Best TWAS P=7.47e-13 · Best GWAS P=3.28e-17 conditioned to 0.000321
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | MAP3K11 | 0.08 | 0.08 | lasso | 4 | 0.05 | 1.7e-03 | 5.9 | 6.0 | 1.7e-09 | -0.58 | 0.47 | 0.09 | FALSE |
| 2 | GTEx | Artery Tibial | EFEMP2 | 0.11 | 0.07 | lasso | 8 | 0.05 | 1.3e-04 | 6.7 | -6.4 | 1.9e-10 | 0.53 | 0.87 | 0.08 | FALSE |
| 3 | GTEx | Artery Tibial | BANF1 | 0.05 | 0.05 | lasso | 5 | 0.06 | 3.4e-05 | -5.7 | 5.9 | 3.9e-09 | -0.48 | 0.46 | 0.04 | FALSE |
| 4 | GTEx | Brain Cerebellar Hemisphere | EFEMP2 | 0.35 | 0.15 | enet | 5 | 0.09 | 2.2e-03 | -5.7 | -5.4 | 6.0e-08 | 0.48 | 0.34 | 0.08 | FALSE |
| 5 | GTEx | Breast Mammary Tissue | FIBP | 0.07 | 0.00 | lasso | 4 | 0.01 | 9.7e-02 | 3.5 | -5.4 | 5.3e-08 | 0.50 | 0.08 | 0.42 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | EIF1AD | 0.28 | 0.20 | lasso | 8 | 0.21 | 1.8e-15 | -4.9 | -5.3 | 1.4e-07 | 0.41 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Colon Sigmoid | CTSW | 0.11 | 0.06 | lasso | 3 | 0.07 | 1.4e-03 | -5.3 | 5.5 | 3.1e-08 | -0.47 | 0.24 | 0.04 | FALSE |
| 8 | GTEx | Colon Sigmoid | MAP3K11 | 0.23 | 0.05 | enet | 8 | 0.08 | 6.5e-04 | 5.0 | 5.4 | 5.9e-08 | -0.58 | 0.33 | 0.48 | FALSE |
| 9 | GTEx | Lung | CFL1 | 0.04 | 0.02 | lasso | 10 | 0.01 | 5.8e-02 | -4.9 | 5.5 | 3.6e-08 | -0.40 | 0.38 | 0.02 | FALSE |
| 10 | GTEx | Skin Sun Exposed Lower leg | EIF1AD | 0.08 | 0.07 | lasso | 4 | 0.07 | 3.6e-06 | 4.3 | -5.5 | 4.4e-08 | 0.41 | 0.98 | 0.00 | FALSE |
| 11 | GTEx | Stomach | MAP3K11 | 0.09 | 0.02 | lasso | 3 | 0.04 | 4.4e-03 | 3.5 | 5.4 | 6.4e-08 | -0.47 | 0.20 | 0.06 | FALSE |
| 12 | METSIM | Adipose | EFEMP2 | 0.07 | 0.05 | lasso | 8 | 0.04 | 4.2e-06 | -6.7 | -6.9 | 6.4e-12 | 0.50 | 1.00 | 0.00 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | EFEMP2 | 0.08 | 0.09 | enet | 13 | 0.09 | 6.8e-12 | 6.4 | -6.1 | 9.3e-10 | 0.49 | 1.00 | 0.00 | FALSE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | OVOL1 | 0.16 | 0.24 | lasso | 2 | 0.24 | 1.3e-30 | 5.9 | 5.8 | 5.6e-09 | -0.61 | 1.00 | 0.00 | FALSE |
| 15 | YFS | Blood | EFEMP2 | 0.12 | 0.07 | bslmm | 348 | 0.13 | 4.3e-41 | -5.7 | -5.6 | 2.1e-08 | 0.36 | 1.00 | 0.00 | TRUE |
| 16 | YFS | Blood | MUS81 | 0.04 | 0.02 | blup | 348 | 0.04 | 6.3e-12 | -5.3 | 6.5 | 8.8e-11 | -0.47 | 1.00 | 0.00 | FALSE |
| 17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EFEMP2 | 0.04 | 0.02 | lasso | 5 | 0.02 | 1.4e-05 | -6.0 | -6.0 | 1.7e-09 | 0.47 | 0.03 | 0.97 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | DKFZp761E198 | 0.11 | 0.02 | blup | 39 | 0.03 | 4.6e-03 | -5.3 | -5.6 | 2.5e-08 | 0.47 | 0.05 | 0.25 | FALSE |
| 19 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | EIF1AD | 0.06 | 0.04 | lasso | 3 | 0.05 | 1.3e-03 | -4.9 | -5.2 | 1.8e-07 | 0.38 | 0.01 | 0.97 | FALSE |
| 20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C11orf68 | 0.03 | 0.03 | lasso | 3 | 0.03 | 1.1e-04 | -4.7 | 5.4 | 6.5e-08 | -0.37 | 0.01 | 0.90 | FALSE |
| 21 | The Cancer Genome Atlas | Brain Lower Grade Glioma | OVOL1 | 0.03 | 0.03 | blup | 36 | 0.02 | 8.3e-04 | 5.9 | 7.2 | 7.5e-13 | -0.74 | 0.03 | 0.84 | TRUE |
| 22 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RNASEH2C | 0.10 | 0.01 | blup | 32 | 0.05 | 7.9e-03 | -3.0 | -5.3 | 9.1e-08 | 0.57 | 0.01 | 0.26 | FALSE |