.1
Height 0.4 6.8 17.6 -2.1 -4.0 3.9 -4.2 3.2 2.2 -0.6 -2.3 1.6 -2.0 -0.2 -2.2 -1.5
Waist Hip Ratio (WHR) 0.1 0.5 2.0 -0.5 0.3 -0.9 -0.0 -0.5 0.6 -0.4 -0.7 -1.4 -0.6 -0.7 -0.9 -0.6
Systolic Blood Pressure 0.3 1.6 4.0 1.4 2.0 -1.7 1.8 -1.2 -1.1 0.5 0.8 1.2 1.0 -0.5 1.3 0.7
Smoking Status 0.4 1.0 3.1 1.1 0.2 0.7 -0.1 0.5 -1.0 0.9 1.1 1.0 1.2 1.7 0.9 1.3
Allergy or Eczema 0.4 1.0 4.2 0.5 -0.9 1.1 -0.4 1.8 -0.3 0.9 0.4 -2.0 1.1 0.8 -0.1 0.5
Cardiovascular Disease 0.4 1.2 2.4 1.2 1.5 -1.3 1.5 -0.7 -0.6 0.6 1.2 0.3 1.3 0.3 1.5 1.0
Hypothyroidism (self reported) 0.1 0.2 0.8 -0.1 0.2 -0.9 0.4 -0.5 -0.3 -0.2 0.2 -0.8 0.2 0.2 0.1 0.0
Respiratory disease 0.1 0.1 1.4 0.2 0.3 0.3 0.4 -0.2 -0.0 -0.1 0.0 -1.2 0.1 -0.4 -0.0 -0.1
Type 2 Diabetes (T2D) (2018) 1.2 2.3 3.6 1.7 1.7 -1.6 1.8 -0.8 -1.6 1.6 1.7 -0.1 1.9 1.0 1.7 1.5
Lung FEV1/FVC ratio 0.1 0.3 0.7 -0.3 -0.2 -0.8 -0.2 0.1 -0.7 -0.5 -0.4 0.8 -0.7 -0.2 -0.5 -0.5
Lung FVC 0.8 4.3 17.3 -0.7 -3.0 4.2 -2.7 2.7 0.7 -0.2 -0.8 3.3 -1.0 0.7 -0.3 -0.2
Neuroticism 0.5 1.3 2.8 1.6 1.2 0.1 1.1 -0.6 -1.7 0.9 1.3 0.5 1.1 0.7 1.4 1.2
Chronotype (morning person) 0.5 1.2 2.5 -1.3 0.1 -0.2 0.1 -0.8 1.1 -1.3 -1.2 -0.5 -1.6 -1.4 -1.3 -1.4
Hair Pigment 0.2 5.9 8.5 2.6 2.9 -2.1 2.8 -2.2 -2.5 2.1 2.9 1.5 2.3 1.8 2.8 2.4
Tanning 0.0 0.1 0.5 -0.2 -0.5 -0.2 -0.7 -0.2 0.1 -0.1 -0.0 -0.4 0.1 0.2 -0.1 0.1
Hand grip strength (left) 0.3 0.7 1.8 0.1 1.1 -1.4 1.2 -1.3 0.6 -0.9 -0.1 -0.0 -0.0 -1.4 0.4 -0.4
Number of treatments/medications taken 0.1 0.2 1.0 0.5 -0.0 0.3 -0.2 0.5 -0.1 0.4 0.2 1.0 0.2 0.0 0.2 0.4
Average weekly spirits intake 1.1 1.3 2.6 1.4 1.1 -0.7 1.3 -0.7 -1.6 1.0 1.4 -1.1 1.4 0.7 0.9 1.1
Sensitivity / hurt feelings 1.0 1.8 7.1 -0.1 -2.1 2.5 -2.0 2.7 0.1 0.3 -0.7 0.7 -0.2 0.3 -0.5 0.0
Frequency of depressed mood in last 2 weeks 1.9 2.7 4.6 2.1 1.2 -0.7 1.3 0.0 -1.9 1.7 2.2 1.2 2.0 1.8 1.8 2.1
Hearing difficulty/problems: Yes 2.4 3.6 6.7 -1.7 -2.6 2.4 -2.6 2.6 2.2 -1.2 -1.9 -0.5 -1.4 -0.7 -1.8 -1.3
Relative age of first facial hair 0.5 1.1 4.5 1.1 0.2 0.3 0.3 0.9 -0.9 1.4 0.7 2.1 1.0 0.8 1.3 1.0
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 2.6 -0.3 -1.0 1.1 -0.8 1.6 0.1 0.1 -0.1 0.4 -0.2 0.4 -0.3 0.0
Ever used hormone-replacement therapy (HRT) 2.4 3.1 10.2 -0.3 2.7 -2.6 2.7 -3.2 0.0 -1.6 -0.1 -0.7 -0.7 -1.9 0.2 -1.1
Ever had hysterectomy (womb removed) 0.4 0.4 1.8 0.1 1.0 -0.4 1.0 -1.3 -0.9 0.2 0.4 0.2 0.1 -0.0 0.7 -0.0
Systolic blood pressure, automated reading 0.1 0.3 0.8 0.8 0.2 0.2 0.1 0.4 -0.3 0.8 0.4 0.2 0.9 0.3 0.5 0.7
Eye problems/disorders: Diabetes related eye disease 1.6 1.7 3.6 1.8 0.3 0.6 0.0 1.0 -1.1 1.9 1.2 1.1 1.9 1.4 1.3 1.8
Angina 1.1 1.4 5.2 0.6 -1.4 1.4 -1.3 2.3 -0.7 1.1 0.3 1.6 0.4 1.4 0.1 0.8
Medication for hormone replacement therapy 3.0 3.3 5.9 -2.2 0.0 -1.0 -0.2 -0.4 1.8 -2.4 -2.0 -2.0 -2.2 -2.3 -2.1 -2.4
Vitamin and mineral supplements 0.7 0.9 4.0 -1.2 -0.9 0.1 -0.6 0.5 1.3 -0.6 -0.6 -2.0 -0.9 -0.1 -1.2 -0.8
Supplements: Zinc 0.1 0.1 0.6 -0.3 -0.1 -0.4 -0.4 -0.2 0.7 0.1 -0.4 0.1 -0.1 -0.8 0.1 -0.1
Medication: Co-codamol 0.7 0.9 2.6 -1.2 0.1 -0.1 0.1 -0.8 1.6 -0.8 -0.7 -0.9 -1.3 -0.8 -0.9 -1.2
Medication: Metformin 0.5 0.7 2.4 -0.1 1.0 -1.6 1.0 -1.1 0.5 -0.1 -0.1 -1.4 0.2 -0.9 -0.0 -0.4
Diabetes (father) 0.2 0.3 1.3 -0.4 0.1 -0.4 0.1 0.5 0.3 -0.3 -0.7 -0.6 -0.2 -1.1 -0.4 -0.6
Diabetes (mother) 1.1 1.4 2.6 1.5 1.3 -0.5 1.5 -0.4 -0.8 1.2 1.4 -1.1 1.6 0.7 1.3 1.2
Severe depression (siblings) 0.2 0.2 0.7 0.3 -0.5 0.4 -0.3 0.7 -0.9 0.2 -0.2 -0.7 0.7 0.0 -0.0 0.1
Pack years adult smoking proportion 0.2 0.3 0.9 0.1 0.7 -0.8 0.6 -1.0 0.0 -0.4 0.3 -0.7 -0.1 0.2 0.0 0.0
Impedance of leg (right) 1.0 4.7 16.3 -0.6 -3.4 4.0 -3.2 3.1 0.5 0.6 -1.3 3.0 -0.9 0.2 -0.6 -0.2
