[Hub]/) : Traits : Hayfever, allergic rhinitis or eczema :

chr17:36,710,513-39,502,398

Best TWAS P=1.33e-23 · Best GWAS P=7.05e-22 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex MED24 0.23 0.28 bslmm 313 0.29 2.2e-35 -5.5 6.2 5.0e-10 -0.07 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex ORMDL3 0.09 0.08 enet 10 0.06 4.2e-08 7.1 7.1 1.2e-12 0.05 0.01 0.99 FALSE
3 CommonMind Brain Pre-frontal Cortex SMARCE1 0.10 0.12 lasso 4 0.11 5.7e-13 7.6 -7.6 3.5e-14 0.75 0.86 0.14 FALSE
4 GTEx Adipose Subcutaneous MED24 0.17 0.14 lasso 4 0.14 1.9e-11 5.2 -5.4 7.6e-08 0.07 1.00 0.00 FALSE
5 GTEx Adipose Subcutaneous THRA 0.12 0.00 enet 23 0.02 1.6e-02 -5.2 6.8 7.2e-12 -0.12 0.08 0.17 TRUE
6 GTEx Adipose Subcutaneous KRT222 0.11 0.09 lasso 4 0.10 1.3e-08 -8.7 9.7 2.1e-22 -0.91 0.06 0.94 FALSE
7 GTEx Artery Aorta MED24 0.28 0.25 lasso 8 0.24 2.6e-13 5.9 -5.3 9.8e-08 0.07 0.99 0.01 FALSE
8 GTEx Artery Tibial MED24 0.32 0.38 lasso 6 0.36 6.9e-30 5.9 -5.8 7.5e-09 0.06 0.96 0.04 FALSE
9 GTEx Brain Nucleus accumbens basal ganglia RAPGEFL1 0.16 0.06 lasso 4 0.07 7.7e-03 -5.6 -6.7 1.7e-11 -0.04 0.13 0.05 FALSE
10 GTEx Breast Mammary Tissue ORMDL3 0.17 0.04 enet 27 0.06 7.2e-04 -5.0 -5.6 2.1e-08 0.00 0.06 0.89 FALSE
11 GTEx Breast Mammary Tissue KRT222 0.26 0.12 lasso 5 0.11 3.4e-06 -8.7 8.4 6.0e-17 -0.83 0.09 0.90 FALSE
12 GTEx Breast Mammary Tissue (Female) MSL1 0.09 0.00 enet 9 0.03 5.8e-02 4.9 -5.3 1.4e-07 0.00 0.03 0.06 FALSE
13 GTEx Breast Mammary Tissue (Female) KRT222 0.20 0.01 lasso 5 0.03 4.2e-02 -8.7 7.8 6.0e-15 -0.75 0.04 0.46 FALSE
14 GTEx Cells Transformed fibroblasts GSDMB 0.11 0.02 enet 18 0.06 4.9e-05 7.0 6.7 2.4e-11 0.01 0.02 0.98 FALSE
15 GTEx Cells Transformed fibroblasts ORMDL3 0.24 0.09 enet 21 0.07 7.8e-06 7.1 8.0 9.8e-16 0.01 0.02 0.98 TRUE
16 GTEx Cells Transformed fibroblasts KRT222 0.12 0.14 lasso 2 0.13 8.1e-10 -8.7 8.8 1.9e-18 -0.86 0.51 0.49 FALSE
17 GTEx Colon Transverse GSDMB 0.14 0.11 enet 18 0.12 2.0e-06 -5.9 6.9 5.1e-12 0.08 0.02 0.98 FALSE
18 GTEx Esophagus Mucosa GSDMB 0.06 0.04 lasso 3 0.03 4.7e-03 6.8 7.3 2.6e-13 -0.02 0.03 0.89 FALSE
19 GTEx Esophagus Mucosa ORMDL3 0.09 0.01 enet 20 0.00 1.8e-01 4.8 5.4 7.0e-08 0.07 0.02 0.80 TRUE
20 GTEx Esophagus Mucosa KRT222 0.18 0.12 enet 8 0.12 1.1e-08 -9.6 9.3 1.4e-20 -0.96 0.01 0.99 FALSE
