Hub : Genes

C9orf96

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.1850	0.0700	0.00560	0.046	NA	0.027	NA	0.034	4.0e-03	NA	2.4e-02	NA	1.2e-02
2	METSIM	Adipose	0.0652	0.0240	0.00250	0.006	0.026	0.023	0.025	0.010	4.3e-02	7.8e-05	1.7e-04	0.00011	1.1e-02
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0180	0.0118	0.00970	0.006	0.016	0.006	NA	0.005	6.2e-02	6.1e-03	5.8e-02	NA	8.9e-02
4	TCGA	Brain Lower Grade Glioma	0.0393	0.0232	0.00024	0.034	0.036	0.039	NA	0.042	8.2e-05	5.6e-05	2.6e-05	NA	1.5e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.4	0.7	1.3	-1.1	0.1	1.0	0.6
Bipolar Disorder or Schizophrenia	0.2	0.5	0.7	-0.4	-0.8	0.7	0.8
Depressed Affect (Nagel 2018)	1.3	2.8	4.9	2.1	-1.1	-2.2	-0.8
Depression (Nagel 2018)	4.8	7.2	9.9	3.1	-2.6	-3.2	-1.5
Intelligence (Savage-Jansen 2018)	0.2	0.8	1.5	1.0	0.1	-0.8	-1.2
Neuroticism (Nagel 2018)	0.6	1.4	2.0	1.4	-1.4	-1.2	-0.4
Schizophrenia (2018)	0.2	0.5	1.6	0.4	-1.3	0.0	0.5
Schizophrenia vs Biploar Disorder	1.5	1.9	3.8	2.0	-0.8	-1.8	-0.3
Worry (Nagel 2018)	0.2	0.3	0.9	0.1	-1.0	-0.3	0.5
Alzheimer’s Disease (in mother)	0.1	0.1	0.3	0.5	0.4	0.0	0.2
Alzheimer’s Disease (in father)	1.0	1.1	2.2	1.0	-1.5	-0.7	-0.7
Alzheimer’s Disease (including proxy)	0.2	0.2	0.7	0.8	-0.3	-0.4	-0.1
Crohns Disease (2017)	0.4	0.9	2.0	0.5	1.4	0.3	-1.1
Irritable Bowel Disease (IBD)	0.4	0.9	2.7	0.8	0.5	-0.3	-1.6
Ulcerative Colitis (UC)	0.6	1.1	2.1	0.9	-0.8	-0.9	-1.4
Major Depression (MDD)	0.7	0.9	2.2	0.0	0.0	1.5	1.2
Reaction Time	0.1	0.2	0.3	-0.5	0.4	0.1	0.6
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.7	0.8	1.1	-0.4	-1.6
Breast Cancer	0.8	1.9	4.4	-1.4	1.1	2.1	-0.4
Ovarian Cancer	2.8	3.7	8.4	1.2	-1.8	-1.2	-2.9
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.1	0.1	0.3	0.6	0.0	-0.3	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.6	1.5	1.0	-1.2	0.0	0.0
Coronary Artery Disease (CAD)	0.1	0.1	0.3	0.0	0.0	0.6	0.0
Crohns Disease (2012)	0.5	0.8	2.3	0.5	0.9	0.2	-1.5
Mean Putamen Volume	0.3	0.3	0.4	-0.6	-0.6	0.6	-0.4
Fasting Glucose	1.5	1.8	2.9	-1.4	1.7	1.4	0.5
HbA1C	0.3	0.3	0.6	-0.8	0.3	0.8	0.0
HDL Cholesterol	0.2	0.3	1.1	0.4	1.1	0.0	0.0
LDL Cholesterol	0.9	1.4	3.1	-1.8	1.6	0.0	0.0
Lupus	1.0	1.5	3.2	1.5	-0.2	-1.8	-0.6
Neuroticism (2016)	0.1	0.1	0.3	-0.1	-0.4	0.2	0.6
Primary Biliary Cirrhosis	0.5	0.7	1.2	1.1	-0.3	-1.1	-0.7
Rheumatoid Arthritis	0.4	0.5	1.7	0.4	0.1	0.1	-1.3
Schizophrenia (2014)	0.3	0.6	1.7	0.7	-1.3	-0.3	0.3
Triglycerides	0.5	0.8	2.7	-0.8	-1.6	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.9	-0.4	-1.0	0.0	0.0
Ulcerative Colitis	0.6	0.8	1.4	0.8	0.7	-0.8	-1.2
Blood Eosinophil Count	0.5	3.8	13.3	1.1	-0.8	-0.3	-3.6