Leg fat-free mass (left) 0.2 0.8 3.1 -0.6 0.8 -1.3 0.9 -0.5 0.7 -0.9 -0.4 -1.8 -0.6 -0.9 -0.8 -0.9
Trunk fat percentage 0.3 1.4 5.9 -0.9 -1.4 2.4 -1.2 1.2 1.2 -0.2 -0.8 -1.4 -0.7 -0.1 -1.2 -0.6
Hand grip strength (right) 0.8 2.2 6.6 -1.0 1.2 -1.6 1.3 -1.2 1.5 -2.3 -1.2 -0.1 -1.4 -2.6 -0.7 -1.8
Townsend deprivation index at recruitment 0.6 0.9 1.7 -1.0 0.5 -1.3 0.3 -0.7 1.1 -1.1 -0.8 -0.9 -0.8 -1.2 -0.7 -1.1
Current tobacco smoking 0.5 0.8 1.6 0.9 1.1 0.1 0.9 -1.0 -0.8 0.2 1.2 -0.3 0.9 1.2 0.9 1.0
Average weekly fortified wine intake 0.8 1.0 2.1 -0.5 -1.5 1.3 -1.1 1.4 1.2 0.0 -1.1 -0.3 -0.6 -0.9 -1.0 -0.6
Maternal smoking around birth 0.1 0.2 1.1 -0.2 0.5 -1.1 0.4 -0.7 -0.1 -0.5 0.2 -0.3 -0.3 0.3 -0.1 -0.2
Fed-up feelings 0.2 0.4 1.2 0.7 0.1 0.7 0.0 0.6 -0.8 0.8 0.7 -0.5 0.7 1.1 0.4 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 2.0 2.7 5.5 1.9 0.7 -0.6 0.4 0.1 -2.3 1.8 1.9 1.5 1.8 2.3 1.7 2.1
Relative age voice broke 2.0 3.0 6.6 2.0 0.4 0.6 0.4 0.7 -1.6 2.6 1.9 1.5 2.4 1.9 2.2 2.2
Taking other prescription medications 0.0 0.1 0.2 0.1 0.2 -0.4 0.0 0.2 0.4 0.1 -0.2 -0.3 0.1 -0.5 -0.2 -0.0
Age when periods started (menarche) 0.2 0.5 2.5 -0.4 -0.7 0.4 -0.5 1.6 0.6 -0.1 -0.5 -1.2 0.1 -0.4 -0.6 -0.3
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 2.2 -0.2 1.1 -1.1 1.0 -1.5 -0.0 -0.7 0.2 -1.2 0.0 -0.4 0.1 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.3 6.5 1.6 1.7 -1.6 1.8 -1.0 -1.2 1.1 1.4 2.5 1.2 0.5 1.9 1.3
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 2.0 -0.6 0.4 -0.8 0.4 -0.3 0.1 -0.6 -0.5 -1.4 -0.2 -0.6 -0.5 -0.7
Qualifications: CSEs or equivalent 1.2 1.6 6.2 0.9 1.9 -1.6 1.6 -2.5 -0.8 0.4 1.2 -0.2 0.7 0.4 1.3 0.5
Serious illness, injury or assault to yourself 0.2 0.2 1.0 0.3 0.5 0.3 0.3 -0.1 -0.2 0.5 0.1 0.4 0.6 -1.0 0.8 0.3
High blood pressure 1.8 4.9 9.6 2.7 1.6 -0.7 1.4 -0.4 -2.3 2.1 2.5 3.1 2.5 2.0 2.8 2.7
Hayfever, allergic rhinitis or eczema 0.3 0.7 3.1 0.6 -0.0 0.2 0.4 0.9 -0.7 0.7 0.7 -1.8 1.3 0.8 0.4 0.6
Multivitamins +/- minerals 0.2 0.3 1.9 0.3 0.1 0.3 -0.0 0.1 -0.6 -0.4 -0.4 1.4 -0.0 -0.6 0.2 -0.2
Stomach or abdominal pain in last month 0.7 0.8 1.7 0.9 1.0 -1.3 1.0 -1.0 -0.9 0.5 1.0 0.7 0.9 0.5 0.9 0.9
Supplements: Glucosamine 0.7 0.9 4.8 0.6 -0.5 1.8 -0.1 1.0 -0.5 0.6 0.2 2.2 0.4 -0.1 0.7 0.5
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.8 -0.1 0.1 -0.3 0.1 0.0 0.1 -0.4 -0.0 0.9 -0.3 -0.4 0.1 -0.0
Medication: Atenolol 0.0 0.0 0.2 0.1 0.2 -0.4 0.2 -0.2 0.0 -0.0 0.1 0.1 0.0 0.4 0.0 0.1
Medication: Levothyroxine sodium 0.4 0.6 1.6 0.9 0.2 -0.1 0.3 0.5 -1.2 0.8 0.8 0.6 1.3 0.6 1.1 1.0
Sitting height 0.7 4.8 9.2 -2.1 -3.0 2.9 -2.8 2.2 1.9 -1.1 -2.4 1.5 -2.5 -1.4 -1.9 -1.9
Chronic bronchitis/emphysema (father) 1.4 1.7 3.5 -1.1 -1.7 1.2 -1.9 1.6 1.4 -0.7 -1.5 0.6 -1.4 -0.5 -1.4 -0.9
High blood pressure (mother) 0.8 1.1 4.4 -0.1 1.6 -1.4 1.4 -2.1 -0.2 -0.8 0.0 -1.3 -0.1 -1.0 0.1 -0.5
Body mass index (BMI) 0.2 1.0 2.3 1.0 1.4 -1.0 1.5 -0.9 -0.8 0.6 1.3 -0.3 0.9 0.9 0.9 0.9
Impedance of leg (left) 1.0 4.8 16.4 -0.7 -3.3 4.0 -3.3 2.9 0.7 0.4 -1.5 3.2 -1.1 0.1 -0.7 -0.2
Leg predicted mass (left) 0.2 0.9 3.3 -0.7 0.8 -1.3 1.0 -0.5 0.7 -1.0 -0.4 -1.8 -0.6 -0.9 -0.8 -1.0
Trunk fat mass 0.2 0.8 2.9 -0.7 -1.0 1.7 -0.8 1.0 1.0 -0.2 -0.6 -1.2 -0.6 -0.1 -1.1 -0.5
Waist circumference 0.0 0.1 0.4 0.1 0.0 0.1 0.2 0.3 0.0 0.2 0.3 -0.6 0.1 0.6 -0.2 0.2
Number of incorrect matches in round 0.2 0.3 0.5 -0.7 -0.7 0.2 -0.6 0.4 0.3 -0.7 -0.6 -0.7 -0.4 -0.1 -0.7 -0.5
Past tobacco smoking 0.8 1.5 4.5 -1.1 0.0 -0.2 0.2 -1.7 1.1 -1.3 -1.2 -1.5 -1.2 -2.1 -1.0 -1.4
Alcohol usually taken with meals 0.3 0.5 1.0 -0.4 0.8 -1.0 0.9 -0.4 1.0 -0.7 -0.2 -0.3 -0.3 -1.0 -0.3 -0.5
Nervous feelings 0.2 0.3 0.6 -0.7 -0.5 0.3 -0.4 0.6 0.5 -0.8 -0.6 -0.2 -0.8 -0.5 -0.5 -0.7
