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chr15:89,921,477-91,886,448

Best TWAS P=1.13e-22 · Best GWAS P=1.15e-19 conditioned to 0.00411

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
46	The Cancer Genome Atlas	Prostate Adenocarcinoma	IQGAP1	0.11	0.03	enet	8	0.06	1.4e-06	-8.3	-9.8	1.1e-22	0.83	0.01	0.98	TRUE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF774	0.04	0.00	enet	7	0.01	5.1e-02	-6.9	-5.2	1.9e-07	0.75	0.01	0.78	TRUE
31	YFS	Blood	IQGAP1	0.18	0.17	enet	46	0.20	5.8e-65	-9.0	-9.5	2.8e-21	0.91	0.00	1.00	FALSE
28	METSIM	Adipose	IQGAP1	0.11	0.08	enet	32	0.12	3.9e-17	-7.3	-9.4	5.6e-21	0.86	0.08	0.92	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	IQGAP1	0.03	0.02	blup	94	0.02	6.5e-05	-8.9	-9.2	4.8e-20	0.92	0.01	0.99	FALSE
44	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IQGAP1	0.02	0.02	blup	94	0.02	6.2e-03	-8.9	-8.7	3.9e-18	0.92	0.02	0.87	FALSE
23	GTEx	Testis	ZNF774	0.13	0.09	lasso	4	0.08	1.5e-04	-8.8	8.7	4.4e-18	-0.99	0.00	0.99	FALSE
36	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IQGAP1	0.15	0.05	enet	10	0.08	2.5e-09	-8.3	-8.6	1.2e-17	0.88	0.01	0.99	FALSE
1	CommonMind	Brain Pre-frontal Cortex	IQGAP1	0.19	0.21	lasso	5	0.20	1.7e-24	-8.3	-8.2	3.1e-16	0.94	0.01	0.99	FALSE
27	GTEx	Vagina	IQGAP1	0.32	0.11	lasso	6	0.17	1.3e-04	-8.8	-8.1	6.7e-16	0.85	0.02	0.93	FALSE
6	GTEx	Cells Transformed fibroblasts	IQGAP1	0.13	0.06	enet	19	0.11	9.2e-09	-3.4	-8.0	1.0e-15	0.55	0.38	0.44	FALSE
12	GTEx	Esophagus Mucosa	IQGAP1	0.26	0.19	enet	39	0.21	2.3e-14	-8.8	-8.0	1.6e-15	0.73	0.02	0.98	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	IQGAP1	0.06	0.04	blup	95	0.08	3.0e-08	-8.8	-7.9	2.3e-15	0.85	0.04	0.96	FALSE
34	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	IQGAP1	0.15	0.09	lasso	4	0.12	1.9e-06	-7.4	-7.8	4.8e-15	0.81	0.12	0.86	FALSE
21	GTEx	Stomach	IQGAP1	0.21	0.14	enet	17	0.18	8.3e-09	-8.8	-7.5	5.7e-14	0.86	0.03	0.97	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	IQGAP1	0.05	0.04	enet	12	0.03	1.1e-04	-5.2	-7.3	2.9e-13	0.54	0.51	0.28	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF774	0.06	0.06	lasso	3	0.04	1.2e-05	-6.9	7.2	5.8e-13	-0.77	0.07	0.92	FALSE
13	GTEx	Esophagus Mucosa	CRTC3	0.08	0.07	enet	7	0.04	6.1e-04	-6.8	7.2	8.1e-13	-0.81	0.26	0.69	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	ZNF774	0.16	0.16	lasso	2	0.11	7.8e-05	-6.9	-7.2	8.7e-13	0.75	0.37	0.26	FALSE
4	GTEx	Artery Aorta	ZNF774	0.22	0.24	enet	16	0.23	7.6e-13	-6.3	-7.1	1.5e-12	0.78	0.90	0.10	FALSE
29	NTR	Blood	IQGAP1	0.03	0.04	enet	10	0.04	1.5e-12	-7.1	-7.0	2.0e-12	0.70	1.00	0.00	FALSE
47	The Cancer Genome Atlas	Stomach Adenocarcinoma	IQGAP1	0.12	0.07	lasso	4	0.07	1.4e-05	-7.3	-7.0	2.1e-12	0.77	0.48	0.49	FALSE
30	YFS	Blood	CRTC3	0.02	0.01	blup	503	0.01	4.2e-05	-7.3	6.9	6.3e-12	-0.75	0.46	0.54	FALSE