21 GTEx Esophagus Muscularis MSL1 0.25 0.18 lasso 8 0.22 1.7e-13 4.8 -5.3 8.7e-08 0.14 1.00 0.00 FALSE
22 GTEx Esophagus Muscularis KRT222 0.12 0.08 lasso 3 0.08 2.5e-05 -9.5 9.6 1.2e-21 -0.99 0.00 0.99 FALSE
23 GTEx Heart Atrial Appendage PPP1R1B 0.09 0.04 enet 10 0.08 2.2e-04 7.0 7.3 2.8e-13 0.02 0.03 0.95 FALSE
24 GTEx Heart Atrial Appendage PNMT 0.14 -0.01 lasso 8 0.00 5.3e-01 -5.6 6.1 8.3e-10 0.07 0.14 0.32 FALSE
25 GTEx Liver PGAP3 0.27 0.17 lasso 4 0.13 1.7e-04 4.7 5.4 7.9e-08 0.09 0.58 0.20 FALSE
26 GTEx Lung GSDMB 0.07 0.07 lasso 4 0.05 1.5e-04 7.1 7.7 2.0e-14 0.07 0.01 0.98 FALSE
27 GTEx Lung ORMDL3 0.16 0.13 enet 15 0.14 1.6e-10 7.0 7.5 9.4e-14 0.04 0.02 0.98 FALSE
28 GTEx Muscle Skeletal PGAP3 0.04 0.03 lasso 5 0.04 1.3e-04 4.1 5.5 2.9e-08 0.07 0.64 0.05 FALSE
29 GTEx Nerve Tibial KRT222 0.19 0.14 lasso 3 0.14 2.9e-10 -9.0 8.8 1.6e-18 -0.87 0.29 0.71 FALSE
30 GTEx Ovary MED24 0.39 0.34 lasso 4 0.34 3.4e-09 5.9 -5.7 1.0e-08 0.07 0.72 0.04 FALSE
31 GTEx Pancreas PGAP3 0.37 0.25 lasso 6 0.21 1.9e-09 4.7 5.5 4.3e-08 0.08 0.92 0.07 FALSE
32 GTEx Pituitary MED24 0.37 0.28 lasso 3 0.21 6.1e-06 5.3 -5.3 9.0e-08 0.02 0.48 0.04 TRUE
33 GTEx Pituitary MSL1 0.40 0.27 lasso 7 0.24 1.3e-06 4.5 -5.1 2.9e-07 0.13 0.24 0.07 TRUE
34 GTEx Prostate PGAP3 0.23 0.03 enet 26 0.06 1.6e-02 4.1 5.5 3.7e-08 0.11 0.20 0.17 FALSE
35 GTEx Skin Not Sun Exposed Suprapubic PGAP3 0.22 0.09 enet 33 0.14 3.4e-08 4.1 5.5 3.2e-08 0.09 0.92 0.07 FALSE
36 GTEx Skin Not Sun Exposed Suprapubic KRT222 0.15 0.02 enet 14 0.02 4.6e-02 2.4 6.9 5.5e-12 -0.68 0.12 0.66 FALSE
37 GTEx Skin Sun Exposed Lower leg MED24 0.20 0.18 lasso 4 0.18 2.0e-14 5.2 -5.2 1.6e-07 0.07 1.00 0.00 FALSE
38 GTEx Skin Sun Exposed Lower leg ERBB2 0.10 0.01 enet 8 0.01 3.5e-02 5.1 5.9 4.5e-09 0.10 0.17 0.57 FALSE
39 GTEx Spleen GSDMB 0.50 0.45 enet 14 0.43 1.9e-12 7.2 7.5 4.3e-14 0.03 0.01 0.99 FALSE
40 GTEx Spleen ORMDL3 0.40 0.44 enet 11 0.39 5.7e-11 7.2 7.4 1.0e-13 0.04 0.01 0.99 FALSE
41 GTEx Thyroid SMARCE1 0.08 0.07 lasso 3 0.06 2.9e-05 -9.0 9.1 7.2e-20 -0.89 0.02 0.98 FALSE
42 GTEx Thyroid CASC3 0.07 0.00 enet 8 0.00 2.2e-01 2.6 6.5 9.1e-11 0.02 0.07 0.04 TRUE
43 GTEx Thyroid THRA 0.06 0.01 lasso 4 0.00 3.5e-01 -5.5 5.6 2.7e-08 -0.01 0.05 0.50 FALSE