Frequency of tenseness / restlessness in last 2 weeks 2.4 3.7 6.1 2.1 1.8 -1.5 1.8 -1.2 -2.0 1.7 2.5 1.6 1.9 1.9 2.3 2.2
Hearing difficulty/problems with background noise 0.6 0.9 6.0 0.0 -1.0 1.4 -0.9 2.4 0.7 0.1 -0.1 1.1 0.1 0.9 -0.1 0.3
Hair/balding pattern: Pattern 2 0.7 0.8 2.3 -0.9 -0.3 0.1 -0.3 0.0 1.5 -1.2 -1.1 0.5 -1.2 -1.1 -0.9 -1.0
Had menopause 0.2 0.2 0.8 -0.2 0.6 -0.6 0.6 -0.9 -0.1 0.1 0.3 -0.8 -0.0 0.4 -0.1 -0.0
Had other major operations 0.4 0.5 1.3 -0.6 -1.0 1.2 -0.9 0.8 0.5 -0.0 -0.5 -0.5 -0.6 0.2 -0.8 -0.4
Forced vital capacity (FVC) 1.5 5.6 18.4 -1.2 -3.5 4.3 -3.4 3.1 1.5 -0.1 -1.8 3.0 -1.8 -0.3 -1.1 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 1.6 3.7 10.9 2.2 1.5 -1.0 1.7 -1.1 -1.6 1.9 2.0 3.3 1.8 1.2 2.5 2.0
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.5 0.0 0.3 -0.7 0.1 0.0 -0.2 -0.0 0.2 -0.5 0.2 0.2 0.2 0.2
Qualifications: None of the above 0.9 2.0 3.6 1.4 1.1 -0.9 0.9 -1.4 -1.9 1.5 1.7 0.2 1.5 1.9 1.4 1.7
Financial difficulties in last 2 years 0.4 0.5 1.0 0.9 0.4 -0.0 0.2 0.1 -0.8 0.8 0.7 1.0 0.8 0.8 0.9 0.8
Mouth/teeth dental problems 0.4 0.7 3.2 -0.3 0.9 -1.0 1.2 -0.6 0.5 -0.6 -0.5 0.5 -0.4 -1.8 0.1 -0.8
Heart attack 0.1 0.1 0.5 0.1 0.1 -0.1 -0.1 -0.3 0.2 0.3 0.3 -0.7 0.2 0.4 -0.1 0.3
Allergy 0.5 1.2 13.0 -0.2 0.0 -0.2 -0.2 -0.6 -0.0 -0.7 -0.4 3.6 -1.1 -0.4 0.2 -0.3
Pain all over the body in last month 2.6 2.8 4.6 1.7 1.6 -1.2 1.6 -1.4 -2.1 1.5 1.9 1.5 1.6 1.4 2.1 1.6
Diabetes (self-reported) 0.2 0.3 1.0 0.8 0.5 0.2 0.5 0.4 -0.1 0.8 0.4 0.0 1.0 -0.0 0.6 0.6
Hayfever/allergic rhinitis (self-reported) 0.7 1.0 6.6 -1.1 0.0 0.2 0.2 0.6 0.8 -0.9 -0.7 -2.6 -0.3 -1.0 -0.7 -0.9
Medication: Ramipril 0.2 0.2 0.5 0.6 0.3 0.1 0.4 -0.1 -0.6 0.6 0.7 0.2 0.5 0.6 0.4 0.5
Medication: Simvastatin 0.2 0.4 3.0 0.1 -0.4 0.5 -0.4 0.8 0.4 0.1 -0.1 -1.7 0.5 -0.3 -0.3 0.0
Fluid intelligence score 0.4 0.9 3.9 -0.1 -1.2 0.8 -1.1 1.7 0.2 0.1 -0.6 2.0 -0.5 -0.6 -0.3 -0.3
Illnesses of siblings 2.8 3.9 8.6 -2.3 -1.1 0.6 -1.0 0.8 2.9 -2.0 -2.4 -1.0 -2.4 -2.5 -2.1 -2.4
Neuroticism score 0.4 0.9 2.4 1.3 0.9 -0.3 0.9 0.2 -1.5 0.7 1.1 0.5 1.0 0.5 1.1 0.9
Weight 0.0 0.0 0.1 -0.1 0.1 0.0 0.3 0.3 0.2 0.0 0.1 -0.3 -0.2 0.2 -0.3 -0.1
Impedance of arm (right) 2.2 10.4 16.6 -3.3 -3.9 4.1 -3.8 2.2 3.3 -1.8 -3.6 -3.4 -2.7 -2.2 -3.5 -2.9
Arm fat percentage (right) 0.1 0.5 5.2 -0.1 0.1 0.7 0.2 -0.3 0.3 0.2 0.1 -2.3 0.2 0.1 -0.4 -0.1
Trunk fat-free mass 0.1 0.6 2.1 0.6 1.1 -1.5 1.2 -0.5 -0.7 0.2 0.8 0.8 0.3 0.3 0.6 0.4
Hip circumference 0.1 0.4 1.4 -0.2 -0.8 1.1 -0.5 1.2 0.2 0.0 -0.1 -0.2 -0.4 0.6 -0.6 -0.1
Time employed in main current job 1.4 1.6 4.4 1.2 1.9 -2.1 1.8 -1.0 -0.8 0.6 1.1 1.2 0.9 0.2 1.3 0.8
Alcohol intake versus 10 years previously 2.5 3.8 6.0 2.4 2.1 -1.9 1.9 -1.5 -1.6 1.9 2.0 1.9 2.2 1.2 2.5 2.0
Father’s age at death 0.8 1.1 8.7 0.4 -0.6 0.6 -0.4 1.9 -0.3 0.2 -0.1 3.0 0.1 0.1 0.4 0.3
Worrier / anxious feelings 0.2 0.3 1.2 0.7 -0.2 -0.1 0.1 0.7 -1.1 0.3 0.4 1.0 0.3 0.3 0.4 0.3
Frequency of tiredness / lethargy in last 2 weeks 2.2 3.6 5.7 2.4 1.6 -1.8 1.2 -1.1 -2.4 2.1 2.2 0.9 2.1 2.0 1.9 2.2
Falls in the last year 3.1 4.1 6.8 2.5 1.2 0.3 1.1 -0.3 -2.6 2.4 2.4 2.0 2.5 2.1 2.4 2.5
Hair/balding pattern: Pattern 3 0.4 0.6 1.4 0.6 0.6 -0.8 0.5 -0.6 -0.5 0.6 1.1 -0.4 0.9 1.2 0.7 0.8
Number of live births 2.6 3.7 6.2 2.4 1.4 -0.5 1.6 -0.8 -2.5 1.8 2.4 2.0 2.0 2.0 2.5 2.1
Forced expiratory volume in 1-second (FEV1) 1.2 4.0 10.8 -1.1 -2.7 3.3 -2.6 2.4 1.1 -0.4 -1.7 3.2 -1.8 -0.6 -0.9 -0.9
Pulse rate 1.1 1.9 3.8 -1.4 -1.4 1.4 -1.5 0.8 1.3 -1.5 -1.6 -0.9 -1.6 -0.3 -1.9 -1.4
Happiness 1.7 2.1 4.2 -1.6 -1.4 1.2 -1.6 1.3 2.0 -1.2 -1.7 -0.7 -1.4 -1.1 -1.6 -1.4
Noisy workplace 0.9 1.1 3.4 1.1 1.7 -1.5 1.9 -0.7 -0.7 0.3 1.0 -0.5 1.0 0.5 0.8 0.7
