Hub : Genes

REXO4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2940	0.0360	0.0e+00	0.268	0.297	0.321	0.313	0.330	1.4e-32	1.6e-36	6.4e-40	8.1e-39	2.6e-41
2	GTEx	Brain Frontal Cortex BA9	0.3640	0.1004	3.8e-04	-0.007	NA	0.052	NA	0.005	5.4e-01	NA	1.7e-02	NA	2.3e-01
3	GTEx	Cells Transformed fibroblasts	0.3120	0.0530	1.6e-11	0.128	NA	0.203	NA	0.126	7.6e-10	NA	3.3e-15	NA	1.2e-09
4	GTEx	Esophagus Muscularis	0.1560	0.0560	3.4e-03	0.017	NA	0.027	NA	0.048	3.0e-02	NA	8.8e-03	NA	7.0e-04
5	GTEx	Liver	0.3670	0.1280	7.7e-03	0.107	NA	0.075	NA	0.102	6.7e-04	NA	4.1e-03	NA	9.1e-04
6	GTEx	Testis	0.2800	0.0760	4.9e-05	0.016	NA	-0.004	NA	0.014	6.4e-02	NA	5.6e-01	NA	7.3e-02
7	METSIM	Adipose	0.0997	0.0253	2.7e-07	0.060	0.043	0.055	0.064	0.050	2.5e-09	4.4e-07	1.0e-08	6.8e-10	4.8e-08
8	TCGA	Breast Invasive Carcinoma	0.0261	0.0124	2.0e-06	0.008	0.023	0.014	NA	0.018	7.9e-03	1.1e-05	5.5e-04	NA	1.2e-04
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0429	0.0298	1.7e-03	0.009	0.014	0.021	NA	0.022	2.9e-02	9.2e-03	1.8e-03	NA	1.4e-03
10	TCGA	Brain Lower Grade Glioma	0.0850	0.0357	4.1e-11	0.066	0.108	0.096	NA	0.088	5.3e-08	3.0e-12	5.2e-11	NA	3.5e-10
11	TCGA	Lung Squamous Cell Carcinoma	0.0318	0.0231	1.7e-03	0.028	0.021	0.008	NA	0.026	3.4e-04	1.5e-03	3.5e-02	NA	5.1e-04
12	TCGA	Pheochromocytoma and Paraganglioma	0.1270	0.0680	2.3e-05	0.050	0.104	0.111	NA	0.083	4.6e-03	6.3e-05	3.6e-05	NA	3.4e-04
13	TCGA	Prostate Adenocarcinoma	0.0392	0.0210	2.1e-05	0.035	0.039	0.025	NA	0.033	1.3e-04	5.1e-05	1.2e-03	NA	1.8e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.5	0.8	1.4	-1.0	0.0	0.2	-0.2	-0.3	1.0	-1.2	-1.0	-0.7	-0.9	-1.1	-1.1	-1.1
Bipolar Disorder or Schizophrenia	0.2	0.4	1.3	-0.5	0.2	-1.1	0.1	-0.4	-0.1	-1.0	-0.3	-0.8	-0.8	-0.2	-0.9	-0.7
Depressed Affect (Nagel 2018)	1.5	3.2	5.7	2.3	1.4	0.0	1.1	-0.8	-2.4	1.8	2.3	0.5	2.1	1.9	2.1	2.2
Depression (Nagel 2018)	3.9	5.9	10.6	3.0	1.3	-0.5	1.3	-0.4	-3.2	2.5	3.1	1.6	2.8	3.3	2.7	3.1
Intelligence (Savage-Jansen 2018)	0.3	0.9	4.0	0.8	-0.4	1.2	-0.3	2.0	-0.5	1.0	0.4	1.5	0.8	0.3	0.6	0.8
Neuroticism (Nagel 2018)	0.4	1.0	2.3	1.3	0.1	0.9	0.1	0.5	-1.5	0.9	1.2	0.5	1.1	1.1	1.1	1.3
Schizophrenia (2018)	0.2	0.4	2.7	0.2	0.3	-1.6	0.3	-0.2	-1.0	-0.3	0.4	-0.5	-0.2	0.7	-0.3	0.0
Schizophrenia vs Biploar Disorder	2.2	2.9	5.1	2.0	1.6	-1.8	1.5	-0.4	-2.3	1.5	2.1	1.0	1.8	1.9	1.8	1.8
Worry (Nagel 2018)	0.1	0.3	1.0	0.6	0.8	-0.5	0.8	-0.5	-1.0	-0.2	0.5	-0.2	0.2	0.0	0.6	0.3
Alzheimer’s Disease (in mother)	0.4	0.5	2.4	0.1	-0.8	0.9	-0.9	0.9	-0.4	0.3	0.3	-0.7	0.3	1.6	-0.3	0.4
Alzheimer’s Disease (in father)	0.6	0.7	1.8	0.9	0.1	0.5	-0.2	-0.6	-0.6	1.2	0.9	0.4	1.0	1.3	0.6	1.1
Alzheimer’s Disease (including proxy)	0.4	0.6	3.2	0.7	-0.3	0.5	-0.4	0.1	-0.7	0.6	0.8	-0.4	0.8	1.8	0.1	0.9
Crohns Disease (2017)	1.1	2.3	7.6	-0.4	-2.6	2.5	-2.8	2.4	0.2	1.1	-0.9	0.4	-0.3	0.5	-0.8	0.1
Irritable Bowel Disease (IBD)	0.9	2.1	6.9	0.2	-2.2	2.5	-2.2	2.6	0.1	1.6	-0.4	0.7	0.3	0.5	-0.3	0.6
Ulcerative Colitis (UC)	0.5	0.9	3.4	0.7	-1.0	1.5	-0.9	1.9	-0.1	1.2	0.3	0.9	0.7	0.5	0.4	0.8
Major Depression (MDD)	0.6	0.8	2.6	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-1.5	-0.8	-1.5	-0.8	-1.6	-1.4
Reaction Time	0.3	0.5	3.4	-0.2	1.1	-1.0	0.8	-1.8	-0.1	-0.5	0.1	-0.1	-0.3	-0.6	0.3	-0.1
Verbal and Numeric Reasoning (VNR)	0.4	1.0	4.8	0.6	-0.8	1.5	-0.6	2.2	-0.3	0.6	-0.1	2.1	0.2	-0.1	0.3	0.4
Breast Cancer	1.5	3.6	7.1	-2.1	-2.7	2.1	-2.4	0.8	1.9	-1.1	-2.3	0.7	-2.4	-1.5	-1.8	-1.7
Ovarian Cancer	1.2	1.6	13.2	1.0	-0.4	-0.0	-0.4	0.9	-0.8	1.1	0.7	3.6	0.4	1.1	1.0	1.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.2	0.3	1.6	0.2	-1.0	0.8	-0.9	1.2	-0.2	0.7	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.6	1.3	1.1	1.0	-1.2	0.9	-0.9	-1.1	0.9	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	1.5	2.5	6.7	-0.4	-2.6	2.5	-2.6	2.5	0.1	0.8	-0.9	2.1	-0.4	0.4	-0.4	-0.1
Mean Putamen Volume	0.4	0.4	1.0	-0.6	-0.5	1.0	-0.6	0.8	1.0	-0.3	-0.7	0.3	-0.6	-0.6	-0.5	-0.5
Fasting Glucose	1.4	1.7	3.1	-1.7	-1.3	1.0	-1.6	0.8	1.8	-1.1	-1.4	-0.8	-1.5	-0.4	-1.6	-1.3
HbA1C	0.4	0.5	1.6	-1.1	-0.4	1.3	-0.5	1.2	1.0	-0.8	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.5	0.9	4.0	-0.4	-1.9	2.0	-1.5	0.8	0.6	-0.1	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.7	1.1	3.2	-1.1	1.3	-1.5	1.2	-1.4	1.8	-1.2	0.0	0.0	0.0	0.0	0.0	0.0
Lupus	1.9	2.8	4.7	1.8	2.0	-1.3	2.0	-1.1	-2.0	1.1	2.0	0.6	1.8	1.1	2.2	1.8
Neuroticism (2016)	0.1	0.1	1.0	0.1	0.3	-0.1	0.3	0.1	-0.1	-0.4	0.1	-1.0	0.2	0.2	-0.3	-0.1