Blood Platelet Count	0.3	3.9	11.7	0.6	-1.1	-3.4	1.5
Blood Red Count	4.4	42.7	121.0	3.1	-6.3	0.6	-11.0
Blood White Count	1.9	13.9	30.9	1.7	-5.6	-1.3	-4.5
Heel T-Score	3.5	27.5	46.0	4.3	-5.5	-3.9	-6.8
BMI	0.2	1.1	2.2	-0.2	-1.5	-0.5	1.4
Height	0.1	1.9	5.0	-0.7	-0.2	2.2	-1.4
Waist Hip Ratio (WHR)	0.3	1.2	3.1	-0.6	1.8	0.6	0.9
Systolic Blood Pressure	0.6	3.2	10.6	0.5	-3.2	-0.9	-1.1
Smoking Status	0.5	1.2	1.8	1.4	1.0	-1.0	-0.9
Allergy or Eczema	0.3	0.8	1.8	0.6	-0.9	-0.4	1.4
Cardiovascular Disease	0.5	1.5	3.7	0.9	-1.9	-1.2	0.4
Hypothyroidism (self reported)	0.4	0.8	2.8	-0.0	-1.7	0.1	0.7
Respiratory disease	0.1	0.3	0.8	-0.1	0.4	-0.1	0.9
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.6	1.3	-0.2	-1.6	-0.0
Lung FEV1/FVC ratio	0.3	1.8	6.8	-0.4	-2.6	0.3	-0.1
Lung FVC	0.3	1.5	4.8	0.5	0.6	0.7	-2.2
Neuroticism	0.4	1.0	1.9	1.1	-0.7	-1.4	-0.5
Chronotype (morning person)	0.6	1.5	2.3	-1.4	1.5	1.1	0.6
Hair Pigment	0.2	5.2	8.0	2.1	-2.8	-2.7	-1.0
Tanning	0.0	0.0	0.0	0.0	0.0	-0.1	-0.1
Hand grip strength (left)	0.2	0.6	1.7	-0.9	-1.3	0.1	0.1
Number of treatments/medications taken	0.3	0.5	0.8	0.6	-0.9	-0.6	-0.5
Average weekly spirits intake	0.6	0.7	1.4	1.0	-0.6	-1.2	0.3
Sensitivity / hurt feelings	0.2	0.3	0.8	0.7	0.1	0.2	-0.9
Frequency of depressed mood in last 2 weeks	2.4	3.3	4.5	2.0	-1.8	-2.1	-1.3
Hearing difficulty/problems: Yes	1.2	1.8	3.2	-0.9	1.8	1.6	-0.7
Relative age of first facial hair	0.6	1.2	2.8	1.0	-0.3	-0.9	-1.7
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.3	-0.4	-0.0	-0.4
Ever used hormone-replacement therapy (HRT)	1.7	2.1	5.8	-1.6	0.1	0.5	2.4
Ever had hysterectomy (womb removed)	0.2	0.2	0.8	-0.2	-0.9	-0.1	0.1
Systolic blood pressure, automated reading	0.4	1.1	2.7	0.8	-1.7	-0.5	-0.9
Eye problems/disorders: Diabetes related eye disease	2.9	3.2	5.3	1.8	-1.2	-1.7	-2.3
Angina	1.1	1.5	2.1	1.3	1.5	-0.4	-1.4
Medication for hormone replacement therapy	3.3	3.7	5.7	-2.4	0.1	2.0	2.2
Vitamin and mineral supplements	1.0	1.3	3.3	-0.9	0.7	0.9	1.8
Supplements: Zinc	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.4
Medication: Co-codamol	1.3	1.5	2.9	-1.1	0.9	1.0	1.7
Medication: Metformin	0.3	0.4	0.7	-0.5	0.9	0.2	0.8
Diabetes (father)	1.3	1.7	6.0	-0.6	2.4	0.3	0.4
Diabetes (mother)	0.6	0.8	1.6	1.0	0.5	-1.2	0.6
Severe depression (siblings)	0.0	0.0	0.1	0.3	0.3	-0.1	-0.1
Pack years adult smoking proportion	0.1	0.2	0.5	-0.1	0.4	-0.0	0.7
Impedance of leg (right)	0.5	2.5	8.5	0.4	1.0	0.5	-2.9
Leg fat-free mass (left)	0.2	1.2	2.7	-1.0	-0.5	0.8	1.7
Trunk fat percentage	0.2	0.7	1.7	-0.4	1.3	0.8	0.7
Hand grip strength (right)	0.7	1.8	4.2	-2.0	-0.7	1.4	0.7
