TWAS
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Traits
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Hayfever, allergic rhinitis or eczema
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chr15:66,662,107-68,183,665
Best TWAS P=1.34e-16 · Best GWAS P=2.64e-21 conditioned to 3.67e-06
66.6M
66.8M
67M
67.2M
67.4M
67.6M
67.8M
68M
68.2M
0
5
10
15
20
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
The Cancer Genome Atlas
Thyroid Carcinoma
SMAD3
0.22
0.12
enet
12
0.11
5.2e-11
7.4
-8.3
1.3e-16
-0.88
0.01
0.99
TRUE
1
GTEx
Thyroid
SMAD3
0.19
0.02
enet
3
0.03
2.3e-03
9.5
-6.3
3.9e-10
-0.75
0.00
0.97
FALSE