Primary Biliary Cirrhosis	0.5	0.8	1.3	1.0	0.3	-1.1	-0.1	0.4	-0.9	1.1	0.8	1.0	1.0	0.9	0.9	1.0
Rheumatoid Arthritis	0.4	0.6	2.1	-0.2	-1.0	1.4	-1.3	0.5	0.1	-0.1	-0.4	1.2	-0.3	0.8	-0.5	0.1
Schizophrenia (2014)	0.3	0.6	3.2	0.5	0.5	-1.8	0.6	0.1	-1.3	-0.1	0.7	-0.4	0.1	0.9	-0.2	0.3
Triglycerides	0.8	1.2	4.5	-0.0	1.9	-2.0	1.9	-2.1	0.3	-0.4	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.8	-0.2	0.3	-0.2	0.3	-0.5	0.9	-0.1	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.4	0.5	1.1	0.9	-0.1	-0.1	0.0	1.0	-0.6	0.8	0.7	1.1	0.8	0.6	0.8	0.8
Blood Eosinophil Count	0.9	6.9	26.2	-0.1	-3.4	4.2	-3.3	5.1	0.2	1.0	-0.8	4.6	-0.6	0.8	-0.2	0.5
Blood Platelet Count	1.5	17.8	58.7	3.7	6.6	-7.1	7.7	-3.4	-3.1	0.6	3.6	-1.7	3.4	-0.7	3.5	1.8
Blood Red Count	4.9	47.4	171.6	-1.1	-10.0	12.0	-10.3	7.3	1.1	3.2	-2.0	13.1	-2.3	4.1	-0.6	1.4
Blood White Count	0.7	5.5	45.0	1.1	-1.4	2.4	-1.7	2.4	-0.9	1.1	0.5	6.7	0.2	1.4	1.5	1.4
Heel T-Score	1.9	14.7	71.1	3.8	0.1	1.8	0.1	1.5	-3.5	4.3	3.4	8.4	3.1	3.7	4.2	4.1
BMI	0.2	1.2	5.1	0.6	2.0	-1.6	2.3	-1.1	-0.6	-0.2	0.8	-0.8	0.4	-0.2	0.5	0.1
Height	0.4	6.8	17.6	-2.1	-4.0	3.9	-4.2	3.2	2.2	-0.6	-2.3	1.6	-2.0	-0.2	-2.2	-1.5
Waist Hip Ratio (WHR)	0.1	0.5	2.0	-0.5	0.3	-0.9	-0.0	-0.5	0.6	-0.4	-0.7	-1.4	-0.6	-0.7	-0.9	-0.6
Systolic Blood Pressure	0.3	1.6	4.0	1.4	2.0	-1.7	1.8	-1.2	-1.1	0.5	0.8	1.2	1.0	-0.5	1.3	0.7
Smoking Status	0.4	1.0	3.1	1.1	0.2	0.7	-0.1	0.5	-1.0	0.9	1.1	1.0	1.2	1.7	0.9	1.3
Allergy or Eczema	0.4	1.0	4.2	0.5	-0.9	1.1	-0.4	1.8	-0.3	0.9	0.4	-2.0	1.1	0.8	-0.1	0.5
Cardiovascular Disease	0.4	1.2	2.4	1.2	1.5	-1.3	1.5	-0.7	-0.6	0.6	1.2	0.3	1.3	0.3	1.5	1.0
Hypothyroidism (self reported)	0.1	0.2	0.8	-0.1	0.2	-0.9	0.4	-0.5	-0.3	-0.2	0.2	-0.8	0.2	0.2	0.1	0.0
Respiratory disease	0.1	0.1	1.4	0.2	0.3	0.3	0.4	-0.2	-0.0	-0.1	0.0	-1.2	0.1	-0.4	-0.0	-0.1
Type 2 Diabetes (T2D) (2018)	1.2	2.3	3.6	1.7	1.7	-1.6	1.8	-0.8	-1.6	1.6	1.7	-0.1	1.9	1.0	1.7	1.5
Lung FEV1/FVC ratio	0.1	0.3	0.7	-0.3	-0.2	-0.8	-0.2	0.1	-0.7	-0.5	-0.4	0.8	-0.7	-0.2	-0.5	-0.5
Lung FVC	0.8	4.3	17.3	-0.7	-3.0	4.2	-2.7	2.7	0.7	-0.2	-0.8	3.3	-1.0	0.7	-0.3	-0.2
Neuroticism	0.5	1.3	2.8	1.6	1.2	0.1	1.1	-0.6	-1.7	0.9	1.3	0.5	1.1	0.7	1.4	1.2
Chronotype (morning person)	0.5	1.2	2.5	-1.3	0.1	-0.2	0.1	-0.8	1.1	-1.3	-1.2	-0.5	-1.6	-1.4	-1.3	-1.4
Hair Pigment	0.2	5.9	8.5	2.6	2.9	-2.1	2.8	-2.2	-2.5	2.1	2.9	1.5	2.3	1.8	2.8	2.4
Tanning	0.0	0.1	0.5	-0.2	-0.5	-0.2	-0.7	-0.2	0.1	-0.1	-0.0	-0.4	0.1	0.2	-0.1	0.1
Hand grip strength (left)	0.3	0.7	1.8	0.1	1.1	-1.4	1.2	-1.3	0.6	-0.9	-0.1	-0.0	-0.0	-1.4	0.4	-0.4
Number of treatments/medications taken	0.1	0.2	1.0	0.5	-0.0	0.3	-0.2	0.5	-0.1	0.4	0.2	1.0	0.2	0.0	0.2	0.4
Average weekly spirits intake	1.1	1.3	2.6	1.4	1.1	-0.7	1.3	-0.7	-1.6	1.0	1.4	-1.1	1.4	0.7	0.9	1.1
Sensitivity / hurt feelings	1.0	1.8	7.1	-0.1	-2.1	2.5	-2.0	2.7	0.1	0.3	-0.7	0.7	-0.2	0.3	-0.5	0.0
Frequency of depressed mood in last 2 weeks	1.9	2.7	4.6	2.1	1.2	-0.7	1.3	0.0	-1.9	1.7	2.2	1.2	2.0	1.8	1.8	2.1
Hearing difficulty/problems: Yes	2.4	3.6	6.7	-1.7	-2.6	2.4	-2.6	2.6	2.2	-1.2	-1.9	-0.5	-1.4	-0.7	-1.8	-1.3
Relative age of first facial hair	0.5	1.1	4.5	1.1	0.2	0.3	0.3	0.9	-0.9	1.4	0.7	2.1	1.0	0.8	1.3	1.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	2.6	-0.3	-1.0	1.1	-0.8	1.6	0.1	0.1	-0.1	0.4	-0.2	0.4	-0.3	0.0
Ever used hormone-replacement therapy (HRT)	2.4	3.1	10.2	-0.3	2.7	-2.6	2.7	-3.2	0.0	-1.6	-0.1	-0.7	-0.7	-1.9	0.2	-1.1
Ever had hysterectomy (womb removed)	0.4	0.4	1.8	0.1	1.0	-0.4	1.0	-1.3	-0.9	0.2	0.4	0.2	0.1	-0.0	0.7	-0.0
Systolic blood pressure, automated reading	0.1	0.3	0.8	0.8	0.2	0.2	0.1	0.4	-0.3	0.8	0.4	0.2	0.9	0.3	0.5	0.7
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	3.6	1.8	0.3	0.6	0.0	1.0	-1.1	1.9	1.2	1.1	1.9	1.4	1.3	1.8
Angina	1.1	1.4	5.2	0.6	-1.4	1.4	-1.3	2.3	-0.7	1.1	0.3	1.6	0.4	1.4	0.1	0.8
Medication for hormone replacement therapy	3.0	3.3	5.9	-2.2	0.0	-1.0	-0.2	-0.4	1.8	-2.4	-2.0	-2.0	-2.2	-2.3	-2.1	-2.4
Vitamin and mineral supplements	0.7	0.9	4.0	-1.2	-0.9	0.1	-0.6	0.5	1.3	-0.6	-0.6	-2.0	-0.9	-0.1	-1.2	-0.8
Supplements: Zinc	0.1	0.1	0.6	-0.3	-0.1	-0.4	-0.4	-0.2	0.7	0.1	-0.4	0.1	-0.1	-0.8	0.1	-0.1
Medication: Co-codamol	0.7	0.9	2.6	-1.2	0.1	-0.1	0.1	-0.8	1.6	-0.8	-0.7	-0.9	-1.3	-0.8	-0.9	-1.2
Medication: Metformin	0.5	0.7	2.4	-0.1	1.0	-1.6	1.0	-1.1	0.5	-0.1	-0.1	-1.4	0.2	-0.9	-0.0	-0.4
Diabetes (father)	0.2	0.3	1.3	-0.4	0.1	-0.4	0.1	0.5	0.3	-0.3	-0.7	-0.6	-0.2	-1.1	-0.4	-0.6
Diabetes (mother)	1.1	1.4	2.6	1.5	1.3	-0.5	1.5	-0.4	-0.8	1.2	1.4	-1.1	1.6	0.7	1.3	1.2