Townsend deprivation index at recruitment	0.8	1.1	2.0	-1.2	-0.2	0.9	1.4
Current tobacco smoking	0.5	0.8	1.6	0.7	1.3	-1.0	0.4
Average weekly fortified wine intake	0.3	0.3	0.4	-0.4	0.6	0.6	-0.5
Maternal smoking around birth	0.4	0.6	1.4	-0.3	0.9	0.1	1.2
Fed-up feelings	0.2	0.3	0.7	0.8	-0.1	-0.7	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.8	4.3	2.1	-1.0	-2.1	-1.2
Relative age voice broke	2.1	3.2	4.4	2.1	-0.3	-2.1	-2.0
Taking other prescription medications	0.1	0.1	0.4	0.1	-0.6	-0.2	0.1
Age when periods started (menarche)	0.1	0.2	0.7	-0.2	0.8	0.3	0.2
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.1	-0.6	0.8	0.1	1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	3.1	1.1	-1.6	-1.6	-1.8
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.7	-0.8	-0.1	0.7	1.3
Qualifications: CSEs or equivalent	0.6	0.8	1.5	0.3	1.2	-0.7	1.1
Serious illness, injury or assault to yourself	0.3	0.4	1.2	0.1	1.1	-0.5	-0.3
High blood pressure	3.2	8.9	15.6	2.7	-4.0	-2.7	-2.4
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.6	0.6	-0.0	-0.7	1.3
Multivitamins +/- minerals	0.4	0.5	1.4	-0.0	0.8	0.2	-1.2
Stomach or abdominal pain in last month	0.4	0.6	1.1	0.7	-0.6	-1.1	-0.4
Supplements: Glucosamine	1.0	1.4	3.7	0.5	1.1	-0.4	-1.9
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.0	-0.1	-1.0	-0.2	0.0
Medication: Atenolol	0.0	0.0	0.1	0.1	0.3	-0.0	-0.0
Medication: Levothyroxine sodium	0.5	0.9	1.1	0.9	-1.0	-1.0	-0.9
Sitting height	0.3	2.0	5.3	-1.4	-0.5	2.3	-0.8
Chronic bronchitis/emphysema (father)	0.4	0.5	1.0	-0.6	0.3	1.0	-0.6
High blood pressure (mother)	1.0	1.4	2.6	-0.9	-1.6	0.3	1.4
Body mass index (BMI)	0.3	1.2	3.0	0.7	-1.7	-1.0	0.6
Impedance of leg (left)	0.5	2.4	8.8	0.3	0.3	0.7	-3.0
Leg predicted mass (left)	0.2	1.2	2.9	-1.0	-0.5	0.8	1.7
Trunk fat mass	0.1	0.3	0.5	-0.4	0.4	0.6	0.7
Waist circumference	0.1	0.4	1.1	0.2	-1.1	-0.1	0.5
Number of incorrect matches in round	0.2	0.3	0.6	-0.4	-0.6	0.8	0.2
Past tobacco smoking	0.8	1.4	2.3	-1.5	-0.6	1.1	1.3
Alcohol usually taken with meals	0.5	0.7	2.5	-0.6	-1.6	0.3	0.1
Nervous feelings	0.1	0.3	0.7	-0.6	-0.1	0.8	0.2
Frequency of tenseness / restlessness in last 2 weeks	2.5	3.8	5.6	2.0	-2.0	-2.4	-1.4
Hearing difficulty/problems with background noise	0.3	0.5	1.5	0.6	-0.6	-0.1	-1.2
Hair/balding pattern: Pattern 2	0.5	0.7	1.0	-0.8	0.7	1.0	-0.8
Had menopause	0.2	0.2	0.4	-0.2	0.7	-0.0	0.6
Had other major operations	0.3	0.4	0.9	-0.2	0.9	0.7	0.2
Forced vital capacity (FVC)	0.4	1.6	4.4	-0.1	0.4	1.3	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	2.6	6.0	8.4	1.8	-2.9	-2.2	-2.7
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	0.1	-0.5	-0.2	0.4