19	GTEx	Skin Sun Exposed Lower leg	CRTC3	0.10	0.08	lasso	3	0.05	7.5e-05	-7.3	6.6	3.3e-11	-0.73	0.51	0.47	FALSE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IQGAP1	0.07	0.06	blup	94	0.07	9.5e-09	-7.3	-6.6	3.6e-11	0.70	0.97	0.03	FALSE
39	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	IQGAP1	0.06	0.05	blup	94	0.04	2.6e-03	-5.3	-6.6	4.0e-11	0.71	0.12	0.54	FALSE
14	GTEx	Esophagus Muscularis	IQGAP1	0.24	0.14	enet	18	0.14	5.7e-09	-5.5	-6.6	4.1e-11	0.69	0.38	0.62	FALSE
15	GTEx	Esophagus Muscularis	ZNF774	0.18	0.19	lasso	5	0.18	4.1e-11	-6.2	6.5	9.4e-11	-0.74	1.00	0.00	FALSE
3	GTEx	Artery Aorta	IQGAP1	0.44	0.51	enet	27	0.51	5.3e-32	-5.5	-6.4	1.8e-10	0.69	1.00	0.00	FALSE
18	GTEx	Pituitary	IQGAP1	0.60	0.45	enet	26	0.52	3.7e-15	-5.5	-6.4	1.8e-10	0.67	0.94	0.06	FALSE
43	The Cancer Genome Atlas	Lung Adenocarcinoma	IQGAP1	0.06	0.04	blup	94	0.03	5.8e-05	-6.5	-6.2	5.2e-10	0.63	0.82	0.10	FALSE
24	GTEx	Thyroid	ZNF774	0.09	0.06	enet	9	0.05	6.0e-05	-6.3	-6.0	1.5e-09	0.65	0.36	0.07	FALSE
25	GTEx	Thyroid	RP11-617F23.1	0.11	0.01	lasso	4	0.04	1.0e-03	-5.9	-6.0	2.0e-09	0.53	0.24	0.24	FALSE
45	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	IQGAP1	0.40	0.06	enet	13	0.07	9.0e-04	-6.2	-5.8	7.3e-09	0.49	0.21	0.24	FALSE
5	GTEx	Artery Coronary	IQGAP1	0.33	0.42	enet	19	0.44	2.6e-16	-5.5	-5.8	9.0e-09	0.61	1.00	0.00	FALSE
32	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IQGAP1	0.04	0.03	lasso	4	0.02	6.5e-03	-7.1	-5.7	9.8e-09	0.62	0.12	0.13	FALSE
8	GTEx	Colon Transverse	IQGAP1	0.23	0.15	lasso	2	0.10	1.4e-05	-5.5	-5.7	1.4e-08	0.63	0.73	0.19	FALSE
7	GTEx	Colon Sigmoid	IQGAP1	0.18	0.16	lasso	7	0.15	6.6e-06	-5.6	-5.6	1.7e-08	0.63	0.76	0.20	FALSE
10	GTEx	Esophagus Gastroesophageal Junction	IQGAP1	0.11	0.15	lasso	3	0.14	7.9e-06	-5.6	-5.6	1.7e-08	0.64	0.55	0.25	FALSE
17	GTEx	Ovary	IQGAP1	0.43	0.53	lasso	3	0.53	2.3e-15	-5.5	-5.6	2.7e-08	0.64	0.96	0.04	FALSE
26	GTEx	Uterus	IQGAP1	0.29	0.16	lasso	5	0.13	1.3e-03	-5.5	-5.5	2.8e-08	0.64	0.08	0.71	FALSE
22	GTEx	Testis	IQGAP1	0.25	0.37	lasso	4	0.36	1.2e-16	-5.6	-5.5	3.9e-08	0.63	1.00	0.00	FALSE
16	GTEx	Lung	ZNF774	0.06	0.09	enet	6	0.03	1.5e-03	-6.9	-5.5	4.0e-08	0.57	0.79	0.03	FALSE
20	GTEx	Small Intestine Terminal Ileum	IQGAP1	0.27	0.26	lasso	4	0.20	2.7e-05	-5.5	-5.5	4.0e-08	0.64	0.12	0.65	FALSE
35	The Cancer Genome Atlas	Glioblastoma Multiforme	IQGAP1	0.10	-0.01	blup	95	0.02	1.0e-01	-5.3	-5.5	4.3e-08	0.64	0.08	0.22	FALSE
2	GTEx	Adipose Subcutaneous	ZNF774	0.10	0.01	lasso	6	0.02	1.3e-02	-5.3	-5.4	6.3e-08	0.58	0.34	0.50	FALSE
9	GTEx	Colon Transverse	ZNF774	0.24	0.09	lasso	4	0.08	1.5e-04	-4.7	-5.4	6.4e-08	0.36	0.44	0.15	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	CRTC3	0.03	0.01	blup	78	0.01	4.2e-02	-3.5	5.3	1.0e-07	-0.44	0.05	0.04	FALSE