44 GTEx Thyroid PGAP3 0.19 0.21 lasso 10 0.24 3.5e-18 5.2 5.8 8.5e-09 0.07 1.00 0.00 FALSE
45 GTEx Thyroid KRT222 0.10 0.02 lasso 4 0.03 4.1e-03 -8.8 7.0 3.1e-12 -0.78 0.04 0.78 FALSE
46 GTEx Thyroid RP11-690G19.3 0.04 0.03 enet 6 0.02 1.5e-02 5.9 -5.6 2.4e-08 -0.14 0.01 0.98 FALSE
47 GTEx Whole Blood GSDMB 0.15 0.10 lasso 4 0.10 4.5e-09 7.0 6.9 6.2e-12 0.05 0.02 0.98 FALSE
48 GTEx Whole Blood ORMDL3 0.18 0.12 lasso 5 0.14 1.8e-12 7.1 6.8 7.5e-12 0.04 0.01 0.99 FALSE
49 METSIM Adipose GSDMA 0.14 0.16 lasso 7 0.17 2.6e-24 6.8 -7.1 9.3e-13 0.05 0.09 0.91 FALSE
50 METSIM Adipose MSL1 0.12 0.06 lasso 10 0.06 1.8e-09 4.9 -5.5 4.3e-08 0.07 0.99 0.00 FALSE
51 METSIM Adipose SMARCE1 0.10 0.12 lasso 2 0.13 2.3e-18 7.6 -7.6 3.1e-14 0.75 1.00 0.00 FALSE
52 NTR Blood GSDMB 0.09 0.10 enet 16 0.12 3.8e-36 6.7 6.1 8.4e-10 0.06 0.04 0.96 FALSE
53 NTR Blood IKZF3 0.04 0.03 blup 319 0.02 1.5e-08 -5.6 -6.7 2.2e-11 -0.01 0.09 0.91 FALSE
54 NTR Blood ORMDL3 0.10 0.10 enet 24 0.12 4.4e-36 -5.9 5.4 7.1e-08 0.06 0.05 0.95 FALSE
55 NTR Blood SMARCE1 0.04 0.03 lasso 4 0.04 6.5e-13 -9.6 -9.3 1.0e-20 0.95 0.00 1.00 FALSE
56 YFS Blood GSDMB 0.36 0.41 lasso 12 0.49 4.0e-186 7.1 6.1 9.3e-10 0.06 0.02 0.98 FALSE
57 YFS Blood ORMDL3 0.31 0.36 lasso 9 0.45 2.2e-165 7.1 5.8 6.9e-09 0.05 0.02 0.98 FALSE
58 YFS Blood SMARCE1 0.32 0.48 lasso 10 0.49 1.0e-187 7.6 -8.1 6.0e-16 0.81 1.00 0.00 FALSE
59 The Cancer Genome Atlas Bladder Urothelial Carcinoma GSDMA 0.05 0.06 lasso 4 0.05 7.8e-05 6.1 -6.0 1.6e-09 0.05 0.20 0.27 FALSE
60 The Cancer Genome Atlas Bladder Urothelial Carcinoma KRT24 0.08 0.08 blup 49 0.09 3.6e-08 -6.5 8.2 3.0e-16 -0.71 0.03 0.97 FALSE
61 The Cancer Genome Atlas Breast Invasive Carcinoma GSDMA 0.61 0.49 lasso 5 0.51 5.0e-124 6.1 -6.2 4.0e-10 0.05 0.81 0.19 FALSE
62 The Cancer Genome Atlas Breast Invasive Carcinoma SMARCE1 0.02 0.01 blup 42 0.02 1.3e-04 7.6 -9.3 1.2e-20 0.87 0.01 0.98 FALSE
63 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma GSDMA 0.08 0.03 enet 10 0.08 9.7e-05 6.1 -5.5 3.3e-08 0.06 0.07 0.17 TRUE
64 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma KRT24 0.05 0.05 lasso 3 0.05 1.8e-03 -6.4 6.4 1.5e-10 -0.56 0.04 0.27 FALSE
65 The Cancer Genome Atlas Colon Adenocarcinoma GSDMB 0.10 0.15 blup 40 0.14 1.2e-08 -5.9 6.2 4.8e-10 0.05 0.03 0.97 FALSE