Qualifications: A levels/AS levels or equivalent 1.0 2.2 3.8 1.6 -0.8 1.5 -0.5 1.9 -1.7 1.9 1.2 1.6 1.5 1.6 1.1 1.6
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 2.6 -0.0 0.5 -0.9 0.4 -0.2 0.4 -0.5 -0.6 -0.8 -0.1 -1.6 -0.3 -0.6
Mouth/teeth dental problems: Dentures 0.3 0.6 2.0 -0.9 -0.4 0.3 -0.6 -1.2 0.7 -0.7 -0.6 -1.4 -0.7 -0.2 -0.8 -0.7
Asthma 0.1 0.3 1.3 -0.1 0.5 -0.3 0.6 -0.7 0.7 -0.5 -0.0 -1.1 -0.2 -0.5 -0.2 -0.4
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.6 2.9 -1.4 -0.7 0.4 -0.7 0.4 1.4 -1.5 -1.7 -0.1 -1.7 -1.4 -1.6 -1.6
Medication: Cholesterol lowering 0.4 0.6 5.5 0.0 0.4 -0.8 0.2 0.2 0.6 -0.2 -0.1 -2.3 0.5 -0.4 -0.5 -0.1
Depression (self-reported) 0.1 0.1 0.3 -0.0 -0.5 0.1 -0.5 0.5 -0.0 -0.1 -0.1 0.3 -0.3 0.2 -0.2 -0.0
Medication: Lansoprazole 0.2 0.2 0.6 0.6 0.5 -0.8 0.5 0.2 -0.6 0.1 0.4 -0.1 0.7 0.2 0.5 0.3
Prospective memory result 0.8 0.9 2.8 0.7 1.7 -1.6 1.6 -0.8 -0.7 0.0 0.8 -0.9 0.7 0.2 0.6 0.3
Lung cancer (father) 2.2 2.5 7.0 -1.4 -2.0 2.6 -1.9 1.8 1.2 -1.2 -1.8 0.4 -1.5 -1.3 -1.2 -1.3
Illnesses of mother 0.2 0.2 1.6 0.2 -0.0 0.0 0.3 0.7 0.3 0.4 0.2 1.3 -0.0 0.1 0.3 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.1 10.3 -1.6 -2.6 3.2 -2.4 2.3 1.5 -0.9 -1.9 2.5 -2.3 -0.8 -1.4 -1.3
Pulse wave Arterial Stiffness index 1.6 1.9 4.3 -1.0 -1.7 1.7 -1.7 2.1 1.8 -0.7 -1.5 0.9 -0.7 -1.0 -1.1 -0.8
Impedance of arm (left) 1.6 7.5 11.6 -2.8 -3.3 3.4 -3.2 2.0 2.7 -1.5 -3.0 -3.1 -2.3 -1.7 -3.1 -2.5
Arm fat mass (right) 0.1 0.2 1.6 0.3 0.4 0.2 0.6 -0.3 -0.2 0.3 0.5 -1.3 0.4 0.4 0.0 0.3
Trunk predicted mass 0.1 0.5 1.8 0.6 1.1 -1.4 1.1 -0.5 -0.6 0.1 0.7 0.8 0.2 0.2 0.6 0.3
Standing height 0.5 4.6 7.8 -2.3 -2.8 2.2 -2.7 2.5 2.2 -1.2 -2.4 0.0 -2.3 -1.4 -2.4 -1.9
Length of working week for main job 2.7 3.0 9.4 0.8 2.9 -2.6 3.1 -2.8 -1.1 -0.4 1.5 -0.9 0.4 0.2 1.0 0.3
Exposure to tobacco smoke at home 0.1 0.2 0.7 0.3 0.1 0.8 -0.1 0.3 -0.1 0.6 0.1 0.5 0.5 -0.3 0.4 0.4
Breastfed as a baby 0.4 0.5 1.4 -0.7 -0.3 0.5 -0.1 0.6 1.2 -0.9 -0.9 0.5 -0.6 -1.1 -0.4 -0.8
Tense / ‘highly strung’ 0.4 0.6 1.7 1.0 -0.1 0.1 -0.1 0.9 -1.3 0.7 0.7 1.0 0.9 0.8 0.7 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 1.1 -0.3 0.9 -0.6 0.8 -0.3 0.2 -1.1 -0.3 -0.8 -0.3 -1.0 -0.3 -0.7
Hair/balding pattern: Pattern 4 0.4 0.9 3.1 0.6 -0.9 1.8 -0.8 1.1 -0.8 1.3 0.4 0.1 0.9 0.8 0.6 0.9
Birth weight of first child 3.2 5.9 8.4 -2.8 -2.7 1.6 -2.5 2.2 2.7 -2.3 -2.9 -0.3 -2.7 -2.3 -2.6 -2.6
Peak expiratory flow (PEF) 1.8 4.1 12.2 -1.1 -2.7 3.5 -2.6 2.5 1.2 -0.7 -1.5 3.2 -1.8 -0.3 -0.8 -0.9
Pulse wave reflection index 0.6 0.8 2.4 1.0 -0.6 0.3 -0.4 1.5 -0.4 1.0 0.4 1.5 1.2 0.3 0.6 0.9
Ever highly irritable/argumentative for 2 days 0.4 0.4 0.9 0.8 0.3 -0.3 0.2 0.2 -0.8 0.9 0.8 0.2 0.9 0.8 0.6 0.9
Loud music exposure frequency 0.1 0.2 0.9 0.2 -0.3 0.6 -0.4 0.9 0.1 0.4 -0.1 0.3 0.3 0.1 -0.2 0.2
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 2.0 -1.0 -0.6 0.1 -0.5 1.1 1.1 -1.4 -1.2 -0.2 -1.3 -1.1 -1.3 -1.3
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 3.4 -0.3 -1.1 1.2 -1.2 1.9 0.5 0.3 -0.5 -0.1 -0.2 0.3 -0.6 -0.2
Blood clot in the leg (DVT) 2.8 3.6 42.5 -0.5 -0.5 0.6 -0.3 -0.7 0.8 0.9 -0.1 -6.5 1.0 -0.2 -0.9 -0.1
Medication: Paracetamol 0.1 0.2 1.6 -0.1 0.2 0.2 0.1 0.2 0.4 -0.5 -0.4 1.3 -0.3 -0.8 0.1 -0.4
Headache pain in last month 0.3 0.5 1.6 0.8 0.6 -0.8 0.5 -0.4 -0.5 0.6 0.5 1.3 0.6 0.0 0.8 0.6
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 1.1 -0.8 0.0 -0.5 0.2 -1.0 0.0 -0.7 -0.4 -0.2 -1.1 -0.2 -0.6 -0.8
Glaucoma (self-reported) 0.3 0.4 1.6 -0.2 -1.2 0.5 -1.3 0.8 0.4 0.6 -0.3 -0.2 -0.2 0.4 -0.6 0.1
Gout (self-reported) 0.5 0.7 1.6 1.0 0.5 0.2 0.6 -0.5 -0.4 1.2 1.1 0.4 1.0 1.3 0.9 1.0
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.7 -0.7 -0.6 0.0 -0.4 0.1 0.3 -0.6 -0.6 -0.8 -0.3 -0.4 -0.5 -0.5