Severe depression (siblings)	0.2	0.2	0.7	0.3	-0.5	0.4	-0.3	0.7	-0.9	0.2	-0.2	-0.7	0.7	0.0	-0.0	0.1
Pack years adult smoking proportion	0.2	0.3	0.9	0.1	0.7	-0.8	0.6	-1.0	0.0	-0.4	0.3	-0.7	-0.1	0.2	0.0	0.0
Impedance of leg (right)	1.0	4.7	16.3	-0.6	-3.4	4.0	-3.2	3.1	0.5	0.6	-1.3	3.0	-0.9	0.2	-0.6	-0.2
Leg fat-free mass (left)	0.2	0.8	3.1	-0.6	0.8	-1.3	0.9	-0.5	0.7	-0.9	-0.4	-1.8	-0.6	-0.9	-0.8	-0.9
Trunk fat percentage	0.3	1.4	5.9	-0.9	-1.4	2.4	-1.2	1.2	1.2	-0.2	-0.8	-1.4	-0.7	-0.1	-1.2	-0.6
Hand grip strength (right)	0.8	2.2	6.6	-1.0	1.2	-1.6	1.3	-1.2	1.5	-2.3	-1.2	-0.1	-1.4	-2.6	-0.7	-1.8
Townsend deprivation index at recruitment	0.6	0.9	1.7	-1.0	0.5	-1.3	0.3	-0.7	1.1	-1.1	-0.8	-0.9	-0.8	-1.2	-0.7	-1.1
Current tobacco smoking	0.5	0.8	1.6	0.9	1.1	0.1	0.9	-1.0	-0.8	0.2	1.2	-0.3	0.9	1.2	0.9	1.0
Average weekly fortified wine intake	0.8	1.0	2.1	-0.5	-1.5	1.3	-1.1	1.4	1.2	0.0	-1.1	-0.3	-0.6	-0.9	-1.0	-0.6
Maternal smoking around birth	0.1	0.2	1.1	-0.2	0.5	-1.1	0.4	-0.7	-0.1	-0.5	0.2	-0.3	-0.3	0.3	-0.1	-0.2
Fed-up feelings	0.2	0.4	1.2	0.7	0.1	0.7	0.0	0.6	-0.8	0.8	0.7	-0.5	0.7	1.1	0.4	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.7	5.5	1.9	0.7	-0.6	0.4	0.1	-2.3	1.8	1.9	1.5	1.8	2.3	1.7	2.1
Relative age voice broke	2.0	3.0	6.6	2.0	0.4	0.6	0.4	0.7	-1.6	2.6	1.9	1.5	2.4	1.9	2.2	2.2
Taking other prescription medications	0.0	0.1	0.2	0.1	0.2	-0.4	0.0	0.2	0.4	0.1	-0.2	-0.3	0.1	-0.5	-0.2	-0.0
Age when periods started (menarche)	0.2	0.5	2.5	-0.4	-0.7	0.4	-0.5	1.6	0.6	-0.1	-0.5	-1.2	0.1	-0.4	-0.6	-0.3
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.2	-0.2	1.1	-1.1	1.0	-1.5	-0.0	-0.7	0.2	-1.2	0.0	-0.4	0.1	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	6.5	1.6	1.7	-1.6	1.8	-1.0	-1.2	1.1	1.4	2.5	1.2	0.5	1.9	1.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	2.0	-0.6	0.4	-0.8	0.4	-0.3	0.1	-0.6	-0.5	-1.4	-0.2	-0.6	-0.5	-0.7
Qualifications: CSEs or equivalent	1.2	1.6	6.2	0.9	1.9	-1.6	1.6	-2.5	-0.8	0.4	1.2	-0.2	0.7	0.4	1.3	0.5
Serious illness, injury or assault to yourself	0.2	0.2	1.0	0.3	0.5	0.3	0.3	-0.1	-0.2	0.5	0.1	0.4	0.6	-1.0	0.8	0.3
High blood pressure	1.8	4.9	9.6	2.7	1.6	-0.7	1.4	-0.4	-2.3	2.1	2.5	3.1	2.5	2.0	2.8	2.7
Hayfever, allergic rhinitis or eczema	0.3	0.7	3.1	0.6	-0.0	0.2	0.4	0.9	-0.7	0.7	0.7	-1.8	1.3	0.8	0.4	0.6
Multivitamins +/- minerals	0.2	0.3	1.9	0.3	0.1	0.3	-0.0	0.1	-0.6	-0.4	-0.4	1.4	-0.0	-0.6	0.2	-0.2
Stomach or abdominal pain in last month	0.7	0.8	1.7	0.9	1.0	-1.3	1.0	-1.0	-0.9	0.5	1.0	0.7	0.9	0.5	0.9	0.9
Supplements: Glucosamine	0.7	0.9	4.8	0.6	-0.5	1.8	-0.1	1.0	-0.5	0.6	0.2	2.2	0.4	-0.1	0.7	0.5
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.8	-0.1	0.1	-0.3	0.1	0.0	0.1	-0.4	-0.0	0.9	-0.3	-0.4	0.1	-0.0
Medication: Atenolol	0.0	0.0	0.2	0.1	0.2	-0.4	0.2	-0.2	0.0	-0.0	0.1	0.1	0.0	0.4	0.0	0.1
Medication: Levothyroxine sodium	0.4	0.6	1.6	0.9	0.2	-0.1	0.3	0.5	-1.2	0.8	0.8	0.6	1.3	0.6	1.1	1.0
Sitting height	0.7	4.8	9.2	-2.1	-3.0	2.9	-2.8	2.2	1.9	-1.1	-2.4	1.5	-2.5	-1.4	-1.9	-1.9
Chronic bronchitis/emphysema (father)	1.4	1.7	3.5	-1.1	-1.7	1.2	-1.9	1.6	1.4	-0.7	-1.5	0.6	-1.4	-0.5	-1.4	-0.9
High blood pressure (mother)	0.8	1.1	4.4	-0.1	1.6	-1.4	1.4	-2.1	-0.2	-0.8	0.0	-1.3	-0.1	-1.0	0.1	-0.5
Body mass index (BMI)	0.2	1.0	2.3	1.0	1.4	-1.0	1.5	-0.9	-0.8	0.6	1.3	-0.3	0.9	0.9	0.9	0.9
Impedance of leg (left)	1.0	4.8	16.4	-0.7	-3.3	4.0	-3.3	2.9	0.7	0.4	-1.5	3.2	-1.1	0.1	-0.7	-0.2
Leg predicted mass (left)	0.2	0.9	3.3	-0.7	0.8	-1.3	1.0	-0.5	0.7	-1.0	-0.4	-1.8	-0.6	-0.9	-0.8	-1.0
Trunk fat mass	0.2	0.8	2.9	-0.7	-1.0	1.7	-0.8	1.0	1.0	-0.2	-0.6	-1.2	-0.6	-0.1	-1.1	-0.5
Waist circumference	0.0	0.1	0.4	0.1	0.0	0.1	0.2	0.3	0.0	0.2	0.3	-0.6	0.1	0.6	-0.2	0.2
Number of incorrect matches in round	0.2	0.3	0.5	-0.7	-0.7	0.2	-0.6	0.4	0.3	-0.7	-0.6	-0.7	-0.4	-0.1	-0.7	-0.5
Past tobacco smoking	0.8	1.5	4.5	-1.1	0.0	-0.2	0.2	-1.7	1.1	-1.3	-1.2	-1.5	-1.2	-2.1	-1.0	-1.4
Alcohol usually taken with meals	0.3	0.5	1.0	-0.4	0.8	-1.0	0.9	-0.4	1.0	-0.7	-0.2	-0.3	-0.3	-1.0	-0.3	-0.5
Nervous feelings	0.2	0.3	0.6	-0.7	-0.5	0.3	-0.4	0.6	0.5	-0.8	-0.6	-0.2	-0.8	-0.5	-0.5	-0.7
Frequency of tenseness / restlessness in last 2 weeks	2.4	3.7	6.1	2.1	1.8	-1.5	1.8	-1.2	-2.0	1.7	2.5	1.6	1.9	1.9	2.3	2.2
Hearing difficulty/problems with background noise	0.6	0.9	6.0	0.0	-1.0	1.4	-0.9	2.4	0.7	0.1	-0.1	1.1	0.1	0.9	-0.1	0.3
Hair/balding pattern: Pattern 2	0.7	0.8	2.3	-0.9	-0.3	0.1	-0.3	0.0	1.5	-1.2	-1.1	0.5	-1.2	-1.1	-0.9	-1.0
