[Hub]/) : Traits : Asthma : ← →

chr5:130,588,008-132,900,729

Best TWAS P=1.41e-23 · Best GWAS P=7.45e-26 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PDLIM4	0.11	0.18	lasso	5	0.18	8.0e-21	7.54	7.7	1.3e-14	0.15	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	KIF3A	0.08	0.07	lasso	3	0.07	1.2e-06	7.56	-7.8	6.1e-15	-0.05	0.95	0.00	FALSE
3	GTEx	Adipose Subcutaneous	SLC22A5	0.05	0.04	lasso	4	0.04	4.2e-04	-9.25	8.2	2.4e-16	0.21	0.62	0.03	FALSE
4	GTEx	Adipose Subcutaneous	AC034220.3	0.11	0.11	lasso	10	0.09	4.8e-08	5.83	-5.8	5.3e-09	-0.30	1.00	0.00	FALSE
5	GTEx	Adipose Visceral Omentum	AC034220.3	0.10	0.09	lasso	7	0.08	7.3e-05	5.80	-5.8	6.8e-09	-0.30	0.59	0.03	FALSE
6	GTEx	Adrenal Gland	AC034220.3	0.12	0.11	lasso	16	0.08	7.7e-04	5.81	-5.8	5.0e-09	-0.30	0.73	0.04	FALSE
7	GTEx	Artery Aorta	P4HA2	0.12	0.14	lasso	2	0.11	1.2e-06	-8.73	-8.7	2.5e-18	-0.20	0.97	0.00	FALSE
8	GTEx	Artery Aorta	KIF3A	0.13	0.07	enet	7	0.07	6.3e-05	7.22	-8.1	7.6e-16	-0.12	0.92	0.01	FALSE
9	GTEx	Artery Aorta	AC034220.3	0.08	0.06	lasso	3	0.05	1.1e-03	5.96	-6.3	3.9e-10	-0.29	0.60	0.09	FALSE
10	GTEx	Artery Aorta	P4HA2-AS1	0.08	0.03	lasso	3	0.01	6.6e-02	-8.68	-8.5	1.2e-17	-0.23	0.48	0.02	FALSE
11	GTEx	Artery Tibial	P4HA2	0.12	0.15	lasso	6	0.14	3.2e-11	-8.56	-8.4	5.2e-17	-0.24	1.00	0.00	FALSE
12	GTEx	Artery Tibial	KIF3A	0.11	0.08	lasso	5	0.09	3.2e-07	7.58	-8.1	4.5e-16	-0.10	0.98	0.00	FALSE
13	GTEx	Artery Tibial	SLC22A5	0.18	0.12	enet	8	0.12	2.5e-09	-9.25	9.9	6.5e-23	0.18	0.99	0.01	TRUE
14	GTEx	Artery Tibial	P4HA2-AS1	0.10	0.09	lasso	4	0.11	1.0e-08	-8.40	-8.8	1.1e-18	-0.25	1.00	0.00	TRUE
15	GTEx	Brain Caudate basal ganglia	AC034220.3	0.41	0.45	enet	19	0.46	8.8e-15	5.80	-6.1	8.7e-10	-0.30	1.00	0.00	FALSE
16	GTEx	Brain Cortex	AC034220.3	0.43	0.39	lasso	15	0.17	2.4e-05	5.80	-5.4	5.8e-08	-0.31	1.00	0.00	FALSE
17	GTEx	Brain Hippocampus	AC034220.3	0.21	0.15	lasso	14	0.18	5.8e-05	6.08	-7.1	9.5e-13	-0.29	0.52	0.04	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	AC034220.3	0.24	0.24	enet	34	0.24	3.7e-07	5.73	-5.9	2.9e-09	-0.29	0.93	0.00	FALSE
19	GTEx	Breast Mammary Tissue	SLC22A5	0.10	0.02	enet	16	0.06	4.5e-04	-9.49	5.4	7.4e-08	0.32	0.69	0.02	FALSE
20	GTEx	Cells EBV-transformed lymphocytes	SLC22A5	0.37	0.05	lasso	13	0.10	2.8e-04	-9.49	8.8	2.1e-18	0.24	0.49	0.03	FALSE
21	GTEx	Cells Transformed fibroblasts	PDLIM4	0.08	0.09	lasso	1	0.07	6.4e-06	7.62	7.6	2.6e-14	0.15	0.85	0.01	FALSE
22	GTEx	Cells Transformed fibroblasts	KIF3A	0.15	0.16	enet	7	0.15	2.6e-11	7.27	-7.9	3.9e-15	-0.10	1.00	0.00	FALSE