66 The Cancer Genome Atlas Glioblastoma Multiforme GSDMA 0.58 0.33 enet 10 0.34 5.3e-11 6.1 -6.9 4.3e-12 0.05 0.82 0.17 TRUE
67 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma KRT222 0.02 0.01 lasso 5 0.01 6.8e-02 -9.2 9.8 1.3e-22 -0.86 0.02 0.68 FALSE
68 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma KRT24 0.11 0.16 enet 14 0.16 2.6e-17 -6.5 6.0 2.6e-09 -0.45 1.00 0.00 FALSE
69 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma GSDMA 0.66 0.48 enet 21 0.51 1.2e-65 6.1 -6.1 8.8e-10 0.05 0.81 0.19 FALSE
70 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma KRT222 0.06 0.03 lasso 1 0.03 2.7e-04 -8.7 8.7 2.5e-18 -0.88 0.11 0.23 FALSE
71 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ORMDL3 0.01 0.01 blup 36 0.00 8.5e-02 -5.9 6.5 7.3e-11 0.03 0.02 0.59 FALSE
72 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SMARCE1 0.07 0.05 lasso 3 0.06 8.0e-08 7.6 -8.5 1.8e-17 0.77 0.07 0.92 FALSE
73 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma GSDMA 0.37 0.44 lasso 1 0.44 3.3e-27 6.1 -6.1 9.6e-10 0.05 0.81 0.19 FALSE
74 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SMARCE1 0.06 0.08 enet 8 0.05 5.0e-04 -6.8 -7.0 1.9e-12 0.63 0.46 0.14 FALSE
75 The Cancer Genome Atlas Brain Lower Grade Glioma GSDMA 0.65 0.56 lasso 4 0.58 1.5e-81 6.1 -6.3 2.2e-10 0.05 0.81 0.19 FALSE
76 The Cancer Genome Atlas Brain Lower Grade Glioma GSDMB 0.06 0.05 enet 7 0.05 2.2e-06 7.1 7.2 5.0e-13 0.05 0.01 0.99 FALSE
77 The Cancer Genome Atlas Brain Lower Grade Glioma SMARCE1 0.04 0.00 enet 6 0.03 6.1e-04 -9.0 -7.6 2.5e-14 0.75 0.02 0.66 FALSE
78 The Cancer Genome Atlas Liver Hepatocellular Carcinoma GSDMA 0.41 0.37 lasso 2 0.38 3.7e-19 6.1 -6.0 2.2e-09 0.04 0.81 0.19 FALSE
79 The Cancer Genome Atlas Lung Adenocarcinoma GSDMA 0.30 0.35 lasso 4 0.35 6.3e-43 6.1 -6.0 1.5e-09 0.06 0.81 0.19 FALSE
80 The Cancer Genome Atlas Lung Adenocarcinoma GSDMB 0.05 0.07 blup 39 0.05 1.4e-06 7.1 7.5 6.5e-14 0.03 0.01 0.99 FALSE
81 The Cancer Genome Atlas Lung Adenocarcinoma KRT222 0.03 0.03 blup 45 0.03 2.0e-04 -8.7 8.8 1.2e-18 -0.89 0.05 0.88 FALSE
82 The Cancer Genome Atlas Lung Adenocarcinoma PGAP3 0.06 0.06 lasso 4 0.06 4.5e-07 5.2 5.1 3.0e-07 0.07 0.07 0.93 FALSE