Had menopause	0.2	0.2	0.8	-0.2	0.6	-0.6	0.6	-0.9	-0.1	0.1	0.3	-0.8	-0.0	0.4	-0.1	-0.0
Had other major operations	0.4	0.5	1.3	-0.6	-1.0	1.2	-0.9	0.8	0.5	-0.0	-0.5	-0.5	-0.6	0.2	-0.8	-0.4
Forced vital capacity (FVC)	1.5	5.6	18.4	-1.2	-3.5	4.3	-3.4	3.1	1.5	-0.1	-1.8	3.0	-1.8	-0.3	-1.1	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.7	10.9	2.2	1.5	-1.0	1.7	-1.1	-1.6	1.9	2.0	3.3	1.8	1.2	2.5	2.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.5	0.0	0.3	-0.7	0.1	0.0	-0.2	-0.0	0.2	-0.5	0.2	0.2	0.2	0.2
Qualifications: None of the above	0.9	2.0	3.6	1.4	1.1	-0.9	0.9	-1.4	-1.9	1.5	1.7	0.2	1.5	1.9	1.4	1.7
Financial difficulties in last 2 years	0.4	0.5	1.0	0.9	0.4	-0.0	0.2	0.1	-0.8	0.8	0.7	1.0	0.8	0.8	0.9	0.8
Mouth/teeth dental problems	0.4	0.7	3.2	-0.3	0.9	-1.0	1.2	-0.6	0.5	-0.6	-0.5	0.5	-0.4	-1.8	0.1	-0.8
Heart attack	0.1	0.1	0.5	0.1	0.1	-0.1	-0.1	-0.3	0.2	0.3	0.3	-0.7	0.2	0.4	-0.1	0.3
Allergy	0.5	1.2	13.0	-0.2	0.0	-0.2	-0.2	-0.6	-0.0	-0.7	-0.4	3.6	-1.1	-0.4	0.2	-0.3
Pain all over the body in last month	2.6	2.8	4.6	1.7	1.6	-1.2	1.6	-1.4	-2.1	1.5	1.9	1.5	1.6	1.4	2.1	1.6
Diabetes (self-reported)	0.2	0.3	1.0	0.8	0.5	0.2	0.5	0.4	-0.1	0.8	0.4	0.0	1.0	-0.0	0.6	0.6
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	6.6	-1.1	0.0	0.2	0.2	0.6	0.8	-0.9	-0.7	-2.6	-0.3	-1.0	-0.7	-0.9
Medication: Ramipril	0.2	0.2	0.5	0.6	0.3	0.1	0.4	-0.1	-0.6	0.6	0.7	0.2	0.5	0.6	0.4	0.5
Medication: Simvastatin	0.2	0.4	3.0	0.1	-0.4	0.5	-0.4	0.8	0.4	0.1	-0.1	-1.7	0.5	-0.3	-0.3	0.0
Fluid intelligence score	0.4	0.9	3.9	-0.1	-1.2	0.8	-1.1	1.7	0.2	0.1	-0.6	2.0	-0.5	-0.6	-0.3	-0.3
Illnesses of siblings	2.8	3.9	8.6	-2.3	-1.1	0.6	-1.0	0.8	2.9	-2.0	-2.4	-1.0	-2.4	-2.5	-2.1	-2.4
Neuroticism score	0.4	0.9	2.4	1.3	0.9	-0.3	0.9	0.2	-1.5	0.7	1.1	0.5	1.0	0.5	1.1	0.9
Weight	0.0	0.0	0.1	-0.1	0.1	0.0	0.3	0.3	0.2	0.0	0.1	-0.3	-0.2	0.2	-0.3	-0.1
Impedance of arm (right)	2.2	10.4	16.6	-3.3	-3.9	4.1	-3.8	2.2	3.3	-1.8	-3.6	-3.4	-2.7	-2.2	-3.5	-2.9
Arm fat percentage (right)	0.1	0.5	5.2	-0.1	0.1	0.7	0.2	-0.3	0.3	0.2	0.1	-2.3	0.2	0.1	-0.4	-0.1
Trunk fat-free mass	0.1	0.6	2.1	0.6	1.1	-1.5	1.2	-0.5	-0.7	0.2	0.8	0.8	0.3	0.3	0.6	0.4
Hip circumference	0.1	0.4	1.4	-0.2	-0.8	1.1	-0.5	1.2	0.2	0.0	-0.1	-0.2	-0.4	0.6	-0.6	-0.1
Time employed in main current job	1.4	1.6	4.4	1.2	1.9	-2.1	1.8	-1.0	-0.8	0.6	1.1	1.2	0.9	0.2	1.3	0.8
Alcohol intake versus 10 years previously	2.5	3.8	6.0	2.4	2.1	-1.9	1.9	-1.5	-1.6	1.9	2.0	1.9	2.2	1.2	2.5	2.0
Father’s age at death	0.8	1.1	8.7	0.4	-0.6	0.6	-0.4	1.9	-0.3	0.2	-0.1	3.0	0.1	0.1	0.4	0.3
Worrier / anxious feelings	0.2	0.3	1.2	0.7	-0.2	-0.1	0.1	0.7	-1.1	0.3	0.4	1.0	0.3	0.3	0.4	0.3
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.6	5.7	2.4	1.6	-1.8	1.2	-1.1	-2.4	2.1	2.2	0.9	2.1	2.0	1.9	2.2
Falls in the last year	3.1	4.1	6.8	2.5	1.2	0.3	1.1	-0.3	-2.6	2.4	2.4	2.0	2.5	2.1	2.4	2.5
Hair/balding pattern: Pattern 3	0.4	0.6	1.4	0.6	0.6	-0.8	0.5	-0.6	-0.5	0.6	1.1	-0.4	0.9	1.2	0.7	0.8
Number of live births	2.6	3.7	6.2	2.4	1.4	-0.5	1.6	-0.8	-2.5	1.8	2.4	2.0	2.0	2.0	2.5	2.1
Forced expiratory volume in 1-second (FEV1)	1.2	4.0	10.8	-1.1	-2.7	3.3	-2.6	2.4	1.1	-0.4	-1.7	3.2	-1.8	-0.6	-0.9	-0.9
Pulse rate	1.1	1.9	3.8	-1.4	-1.4	1.4	-1.5	0.8	1.3	-1.5	-1.6	-0.9	-1.6	-0.3	-1.9	-1.4
Happiness	1.7	2.1	4.2	-1.6	-1.4	1.2	-1.6	1.3	2.0	-1.2	-1.7	-0.7	-1.4	-1.1	-1.6	-1.4
Noisy workplace	0.9	1.1	3.4	1.1	1.7	-1.5	1.9	-0.7	-0.7	0.3	1.0	-0.5	1.0	0.5	0.8	0.7
Qualifications: A levels/AS levels or equivalent	1.0	2.2	3.8	1.6	-0.8	1.5	-0.5	1.9	-1.7	1.9	1.2	1.6	1.5	1.6	1.1	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	2.6	-0.0	0.5	-0.9	0.4	-0.2	0.4	-0.5	-0.6	-0.8	-0.1	-1.6	-0.3	-0.6
Mouth/teeth dental problems: Dentures	0.3	0.6	2.0	-0.9	-0.4	0.3	-0.6	-1.2	0.7	-0.7	-0.6	-1.4	-0.7	-0.2	-0.8	-0.7
Asthma	0.1	0.3	1.3	-0.1	0.5	-0.3	0.6	-0.7	0.7	-0.5	-0.0	-1.1	-0.2	-0.5	-0.2	-0.4
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.6	2.9	-1.4	-0.7	0.4	-0.7	0.4	1.4	-1.5	-1.7	-0.1	-1.7	-1.4	-1.6	-1.6
Medication: Cholesterol lowering	0.4	0.6	5.5	0.0	0.4	-0.8	0.2	0.2	0.6	-0.2	-0.1	-2.3	0.5	-0.4	-0.5	-0.1
Depression (self-reported)	0.1	0.1	0.3	-0.0	-0.5	0.1	-0.5	0.5	-0.0	-0.1	-0.1	0.3	-0.3	0.2	-0.2	-0.0
Medication: Lansoprazole	0.2	0.2	0.6	0.6	0.5	-0.8	0.5	0.2	-0.6	0.1	0.4	-0.1	0.7	0.2	0.5	0.3
Prospective memory result	0.8	0.9	2.8	0.7	1.7	-1.6	1.6	-0.8	-0.7	0.0	0.8	-0.9	0.7	0.2	0.6	0.3
Lung cancer (father)	2.2	2.5	7.0	-1.4	-2.0	2.6	-1.9	1.8	1.2	-1.2	-1.8	0.4	-1.5	-1.3	-1.2	-1.3