23	GTEx	Cells Transformed fibroblasts	SEPT8	0.15	0.12	lasso	4	0.11	6.9e-09	7.55	-8.0	1.2e-15	-0.06	1.00	0.00	FALSE
24	GTEx	Cells Transformed fibroblasts	SLC22A5	0.32	0.28	lasso	7	0.35	1.6e-27	8.05	9.5	2.3e-21	0.19	1.00	0.00	FALSE
25	GTEx	Colon Sigmoid	AC034220.3	0.18	0.11	lasso	12	0.06	3.7e-03	6.06	-6.2	5.0e-10	-0.37	0.25	0.13	FALSE
26	GTEx	Colon Transverse	SLC22A5	0.12	0.07	enet	8	0.07	2.5e-04	-9.49	8.1	8.2e-16	0.21	0.55	0.04	FALSE
27	GTEx	Colon Transverse	AC034220.3	0.30	0.15	lasso	3	0.11	8.4e-06	5.96	-6.4	1.4e-10	-0.28	0.96	0.00	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	SEPT8	0.22	0.08	lasso	12	0.10	2.2e-04	4.72	-5.7	1.5e-08	-0.20	0.67	0.02	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	UQCRQ	0.21	0.01	enet	30	0.04	2.0e-02	7.37	8.8	1.2e-18	-0.14	0.10	0.09	FALSE
30	GTEx	Esophagus Mucosa	P4HA2	0.23	0.10	lasso	6	0.14	6.1e-10	-8.73	-8.5	2.0e-17	-0.26	1.00	0.00	FALSE
31	GTEx	Esophagus Mucosa	SLC22A5	0.16	0.16	enet	8	0.16	6.3e-11	-9.49	8.7	4.3e-18	0.25	0.99	0.01	FALSE
32	GTEx	Esophagus Mucosa	AC034220.3	0.08	0.03	lasso	3	0.05	4.7e-04	6.08	-5.9	3.4e-09	-0.30	0.98	0.00	FALSE
33	GTEx	Esophagus Mucosa	P4HA2-AS1	0.09	0.06	lasso	6	0.08	5.4e-06	-8.73	-8.5	1.3e-17	-0.25	0.94	0.01	FALSE
34	GTEx	Esophagus Muscularis	KIF3A	0.31	0.17	lasso	5	0.20	2.2e-12	7.25	-7.7	9.3e-15	-0.10	1.00	0.00	FALSE
35	GTEx	Heart Atrial Appendage	KIF3A	0.11	0.00	enet	18	0.01	1.8e-01	5.83	-6.7	2.3e-11	-0.24	0.12	0.12	FALSE
36	GTEx	Heart Atrial Appendage	AC034220.3	0.16	0.09	enet	17	0.18	1.7e-08	5.84	-5.4	8.3e-08	-0.37	1.00	0.00	TRUE
37	GTEx	Heart Left Ventricle	AC034220.3	0.25	0.22	lasso	6	0.25	8.6e-14	5.96	-5.9	2.9e-09	-0.30	1.00	0.00	FALSE
38	GTEx	Lung	SLC22A5	0.10	0.15	enet	11	0.13	3.4e-10	-9.49	9.2	2.7e-20	0.30	0.99	0.01	FALSE
39	GTEx	Lung	AC004041.2	0.13	0.08	lasso	9	0.08	8.8e-07	6.06	5.5	4.2e-08	-0.09	0.97	0.00	FALSE
40	GTEx	Muscle Skeletal	SLC22A5	0.10	0.01	lasso	3	0.02	6.6e-03	5.25	10.0	1.4e-23	0.53	0.12	0.57	TRUE
41	GTEx	Muscle Skeletal	AC034220.3	0.27	0.23	lasso	9	0.24	9.1e-24	5.80	-6.9	4.1e-12	-0.28	1.00	0.00	FALSE
42	GTEx	Muscle Skeletal	MIR3936	0.04	0.01	lasso	4	0.00	9.9e-02	7.62	-8.9	8.0e-19	-0.21	0.24	0.05	FALSE
43	GTEx	Nerve Tibial	P4HA2	0.19	0.12	enet	26	0.14	6.2e-10	5.84	-6.8	9.5e-12	-0.30	1.00	0.00	FALSE
44	GTEx	Nerve Tibial	KIF3A	0.23	0.17	lasso	5	0.15	5.3e-11	7.20	-7.8	6.3e-15	-0.12	1.00	0.00	FALSE
45	GTEx	Nerve Tibial	SLC22A5	0.17	0.11	lasso	9	0.09	5.5e-07	3.71	5.3	1.1e-07	0.02	0.94	0.01	FALSE