Qualifications: None of the above	0.6	1.3	2.4	1.5	-0.8	-1.5	-0.1
Financial difficulties in last 2 years	0.6	0.8	0.9	0.8	-0.9	-0.8	-0.9
Mouth/teeth dental problems	1.1	1.7	5.4	-1.0	-2.3	0.5	-0.3
Heart attack	1.1	1.4	5.4	0.3	2.3	-0.3	0.4
Allergy	1.0	2.3	4.9	-0.2	-2.0	0.4	-2.2
Pain all over the body in last month	1.5	1.6	4.3	1.3	-0.0	-2.1	-0.7
Diabetes (self-reported)	0.2	0.4	0.5	0.6	-0.2	-0.7	-0.7
Hayfever/allergic rhinitis (self-reported)	1.4	1.8	3.8	-1.2	1.2	0.7	2.0
Medication: Ramipril	0.1	0.2	0.4	0.7	-0.2	-0.5	0.1
Medication: Simvastatin	0.5	0.8	2.4	0.2	1.6	-0.1	0.8
Fluid intelligence score	0.5	1.1	2.7	0.2	1.6	0.3	-1.3
Illnesses of siblings	2.3	3.2	5.9	-2.4	1.1	2.1	1.1
Neuroticism score	0.3	0.6	1.2	1.0	-0.2	-1.1	-0.6
Weight	0.1	0.7	2.5	-0.0	-1.6	0.1	0.6
Impedance of arm (right)	2.4	11.2	25.1	-2.4	5.0	3.2	1.8
Arm fat percentage (right)	0.2	0.7	2.2	-0.1	0.7	0.0	1.5
Trunk fat-free mass	0.3	2.0	7.6	0.3	-2.8	-0.5	-0.0
Hip circumference	0.1	0.3	0.9	0.1	-0.9	0.3	0.0
Time employed in main current job	1.0	1.2	2.2	0.5	-1.5	-1.2	-0.8
Alcohol intake versus 10 years previously	2.2	3.4	4.4	1.8	-1.8	-2.1	-1.6
Father’s age at death	1.4	1.9	4.0	0.5	-1.9	-0.3	-2.0
Worrier / anxious feelings	0.1	0.2	0.3	0.5	-0.2	-0.4	-0.6
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.2	6.1	2.1	-1.0	-2.5	-1.1
Falls in the last year	3.2	4.3	6.6	2.4	0.8	-2.6	-2.1
Hair/balding pattern: Pattern 3	0.6	0.8	2.2	0.7	-1.5	-0.8	0.3
Number of live births	1.7	2.4	5.1	2.1	0.1	-2.2	-0.4
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	4.8	-0.3	-0.3	1.3	-2.2
Pulse rate	0.9	1.5	3.1	-1.1	-1.1	1.8	0.7
Happiness	1.1	1.3	2.0	-1.3	-1.3	1.4	-0.0
Noisy workplace	0.4	0.5	0.8	0.3	-0.8	-0.9	0.6
Qualifications: A levels/AS levels or equivalent	1.2	2.6	4.9	1.9	0.0	-1.3	-2.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	-0.8	0.3	0.3	0.3
Mouth/teeth dental problems: Dentures	0.8	1.3	2.7	-0.6	1.6	0.7	1.3
Asthma	0.3	0.6	1.6	-0.5	-0.6	0.2	1.3
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.3	4.3	-1.7	2.1	1.5	-0.1
Medication: Cholesterol lowering	0.7	1.1	2.6	-0.1	1.6	-0.0	1.3
Depression (self-reported)	0.2	0.2	0.5	0.2	-0.7	0.0	0.7
Medication: Lansoprazole	0.2	0.2	0.7	0.4	-0.2	-0.4	0.8
Prospective memory result	0.1	0.1	0.4	0.1	-0.0	-0.4	0.6
Lung cancer (father)	0.7	0.8	2.1	-1.0	-0.2	1.5	0.0
Illnesses of mother	0.4	0.5	1.7	0.2	-0.4	-0.3	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.4	2.9	-0.8	-0.8	1.7	-1.3
Pulse wave Arterial Stiffness index	1.5	1.8	4.5	-0.7	-1.2	0.8	-2.1
Impedance of arm (left)	2.0	9.3	23.0	-2.0	4.8	2.7	1.7
Arm fat mass (right)	0.1	0.3	0.8	0.3	-0.4	-0.3	0.9
