TWAS
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Traits
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Traits
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Hayfever, allergic rhinitis or eczema
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chr11:75,453,877-77,069,746
Best TWAS P=6.17e-36 · Best GWAS P=4.83e-57 conditioned to 1.98e-25
75.4M
75.6M
75.8M
76M
76.2M
76.4M
76.6M
76.8M
77M
0
10
20
30
40
50
60
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Adipose Visceral Omentum
LRRC32
0.21
0.00
enet
15
0.01
1.5e-01
14.3
12.5
6.2e-36
0.62
0.00
0.96
TRUE
4
YFS
Blood
LRRC32
0.02
0.00
bslmm
481
0.00
9.1e-02
7.2
-7.8
6.8e-15
-0.55
0.17
0.41
FALSE
1
CommonMind
Brain Pre-frontal Cortex
C11orf30
0.07
0.06
lasso
6
0.06
2.1e-07
6.9
-6.7
1.6e-11
-0.50
1.00
0.00
FALSE
3
ROSMAP
Brain Pre-frontal Cortex
RP11-111M22.3
0.21
0.05
enet
16
0.12
1.3e-14
5.1
-5.2
2.0e-07
-0.36
0.99
0.00
FALSE