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chr11:64,669,105-66,456,387

Best TWAS P=7.47e-13 · Best GWAS P=3.28e-17 conditioned to 0.000321

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	OVOL1	0.03	0.03	blup	36	0.02	8.3e-04	5.9	7.2	7.5e-13	-0.74	0.03	0.84	TRUE
15	YFS	Blood	EFEMP2	0.12	0.07	bslmm	348	0.13	4.3e-41	-5.7	-5.6	2.1e-08	0.36	1.00	0.00	TRUE
12	METSIM	Adipose	EFEMP2	0.07	0.05	lasso	8	0.04	4.2e-06	-6.7	-6.9	6.4e-12	0.50	1.00	0.00	FALSE
16	YFS	Blood	MUS81	0.04	0.02	blup	348	0.04	6.3e-12	-5.3	6.5	8.8e-11	-0.47	1.00	0.00	FALSE
2	GTEx	Artery Tibial	EFEMP2	0.11	0.07	lasso	8	0.05	1.3e-04	6.7	-6.4	1.9e-10	0.53	0.87	0.08	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	EFEMP2	0.08	0.09	enet	13	0.09	6.8e-12	6.4	-6.1	9.3e-10	0.49	1.00	0.00	FALSE
1	GTEx	Adipose Visceral Omentum	MAP3K11	0.08	0.08	lasso	4	0.05	1.7e-03	5.9	6.0	1.7e-09	-0.58	0.47	0.09	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	EFEMP2	0.04	0.02	lasso	5	0.02	1.4e-05	-6.0	-6.0	1.7e-09	0.47	0.03	0.97	FALSE
3	GTEx	Artery Tibial	BANF1	0.05	0.05	lasso	5	0.06	3.4e-05	-5.7	5.9	3.9e-09	-0.48	0.46	0.04	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	OVOL1	0.16	0.24	lasso	2	0.24	1.3e-30	5.9	5.8	5.6e-09	-0.61	1.00	0.00	FALSE
18	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DKFZp761E198	0.11	0.02	blup	39	0.03	4.6e-03	-5.3	-5.6	2.5e-08	0.47	0.05	0.25	FALSE
7	GTEx	Colon Sigmoid	CTSW	0.11	0.06	lasso	3	0.07	1.4e-03	-5.3	5.5	3.1e-08	-0.47	0.24	0.04	FALSE
9	GTEx	Lung	CFL1	0.04	0.02	lasso	10	0.01	5.8e-02	-4.9	5.5	3.6e-08	-0.40	0.38	0.02	FALSE
10	GTEx	Skin Sun Exposed Lower leg	EIF1AD	0.08	0.07	lasso	4	0.07	3.6e-06	4.3	-5.5	4.4e-08	0.41	0.98	0.00	FALSE
5	GTEx	Breast Mammary Tissue	FIBP	0.07	0.00	lasso	4	0.01	9.7e-02	3.5	-5.4	5.3e-08	0.50	0.08	0.42	FALSE
8	GTEx	Colon Sigmoid	MAP3K11	0.23	0.05	enet	8	0.08	6.5e-04	5.0	5.4	5.9e-08	-0.58	0.33	0.48	FALSE
4	GTEx	Brain Cerebellar Hemisphere	EFEMP2	0.35	0.15	enet	5	0.09	2.2e-03	-5.7	-5.4	6.0e-08	0.48	0.34	0.08	FALSE
11	GTEx	Stomach	MAP3K11	0.09	0.02	lasso	3	0.04	4.4e-03	3.5	5.4	6.4e-08	-0.47	0.20	0.06	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	C11orf68	0.03	0.03	lasso	3	0.03	1.1e-04	-4.7	5.4	6.5e-08	-0.37	0.01	0.90	FALSE
22	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RNASEH2C	0.10	0.01	blup	32	0.05	7.9e-03	-3.0	-5.3	9.1e-08	0.57	0.01	0.26	FALSE
6	GTEx	Cells Transformed fibroblasts	EIF1AD	0.28	0.20	lasso	8	0.21	1.8e-15	-4.9	-5.3	1.4e-07	0.41	1.00	0.00	FALSE
19	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EIF1AD	0.06	0.04	lasso	3	0.05	1.3e-03	-4.9	-5.2	1.8e-07	0.38	0.01	0.97	FALSE