83 The Cancer Genome Atlas Lung Squamous Cell Carcinoma GSDMA 0.15 0.19 enet 9 0.19 1.7e-21 6.1 -6.3 3.0e-10 0.06 0.81 0.19 FALSE
84 The Cancer Genome Atlas Lung Squamous Cell Carcinoma GSDMB 0.02 0.01 blup 39 0.01 1.5e-02 7.1 6.6 3.1e-11 0.05 0.02 0.81 FALSE
85 The Cancer Genome Atlas Lung Squamous Cell Carcinoma KRT24 0.04 0.03 blup 49 0.03 2.2e-04 -6.4 7.7 1.8e-14 -0.70 0.04 0.96 FALSE
86 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ORMDL3 0.03 0.04 lasso 2 0.04 2.9e-05 -5.9 6.6 3.4e-11 0.05 0.03 0.97 FALSE
87 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SMARCE1 0.02 0.01 blup 43 0.01 9.7e-03 7.6 -6.0 1.7e-09 0.51 0.04 0.26 FALSE
88 The Cancer Genome Atlas Lung Squamous Cell Carcinoma STARD3 0.03 0.03 enet 8 0.04 6.6e-05 5.1 5.2 1.5e-07 0.10 0.07 0.89 FALSE
89 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma GSDMA 0.50 0.37 enet 15 0.43 4.2e-31 6.1 -5.8 5.2e-09 0.06 0.81 0.19 FALSE
90 The Cancer Genome Atlas Pancreatic Adenocarcinoma GSDMA 0.23 0.29 enet 6 0.24 2.8e-10 6.1 -6.1 9.8e-10 0.05 0.81 0.19 FALSE
91 The Cancer Genome Atlas Pancreatic Adenocarcinoma GSDMB 0.14 0.16 lasso 4 0.14 2.4e-06 -5.9 5.7 1.1e-08 0.06 0.18 0.80 FALSE
92 The Cancer Genome Atlas Pancreatic Adenocarcinoma PGAP3 0.07 0.10 lasso 2 0.08 3.7e-04 5.9 5.9 3.5e-09 0.16 0.00 0.95 FALSE
93 The Cancer Genome Atlas Pancreatic Adenocarcinoma SMARCE1 0.13 0.11 lasso 4 0.11 2.6e-05 -9.6 -10.0 1.3e-23 0.97 0.00 0.99 TRUE
94 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma GSDMA 0.52 0.34 lasso 4 0.36 5.1e-15 6.1 -5.8 5.4e-09 0.05 0.81 0.19 FALSE
95 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma PGAP3 0.17 0.13 blup 41 0.10 6.8e-05 5.2 5.2 2.3e-07 0.06 0.06 0.87 FALSE
96 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma SMARCE1 0.12 0.06 blup 42 0.11 4.7e-05 -6.5 -7.3 2.9e-13 0.58 0.15 0.28 FALSE
97 The Cancer Genome Atlas Prostate Adenocarcinoma GSDMA 0.16 0.12 lasso 2 0.12 1.1e-12 6.1 -6.0 1.7e-09 0.05 0.81 0.19 FALSE
98 The Cancer Genome Atlas Prostate Adenocarcinoma KRT222 0.06 0.04 enet 7 0.06 9.7e-07 -8.7 9.3 9.0e-21 -0.90 0.05 0.94 FALSE
99 The Cancer Genome Atlas Prostate Adenocarcinoma SMARCE1 0.12 0.09 lasso 1 0.08 5.5e-09 7.6 -7.6 2.5e-14 0.77 0.26 0.74 FALSE
100 The Cancer Genome Atlas Rectum Adenocarcinoma GSDMB 0.14 0.09 blup 39 0.17 7.0e-05 -5.9 6.8 9.9e-12 0.03 0.02 0.88 FALSE