Trunk predicted mass	0.3	1.9	7.5	0.3	-2.7	-0.4	-0.0
Standing height	0.2	1.8	5.2	-1.4	-0.1	2.3	-0.0
Length of working week for main job	0.5	0.6	1.8	-0.2	0.1	-0.7	1.3
Exposure to tobacco smoke at home	0.7	0.8	1.8	0.2	1.2	-0.3	-1.3
Breastfed as a baby	0.2	0.3	0.5	-0.7	0.1	0.7	-0.2
Tense / ‘highly strung’	0.5	0.9	1.6	1.1	0.2	-0.8	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.4	-0.8	-0.8	0.5	1.2
Hair/balding pattern: Pattern 4	0.2	0.4	0.9	1.0	0.3	-0.6	-0.6
Birth weight of first child	1.7	3.0	6.4	-2.2	0.8	2.5	-0.1
Peak expiratory flow (PEF)	0.9	2.1	3.5	-0.2	-1.8	1.2	-1.9
Pulse wave reflection index	1.6	2.0	5.9	1.0	0.3	-0.9	-2.4
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.8	0.9	0.5	-0.8	-0.5
Loud music exposure frequency	0.4	0.4	0.9	0.2	-0.7	-0.2	-1.0
Qualifications: O levels/GCSEs or equivalent	0.7	1.0	1.9	-1.2	0.8	1.4	0.5
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.7	0.1	1.3	0.3	-0.1
Blood clot in the leg (DVT)	14.2	18.4	62.4	-0.2	7.9	0.4	3.3
Medication: Paracetamol	0.6	1.0	3.8	-0.4	-2.0	0.1	-0.4
Headache pain in last month	0.6	1.0	2.2	0.5	-1.5	-0.7	-0.9
Medication for cholesterol, blood pressure or diabetes	0.5	0.7	0.9	-1.0	1.0	0.7	0.8
Glaucoma (self-reported)	0.2	0.2	0.9	0.2	-0.2	-0.0	-0.9
Gout (self-reported)	0.5	0.6	0.9	0.9	-0.8	-1.0	-0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.4	-0.5	-0.6	0.7	0.2
Medication: Amlodipine	1.9	2.6	6.8	1.0	-2.6	-1.5	-0.7
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.8	0.1	0.9	-0.1	0.3
Birth weight	1.5	3.3	4.6	-1.9	0.9	2.1	2.0
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.4	0.1	0.1	-0.2
High blood pressure (siblings)	1.4	2.0	3.9	1.4	-2.0	-1.0	-1.1
Forced vital capacity (FVC), Best measure	0.4	1.3	2.5	-0.3	-0.6	1.5	-1.6
Body fat percentage	0.0	0.0	0.0	0.1	0.1	0.2	0.2
Leg fat percentage (right)	0.6	2.1	4.0	1.1	-2.0	-0.9	-1.5
Arm fat-free mass (right)	0.4	2.3	6.9	0.8	-2.6	-0.9	-0.9
Exposure to tobacco smoke outside home	0.1	0.2	0.5	0.3	0.3	-0.7	-0.1
Comparative body size at age 10	0.7	2.0	3.1	1.5	-1.7	-1.6	-0.5
Number of full brothers	0.7	0.9	1.8	1.3	0.0	-1.3	-0.5
Worry too long after embarrassment	0.6	1.0	1.6	-0.9	1.3	1.1	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	-0.1	-0.7	-0.3	0.8
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	0.0	0.2	-0.4	0.6
Number of children fathered	0.8	1.0	1.1	1.0	-0.9	-1.1	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.0	1.1	0.7	-1.3	-1.4
Age at first live birth	2.2	3.9	8.0	1.2	-2.8	-0.4	-2.5
Pulse wave peak to peak time	1.5	1.8	5.2	0.4	1.3	-0.5	2.3
Health satisfaction	1.0	1.3	2.6	1.2	-0.3	-1.6	-1.0
