TWAS
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Traits
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Traits
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Hayfever, allergic rhinitis or eczema
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chr9:5,091,675-7,345,304
Best TWAS P=8.35e-17 · Best GWAS P=2.73e-18 conditioned to 7.11e-09
5M
5.5M
6M
6.5M
7M
0
5
10
15
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
ROSMAP
Brain Pre-frontal Cortex
RANBP6
0.07
0.01
blup
396
0.02
0.0017
-4.5
8.3
8.4e-17
0.06
0.89
0.00
TRUE
3
ROSMAP
Brain Pre-frontal Cortex
GLDC
0.11
0.00
enet
5
0.01
0.0074
8.7
5.9
4.2e-09
0.70
0.01
0.88
TRUE
1
GTEx
Adipose Visceral Omentum
ERMP1
0.10
0.04
enet
9
0.03
0.0118
-5.2
5.8
6.3e-09
-0.08
0.31
0.03
FALSE