46	GTEx	Nerve Tibial	AC034220.3	0.15	0.11	lasso	5	0.10	1.9e-07	5.81	-6.0	1.8e-09	-0.29	1.00	0.00	FALSE
47	GTEx	Nerve Tibial	P4HA2-AS1	0.14	0.05	lasso	8	0.08	3.8e-06	-7.09	-7.3	2.6e-13	-0.23	0.98	0.00	FALSE
48	GTEx	Ovary	PDLIM4	0.25	0.22	enet	10	0.05	2.1e-02	4.33	-8.0	1.5e-15	-0.28	0.39	0.12	FALSE
49	GTEx	Ovary	AC004041.2	0.21	-0.01	lasso	2	-0.01	7.7e-01	7.05	-6.0	1.8e-09	-0.16	0.08	0.07	FALSE
50	GTEx	Pituitary	AC034220.3	0.25	0.22	lasso	12	0.18	3.1e-05	5.14	-5.7	1.3e-08	-0.27	0.72	0.02	FALSE
51	GTEx	Prostate	AC034220.3	0.38	0.37	lasso	5	0.37	3.0e-10	5.96	-5.9	3.7e-09	-0.30	0.97	0.02	FALSE
52	GTEx	Skin Not Sun Exposed Suprapubic	PDLIM4	0.13	0.08	lasso	2	0.06	2.6e-04	-9.49	8.4	3.5e-17	0.25	0.56	0.03	FALSE
53	GTEx	Skin Not Sun Exposed Suprapubic	SEPT8	0.15	0.17	lasso	2	0.17	1.4e-09	7.20	7.8	8.0e-15	0.11	0.99	0.00	FALSE
54	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A4	0.13	0.00	lasso	4	0.01	7.1e-02	8.05	8.0	9.0e-16	0.10	0.15	0.06	FALSE
55	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A5	0.13	0.05	lasso	8	0.05	8.3e-04	5.73	6.9	4.3e-12	0.33	0.98	0.01	FALSE
56	GTEx	Skin Sun Exposed Lower leg	PDLIM4	0.09	0.08	lasso	8	0.09	1.0e-07	-8.73	9.0	1.5e-19	0.24	1.00	0.00	FALSE
57	GTEx	Skin Sun Exposed Lower leg	KIF3A	0.11	0.04	lasso	4	0.04	6.2e-04	7.56	-8.0	8.4e-16	-0.07	0.63	0.03	FALSE
58	GTEx	Skin Sun Exposed Lower leg	SEPT8	0.46	0.35	lasso	6	0.33	3.2e-28	7.55	7.8	5.0e-15	0.03	1.00	0.00	FALSE
59	GTEx	Skin Sun Exposed Lower leg	SLC22A5	0.25	0.21	lasso	3	0.20	1.4e-16	-9.25	9.0	2.8e-19	0.28	1.00	0.00	FALSE
60	GTEx	Spleen	SLC22A5	0.26	0.28	lasso	4	0.28	6.6e-08	-9.49	-8.9	7.6e-19	-0.28	0.37	0.05	FALSE
61	GTEx	Stomach	SLC22A5	0.09	0.04	lasso	4	0.01	9.0e-02	8.77	7.9	2.8e-15	0.24	0.16	0.05	FALSE
62	GTEx	Stomach	AC034220.3	0.17	0.15	enet	21	0.16	4.2e-08	5.16	-6.2	5.2e-10	-0.23	1.00	0.00	FALSE
63	GTEx	Testis	P4HA2	0.14	0.13	lasso	5	0.11	1.4e-05	-8.73	-9.5	1.4e-21	-0.20	0.95	0.00	FALSE
64	GTEx	Testis	PDLIM4	0.15	0.07	enet	8	0.05	2.5e-03	6.08	-5.6	1.7e-08	-0.29	0.27	0.04	FALSE
65	GTEx	Testis	AC034220.3	0.15	0.12	lasso	9	0.12	4.4e-06	5.80	-5.8	7.4e-09	-0.30	0.90	0.01	FALSE
66	GTEx	Thyroid	P4HA2	0.08	0.07	enet	9	0.06	3.5e-05	-8.56	-8.2	2.3e-16	-0.21	0.80	0.01	FALSE
67	GTEx	Thyroid	PDLIM4	0.05	0.02	enet	5	0.01	3.1e-02	-7.09	9.5	2.7e-21	0.31	0.44	0.04	FALSE
68	GTEx	Thyroid	SLC22A5	0.17	0.07	lasso	5	0.13	4.8e-10	3.71	8.1	4.9e-16	0.15	0.96	0.00	FALSE
69	GTEx	Thyroid	P4HA2-AS1	0.08	0.06	enet	14	0.05	1.6e-04	-8.56	-8.4	3.3e-17	-0.15	0.74	0.01	FALSE