Shortness of breath walking on level ground	1.2	1.5	2.1	1.0	-1.4	-1.3	-1.0
Qualifications: College or University degree	0.7	2.3	5.5	-1.7	0.7	2.3	-0.4
Eye problems/disorders: None of the above	1.6	1.9	3.0	-1.7	-0.6	1.1	1.7
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.5	1.6	0.8	-1.4	-0.4
Emphysema/chronic bronchitis	0.3	0.3	0.9	-0.3	0.9	0.1	0.5
Medication for pain relief, constipation, heartburn	0.1	0.1	0.1	0.2	-0.4	0.4	-0.4
Neck or shoulder pain in last month	0.1	0.1	0.4	-0.1	0.6	0.0	0.1
Medication: Blood pressure	1.6	2.9	5.5	1.5	-2.3	-1.3	-1.4
Angina (self-reported)	1.4	1.9	2.5	1.6	1.4	-0.8	-1.6
Migraine (self-reported)	0.4	0.5	1.5	-0.1	1.2	0.0	0.7
Medication: Ibuprofen	2.3	2.7	3.8	-1.9	2.0	1.9	-0.0
Medication: Allopurinol	0.6	0.7	1.1	1.1	-0.5	-1.0	-0.8
Medication: Omeprazole	2.3	2.7	4.4	1.5	-2.1	-1.9	-0.7
Medication: Seretide 50 evohaler	1.0	1.2	2.8	-1.1	0.4	0.8	1.7
Mean time to correctly identify matches	0.2	0.3	1.2	-0.4	-1.1	0.2	0.2
Heart disease (mother)	3.2	3.9	8.3	-1.5	1.7	1.5	2.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.6	0.2	-0.3	-0.2	-0.8
Whole body fat mass	0.0	0.1	0.3	0.1	-0.5	0.2	0.3
Leg fat mass (right)	0.2	0.9	3.1	0.5	-1.8	-0.3	-0.5
Arm predicted mass (right)	0.5	2.4	8.0	0.5	-2.8	-0.6	-0.9
Pulse rate, automated reading	0.7	2.3	8.6	-0.2	-2.9	0.6	-0.2
Alcohol intake frequency.	0.8	1.8	2.5	1.3	-1.6	-1.1	-1.4
Comparative height size at age 10	0.6	3.0	6.3	-1.7	1.4	2.5	1.0
Number of full sisters	1.0	1.3	2.5	-1.1	0.7	0.9	1.6
Suffer from ‘nerves’	0.3	0.5	0.9	0.2	-0.5	-0.8	1.0
Overall health rating	1.6	3.4	7.2	2.5	-0.0	-2.7	-0.4
Chest pain or discomfort	0.9	1.3	2.1	1.4	-0.4	-1.2	-1.3
Had major operations	2.9	3.3	4.3	1.5	-1.9	-1.8	-2.1
Age at last live birth	3.2	4.7	7.0	1.9	-2.6	-1.3	-2.6
Family relationship satisfaction	1.1	1.4	4.0	0.4	-2.0	-0.5	-1.0
Leg pain on walking	0.0	0.0	0.0	-0.0	0.1	-0.0	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.4	0.6	-0.9	-1.2	0.1
Commuting to job workplace: Car/motor vehicle	0.7	0.8	3.0	-0.6	-1.7	-0.0	0.2
Illness, injury, bereavement, stress in last 2 years	1.6	2.0	4.6	-1.5	-0.9	2.1	0.4
Medication: Aspirin	1.3	1.8	6.4	0.3	2.5	-0.3	0.7
Supplements: Vitamin C	2.7	3.2	5.4	1.8	-1.8	-2.3	-1.1
Knee pain experienced in last month	1.4	2.2	4.3	1.7	-1.2	-2.1	-0.3
Hypertension (Self-reported)	2.9	8.1	12.8	2.6	-3.6	-2.6	-2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.5	-0.6	1.6	0.5	0.2
Illnesses of father: Heart disease	0.3	0.4	1.2	0.5	1.1	-0.2	0.3
Illnesses of siblings: Diabetes	1.4	1.7	3.4	1.8	0.3	-1.6	-0.9
Smoking status: Previous	0.6	1.0	2.1	1.2	0.2	-0.6	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.5	-0.7	0.3	0.7	-0.0
