Best TWAS P=2.97e-11 · Best GWAS P=1.63e-12 conditioned to 0.00115
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | EXD1 | 0.04 | 0.04 | lasso | 3 | 0.04 | 8.1e-06 | 5.9 | -5.8 | 5.8e-09 | 0.64 | 0.35 | 0.63 | FALSE |
| 2 | GTEx | Artery Aorta | OIP5-AS1 | 0.16 | 0.21 | enet | 26 | 0.23 | 5.2e-13 | 4.4 | 5.3 | 1.4e-07 | -0.69 | 0.98 | 0.02 | FALSE |
| 3 | GTEx | Brain Frontal Cortex BA9 | OIP5 | 0.13 | 0.00 | enet | 16 | 0.01 | 2.1e-01 | 2.0 | 5.5 | 3.4e-08 | -0.41 | 0.05 | 0.45 | FALSE |
| 4 | GTEx | Brain Hypothalamus | NUSAP1 | 0.26 | 0.36 | lasso | 4 | 0.27 | 5.6e-07 | 5.6 | 5.2 | 2.6e-07 | -0.64 | 0.43 | 0.49 | FALSE |
| 5 | GTEx | Breast Mammary Tissue | OIP5-AS1 | 0.20 | 0.24 | lasso | 7 | 0.22 | 1.8e-11 | 4.5 | 5.2 | 2.5e-07 | -0.71 | 0.92 | 0.08 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Male) | OIP5-AS1 | 0.26 | 0.10 | enet | 20 | 0.22 | 7.3e-06 | 4.4 | 5.7 | 9.5e-09 | -0.63 | 0.22 | 0.46 | FALSE |
| 7 | GTEx | Breast Mammary Tissue (Female) | OIP5-AS1 | 0.28 | 0.31 | lasso | 3 | 0.29 | 3.0e-09 | 4.5 | 5.3 | 1.1e-07 | -0.75 | 0.16 | 0.84 | FALSE |
| 8 | GTEx | Cells EBV-transformed lymphocytes | NDUFAF1 | 0.35 | 0.46 | enet | 14 | 0.51 | 3.1e-19 | 3.8 | -5.1 | 2.9e-07 | 0.63 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Colon Sigmoid | NDUFAF1 | 0.15 | 0.06 | lasso | 4 | 0.06 | 5.2e-03 | 5.9 | -6.7 | 3.0e-11 | 0.73 | 0.12 | 0.70 | TRUE |
| 10 | GTEx | Esophagus Mucosa | NDUFAF1 | 0.25 | 0.18 | enet | 26 | 0.24 | 4.3e-16 | 5.9 | -5.4 | 7.3e-08 | 0.63 | 0.79 | 0.21 | FALSE |
| 11 | GTEx | Esophagus Mucosa | CHP1 | 0.19 | 0.10 | lasso | 7 | 0.09 | 1.4e-06 | 5.7 | -5.7 | 1.1e-08 | 0.75 | 0.16 | 0.84 | FALSE |
| 12 | GTEx | Lung | OIP5-AS1 | 0.09 | 0.08 | enet | 14 | 0.12 | 2.8e-09 | 6.1 | 6.1 | 1.1e-09 | -0.74 | 0.14 | 0.86 | FALSE |
| 13 | GTEx | Nerve Tibial | NUSAP1 | 0.15 | 0.09 | enet | 10 | 0.15 | 9.8e-11 | 3.4 | 5.3 | 1.1e-07 | -0.67 | 0.88 | 0.12 | FALSE |
| 14 | GTEx | Skin Not Sun Exposed Suprapubic | NDUFAF1 | 0.16 | 0.06 | lasso | 3 | 0.07 | 1.7e-04 | 5.9 | -5.5 | 4.3e-08 | 0.55 | 0.05 | 0.51 | FALSE |
| 15 | GTEx | Skin Sun Exposed Lower leg | CHP1 | 0.06 | 0.04 | enet | 9 | 0.04 | 3.1e-04 | 6.1 | -6.0 | 1.6e-09 | 0.69 | 0.17 | 0.68 | FALSE |
| 16 | GTEx | Thyroid | RTF1 | 0.28 | 0.27 | lasso | 3 | 0.26 | 8.4e-20 | -6.5 | -6.6 | 4.6e-11 | 0.91 | 0.02 | 0.98 | FALSE |
| 17 | NTR | Blood | RTF1 | 0.04 | 0.02 | blup | 338 | 0.03 | 6.9e-09 | -6.0 | 6.3 | 2.5e-10 | -0.68 | 0.11 | 0.89 | FALSE |
| 18 | YFS | Blood | MGA | 0.01 | 0.00 | blup | 454 | 0.00 | 7.1e-02 | 4.4 | 5.5 | 4.9e-08 | -0.58 | 0.08 | 0.41 | FALSE |
| 19 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CHP | 0.01 | 0.01 | blup | 54 | 0.01 | 1.4e-02 | 6.5 | -6.3 | 3.8e-10 | 0.75 | 0.01 | 0.90 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | RTF1 | 0.04 | 0.02 | lasso | 3 | 0.02 | 4.0e-03 | -6.5 | -6.5 | 8.1e-11 | 0.91 | 0.00 | 0.98 | FALSE |