Medication: Amlodipine 1.3 1.8 3.4 1.7 1.6 -1.0 1.5 -0.9 -1.3 1.1 1.3 1.0 1.6 0.0 1.8 1.2
Medication: Ventolin 100micrograms inhaler 0.2 0.3 1.4 0.1 -0.8 0.8 -0.6 1.2 0.2 0.1 -0.3 -0.2 -0.1 -0.2 -0.5 -0.1
Birth weight 1.7 3.7 7.6 -2.2 -1.6 0.7 -1.4 1.6 2.1 -1.8 -2.1 -2.8 -2.0 -1.3 -2.5 -2.1
Chronic bronchitis/emphysema (mother) 0.2 0.3 1.0 -0.1 -0.6 0.6 -1.0 -0.4 -0.1 0.0 -0.1 0.5 -0.3 1.0 -0.2 0.3
High blood pressure (siblings) 0.8 1.1 3.0 1.2 0.0 0.2 -0.2 -0.7 -1.7 1.2 1.0 0.9 1.2 1.3 1.1 1.3
Forced vital capacity (FVC), Best measure 1.4 5.0 15.2 -1.4 -3.2 3.9 -3.1 2.9 1.7 -0.5 -1.9 2.5 -1.9 -0.4 -1.3 -1.0
Body fat percentage 0.2 0.6 4.0 -0.3 -1.0 2.0 -0.8 0.9 0.6 0.3 -0.3 -0.8 -0.2 0.3 -0.6 -0.1
Leg fat percentage (right) 0.3 0.9 2.2 0.8 -0.7 1.5 -0.5 1.0 -0.5 1.2 0.7 1.4 0.7 1.2 0.5 1.0
Arm fat-free mass (right) 0.2 1.2 3.0 1.1 1.3 -1.4 1.5 -0.4 -1.1 0.5 1.2 1.7 0.6 0.7 1.1 0.9
Exposure to tobacco smoke outside home 0.9 1.2 3.3 0.9 1.6 -0.5 1.7 -1.8 -1.6 0.4 1.1 0.6 0.7 0.3 1.1 0.5
Comparative body size at age 10 0.6 1.8 2.9 1.6 0.8 -1.3 0.9 -0.3 -1.5 1.7 1.6 1.3 1.1 1.4 1.4 1.5
Number of full brothers 1.0 1.3 3.0 1.1 0.7 -0.4 0.6 -0.1 -1.5 1.5 1.3 0.6 1.4 1.7 1.1 1.4
Worry too long after embarrassment 0.6 1.0 1.6 -0.9 -1.1 1.3 -0.9 0.9 0.3 -1.1 -1.0 -0.5 -1.3 -0.6 -1.1 -1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 1.0 0.2 0.8 -0.3 1.0 -0.1 -0.2 -0.4 0.4 -0.0 0.0 -0.4 0.3 -0.0
Wheeze or whistling in the chest in last year 0.2 0.3 1.1 0.4 0.9 -0.1 0.6 -1.0 0.1 0.1 0.4 -0.8 0.6 0.0 0.4 0.3
Number of children fathered 0.4 0.5 1.2 0.8 0.2 -0.6 -0.0 -0.1 -0.3 1.1 0.8 0.4 0.9 0.8 0.7 1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 2.6 1.2 0.6 0.2 0.3 0.2 -1.0 1.5 1.0 1.6 1.1 0.7 1.4 1.4
Age at first live birth 0.7 1.2 4.0 0.6 -1.6 0.8 -1.4 2.0 -0.2 1.2 -0.2 2.0 0.3 0.2 0.2 0.6
Pulse wave peak to peak time 1.2 1.4 4.2 0.7 1.6 -1.7 1.6 -2.0 -1.4 0.4 1.1 -1.0 0.4 0.6 0.8 0.4
Health satisfaction 1.1 1.4 2.5 1.4 0.9 -0.3 1.1 -0.1 -0.9 1.3 1.6 0.5 1.6 1.1 1.6 1.5
Shortness of breath walking on level ground 0.9 1.1 3.2 1.5 0.7 -0.7 0.8 1.3 -0.7 1.3 1.0 0.1 1.8 0.2 1.1 1.2
Qualifications: College or University degree 1.6 5.0 8.4 -2.3 -2.9 2.0 -2.7 2.8 2.2 -1.5 -2.5 -0.3 -2.4 -1.5 -2.5 -2.1
Eye problems/disorders: None of the above 2.5 2.8 9.9 -0.8 1.9 -2.6 1.9 -3.1 0.9 -1.9 -0.5 -0.1 -1.4 -1.7 -0.3 -1.5
Mouth/teeth dental problems: Loose teeth 1.0 1.2 4.3 1.1 -0.0 0.5 -0.1 0.5 -1.4 0.9 1.3 0.3 1.3 2.1 0.9 1.4
Emphysema/chronic bronchitis 0.3 0.3 1.3 -0.2 0.6 -1.1 0.1 -1.1 -0.2 -0.5 0.1 -0.4 -0.4 0.6 -0.3 -0.1
Medication for pain relief, constipation, heartburn 0.3 0.5 1.9 -0.5 -1.2 1.4 -1.2 0.4 0.7 0.2 -0.2 -0.3 -0.2 0.7 -0.4 0.1
Neck or shoulder pain in last month 0.0 0.0 0.1 0.1 0.3 0.3 0.2 -0.2 -0.2 0.2 -0.0 0.3 0.1 0.1 0.0 -0.0
Medication: Blood pressure 0.6 1.1 2.2 1.5 0.6 -0.0 0.4 0.4 -1.1 1.3 1.0 1.3 1.5 0.5 1.4 1.4
Angina (self-reported) 1.3 1.7 5.2 0.9 -1.3 1.3 -1.1 2.3 -1.0 1.4 0.6 1.8 0.7 1.6 0.4 1.2
Migraine (self-reported) 0.1 0.1 0.7 -0.1 -0.0 -0.1 -0.1 0.6 0.6 -0.1 -0.2 -0.8 0.1 -0.2 -0.2 -0.0
Medication: Ibuprofen 2.3 2.8 4.9 -1.8 -1.4 1.1 -1.4 1.0 1.9 -1.8 -2.1 -0.5 -2.1 -1.4 -2.2 -1.9
Medication: Allopurinol 0.5 0.6 1.7 1.0 0.1 0.4 0.0 0.5 -0.4 1.3 0.8 0.4 1.1 1.0 0.6 1.1
Medication: Omeprazole 2.0 2.3 4.7 1.6 1.6 -2.2 1.4 -0.8 -1.7 1.2 1.8 1.1 1.6 1.4 1.6 1.6
Medication: Seretide 50 evohaler 0.8 1.0 3.6 -0.7 0.9 -0.9 0.8 -1.1 0.5 -1.1 -0.5 -1.9 -0.8 -1.0 -0.7 -1.0
Mean time to correctly identify matches 0.2 0.3 2.4 -0.3 0.6 -0.6 0.4 -1.6 0.1 -0.2 0.0 0.3 -0.3 -0.5 0.3 -0.1
Heart disease (mother) 1.4 1.7 7.0 -1.4 -0.1 -0.7 -0.3 -1.1 0.9 -1.6 -1.0 -2.6 -1.4 -0.8 -1.6 -1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 1.5 0.1 -0.0 0.4 -0.3 -1.1 0.4 0.4 -0.0 1.2 -0.2 -0.0 0.2 0.2