Whole body fat-free mass	0.2	1.1	4.1	-0.1	-2.0	-0.1	0.5
Leg fat-free mass (right)	0.3	1.4	3.4	-1.0	-0.6	0.8	1.8
Arm fat percentage (left)	0.2	0.6	1.9	0.1	0.7	-0.2	1.4
Average weekly red wine intake	0.1	0.2	0.6	-0.2	-0.3	-0.0	0.8
Handedness (chirality/laterality): Left-handed	1.1	1.3	3.9	0.1	-1.0	-0.5	2.0
Mood swings	2.2	3.9	6.3	2.5	-0.8	-2.2	-1.9
Loneliness, isolation	0.4	0.5	1.2	0.2	-1.1	-0.8	0.4
Long-standing illness, disability or infirmity	0.3	0.5	1.6	-0.2	1.3	0.5	0.3
Ever had bowel cancer screening	1.0	1.1	1.8	1.3	-0.9	-1.1	-0.9
Diabetes diagnosed by doctor	0.3	0.4	1.1	0.7	-0.1	-1.0	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.6	-0.8	-0.6	0.8	0.7
Friendships satisfaction	0.6	0.7	1.4	-0.5	-1.0	0.4	-1.2
Qualifications: nursing, teaching	1.0	1.6	3.7	-1.5	0.0	1.9	0.5
Commuting to job workplace: Walk	0.9	0.9	2.8	-0.3	1.7	0.9	-0.0
Eye problems/disorders: Cataract	0.2	0.3	0.8	0.1	0.9	0.0	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.3	1.5	-0.4	-1.2	-1.1
Medication for cholesterol	0.7	1.0	3.0	0.6	0.7	-0.3	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.3	0.7	-1.8	-0.7	-0.9
Back pain experienced in last month	0.3	0.5	1.0	0.5	-1.0	-0.4	-0.8
Mineral and other dietary supplements	0.3	0.4	1.4	0.0	-0.1	-0.2	1.2
Breast cancer (self-reported)	1.2	1.5	3.0	-1.1	0.5	1.1	1.7
Asthma (self-reported)	0.3	0.6	2.2	-0.5	-0.3	0.2	1.5
Osteoporosis (self-reported)	2.4	2.9	4.8	-1.9	1.5	2.2	1.0
Osteoarthritis (self-reported)	0.1	0.1	0.2	-0.1	0.5	-0.2	-0.1
Medication: Aspirin	1.2	1.6	4.3	1.0	2.1	-1.0	-0.0
Medication: Gliclazide	0.1	0.1	0.2	-0.0	-0.4	-0.4	-0.1
Illnesses of father: None of the above (group 1)	0.7	0.8	1.7	-0.6	-1.3	0.1	1.1
Smoking status: Current	0.5	0.8	1.2	0.9	1.1	-1.1	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.7	-0.1	-1.1	0.5	-1.3
Whole body water mass	0.2	1.1	4.0	-0.2	-2.0	-0.0	0.5
Leg predicted mass (right)	0.3	1.3	3.3	-1.0	-0.7	0.8	1.8
Arm fat mass (left)	0.1	0.3	0.6	0.3	-0.4	-0.4	0.8
Number of self-reported non-cancer illnesses	0.2	0.4	0.5	0.5	-0.7	-0.6	0.5
Average weekly champagne plus white wine intake	1.2	1.7	2.8	-1.7	0.9	1.6	0.5
Miserableness	0.7	1.2	2.2	1.4	-0.6	-1.5	-0.6
Guilty feelings	0.3	0.4	0.8	-0.5	-0.2	0.9	0.8
Wears glasses or contact lenses	0.2	0.2	0.7	-0.4	0.1	0.2	0.8
Ever taken oral contraceptive pill	0.8	0.9	1.5	-1.2	1.2	0.8	0.3
Hearing aid user	0.5	0.6	2.4	0.2	1.6	0.1	0.1
Mother’s age at death	1.0	1.2	3.5	-0.4	-1.9	0.6	-0.9
Financial situation satisfaction	0.7	0.9	3.2	0.0	-1.8	-0.5	0.2
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.9	0.4	-0.2	0.1	-1.7