Illnesses of mother	0.2	0.2	1.6	0.2	-0.0	0.0	0.3	0.7	0.3	0.4	0.2	1.3	-0.0	0.1	0.3	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.1	10.3	-1.6	-2.6	3.2	-2.4	2.3	1.5	-0.9	-1.9	2.5	-2.3	-0.8	-1.4	-1.3
Pulse wave Arterial Stiffness index	1.6	1.9	4.3	-1.0	-1.7	1.7	-1.7	2.1	1.8	-0.7	-1.5	0.9	-0.7	-1.0	-1.1	-0.8
Impedance of arm (left)	1.6	7.5	11.6	-2.8	-3.3	3.4	-3.2	2.0	2.7	-1.5	-3.0	-3.1	-2.3	-1.7	-3.1	-2.5
Arm fat mass (right)	0.1	0.2	1.6	0.3	0.4	0.2	0.6	-0.3	-0.2	0.3	0.5	-1.3	0.4	0.4	0.0	0.3
Trunk predicted mass	0.1	0.5	1.8	0.6	1.1	-1.4	1.1	-0.5	-0.6	0.1	0.7	0.8	0.2	0.2	0.6	0.3
Standing height	0.5	4.6	7.8	-2.3	-2.8	2.2	-2.7	2.5	2.2	-1.2	-2.4	0.0	-2.3	-1.4	-2.4	-1.9
Length of working week for main job	2.7	3.0	9.4	0.8	2.9	-2.6	3.1	-2.8	-1.1	-0.4	1.5	-0.9	0.4	0.2	1.0	0.3
Exposure to tobacco smoke at home	0.1	0.2	0.7	0.3	0.1	0.8	-0.1	0.3	-0.1	0.6	0.1	0.5	0.5	-0.3	0.4	0.4
Breastfed as a baby	0.4	0.5	1.4	-0.7	-0.3	0.5	-0.1	0.6	1.2	-0.9	-0.9	0.5	-0.6	-1.1	-0.4	-0.8
Tense / ‘highly strung’	0.4	0.6	1.7	1.0	-0.1	0.1	-0.1	0.9	-1.3	0.7	0.7	1.0	0.9	0.8	0.7	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.1	-0.3	0.9	-0.6	0.8	-0.3	0.2	-1.1	-0.3	-0.8	-0.3	-1.0	-0.3	-0.7
Hair/balding pattern: Pattern 4	0.4	0.9	3.1	0.6	-0.9	1.8	-0.8	1.1	-0.8	1.3	0.4	0.1	0.9	0.8	0.6	0.9
Birth weight of first child	3.2	5.9	8.4	-2.8	-2.7	1.6	-2.5	2.2	2.7	-2.3	-2.9	-0.3	-2.7	-2.3	-2.6	-2.6
Peak expiratory flow (PEF)	1.8	4.1	12.2	-1.1	-2.7	3.5	-2.6	2.5	1.2	-0.7	-1.5	3.2	-1.8	-0.3	-0.8	-0.9
Pulse wave reflection index	0.6	0.8	2.4	1.0	-0.6	0.3	-0.4	1.5	-0.4	1.0	0.4	1.5	1.2	0.3	0.6	0.9
Ever highly irritable/argumentative for 2 days	0.4	0.4	0.9	0.8	0.3	-0.3	0.2	0.2	-0.8	0.9	0.8	0.2	0.9	0.8	0.6	0.9
Loud music exposure frequency	0.1	0.2	0.9	0.2	-0.3	0.6	-0.4	0.9	0.1	0.4	-0.1	0.3	0.3	0.1	-0.2	0.2
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.0	-1.0	-0.6	0.1	-0.5	1.1	1.1	-1.4	-1.2	-0.2	-1.3	-1.1	-1.3	-1.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	3.4	-0.3	-1.1	1.2	-1.2	1.9	0.5	0.3	-0.5	-0.1	-0.2	0.3	-0.6	-0.2
Blood clot in the leg (DVT)	2.8	3.6	42.5	-0.5	-0.5	0.6	-0.3	-0.7	0.8	0.9	-0.1	-6.5	1.0	-0.2	-0.9	-0.1
Medication: Paracetamol	0.1	0.2	1.6	-0.1	0.2	0.2	0.1	0.2	0.4	-0.5	-0.4	1.3	-0.3	-0.8	0.1	-0.4
Headache pain in last month	0.3	0.5	1.6	0.8	0.6	-0.8	0.5	-0.4	-0.5	0.6	0.5	1.3	0.6	0.0	0.8	0.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.1	-0.8	0.0	-0.5	0.2	-1.0	0.0	-0.7	-0.4	-0.2	-1.1	-0.2	-0.6	-0.8
Glaucoma (self-reported)	0.3	0.4	1.6	-0.2	-1.2	0.5	-1.3	0.8	0.4	0.6	-0.3	-0.2	-0.2	0.4	-0.6	0.1
Gout (self-reported)	0.5	0.7	1.6	1.0	0.5	0.2	0.6	-0.5	-0.4	1.2	1.1	0.4	1.0	1.3	0.9	1.0
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.7	-0.7	-0.6	0.0	-0.4	0.1	0.3	-0.6	-0.6	-0.8	-0.3	-0.4	-0.5	-0.5
Medication: Amlodipine	1.3	1.8	3.4	1.7	1.6	-1.0	1.5	-0.9	-1.3	1.1	1.3	1.0	1.6	0.0	1.8	1.2
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.4	0.1	-0.8	0.8	-0.6	1.2	0.2	0.1	-0.3	-0.2	-0.1	-0.2	-0.5	-0.1
Birth weight	1.7	3.7	7.6	-2.2	-1.6	0.7	-1.4	1.6	2.1	-1.8	-2.1	-2.8	-2.0	-1.3	-2.5	-2.1
Chronic bronchitis/emphysema (mother)	0.2	0.3	1.0	-0.1	-0.6	0.6	-1.0	-0.4	-0.1	0.0	-0.1	0.5	-0.3	1.0	-0.2	0.3
High blood pressure (siblings)	0.8	1.1	3.0	1.2	0.0	0.2	-0.2	-0.7	-1.7	1.2	1.0	0.9	1.2	1.3	1.1	1.3
Forced vital capacity (FVC), Best measure	1.4	5.0	15.2	-1.4	-3.2	3.9	-3.1	2.9	1.7	-0.5	-1.9	2.5	-1.9	-0.4	-1.3	-1.0
Body fat percentage	0.2	0.6	4.0	-0.3	-1.0	2.0	-0.8	0.9	0.6	0.3	-0.3	-0.8	-0.2	0.3	-0.6	-0.1
Leg fat percentage (right)	0.3	0.9	2.2	0.8	-0.7	1.5	-0.5	1.0	-0.5	1.2	0.7	1.4	0.7	1.2	0.5	1.0
Arm fat-free mass (right)	0.2	1.2	3.0	1.1	1.3	-1.4	1.5	-0.4	-1.1	0.5	1.2	1.7	0.6	0.7	1.1	0.9
Exposure to tobacco smoke outside home	0.9	1.2	3.3	0.9	1.6	-0.5	1.7	-1.8	-1.6	0.4	1.1	0.6	0.7	0.3	1.1	0.5
Comparative body size at age 10	0.6	1.8	2.9	1.6	0.8	-1.3	0.9	-0.3	-1.5	1.7	1.6	1.3	1.1	1.4	1.4	1.5
Number of full brothers	1.0	1.3	3.0	1.1	0.7	-0.4	0.6	-0.1	-1.5	1.5	1.3	0.6	1.4	1.7	1.1	1.4
Worry too long after embarrassment	0.6	1.0	1.6	-0.9	-1.1	1.3	-0.9	0.9	0.3	-1.1	-1.0	-0.5	-1.3	-0.6	-1.1	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	1.0	0.2	0.8	-0.3	1.0	-0.1	-0.2	-0.4	0.4	-0.0	0.0	-0.4	0.3	-0.0
Wheeze or whistling in the chest in last year	0.2	0.3	1.1	0.4	0.9	-0.1	0.6	-1.0	0.1	0.1	0.4	-0.8	0.6	0.0	0.4	0.3
Number of children fathered	0.4	0.5	1.2	0.8	0.2	-0.6	-0.0	-0.1	-0.3	1.1	0.8	0.4	0.9	0.8	0.7	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.6	1.2	0.6	0.2	0.3	0.2	-1.0	1.5	1.0	1.6	1.1	0.7	1.4	1.4