70	GTEx	Whole Blood	SLC22A4	0.07	0.05	enet	16	0.05	4.6e-05	8.05	9.4	8.2e-21	0.06	0.60	0.02	FALSE
71	GTEx	Whole Blood	SLC22A5	0.09	0.12	lasso	2	0.10	1.7e-09	-9.49	9.5	2.2e-21	0.27	0.98	0.01	FALSE
72	GTEx	Whole Blood	AC034220.3	0.08	0.05	enet	31	0.06	4.0e-06	-9.22	9.3	1.2e-20	0.12	0.96	0.00	FALSE
73	GTEx	Whole Blood	AC116366.6	0.05	0.04	lasso	17	0.03	5.7e-04	6.06	-6.6	4.5e-11	0.01	0.56	0.02	FALSE
74	METSIM	Adipose	KIF3A	0.08	0.08	lasso	15	0.07	4.0e-11	7.30	-7.8	5.1e-15	-0.08	1.00	0.00	TRUE
75	METSIM	Adipose	P4HA2	0.09	0.08	lasso	12	0.09	2.4e-13	-8.40	-6.8	1.2e-11	-0.25	1.00	0.00	FALSE
76	METSIM	Adipose	PDLIM4	0.05	0.04	lasso	4	0.02	2.8e-04	-7.12	7.2	7.5e-13	0.23	0.91	0.02	FALSE
77	METSIM	Adipose	SLC22A4	0.05	0.02	lasso	3	0.03	8.4e-06	-4.57	6.2	5.0e-10	0.09	0.95	0.00	FALSE
78	METSIM	Adipose	SLC22A5	0.05	0.08	lasso	1	0.08	1.0e-11	-9.49	9.5	2.2e-21	0.27	0.99	0.01	FALSE
79	NTR	Blood	ACSL6	0.01	0.00	bslmm	399	0.00	2.8e-02	1.59	5.2	2.4e-07	0.06	0.19	0.23	FALSE
80	NTR	Blood	C5orf56	0.01	0.01	blup	439	0.01	1.7e-03	9.61	5.3	1.1e-07	-0.29	0.24	0.12	FALSE
81	NTR	Blood	IRF1	0.03	0.02	blup	424	0.01	5.7e-05	6.06	-7.3	2.8e-13	0.11	1.00	0.00	FALSE
82	NTR	Blood	SLC22A5	0.02	0.01	lasso	5	0.02	2.3e-06	-9.77	7.0	3.0e-12	0.16	0.70	0.05	FALSE
83	ROSMAP	Brain Pre-frontal Cortex	PDLIM4	0.25	0.27	lasso	4	0.26	2.7e-33	7.59	7.8	6.1e-15	0.17	1.00	0.00	FALSE
84	ROSMAP	Brain Pre-frontal Cortex	SLC22A4	0.03	0.05	lasso	2	0.04	1.2e-05	7.01	6.8	1.0e-11	0.27	0.82	0.04	FALSE
85	ROSMAP	Brain Pre-frontal Cortex	AC034220.3	0.04	0.02	blup	415	0.04	1.3e-05	0.58	-5.5	4.6e-08	-0.63	0.64	0.34	FALSE
86	YFS	Blood	SLC22A4	0.10	0.12	enet	47	0.14	5.1e-42	5.85	7.0	2.0e-12	0.37	1.00	0.00	FALSE
87	YFS	Blood	SLC22A5	0.38	0.36	bslmm	430	0.37	3.0e-128	-9.49	8.7	3.8e-18	0.23	0.98	0.02	TRUE
88	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PDLIM4	0.05	0.01	enet	4	0.02	1.2e-02	7.05	5.4	5.3e-08	0.14	0.08	0.04	FALSE
89	The Cancer Genome Atlas	Breast Invasive Carcinoma	P4HA2	0.03	0.02	blup	47	0.03	3.1e-06	-8.40	-7.1	1.7e-12	-0.21	0.05	0.94	FALSE
90	The Cancer Genome Atlas	Breast Invasive Carcinoma	PDLIM4	0.05	0.05	lasso	4	0.05	9.0e-11	7.59	7.6	2.1e-14	0.15	0.92	0.08	FALSE
91	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A4	0.05	0.01	enet	7	0.02	1.6e-05	-9.49	7.5	5.5e-14	0.34	0.01	0.99	FALSE
92	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A5	0.05	0.07	enet	11	0.09	5.3e-17	5.16	6.6	5.3e-11	0.23	1.00	0.00	TRUE
93	The Cancer Genome Atlas	Colon Adenocarcinoma	PDLIM4	0.14	0.04	enet	9	0.09	6.8e-06	5.78	6.4	1.3e-10	0.12	0.41	0.31	FALSE
