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chr17:39,993,748-41,538,783

Best TWAS P=9.73e-11 · Best GWAS P=2.43e-08 conditioned to 0.414

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	NAGLU	0.31	0.12	lasso	3	0.11	3.7e-09	-5.4	5.7	1.2e-08	-0.87	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	RP11-400F19.8	0.13	0.08	lasso	2	0.07	1.7e-06	-5.4	5.4	6.4e-08	-0.89	0.01	0.99	FALSE
3	GTEx	Artery Tibial	RP11-400F19.6	0.07	0.01	lasso	5	0.01	3.0e-02	-5.3	5.6	1.8e-08	-0.89	0.02	0.96	FALSE
4	GTEx	Brain Caudate basal ganglia	NAGLU	0.15	0.19	lasso	2	0.15	5.0e-05	-5.4	5.4	5.6e-08	-0.88	0.01	0.92	FALSE
5	GTEx	Cells Transformed fibroblasts	NAGLU	0.28	0.22	lasso	4	0.22	7.5e-17	-5.4	5.4	7.9e-08	-0.87	0.01	0.99	FALSE
6	GTEx	Cells Transformed fibroblasts	CNTNAP1	0.07	0.08	lasso	5	0.06	1.9e-05	-5.2	-5.3	8.7e-08	0.90	0.02	0.94	FALSE
7	GTEx	Cells Transformed fibroblasts	RP11-400F19.8	0.20	0.16	lasso	3	0.15	1.4e-11	-5.4	5.5	4.9e-08	-0.88	0.01	0.99	FALSE
8	GTEx	Cells Transformed fibroblasts	CTD-3193K9.3	0.07	0.08	lasso	3	0.07	1.2e-05	-5.2	-5.2	2.4e-07	0.89	0.02	0.97	FALSE
9	GTEx	Esophagus Gastroesophageal Junction	TUBG2	0.15	0.10	enet	18	0.12	3.7e-05	3.3	5.3	1.3e-07	-0.49	0.22	0.53	FALSE
10	GTEx	Esophagus Muscularis	NAGLU	0.29	0.09	lasso	5	0.07	6.2e-05	-5.5	6.5	9.7e-11	-0.78	0.01	0.99	TRUE
11	GTEx	Esophagus Muscularis	RP11-400F19.8	0.17	0.05	lasso	4	0.02	3.9e-02	-5.5	6.5	1.0e-10	-0.60	0.01	0.82	FALSE
12	GTEx	Lung	TUBG2	0.08	0.02	enet	8	0.04	7.8e-04	3.1	5.3	9.9e-08	-0.68	0.06	0.81	FALSE
13	GTEx	Muscle Skeletal	TUBG2	0.12	0.09	lasso	8	0.10	1.1e-09	-4.7	5.4	7.3e-08	-0.85	0.02	0.98	FALSE
14	GTEx	Nerve Tibial	NAGLU	0.15	0.10	lasso	4	0.08	2.3e-06	-5.4	5.3	1.4e-07	-0.79	0.01	0.99	FALSE
15	GTEx	Nerve Tibial	RP11-400F19.8	0.10	0.03	lasso	3	0.02	8.2e-03	-5.5	5.4	5.7e-08	-0.69	0.01	0.94	FALSE
16	GTEx	Pancreas	CNTNAP1	0.13	0.09	lasso	7	0.09	9.1e-05	-5.5	-5.6	2.6e-08	0.91	0.02	0.96	FALSE
17	GTEx	Pancreas	FAM134C	0.08	0.04	enet	9	0.03	2.0e-02	-5.4	-5.8	4.9e-09	0.90	0.01	0.94	FALSE
18	GTEx	Pancreas	CTD-3193K9.3	0.12	0.07	lasso	5	0.07	5.7e-04	-5.5	-5.7	9.6e-09	0.94	0.02	0.93	FALSE
19	GTEx	Skin Not Sun Exposed Suprapubic	TUBG2	0.15	0.13	lasso	5	0.12	4.0e-07	-5.3	5.2	1.8e-07	-0.79	0.02	0.98	FALSE
20	GTEx	Skin Sun Exposed Lower leg	NAGLU	0.08	0.06	enet	9	0.09	5.8e-08	-5.4	5.2	2.4e-07	-0.73	0.02	0.98	FALSE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	NAGLU	0.19	0.03	lasso	1	0.03	9.1e-07	-5.4	5.4	6.4e-08	-0.89	0.01	0.99	FALSE
22	The Cancer Genome Atlas	Thyroid Carcinoma	NAGLU	0.59	0.09	lasso	2	0.09	6.2e-09	-5.4	5.4	6.4e-08	-0.89	0.01	0.99	FALSE
23	The Cancer Genome Atlas	Thyroid Carcinoma	TUBG2	0.20	0.13	blup	29	0.17	1.7e-16	-4.7	5.2	1.8e-07	-0.70	0.00	0.99	FALSE