Age at first live birth	0.7	1.2	4.0	0.6	-1.6	0.8	-1.4	2.0	-0.2	1.2	-0.2	2.0	0.3	0.2	0.2	0.6
Pulse wave peak to peak time	1.2	1.4	4.2	0.7	1.6	-1.7	1.6	-2.0	-1.4	0.4	1.1	-1.0	0.4	0.6	0.8	0.4
Health satisfaction	1.1	1.4	2.5	1.4	0.9	-0.3	1.1	-0.1	-0.9	1.3	1.6	0.5	1.6	1.1	1.6	1.5
Shortness of breath walking on level ground	0.9	1.1	3.2	1.5	0.7	-0.7	0.8	1.3	-0.7	1.3	1.0	0.1	1.8	0.2	1.1	1.2
Qualifications: College or University degree	1.6	5.0	8.4	-2.3	-2.9	2.0	-2.7	2.8	2.2	-1.5	-2.5	-0.3	-2.4	-1.5	-2.5	-2.1
Eye problems/disorders: None of the above	2.5	2.8	9.9	-0.8	1.9	-2.6	1.9	-3.1	0.9	-1.9	-0.5	-0.1	-1.4	-1.7	-0.3	-1.5
Mouth/teeth dental problems: Loose teeth	1.0	1.2	4.3	1.1	-0.0	0.5	-0.1	0.5	-1.4	0.9	1.3	0.3	1.3	2.1	0.9	1.4
Emphysema/chronic bronchitis	0.3	0.3	1.3	-0.2	0.6	-1.1	0.1	-1.1	-0.2	-0.5	0.1	-0.4	-0.4	0.6	-0.3	-0.1
Medication for pain relief, constipation, heartburn	0.3	0.5	1.9	-0.5	-1.2	1.4	-1.2	0.4	0.7	0.2	-0.2	-0.3	-0.2	0.7	-0.4	0.1
Neck or shoulder pain in last month	0.0	0.0	0.1	0.1	0.3	0.3	0.2	-0.2	-0.2	0.2	-0.0	0.3	0.1	0.1	0.0	-0.0
Medication: Blood pressure	0.6	1.1	2.2	1.5	0.6	-0.0	0.4	0.4	-1.1	1.3	1.0	1.3	1.5	0.5	1.4	1.4
Angina (self-reported)	1.3	1.7	5.2	0.9	-1.3	1.3	-1.1	2.3	-1.0	1.4	0.6	1.8	0.7	1.6	0.4	1.2
Migraine (self-reported)	0.1	0.1	0.7	-0.1	-0.0	-0.1	-0.1	0.6	0.6	-0.1	-0.2	-0.8	0.1	-0.2	-0.2	-0.0
Medication: Ibuprofen	2.3	2.8	4.9	-1.8	-1.4	1.1	-1.4	1.0	1.9	-1.8	-2.1	-0.5	-2.1	-1.4	-2.2	-1.9
Medication: Allopurinol	0.5	0.6	1.7	1.0	0.1	0.4	0.0	0.5	-0.4	1.3	0.8	0.4	1.1	1.0	0.6	1.1
Medication: Omeprazole	2.0	2.3	4.7	1.6	1.6	-2.2	1.4	-0.8	-1.7	1.2	1.8	1.1	1.6	1.4	1.6	1.6
Medication: Seretide 50 evohaler	0.8	1.0	3.6	-0.7	0.9	-0.9	0.8	-1.1	0.5	-1.1	-0.5	-1.9	-0.8	-1.0	-0.7	-1.0
Mean time to correctly identify matches	0.2	0.3	2.4	-0.3	0.6	-0.6	0.4	-1.6	0.1	-0.2	0.0	0.3	-0.3	-0.5	0.3	-0.1
Heart disease (mother)	1.4	1.7	7.0	-1.4	-0.1	-0.7	-0.3	-1.1	0.9	-1.6	-1.0	-2.6	-1.4	-0.8	-1.6	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	1.5	0.1	-0.0	0.4	-0.3	-1.1	0.4	0.4	-0.0	1.2	-0.2	-0.0	0.2	0.2
Whole body fat mass	0.1	0.3	1.8	-0.2	-0.6	1.3	-0.4	0.7	0.4	0.2	-0.1	-0.7	-0.1	0.2	-0.5	-0.1
Leg fat mass (right)	0.1	0.3	1.1	0.3	-0.5	1.0	-0.3	0.8	-0.1	0.6	0.3	0.4	0.2	0.7	-0.0	0.4
Arm predicted mass (right)	0.1	0.7	2.8	0.8	1.0	-1.1	1.2	-0.1	-0.7	0.3	0.9	1.7	0.3	0.4	0.8	0.6
Pulse rate, automated reading	0.1	0.2	0.5	-0.2	-0.3	0.0	-0.3	0.7	-0.4	-0.7	-0.5	0.3	-0.6	0.1	-0.7	-0.4
Alcohol intake frequency.	0.4	1.0	3.0	1.1	-0.3	0.8	-0.2	0.7	-0.8	1.3	0.8	1.7	0.8	1.1	1.0	1.1
Comparative height size at age 10	0.9	4.7	6.7	-2.5	-2.4	2.6	-2.3	1.0	2.2	-1.8	-2.4	-1.1	-2.6	-1.6	-2.6	-2.2
Number of full sisters	1.2	1.4	7.7	-0.8	1.2	-1.5	1.1	-2.8	0.6	-1.4	-0.3	-0.4	-1.2	-0.6	-0.3	-1.0
Suffer from ‘nerves’	1.0	1.6	5.4	1.0	2.1	-1.5	2.3	-1.4	-1.2	0.1	1.2	0.2	0.7	-0.2	1.4	0.5
Overall health rating	2.0	4.4	7.7	2.4	1.6	-1.0	1.4	-0.9	-2.7	2.4	2.8	0.8	2.3	2.6	2.2	2.6
Chest pain or discomfort	0.6	0.9	2.8	0.9	-0.5	0.1	-0.6	0.4	-0.7	1.3	1.0	1.2	0.9	1.7	0.8	1.3
Had major operations	2.5	3.0	7.1	2.0	1.5	-0.0	1.6	-0.2	-2.1	1.6	1.8	2.7	1.7	1.1	2.3	1.7
Age at last live birth	1.4	2.1	7.7	1.3	-1.2	0.9	-1.2	1.7	-0.9	2.1	0.6	2.8	1.1	1.0	1.1	1.5
Family relationship satisfaction	0.2	0.2	0.9	0.1	-0.4	0.5	-0.3	0.9	0.0	0.3	0.3	0.5	0.5	0.7	0.4	0.5
Leg pain on walking	0.2	0.2	1.3	0.2	0.9	-0.0	0.8	-1.1	0.3	-0.0	0.3	-0.4	0.0	-0.1	0.4	-0.0
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	5.2	1.3	2.2	-1.7	2.3	-2.0	-0.9	0.5	1.4	0.1	1.4	0.6	1.6	0.9
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.9	0.1	1.7	-1.5	1.5	-1.1	0.4	-0.4	0.1	-0.4	0.3	-1.1	0.4	-0.2
Illness, injury, bereavement, stress in last 2 years	2.6	3.1	5.8	-2.3	-1.9	1.1	-1.8	1.0	2.3	-1.9	-1.9	-0.2	-2.4	-0.5	-2.1	-1.9
Medication: Aspirin	0.1	0.2	0.8	0.4	0.1	-0.4	0.1	-0.0	-0.7	0.6	0.3	-0.9	0.4	0.1	0.0	0.3
Supplements: Vitamin C	3.5	4.1	6.7	2.2	2.3	-1.2	2.0	-1.9	-2.3	1.9	2.2	2.3	1.9	1.2	2.6	1.9
Knee pain experienced in last month	2.4	3.7	6.0	2.2	2.4	-1.5	2.4	-1.1	-1.6	1.8	2.4	0.0	2.4	1.5	2.2	2.0
Hypertension (Self-reported)	1.6	4.3	8.4	2.6	1.5	-0.5	1.3	-0.3	-1.9	2.0	2.4	2.9	2.5	1.9	2.7	2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.2	-0.7	-0.8	0.3	-0.9	1.1	0.5	-0.6	-0.9	0.0	-0.6	-0.7	-0.8	-0.7
Illnesses of father: Heart disease	0.4	0.6	4.7	0.2	-0.4	0.5	-0.4	0.7	0.2	0.5	0.2	-2.2	0.7	1.0	-0.5	0.4