94	The Cancer Genome Atlas	Colon Adenocarcinoma	SLC22A5	0.08	0.04	blup	92	0.07	1.2e-04	8.05	8.3	1.3e-16	0.19	0.03	0.91	FALSE
95	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A5	0.06	0.05	blup	93	0.08	1.2e-09	5.82	7.0	2.0e-12	0.30	0.05	0.95	FALSE
96	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDLIM4	0.09	0.02	lasso	6	0.05	4.5e-06	7.05	8.5	1.7e-17	0.12	0.14	0.73	FALSE
97	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC22A4	0.03	0.03	lasso	1	0.02	3.5e-03	5.73	5.7	9.8e-09	0.30	0.30	0.36	FALSE
98	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SLC22A4	0.04	0.03	blup	108	0.01	7.1e-02	5.15	5.9	4.5e-09	0.21	0.11	0.24	FALSE
99	The Cancer Genome Atlas	Brain Lower Grade Glioma	C5orf56	0.03	0.01	blup	98	0.02	4.2e-03	6.02	-5.7	1.2e-08	-0.14	0.15	0.03	FALSE
100	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PDLIM4	0.08	0.03	blup	67	0.05	2.4e-03	5.17	6.0	2.3e-09	0.19	0.04	0.40	FALSE
101	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC22A5	0.06	0.03	lasso	4	0.02	9.3e-04	8.05	8.5	1.5e-17	0.08	0.08	0.65	FALSE
102	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A4	0.04	0.01	blup	111	0.03	3.0e-04	4.27	6.5	1.0e-10	0.20	0.03	0.85	FALSE
103	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A5	0.05	0.03	blup	93	0.05	1.9e-06	5.15	6.7	2.8e-11	0.30	0.04	0.95	FALSE
104	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SLC22A5	0.12	0.04	blup	92	0.07	2.2e-05	8.05	6.2	4.8e-10	0.01	0.12	0.59	FALSE
105	The Cancer Genome Atlas	Prostate Adenocarcinoma	PDLIM4	0.32	0.36	enet	13	0.37	3.8e-40	7.05	7.8	6.6e-15	0.17	1.00	0.00	FALSE
106	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A4	0.09	0.07	blup	108	0.09	3.0e-09	5.84	7.3	3.8e-13	0.22	0.08	0.92	FALSE
107	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A5	0.12	0.05	lasso	4	0.08	1.8e-08	5.37	6.0	1.9e-09	0.00	0.96	0.00	FALSE
108	The Cancer Genome Atlas	Stomach Adenocarcinoma	SLC22A5	0.05	0.01	blup	92	0.02	1.1e-02	6.25	6.4	1.8e-10	0.05	0.09	0.13	FALSE
109	The Cancer Genome Atlas	Thyroid Carcinoma	C5orf56	0.06	0.04	blup	98	0.03	1.3e-03	5.91	-8.0	1.4e-15	0.00	0.87	0.03	FALSE
110	The Cancer Genome Atlas	Thyroid Carcinoma	IRF1	0.05	0.02	blup	83	0.03	1.5e-03	-9.32	-8.9	4.9e-19	-0.28	0.05	0.15	FALSE
111	The Cancer Genome Atlas	Thyroid Carcinoma	P4HA2	0.21	0.35	enet	10	0.35	4.7e-35	-8.40	-8.1	4.2e-16	-0.22	0.03	0.97	FALSE
112	The Cancer Genome Atlas	Thyroid Carcinoma	SLC22A5	0.03	0.02	lasso	1	0.01	2.6e-02	8.05	8.0	8.4e-16	0.16	0.02	0.72	FALSE