Whole body fat mass 0.1 0.3 1.8 -0.2 -0.6 1.3 -0.4 0.7 0.4 0.2 -0.1 -0.7 -0.1 0.2 -0.5 -0.1
Leg fat mass (right) 0.1 0.3 1.1 0.3 -0.5 1.0 -0.3 0.8 -0.1 0.6 0.3 0.4 0.2 0.7 -0.0 0.4
Arm predicted mass (right) 0.1 0.7 2.8 0.8 1.0 -1.1 1.2 -0.1 -0.7 0.3 0.9 1.7 0.3 0.4 0.8 0.6
Pulse rate, automated reading 0.1 0.2 0.5 -0.2 -0.3 0.0 -0.3 0.7 -0.4 -0.7 -0.5 0.3 -0.6 0.1 -0.7 -0.4
Alcohol intake frequency. 0.4 1.0 3.0 1.1 -0.3 0.8 -0.2 0.7 -0.8 1.3 0.8 1.7 0.8 1.1 1.0 1.1
Comparative height size at age 10 0.9 4.7 6.7 -2.5 -2.4 2.6 -2.3 1.0 2.2 -1.8 -2.4 -1.1 -2.6 -1.6 -2.6 -2.2
Number of full sisters 1.2 1.4 7.7 -0.8 1.2 -1.5 1.1 -2.8 0.6 -1.4 -0.3 -0.4 -1.2 -0.6 -0.3 -1.0
Suffer from ‘nerves’ 1.0 1.6 5.4 1.0 2.1 -1.5 2.3 -1.4 -1.2 0.1 1.2 0.2 0.7 -0.2 1.4 0.5
Overall health rating 2.0 4.4 7.7 2.4 1.6 -1.0 1.4 -0.9 -2.7 2.4 2.8 0.8 2.3 2.6 2.2 2.6
Chest pain or discomfort 0.6 0.9 2.8 0.9 -0.5 0.1 -0.6 0.4 -0.7 1.3 1.0 1.2 0.9 1.7 0.8 1.3
Had major operations 2.5 3.0 7.1 2.0 1.5 -0.0 1.6 -0.2 -2.1 1.6 1.8 2.7 1.7 1.1 2.3 1.7
Age at last live birth 1.4 2.1 7.7 1.3 -1.2 0.9 -1.2 1.7 -0.9 2.1 0.6 2.8 1.1 1.0 1.1 1.5
Family relationship satisfaction 0.2 0.2 0.9 0.1 -0.4 0.5 -0.3 0.9 0.0 0.3 0.3 0.5 0.5 0.7 0.4 0.5
Leg pain on walking 0.2 0.2 1.3 0.2 0.9 -0.0 0.8 -1.1 0.3 -0.0 0.3 -0.4 0.0 -0.1 0.4 -0.0
Qualifications: NVQ or HND or HNC or equivalent 1.7 2.1 5.2 1.3 2.2 -1.7 2.3 -2.0 -0.9 0.5 1.4 0.1 1.4 0.6 1.6 0.9
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.9 0.1 1.7 -1.5 1.5 -1.1 0.4 -0.4 0.1 -0.4 0.3 -1.1 0.4 -0.2
Illness, injury, bereavement, stress in last 2 years 2.6 3.1 5.8 -2.3 -1.9 1.1 -1.8 1.0 2.3 -1.9 -1.9 -0.2 -2.4 -0.5 -2.1 -1.9
Medication: Aspirin 0.1 0.2 0.8 0.4 0.1 -0.4 0.1 -0.0 -0.7 0.6 0.3 -0.9 0.4 0.1 0.0 0.3
Supplements: Vitamin C 3.5 4.1 6.7 2.2 2.3 -1.2 2.0 -1.9 -2.3 1.9 2.2 2.3 1.9 1.2 2.6 1.9
Knee pain experienced in last month 2.4 3.7 6.0 2.2 2.4 -1.5 2.4 -1.1 -1.6 1.8 2.4 0.0 2.4 1.5 2.2 2.0
Hypertension (Self-reported) 1.6 4.3 8.4 2.6 1.5 -0.5 1.3 -0.3 -1.9 2.0 2.4 2.9 2.5 1.9 2.7 2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.2 -0.7 -0.8 0.3 -0.9 1.1 0.5 -0.6 -0.9 0.0 -0.6 -0.7 -0.8 -0.7
Illnesses of father: Heart disease 0.4 0.6 4.7 0.2 -0.4 0.5 -0.4 0.7 0.2 0.5 0.2 -2.2 0.7 1.0 -0.5 0.4
Illnesses of siblings: Diabetes 1.6 2.0 5.2 1.8 0.2 -0.0 0.3 0.7 -2.3 1.8 1.6 0.1 1.9 1.7 1.3 1.8
Smoking status: Previous 0.7 1.1 4.2 0.6 -0.7 0.4 -0.8 2.1 -0.4 1.1 0.6 1.5 0.6 1.6 0.3 0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.3 0.9 -0.6 -0.2 0.1 -0.4 -0.1 0.8 -0.4 -0.8 0.1 -0.8 -0.9 -0.6 -0.7
Whole body fat-free mass 0.1 0.5 2.1 0.3 1.2 -1.5 1.3 -0.6 -0.3 -0.2 0.5 -0.1 0.0 -0.2 0.2 -0.0
Leg fat-free mass (right) 0.2 1.1 3.4 -0.6 1.1 -1.5 1.1 -0.8 0.7 -1.0 -0.3 -1.9 -0.6 -0.9 -0.8 -0.9
Arm fat percentage (left) 0.1 0.4 4.2 0.1 0.2 0.5 0.4 -0.2 0.1 0.3 0.3 -2.0 0.3 0.4 -0.3 0.1
Average weekly red wine intake 0.3 0.4 1.8 0.1 0.8 -1.3 0.8 -1.1 -0.0 -0.4 0.2 -0.9 0.0 -0.2 -0.1 -0.1
Handedness (chirality/laterality): Left-handed 1.7 2.0 5.8 0.6 1.8 -1.5 1.9 -2.3 -0.7 -0.2 1.2 -2.4 1.3 0.5 1.0 0.4
Mood swings 1.9 3.4 6.0 2.4 0.8 0.1 0.6 0.5 -2.5 2.2 2.1 1.8 2.2 2.2 2.0 2.3
Loneliness, isolation 0.7 0.9 3.2 0.8 1.8 -1.2 1.7 -0.9 -0.6 0.2 0.9 -0.2 0.6 0.0 0.9 0.5
Long-standing illness, disability or infirmity 0.8 1.2 4.7 -0.8 -1.5 1.8 -1.5 2.2 0.4 -0.1 -0.9 -0.4 -0.5 -0.6 -0.8 -0.5
Ever had bowel cancer screening 0.7 0.9 2.6 0.9 0.2 -0.1 0.1 0.7 -1.5 0.9 1.2 0.8 0.8 1.6 0.6 1.2
Diabetes diagnosed by doctor 0.5 0.9 1.9 1.1 1.4 -0.9 1.4 -0.3 -0.6 0.9 1.0 -0.2 1.3 0.0 1.0 0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.1 -0.8 -0.8 1.0 -0.6 0.2 0.6 -0.9 -0.8 -0.1 -1.1 -0.8 -0.9 -0.9
