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chr11:110,721,187-112,335,631

Best TWAS P=3.84e-13 · Best GWAS P=2.26e-14 conditioned to 1

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Esophagus Mucosa	SIK2	0.13	0.03	lasso	4	0.02	2.2e-02	-7.3	-7.3	3.8e-13	0.97	0.02	0.95	TRUE
5	ROSMAP	Brain Pre-frontal Cortex	LAYN	0.19	0.23	enet	26	0.25	2.9e-32	-6.3	6.9	6.2e-12	-0.89	0.97	0.03	FALSE
7	The Cancer Genome Atlas	Breast Invasive Carcinoma	SIK2	0.04	0.01	blup	35	0.01	6.7e-03	-6.9	-6.8	7.7e-12	0.85	0.04	0.78	FALSE
9	The Cancer Genome Atlas	Prostate Adenocarcinoma	SIK2	0.05	0.06	lasso	1	0.05	2.6e-06	-6.8	-6.8	1.2e-11	0.88	0.14	0.86	FALSE
8	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LAYN	0.13	0.07	enet	8	0.07	9.9e-04	-6.2	-6.7	2.0e-11	0.77	0.03	0.60	FALSE
6	The Cancer Genome Atlas	Breast Invasive Carcinoma	LAYN	0.02	0.03	blup	33	0.03	3.7e-06	-6.3	-6.7	2.3e-11	0.86	0.18	0.82	FALSE
1	CommonMind	Brain Pre-frontal Cortex	LAYN	0.19	0.24	bslmm	398	0.25	8.0e-30	-6.3	6.4	1.2e-10	-0.82	0.97	0.03	FALSE
2	GTEx	Brain Putamen basal ganglia	LAYN	0.24	0.12	lasso	7	0.13	6.2e-04	-6.2	6.4	1.2e-10	-0.87	0.03	0.86	FALSE
4	GTEx	Testis	PPP2R1B	0.34	0.21	lasso	10	0.36	1.5e-16	-6.4	5.2	1.6e-07	-0.72	0.98	0.02	FALSE