Illnesses of siblings: Diabetes	1.6	2.0	5.2	1.8	0.2	-0.0	0.3	0.7	-2.3	1.8	1.6	0.1	1.9	1.7	1.3	1.8
Smoking status: Previous	0.7	1.1	4.2	0.6	-0.7	0.4	-0.8	2.1	-0.4	1.1	0.6	1.5	0.6	1.6	0.3	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.9	-0.6	-0.2	0.1	-0.4	-0.1	0.8	-0.4	-0.8	0.1	-0.8	-0.9	-0.6	-0.7
Whole body fat-free mass	0.1	0.5	2.1	0.3	1.2	-1.5	1.3	-0.6	-0.3	-0.2	0.5	-0.1	0.0	-0.2	0.2	-0.0
Leg fat-free mass (right)	0.2	1.1	3.4	-0.6	1.1	-1.5	1.1	-0.8	0.7	-1.0	-0.3	-1.9	-0.6	-0.9	-0.8	-0.9
Arm fat percentage (left)	0.1	0.4	4.2	0.1	0.2	0.5	0.4	-0.2	0.1	0.3	0.3	-2.0	0.3	0.4	-0.3	0.1
Average weekly red wine intake	0.3	0.4	1.8	0.1	0.8	-1.3	0.8	-1.1	-0.0	-0.4	0.2	-0.9	0.0	-0.2	-0.1	-0.1
Handedness (chirality/laterality): Left-handed	1.7	2.0	5.8	0.6	1.8	-1.5	1.9	-2.3	-0.7	-0.2	1.2	-2.4	1.3	0.5	1.0	0.4
Mood swings	1.9	3.4	6.0	2.4	0.8	0.1	0.6	0.5	-2.5	2.2	2.1	1.8	2.2	2.2	2.0	2.3
Loneliness, isolation	0.7	0.9	3.2	0.8	1.8	-1.2	1.7	-0.9	-0.6	0.2	0.9	-0.2	0.6	0.0	0.9	0.5
Long-standing illness, disability or infirmity	0.8	1.2	4.7	-0.8	-1.5	1.8	-1.5	2.2	0.4	-0.1	-0.9	-0.4	-0.5	-0.6	-0.8	-0.5
Ever had bowel cancer screening	0.7	0.9	2.6	0.9	0.2	-0.1	0.1	0.7	-1.5	0.9	1.2	0.8	0.8	1.6	0.6	1.2
Diabetes diagnosed by doctor	0.5	0.9	1.9	1.1	1.4	-0.9	1.4	-0.3	-0.6	0.9	1.0	-0.2	1.3	0.0	1.0	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.1	-0.8	-0.8	1.0	-0.6	0.2	0.6	-0.9	-0.8	-0.1	-1.1	-0.8	-0.9	-0.9
Friendships satisfaction	0.3	0.3	0.9	-0.5	-0.5	0.9	-0.5	0.9	0.6	-0.3	-0.7	0.4	-0.4	-0.5	-0.5	-0.4
Qualifications: nursing, teaching	1.6	2.5	3.6	-1.9	-1.4	1.8	-1.5	-0.2	1.9	-1.6	-1.8	-1.0	-1.9	-1.2	-1.8	-1.7
Commuting to job workplace: Walk	1.2	1.3	4.2	-0.9	-2.0	2.1	-1.9	1.1	0.6	-0.3	-1.1	0.3	-0.9	0.0	-0.9	-0.6
Eye problems/disorders: Cataract	0.5	0.6	3.2	-0.3	-0.9	1.6	-0.9	1.8	0.3	0.3	-0.4	-0.4	0.1	-0.3	-0.4	0.0
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.9	1.2	-0.1	0.1	-0.2	0.7	-1.2	1.1	1.1	0.8	1.1	1.7	0.7	1.4
Medication for cholesterol	0.5	0.7	4.0	0.5	-0.7	0.9	-0.7	0.9	-0.7	0.8	0.1	2.0	0.2	0.8	0.4	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.4	0.6	0.2	0.3	-0.2	1.2	-0.8	0.7	0.4	0.4	0.9	0.3	0.6	0.7
Back pain experienced in last month	0.1	0.2	0.8	0.7	0.3	-0.4	0.5	0.7	-0.2	0.4	0.3	0.9	0.4	0.2	0.2	0.4
Mineral and other dietary supplements	0.3	0.4	2.0	0.0	0.6	-0.9	0.5	-0.7	-0.0	0.3	0.6	-1.4	0.4	0.8	0.1	0.3
Breast cancer (self-reported)	0.7	0.9	2.0	-1.2	-0.0	-0.1	-0.3	-0.1	1.4	-0.9	-0.9	-1.4	-1.0	-1.0	-0.9	-1.2
Asthma (self-reported)	0.2	0.4	1.9	-0.1	0.7	-0.4	0.7	-0.7	0.5	-0.6	-0.0	-1.4	-0.1	-0.6	-0.2	-0.4
Osteoporosis (self-reported)	2.6	3.2	5.9	-2.0	-1.6	0.8	-1.4	1.3	1.6	-1.8	-2.2	-1.9	-1.8	-1.6	-2.4	-2.1
Osteoarthritis (self-reported)	0.1	0.2	0.6	0.3	0.5	-0.3	0.5	-0.4	-0.6	-0.0	0.3	0.8	0.1	-0.1	0.5	0.1
Medication: Aspirin	0.5	0.6	1.6	1.0	0.1	-0.3	0.2	0.2	-1.1	1.3	0.9	-0.1	1.0	0.8	0.6	1.0
Medication: Gliclazide	1.1	1.2	6.5	0.5	1.8	-2.6	1.7	-1.2	-0.2	-0.1	0.6	-0.4	0.6	-0.3	0.4	0.2
Illnesses of father: None of the above (group 1)	0.3	0.3	1.4	-0.0	0.9	-0.8	1.2	-0.7	-0.3	-0.3	0.2	0.3	-0.2	-0.7	0.4	-0.4
Smoking status: Current	0.6	0.9	1.8	1.1	1.0	0.4	0.8	-1.0	-0.9	0.5	1.3	-0.1	1.2	1.2	1.1	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	4.1	-0.5	-1.0	2.0	-0.9	0.4	0.3	-0.2	-0.5	1.6	-0.8	-0.1	-0.1	-0.3
Whole body water mass	0.1	0.5	2.3	0.2	1.2	-1.5	1.3	-0.6	-0.2	-0.3	0.4	-0.1	0.0	-0.2	0.2	-0.1
Leg predicted mass (right)	0.2	1.0	3.2	-0.6	1.1	-1.5	1.2	-0.8	0.7	-1.0	-0.3	-1.8	-0.6	-0.8	-0.7	-0.9
Arm fat mass (left)	0.1	0.2	1.2	0.4	0.4	0.2	0.6	-0.3	-0.2	0.4	0.6	-1.1	0.4	0.6	0.1	0.3
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	0.4	-0.1	0.3	-0.0	0.6	0.2	0.6	0.4	-0.6	0.7	-0.0	0.3	0.5
Average weekly champagne plus white wine intake	1.6	2.2	3.3	-1.6	-0.8	0.5	-0.7	1.5	1.8	-1.7	-1.8	-1.0	-1.5	-1.7	-1.7	-1.8
Miserableness	0.9	1.6	4.3	1.6	1.1	-0.3	0.9	-0.1	-2.1	1.3	1.5	0.3	1.5	1.4	1.3	1.4
Guilty feelings	0.6	0.9	2.0	-0.8	-1.4	1.0	-1.2	1.3	0.7	-0.6	-0.9	-0.8	-1.0	-0.0	-1.3	-0.7
Wears glasses or contact lenses	0.2	0.2	0.7	-0.3	0.5	-0.8	0.4	-0.5	0.7	-0.5	0.1	-0.8	-0.3	0.1	-0.2	-0.3
Ever taken oral contraceptive pill	0.9	1.0	3.5	-0.9	-0.1	0.4	-0.0	0.4	1.4	-1.1	-1.1	0.2	-1.2	-1.9	-0.8	-1.2
Hearing aid user	0.4	0.5	1.5	-0.4	-1.2	1.1	-1.2	0.8	-0.1	-0.2	-0.3	-0.8	-0.2	0.5	-0.7	0.0
Mother’s age at death	0.4	0.5	1.0	-0.6	-1.0	0.9	-0.7	0.8	0.5	-0.5	-0.8	0.3	-0.4	-0.8	-0.6	-0.5
Financial situation satisfaction	0.4	0.5	2.4	0.4	0.9	-1.6	0.8	-1.1	-0.6	-0.2	0.6	0.7	-0.1	0.5	0.4	0.3
