Best TWAS P=2.83e-23 · Best GWAS P=4.22e-38 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | WDR36 | 0.05 | 0.03 | enet | 13 | 0.01 | 1.0e-02 | -2.0 | -5.9 | 4.5e-09 | 0.38 | 0.16 | 0.37 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | WDR36 | 0.32 | 0.12 | lasso | 7 | 0.17 | 4.8e-05 | -4.9 | -7.6 | 3.0e-14 | 0.54 | 0.01 | 0.89 | TRUE |
| 3 | GTEx | Liver | WDR36 | 0.32 | -0.01 | enet | 19 | 0.03 | 5.4e-02 | -3.0 | -5.1 | 2.8e-07 | 0.09 | 0.08 | 0.08 | FALSE |
| 4 | GTEx | Spleen | SLC25A46 | 0.25 | 0.00 | enet | 6 | 0.02 | 1.3e-01 | 6.7 | -6.3 | 2.2e-10 | 0.03 | 0.07 | 0.06 | FALSE |
| 5 | GTEx | Testis | WDR36 | 0.61 | 0.37 | lasso | 10 | 0.34 | 5.7e-16 | -4.8 | -5.7 | 1.4e-08 | 0.20 | 1.00 | 0.00 | TRUE |
| 6 | METSIM | Adipose | CAMK4 | 0.05 | 0.01 | bslmm | 518 | 0.03 | 8.3e-05 | 6.1 | 7.0 | 3.1e-12 | -0.05 | 0.32 | 0.02 | FALSE |
| 7 | METSIM | Adipose | TSLP | 0.16 | 0.18 | lasso | 7 | 0.18 | 8.5e-26 | -9.3 | 9.2 | 5.4e-20 | -0.09 | 1.00 | 0.00 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | TSLP | 0.13 | 0.08 | enet | 14 | 0.09 | 4.1e-11 | -8.8 | 6.9 | 5.4e-12 | 0.05 | 1.00 | 0.00 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | CAMK4 | 0.10 | 0.03 | lasso | 4 | 0.04 | 7.8e-06 | 6.1 | -6.3 | 4.0e-10 | 0.13 | 0.98 | 0.00 | FALSE |
| 10 | YFS | Blood | SLC25A46 | 0.03 | 0.02 | enet | 12 | 0.02 | 9.5e-07 | 6.7 | -9.9 | 2.8e-23 | 0.16 | 0.93 | 0.02 | TRUE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TSLP | 0.03 | 0.03 | lasso | 2 | 0.03 | 5.5e-07 | -9.3 | 7.7 | 1.3e-14 | -0.02 | 1.00 | 0.00 | FALSE |
| 12 | The Cancer Genome Atlas | Colon Adenocarcinoma | TSLP | 0.08 | 0.01 | blup | 39 | 0.03 | 5.4e-03 | -8.7 | 7.4 | 1.0e-13 | 0.02 | 0.04 | 0.04 | TRUE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TSLP | 0.05 | 0.02 | blup | 39 | 0.02 | 7.9e-04 | -8.7 | 8.9 | 7.0e-19 | -0.10 | 0.24 | 0.02 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TMEM232 | 0.09 | 0.03 | blup | 160 | 0.04 | 3.3e-05 | 6.4 | 6.2 | 4.1e-10 | -0.06 | 0.93 | 0.06 | TRUE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TSLP | 0.06 | 0.07 | blup | 39 | 0.06 | 6.4e-07 | -8.7 | 7.8 | 5.9e-15 | -0.08 | 1.00 | 0.00 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Adenocarcinoma | TSLP | 0.02 | 0.02 | blup | 39 | 0.02 | 1.9e-03 | -9.3 | 7.3 | 2.4e-13 | -0.03 | 0.05 | 0.03 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TSLP | 0.04 | 0.03 | enet | 6 | 0.02 | 1.6e-03 | -9.0 | 8.4 | 3.4e-17 | -0.06 | 0.14 | 0.03 | FALSE |
| 18 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | TMEM232 | 0.17 | 0.03 | blup | 162 | 0.06 | 1.9e-03 | 5.9 | 5.6 | 2.6e-08 | -0.02 | 0.12 | 0.19 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TSLP | 0.03 | 0.01 | blup | 39 | 0.02 | 2.7e-03 | -6.1 | 6.3 | 4.0e-10 | 0.06 | 0.08 | 0.03 | TRUE |
| 20 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | TSLP | 0.12 | 0.11 | lasso | 3 | 0.08 | 6.9e-04 | -9.2 | 9.0 | 2.5e-19 | -0.09 | 0.11 | 0.05 | TRUE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | TSLP | 0.13 | 0.14 | blup | 39 | 0.15 | 1.4e-14 | -8.7 | 6.4 | 1.2e-10 | -0.08 | 1.00 | 0.00 | TRUE |