101 The Cancer Genome Atlas Soft Tissue Sarcoma GSDMA 0.44 0.45 lasso 4 0.44 3.2e-28 6.1 -6.2 6.4e-10 0.05 0.81 0.19 FALSE
102 The Cancer Genome Atlas Skin Cutaneous Melanoma GSDMA 0.23 0.16 blup 47 0.18 1.3e-05 6.1 -6.5 6.5e-11 0.05 0.13 0.43 FALSE
103 The Cancer Genome Atlas Stomach Adenocarcinoma GSDMA 0.22 0.09 enet 9 0.13 2.3e-09 6.1 -5.1 3.1e-07 0.07 0.81 0.18 FALSE
104 The Cancer Genome Atlas Stomach Adenocarcinoma GSDMB 0.06 0.08 enet 7 0.08 1.1e-06 7.2 6.8 1.0e-11 0.05 0.02 0.98 FALSE
105 The Cancer Genome Atlas Stomach Adenocarcinoma IKZF3 0.03 0.01 blup 43 0.02 1.3e-02 7.1 -7.3 2.0e-13 -0.03 0.01 0.73 FALSE
106 The Cancer Genome Atlas Stomach Adenocarcinoma PGAP3 0.05 0.05 lasso 4 0.05 1.0e-04 5.2 5.7 1.5e-08 0.14 0.01 0.98 FALSE
107 The Cancer Genome Atlas Stomach Adenocarcinoma SMARCE1 0.06 0.06 lasso 2 0.06 3.1e-05 7.6 -8.7 2.4e-18 0.89 0.01 0.99 FALSE
108 The Cancer Genome Atlas Stomach Adenocarcinoma ZPBP2 0.08 0.09 enet 5 0.10 6.1e-08 7.2 -7.3 3.2e-13 -0.05 0.01 0.99 FALSE
109 The Cancer Genome Atlas Testicular Germ Cell Tumors GSDMA 0.38 0.32 enet 7 0.32 5.9e-12 6.1 -6.2 7.9e-10 0.06 0.84 0.16 FALSE
110 The Cancer Genome Atlas Testicular Germ Cell Tumors KRT222 0.10 0.06 blup 44 0.04 1.4e-02 -9.1 7.9 2.5e-15 -0.85 0.02 0.42 FALSE
111 The Cancer Genome Atlas Testicular Germ Cell Tumors PNMT 0.07 0.14 lasso 1 0.10 1.5e-04 5.9 5.9 3.4e-09 0.16 0.00 0.99 FALSE
112 The Cancer Genome Atlas Thyroid Carcinoma GSDMA 0.19 0.21 lasso 4 0.24 5.5e-23 6.1 -6.7 2.7e-11 0.05 0.79 0.21 FALSE
113 The Cancer Genome Atlas Thyroid Carcinoma GSDMB 0.08 0.08 blup 40 0.09 6.6e-09 7.1 7.7 1.7e-14 0.04 0.01 0.99 FALSE
114 The Cancer Genome Atlas Thyroid Carcinoma KRT222 0.03 0.02 lasso 1 0.02 4.3e-03 -9.5 9.5 2.4e-21 -0.98 0.00 0.88 FALSE
115 The Cancer Genome Atlas Thyroid Carcinoma ORMDL3 0.08 0.13 blup 37 0.15 3.8e-14 7.1 7.6 2.7e-14 0.03 0.01 0.99 FALSE
116 The Cancer Genome Atlas Thyroid Carcinoma PNMT 0.03 0.05 lasso 4 0.04 6.2e-05 5.9 6.0 1.7e-09 0.15 0.00 1.00 FALSE
117 The Cancer Genome Atlas Thyroid Carcinoma SMARCE1 0.05 0.04 lasso 3 0.05 1.2e-05 6.5 -6.6 3.7e-11 0.57 0.06 0.77 FALSE
118 The Cancer Genome Atlas Thyroid Carcinoma STARD3 0.10 0.06 lasso 5 0.05 2.6e-05 5.2 5.3 1.0e-07 0.08 0.06 0.93 FALSE