Commuting to job workplace: Public transport	0.4	0.5	1.4	1.2	0.3	-0.7	-0.1
Eye problems/disorders: Glaucoma	0.3	0.4	1.0	0.0	0.7	0.3	-1.0
Medication: Blood pressure	1.0	1.8	5.1	0.9	-2.3	-1.1	-0.5
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.6	0.4	-0.8	-0.1	-0.7
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.3	-1.0	-1.1	0.8	-0.9
High cholesterol (Self-reported)	1.9	3.3	7.6	-0.9	2.1	0.5	2.7
Medication: Bendroflumethiazide	2.1	3.2	8.5	1.2	-2.9	-1.7	-0.4
Medication: Paracetamol	0.7	1.0	2.7	-0.6	-1.6	0.9	-0.4
Medication: Lisinopril	1.4	1.8	3.8	1.1	-1.2	-0.8	-1.9
Medication: Atorvastatin	4.8	6.0	12.1	-1.6	3.5	1.5	2.7
Illnesses of father: High blood pressure	0.8	1.0	2.9	0.6	0.9	0.1	-1.7
Alcohol drinker status: Never	1.3	1.6	2.9	1.7	0.3	-1.2	-1.4
Ever smoked	2.0	3.5	5.7	2.2	-1.0	-2.4	-1.6
Basal metabolic rate	0.2	1.0	3.8	-0.1	-1.9	-0.0	0.6
Leg fat percentage (left)	0.5	1.9	5.0	0.9	-2.2	-0.7	-1.2
Arm fat-free mass (left)	0.4	2.3	7.5	0.6	-2.7	-0.7	-0.8
Number of operations (self-reported)	0.4	0.5	0.9	-0.6	0.9	0.4	0.8
Average weekly beer plus cider intake	0.8	1.2	2.3	1.4	-0.2	-1.5	-0.8
Irritability	0.8	1.4	2.9	1.3	-0.6	-0.8	-1.7
Risk taking	1.1	1.6	2.4	1.5	0.2	-1.6	-1.3
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.1	0.7	-1.4	-0.8	-0.7
Fractured/broken bones in last 5 years	0.2	0.2	0.8	-0.1	0.9	0.1	0.3
Age started oral contraceptive pill	2.3	2.9	7.7	1.4	-1.0	-0.9	-2.8
Diastolic blood pressure, automated reading	1.3	4.1	15.3	0.5	-3.9	0.0	-1.0
Ever depressed for a whole week	0.2	0.2	0.3	-0.4	-0.5	0.6	-0.3
Unable to work because of sickness or disability	0.1	0.2	0.2	0.4	0.2	-0.5	0.4
Commuting to job workplace: Cycle	0.2	0.2	0.5	-0.2	0.3	0.7	-0.6
Myopia	0.1	0.1	0.4	0.6	0.1	-0.1	0.0
Vascular/heart problems diagnosed by doctor	2.9	7.8	9.8	-2.8	3.1	2.8	2.4
Cholesterol lowering medication	1.5	2.1	4.3	-0.7	1.8	0.7	2.1
Medication: Omeprazole (e.g. Zanprol)	2.2	2.7	4.8	1.4	-2.2	-1.9	-0.6
Pain experienced in last month	3.0	5.1	8.1	-2.5	1.6	2.8	1.8
Supplements: Calcium	1.1	1.2	2.2	-0.9	1.5	1.2	0.5
Basal cell carcinoma (self-reported)	0.8	0.9	2.5	0.8	0.0	-0.6	-1.6
Heart attack/myocardial infarction (self-reported)	1.3	1.7	6.5	0.2	2.5	-0.2	0.5
Deep venous thrombosis (DVT) (self-reported)	15.5	19.9	64.0	-0.6	8.0	0.8	3.8
Heart disease (siblings)	0.2	0.2	0.4	0.6	0.6	-0.1	0.2
Alcohol drinker status: Previous	1.1	1.3	2.6	1.6	-0.3	-1.0	-1.2
Pack years of smoking	0.0	0.0	0.0	0.1	0.0	-0.0	0.2
Impedance of whole body	0.9	4.4	11.7	-1.2	3.4	2.1	-0.5
Leg fat mass (left)	0.3	1.0	3.8	0.5	-1.9	-0.2	-0.4
Arm predicted mass (left)	0.5	2.5	8.3	0.6	-2.9	-0.7	-0.9