Friendships satisfaction 0.3 0.3 0.9 -0.5 -0.5 0.9 -0.5 0.9 0.6 -0.3 -0.7 0.4 -0.4 -0.5 -0.5 -0.4
Qualifications: nursing, teaching 1.6 2.5 3.6 -1.9 -1.4 1.8 -1.5 -0.2 1.9 -1.6 -1.8 -1.0 -1.9 -1.2 -1.8 -1.7
Commuting to job workplace: Walk 1.2 1.3 4.2 -0.9 -2.0 2.1 -1.9 1.1 0.6 -0.3 -1.1 0.3 -0.9 0.0 -0.9 -0.6
Eye problems/disorders: Cataract 0.5 0.6 3.2 -0.3 -0.9 1.6 -0.9 1.8 0.3 0.3 -0.4 -0.4 0.1 -0.3 -0.4 0.0
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 2.9 1.2 -0.1 0.1 -0.2 0.7 -1.2 1.1 1.1 0.8 1.1 1.7 0.7 1.4
Medication for cholesterol 0.5 0.7 4.0 0.5 -0.7 0.9 -0.7 0.9 -0.7 0.8 0.1 2.0 0.2 0.8 0.4 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.4 0.6 0.2 0.3 -0.2 1.2 -0.8 0.7 0.4 0.4 0.9 0.3 0.6 0.7
Back pain experienced in last month 0.1 0.2 0.8 0.7 0.3 -0.4 0.5 0.7 -0.2 0.4 0.3 0.9 0.4 0.2 0.2 0.4
Mineral and other dietary supplements 0.3 0.4 2.0 0.0 0.6 -0.9 0.5 -0.7 -0.0 0.3 0.6 -1.4 0.4 0.8 0.1 0.3
Breast cancer (self-reported) 0.7 0.9 2.0 -1.2 -0.0 -0.1 -0.3 -0.1 1.4 -0.9 -0.9 -1.4 -1.0 -1.0 -0.9 -1.2
Asthma (self-reported) 0.2 0.4 1.9 -0.1 0.7 -0.4 0.7 -0.7 0.5 -0.6 -0.0 -1.4 -0.1 -0.6 -0.2 -0.4
Osteoporosis (self-reported) 2.6 3.2 5.9 -2.0 -1.6 0.8 -1.4 1.3 1.6 -1.8 -2.2 -1.9 -1.8 -1.6 -2.4 -2.1
Osteoarthritis (self-reported) 0.1 0.2 0.6 0.3 0.5 -0.3 0.5 -0.4 -0.6 -0.0 0.3 0.8 0.1 -0.1 0.5 0.1
Medication: Aspirin 0.5 0.6 1.6 1.0 0.1 -0.3 0.2 0.2 -1.1 1.3 0.9 -0.1 1.0 0.8 0.6 1.0
Medication: Gliclazide 1.1 1.2 6.5 0.5 1.8 -2.6 1.7 -1.2 -0.2 -0.1 0.6 -0.4 0.6 -0.3 0.4 0.2
Illnesses of father: None of the above (group 1) 0.3 0.3 1.4 -0.0 0.9 -0.8 1.2 -0.7 -0.3 -0.3 0.2 0.3 -0.2 -0.7 0.4 -0.4
Smoking status: Current 0.6 0.9 1.8 1.1 1.0 0.4 0.8 -1.0 -0.9 0.5 1.3 -0.1 1.2 1.2 1.1 1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 4.1 -0.5 -1.0 2.0 -0.9 0.4 0.3 -0.2 -0.5 1.6 -0.8 -0.1 -0.1 -0.3
Whole body water mass 0.1 0.5 2.3 0.2 1.2 -1.5 1.3 -0.6 -0.2 -0.3 0.4 -0.1 0.0 -0.2 0.2 -0.1
Leg predicted mass (right) 0.2 1.0 3.2 -0.6 1.1 -1.5 1.2 -0.8 0.7 -1.0 -0.3 -1.8 -0.6 -0.8 -0.7 -0.9
Arm fat mass (left) 0.1 0.2 1.2 0.4 0.4 0.2 0.6 -0.3 -0.2 0.4 0.6 -1.1 0.4 0.6 0.1 0.3
Number of self-reported non-cancer illnesses 0.1 0.2 0.5 0.4 -0.1 0.3 -0.0 0.6 0.2 0.6 0.4 -0.6 0.7 -0.0 0.3 0.5
Average weekly champagne plus white wine intake 1.6 2.2 3.3 -1.6 -0.8 0.5 -0.7 1.5 1.8 -1.7 -1.8 -1.0 -1.5 -1.7 -1.7 -1.8
Miserableness 0.9 1.6 4.3 1.6 1.1 -0.3 0.9 -0.1 -2.1 1.3 1.5 0.3 1.5 1.4 1.3 1.4
Guilty feelings 0.6 0.9 2.0 -0.8 -1.4 1.0 -1.2 1.3 0.7 -0.6 -0.9 -0.8 -1.0 -0.0 -1.3 -0.7
Wears glasses or contact lenses 0.2 0.2 0.7 -0.3 0.5 -0.8 0.4 -0.5 0.7 -0.5 0.1 -0.8 -0.3 0.1 -0.2 -0.3
Ever taken oral contraceptive pill 0.9 1.0 3.5 -0.9 -0.1 0.4 -0.0 0.4 1.4 -1.1 -1.1 0.2 -1.2 -1.9 -0.8 -1.2
Hearing aid user 0.4 0.5 1.5 -0.4 -1.2 1.1 -1.2 0.8 -0.1 -0.2 -0.3 -0.8 -0.2 0.5 -0.7 0.0
Mother’s age at death 0.4 0.5 1.0 -0.6 -1.0 0.9 -0.7 0.8 0.5 -0.5 -0.8 0.3 -0.4 -0.8 -0.6 -0.5
Financial situation satisfaction 0.4 0.5 2.4 0.4 0.9 -1.6 0.8 -1.1 -0.6 -0.2 0.6 0.7 -0.1 0.5 0.4 0.3
Tinnitus: Yes, now most or all of the time 0.5 0.6 2.6 0.0 -1.3 0.6 -1.3 1.3 -0.1 0.2 -0.4 1.6 -0.1 0.2 0.0 0.1
Commuting to job workplace: Public transport 0.8 0.9 4.0 0.5 -0.9 1.0 -1.1 0.4 -1.1 1.2 0.7 -0.3 0.6 2.0 -0.0 0.9
Eye problems/disorders: Glaucoma 0.5 0.6 2.1 -0.3 -1.4 0.7 -1.4 1.4 0.3 0.4 -0.6 0.2 -0.3 0.1 -0.7 -0.1
Medication: Blood pressure 0.8 1.6 2.7 1.1 1.6 -1.2 1.6 -1.6 -0.9 0.4 1.5 1.4 0.9 0.7 1.6 1.0
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.8 0.2 -0.2 0.4 -0.3 0.5 0.3 0.1 -0.2 0.9 0.2 0.0 0.0 0.2
Supplements: Fish oil (including cod liver oil) 0.6 0.8 3.0 -0.6 0.1 0.4 -0.1 -0.6 0.9 -1.0 -1.1 1.3 -1.0 -1.7 -0.2 -1.0
