TWAS
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Cholesterol lowering medication
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chr1:15,752,716-17,413,769
Best TWAS P=3.6e-08 · Best GWAS P=1.07e-07 conditioned to 0.459
15.8M
16M
16.2M
16.4M
16.6M
16.8M
17M
17.2M
17.4M
0
2
4
6
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Cervical Squamous Cell Carcinoma
C1orf89
0.09
0.02
blup
44
0.03
1.4e-02
-5.3
-5.5
3.6e-08
0.91
0.00
0.77
TRUE
4
The Cancer Genome Atlas
Glioblastoma Multiforme
C1orf89
0.17
0.07
lasso
2
0.08
1.5e-03
-5.3
-5.2
1.5e-07
0.99
0.00
0.93
FALSE
1
GTEx
Nerve Tibial
EPHA2
0.19
0.13
enet
29
0.14
6.7e-10
-4.7
5.2
2.3e-07
-0.74
0.03
0.96
FALSE
2
ROSMAP
Brain Pre-frontal Cortex
SZRD1
0.04
0.02
lasso
7
0.02
3.6e-03
5.1
5.2
2.3e-07
-0.80
0.03
0.93
FALSE