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.6	0.0	-1.3	0.6	-1.3	1.3	-0.1	0.2	-0.4	1.6	-0.1	0.2	0.0	0.1
Commuting to job workplace: Public transport	0.8	0.9	4.0	0.5	-0.9	1.0	-1.1	0.4	-1.1	1.2	0.7	-0.3	0.6	2.0	-0.0	0.9
Eye problems/disorders: Glaucoma	0.5	0.6	2.1	-0.3	-1.4	0.7	-1.4	1.4	0.3	0.4	-0.6	0.2	-0.3	0.1	-0.7	-0.1
Medication: Blood pressure	0.8	1.6	2.7	1.1	1.6	-1.2	1.6	-1.6	-0.9	0.4	1.5	1.4	0.9	0.7	1.6	1.0
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.8	0.2	-0.2	0.4	-0.3	0.5	0.3	0.1	-0.2	0.9	0.2	0.0	0.0	0.2
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.0	-0.6	0.1	0.4	-0.1	-0.6	0.9	-1.0	-1.1	1.3	-1.0	-1.7	-0.2	-1.0
High cholesterol (Self-reported)	0.9	1.6	13.3	-0.6	0.7	-0.7	0.8	0.1	1.4	-1.0	-0.4	-3.6	0.1	-1.3	-0.8	-0.8
Medication: Bendroflumethiazide	2.0	3.1	6.7	1.7	2.6	-2.2	2.3	-2.2	-1.4	0.7	1.9	0.5	1.6	1.0	1.8	1.4
Medication: Paracetamol	0.8	1.2	2.4	-1.0	-1.3	1.6	-1.4	1.3	1.0	-0.9	-1.2	1.1	-1.0	-0.5	-0.9	-0.9
Medication: Lisinopril	0.5	0.7	2.4	0.8	-0.3	0.6	-0.5	1.5	-0.4	0.8	0.4	1.6	0.7	0.5	0.6	0.8
Medication: Atorvastatin	2.0	2.5	14.4	-1.6	0.1	-0.0	-0.0	-0.8	1.6	-1.7	-1.1	-3.8	-1.0	-1.3	-1.6	-1.4
Illnesses of father: High blood pressure	0.7	0.8	3.0	-0.0	-1.7	0.9	-1.7	1.2	-0.3	0.4	-0.2	1.1	-0.2	0.9	-0.4	0.3
Alcohol drinker status: Never	1.4	1.6	3.8	1.1	-0.2	1.0	-0.3	0.5	-1.8	1.4	1.3	2.0	1.1	1.6	1.3	1.5
Ever smoked	2.1	3.7	5.4	2.3	1.4	-1.1	1.2	0.2	-2.2	2.2	2.3	1.9	2.3	2.1	2.3	2.3
Basal metabolic rate	0.1	0.3	1.3	0.2	0.9	-1.1	1.1	-0.4	-0.2	-0.2	0.4	-0.2	-0.0	-0.1	0.1	-0.1
Leg fat percentage (left)	0.2	0.6	1.6	0.6	-0.5	1.2	-0.4	0.7	-0.3	0.9	0.5	1.3	0.4	1.0	0.4	0.8
Arm fat-free mass (left)	0.2	0.8	2.3	0.9	1.1	-0.9	1.3	-0.4	-0.8	0.5	1.0	1.5	0.5	0.4	1.0	0.7
Number of operations (self-reported)	0.2	0.3	1.8	-0.4	0.5	-0.4	0.5	-0.9	0.1	-0.5	-0.1	-1.3	-0.4	-0.0	-0.4	-0.4
Average weekly beer plus cider intake	1.3	1.9	5.4	1.4	0.7	-1.5	0.6	-0.2	-1.3	1.3	1.6	1.2	1.3	2.3	1.3	1.6
Irritability	0.6	1.1	5.6	0.8	-0.9	0.7	-0.9	2.4	-0.5	0.9	0.4	1.3	0.7	1.2	0.2	0.9
Risk taking	1.0	1.5	2.6	1.6	0.4	-0.4	0.4	-0.2	-1.2	1.6	1.3	1.4	1.5	1.2	1.5	1.6
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.7	0.8	0.8	-0.5	0.7	0.1	-0.8	0.5	0.8	0.6	0.8	0.6	0.7	0.7
Fractured/broken bones in last 5 years	0.1	0.1	0.5	-0.1	-0.2	0.0	0.1	0.4	-0.3	0.1	0.1	-0.7	0.0	0.2	-0.3	-0.0
Age started oral contraceptive pill	1.1	1.3	3.6	0.8	-1.0	1.3	-1.0	1.2	-1.0	1.4	0.6	1.9	0.8	1.5	0.6	1.2
Diastolic blood pressure, automated reading	0.1	0.2	1.5	0.4	0.2	-0.3	-0.0	-0.1	-0.2	-0.2	0.2	1.2	-0.1	0.4	0.1	0.2
Ever depressed for a whole week	0.4	0.5	1.5	-0.6	-1.0	0.6	-1.1	1.2	0.4	-0.3	-0.8	-0.5	-0.4	-0.4	-0.8	-0.4
Unable to work because of sickness or disability	0.3	0.3	1.1	0.5	0.8	-1.1	0.6	-0.2	-0.8	0.5	0.5	-0.2	0.6	0.4	0.4	0.4
Commuting to job workplace: Cycle	1.2	1.4	4.4	-0.9	-1.9	2.1	-1.8	1.4	0.7	-0.6	-0.9	1.1	-0.9	0.2	-0.6	-0.6
Myopia	0.2	0.2	1.3	0.1	-0.5	-0.3	-0.8	0.1	-0.4	0.4	0.2	-0.3	0.1	1.1	-0.3	0.5
Vascular/heart problems diagnosed by doctor	1.9	5.1	10.4	-2.7	-1.5	0.8	-1.3	0.2	2.3	-2.3	-2.6	-3.2	-2.6	-2.0	-2.9	-2.8
Cholesterol lowering medication	0.8	1.1	10.5	-0.8	-0.3	0.5	-0.1	-0.2	1.0	-0.7	-0.4	-3.2	-0.1	-0.7	-0.9	-0.6
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	5.7	1.5	1.5	-2.4	1.3	-0.5	-1.6	1.0	1.7	0.8	1.6	1.3	1.5	1.5
Pain experienced in last month	3.3	5.4	9.3	-3.0	-2.1	1.0	-2.1	0.5	2.7	-2.6	-2.7	-1.6	-3.1	-1.8	-2.7	-2.7
Supplements: Calcium	0.8	0.8	1.8	-1.0	-0.6	0.1	-0.6	0.9	0.8	-0.6	-1.2	-0.4	-1.1	-1.4	-1.1	-1.2
Basal cell carcinoma (self-reported)	0.5	0.6	2.0	0.7	-0.7	1.1	-0.8	1.4	-0.5	0.8	0.1	0.4	0.9	0.7	0.2	0.9
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.7	-0.0	0.2	-0.2	0.0	-0.4	0.2	0.1	0.2	-0.9	0.1	0.3	-0.2	0.2
Deep venous thrombosis (DVT) (self-reported)	3.4	4.3	50.1	-0.8	-0.6	0.7	-0.4	-0.7	1.1	0.5	-0.4	-7.1	0.7	-0.5	-1.3	-0.5
Heart disease (siblings)	0.2	0.3	2.0	0.2	-0.4	0.1	-0.3	0.3	-0.8	0.2	0.4	-0.2	0.2	1.4	-0.1	0.3
Alcohol drinker status: Previous	1.1	1.2	2.9	1.1	-0.5	1.2	-0.7	0.9	-1.2	1.5	0.8	1.2	1.1	1.7	0.5	1.3
Pack years of smoking	0.0	0.0	0.2	0.0	-0.0	-0.0	-0.2	-0.1	0.1	-0.2	0.1	-0.2	-0.1	0.4	-0.1	0.1
Impedance of whole body	1.2	6.1	16.8	-2.2	-3.7	4.1	-3.5	2.7	2.2	-0.8	-2.6	-0.1	-2.0	-1.2	-2.2	-1.7
Leg fat mass (left)	0.0	0.2	0.9	0.3	-0.3	0.9	-0.2	0.6	-0.0	0.5	0.2	0.4	0.1	0.6	-0.0	0.4
Arm predicted mass (left)	0.2	0.8	2.6	0.9	1.0	-0.9	1.1	-0.3	-0.8	0.5	0.9	1.6	0.5	0.5	0.9	0.7