High cholesterol (Self-reported) 0.9 1.6 13.3 -0.6 0.7 -0.7 0.8 0.1 1.4 -1.0 -0.4 -3.6 0.1 -1.3 -0.8 -0.8
Medication: Bendroflumethiazide 2.0 3.1 6.7 1.7 2.6 -2.2 2.3 -2.2 -1.4 0.7 1.9 0.5 1.6 1.0 1.8 1.4
Medication: Paracetamol 0.8 1.2 2.4 -1.0 -1.3 1.6 -1.4 1.3 1.0 -0.9 -1.2 1.1 -1.0 -0.5 -0.9 -0.9
Medication: Lisinopril 0.5 0.7 2.4 0.8 -0.3 0.6 -0.5 1.5 -0.4 0.8 0.4 1.6 0.7 0.5 0.6 0.8
Medication: Atorvastatin 2.0 2.5 14.4 -1.6 0.1 -0.0 -0.0 -0.8 1.6 -1.7 -1.1 -3.8 -1.0 -1.3 -1.6 -1.4
Illnesses of father: High blood pressure 0.7 0.8 3.0 -0.0 -1.7 0.9 -1.7 1.2 -0.3 0.4 -0.2 1.1 -0.2 0.9 -0.4 0.3
Alcohol drinker status: Never 1.4 1.6 3.8 1.1 -0.2 1.0 -0.3 0.5 -1.8 1.4 1.3 2.0 1.1 1.6 1.3 1.5
Ever smoked 2.1 3.7 5.4 2.3 1.4 -1.1 1.2 0.2 -2.2 2.2 2.3 1.9 2.3 2.1 2.3 2.3
Basal metabolic rate 0.1 0.3 1.3 0.2 0.9 -1.1 1.1 -0.4 -0.2 -0.2 0.4 -0.2 -0.0 -0.1 0.1 -0.1
Leg fat percentage (left) 0.2 0.6 1.6 0.6 -0.5 1.2 -0.4 0.7 -0.3 0.9 0.5 1.3 0.4 1.0 0.4 0.8
Arm fat-free mass (left) 0.2 0.8 2.3 0.9 1.1 -0.9 1.3 -0.4 -0.8 0.5 1.0 1.5 0.5 0.4 1.0 0.7
Number of operations (self-reported) 0.2 0.3 1.8 -0.4 0.5 -0.4 0.5 -0.9 0.1 -0.5 -0.1 -1.3 -0.4 -0.0 -0.4 -0.4
Average weekly beer plus cider intake 1.3 1.9 5.4 1.4 0.7 -1.5 0.6 -0.2 -1.3 1.3 1.6 1.2 1.3 2.3 1.3 1.6
Irritability 0.6 1.1 5.6 0.8 -0.9 0.7 -0.9 2.4 -0.5 0.9 0.4 1.3 0.7 1.2 0.2 0.9
Risk taking 1.0 1.5 2.6 1.6 0.4 -0.4 0.4 -0.2 -1.2 1.6 1.3 1.4 1.5 1.2 1.5 1.6
Ever had prostate specific antigen (PSA) test 0.4 0.5 0.7 0.8 0.8 -0.5 0.7 0.1 -0.8 0.5 0.8 0.6 0.8 0.6 0.7 0.7
Fractured/broken bones in last 5 years 0.1 0.1 0.5 -0.1 -0.2 0.0 0.1 0.4 -0.3 0.1 0.1 -0.7 0.0 0.2 -0.3 -0.0
Age started oral contraceptive pill 1.1 1.3 3.6 0.8 -1.0 1.3 -1.0 1.2 -1.0 1.4 0.6 1.9 0.8 1.5 0.6 1.2
Diastolic blood pressure, automated reading 0.1 0.2 1.5 0.4 0.2 -0.3 -0.0 -0.1 -0.2 -0.2 0.2 1.2 -0.1 0.4 0.1 0.2
Ever depressed for a whole week 0.4 0.5 1.5 -0.6 -1.0 0.6 -1.1 1.2 0.4 -0.3 -0.8 -0.5 -0.4 -0.4 -0.8 -0.4
Unable to work because of sickness or disability 0.3 0.3 1.1 0.5 0.8 -1.1 0.6 -0.2 -0.8 0.5 0.5 -0.2 0.6 0.4 0.4 0.4
Commuting to job workplace: Cycle 1.2 1.4 4.4 -0.9 -1.9 2.1 -1.8 1.4 0.7 -0.6 -0.9 1.1 -0.9 0.2 -0.6 -0.6
Myopia 0.2 0.2 1.3 0.1 -0.5 -0.3 -0.8 0.1 -0.4 0.4 0.2 -0.3 0.1 1.1 -0.3 0.5
Vascular/heart problems diagnosed by doctor 1.9 5.1 10.4 -2.7 -1.5 0.8 -1.3 0.2 2.3 -2.3 -2.6 -3.2 -2.6 -2.0 -2.9 -2.8
Cholesterol lowering medication 0.8 1.1 10.5 -0.8 -0.3 0.5 -0.1 -0.2 1.0 -0.7 -0.4 -3.2 -0.1 -0.7 -0.9 -0.6
Medication: Omeprazole (e.g. Zanprol) 1.8 2.2 5.7 1.5 1.5 -2.4 1.3 -0.5 -1.6 1.0 1.7 0.8 1.6 1.3 1.5 1.5
Pain experienced in last month 3.3 5.4 9.3 -3.0 -2.1 1.0 -2.1 0.5 2.7 -2.6 -2.7 -1.6 -3.1 -1.8 -2.7 -2.7
Supplements: Calcium 0.8 0.8 1.8 -1.0 -0.6 0.1 -0.6 0.9 0.8 -0.6 -1.2 -0.4 -1.1 -1.4 -1.1 -1.2
Basal cell carcinoma (self-reported) 0.5 0.6 2.0 0.7 -0.7 1.1 -0.8 1.4 -0.5 0.8 0.1 0.4 0.9 0.7 0.2 0.9
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.7 -0.0 0.2 -0.2 0.0 -0.4 0.2 0.1 0.2 -0.9 0.1 0.3 -0.2 0.2
Deep venous thrombosis (DVT) (self-reported) 3.4 4.3 50.1 -0.8 -0.6 0.7 -0.4 -0.7 1.1 0.5 -0.4 -7.1 0.7 -0.5 -1.3 -0.5
Heart disease (siblings) 0.2 0.3 2.0 0.2 -0.4 0.1 -0.3 0.3 -0.8 0.2 0.4 -0.2 0.2 1.4 -0.1 0.3
Alcohol drinker status: Previous 1.1 1.2 2.9 1.1 -0.5 1.2 -0.7 0.9 -1.2 1.5 0.8 1.2 1.1 1.7 0.5 1.3
Pack years of smoking 0.0 0.0 0.2 0.0 -0.0 -0.0 -0.2 -0.1 0.1 -0.2 0.1 -0.2 -0.1 0.4 -0.1 0.1
Impedance of whole body 1.2 6.1 16.8 -2.2 -3.7 4.1 -3.5 2.7 2.2 -0.8 -2.6 -0.1 -2.0 -1.2 -2.2 -1.7
Leg fat mass (left) 0.0 0.2 0.9 0.3 -0.3 0.9 -0.2 0.6 -0.0 0.5 0.2 0.4 0.1 0.6 -0.0 0.4
Arm predicted mass (left) 0.2 0.8 2.6 0.9 1.0 -0.9 1.1 -0.3 -0.8 0.5 0.9 1.6 0.5 0.5 0.9 0.7