Hub : Genes

EPHA2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.0841 0.0421 1.5e-03 -0.004 NA 0.008 NA -0.004 9.4e-01 NA 7.6e-02 NA 9.3e-01
2 GTEx Nerve Tibial 0.1856 0.0486 2.0e-09 0.130 NA 0.137 NA 0.126 1.9e-09 NA 6.7e-10 NA 3.3e-09
3 GTEx Thyroid 0.0990 0.0330 3.1e-06 0.052 NA 0.059 NA 0.062 8.0e-05 NA 2.4e-05 NA 1.7e-05
4 ROSMAP Brain Pre-frontal Cortex 0.0434 0.0193 1.9e-03 0.027 0.017 0.020 0.018 0.022 1.9e-04 0.0023 1.2e-03 0.0019 6.4e-04
5 TCGA Liver Hepatocellular Carcinoma 0.0750 0.0370 5.0e-04 0.056 0.049 0.039 NA 0.065 1.3e-03 0.0025 6.0e-03 NA 5.1e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.3 0.4 1.0 -0.5 -1.0 -0.7 -0.5 0.4
Bipolar Disorder or Schizophrenia 0.1 0.4 1.4 1.2 -0.3 0.4 -0.2 0.2
Depressed Affect (Nagel 2018) 0.4 0.9 4.0 2.0 -0.2 0.3 -0.5 0.4
Depression (Nagel 2018) 2.3 3.5 5.1 0.6 -2.2 -1.9 -2.0 2.2
Intelligence (Savage-Jansen 2018) 0.4 1.1 1.8 0.7 1.2 1.3 0.8 -1.1
Neuroticism (Nagel 2018) 0.1 0.1 0.5 0.1 0.1 0.7 0.2 0.2
Schizophrenia (2018) 0.5 1.0 3.8 1.9 0.4 1.1 0.1 -0.2
Schizophrenia vs Biploar Disorder 0.5 0.6 1.0 0.2 -1.0 -0.9 -0.9 0.7
Worry (Nagel 2018) 1.1 2.3 2.5 -1.5 1.4 1.6 1.5 -1.6
Alzheimer’s Disease (in mother) 0.6 0.7 1.5 1.2 0.9 0.3 0.7 -0.7
Alzheimer’s Disease (in father) 0.3 0.3 0.9 0.3 0.6 -0.0 -0.2 -0.9
Alzheimer’s Disease (including proxy) 0.7 1.0 1.9 1.4 1.2 0.4 0.7 -1.0
Crohns Disease (2017) 1.4 3.0 6.5 -0.7 -2.1 -2.5 -1.2 1.5
Irritable Bowel Disease (IBD) 1.0 2.4 4.1 -1.4 -1.8 -2.0 -0.7 1.6
Ulcerative Colitis (UC) 0.4 0.8 1.5 -1.2 -0.9 -0.8 0.1 1.1
Major Depression (MDD) 0.3 0.4 1.3 0.2 1.1 0.7 0.1 -0.3
Reaction Time 0.2 0.4 0.9 -0.5 -0.5 -1.0 -0.5 0.7
Verbal and Numeric Reasoning (VNR) 0.6 1.6 3.1 1.4 1.1 1.7 0.6 -1.0
Breast Cancer 0.4 0.9 2.6 0.3 -1.6 -0.8 0.2 1.0
Ovarian Cancer 0.8 1.0 2.8 -0.2 -1.2 -1.7 -0.2 1.0
Prostate Cancer 2.8 4.0 11.1 -3.3 -1.4 -1.7 -1.6 1.3
Age at First Birth 0.9 1.3 3.1 -1.2 -0.9 -1.8 -0.6 1.0
Bipolar Disorder (2011) 0.9 0.9 1.6 -0.8 -1.2 -0.8 -1.3 0.0
Body Mass Index (BMI) (2010) 2.8 3.8 5.9 -0.7 -1.8 -2.4 -2.3 2.0
Coronary Artery Disease (CAD) 4.4 5.3 8.7 2.1 3.0 1.9 2.1 -2.2
Crohns Disease (2012) 1.8 3.0 5.7 -1.3 -1.8 -2.4 -1.8 1.1
Mean Putamen Volume 2.4 2.7 4.8 0.2 -2.1 -1.8 -1.1 2.2
Fasting Glucose 0.8 1.0 1.7 1.3 0.9 1.2 0.4 -0.8
HbA1C 0.3 0.4 1.1 0.2 1.1 0.2 -0.1 -0.7
HDL Cholesterol 0.8 1.4 2.2 1.0 0.4 1.5 1.4 -1.3
LDL Cholesterol 2.1 3.4 5.8 0.5 1.6 2.1 2.4 -2.0
Lupus 0.1 0.2 0.3 -0.6 0.2 -0.4 -0.1 0.6
Neuroticism (2016) 1.0 1.4 1.9 1.4 1.1 1.4 0.8 -1.2
Primary Biliary Cirrhosis 0.2 0.3 1.1 -1.0 -0.6 -0.2 -0.5 0.1
Rheumatoid Arthritis 2.0 2.8 5.0 2.2 1.2 1.9 1.4 -1.3
Schizophrenia (2014) 0.4 0.8 3.5 1.9 -0.2 0.3 -0.5 0.1
Triglycerides 2.2 3.7 5.8 2.4 1.9 2.2 1.5 -1.4
Type 2 Diabetes (T2D) (2012) 0.4 0.4 1.7 0.3 -0.4 -0.4 -1.3 0.3
Ulcerative Colitis 0.4 0.5 1.6 -1.2 -0.6 -0.6 -0.0 0.7
Blood Eosinophil Count 1.9 14.8 23.3 -0.8 -4.5 -3.5 -4.8 4.3
Blood Platelet Count 1.1 12.6 19.6 -0.0 -3.7 -4.1 -4.4 3.6
Blood Red Count 1.3 12.8 23.4 -0.0 4.7 4.8 2.8 -3.3
Blood White Count 0.1 0.9 2.8 0.3 -1.0 -0.5 -1.7 0.5
Heel T-Score 1.6 12.8 23.3 3.0 -2.3 -4.0 -4.8 3.2
BMI 0.6 3.5 7.8 0.0 -2.8 -2.6 -0.6 1.6
Height 1.0 19.0 30.8 -2.2 -5.1 -2.9 -5.0 5.5
Waist Hip Ratio (WHR) 0.9 3.9 6.1 -0.7 2.1 2.5 1.9 -2.2
Systolic Blood Pressure 4.8 24.1 33.9 3.8 5.6 5.8 5.0 -4.1
Smoking Status 0.4 0.9 3.4 0.4 -1.8 -0.5 -0.7 -0.3
Allergy or Eczema 0.1 0.3 0.7 -0.6 0.8 0.8 -0.1 -0.1
Cardiovascular Disease 3.3 10.8 18.1 2.1 3.4 4.3 3.5 -2.8
Hypothyroidism (self reported) 0.5 1.1 2.7 0.9 -1.6 -0.5 -0.2 1.4
Respiratory disease 0.8 1.8 3.4 0.1 1.9 1.5 1.3 -1.2
Type 2 Diabetes (T2D) (2018) 0.3 0.6 2.0 0.1 1.4 0.7 0.4 -0.3
Lung FEV1/FVC ratio 6.5 32.9 59.4 -2.7 -5.6 -7.7 -6.5 4.8
Lung FVC 3.5 17.6 26.9 3.1 4.1 5.2 4.2 -4.1
Neuroticism 0.2 0.4 1.1 -0.6 0.5 1.1 0.5 -0.5
Chronotype (morning person) 0.5 1.2 4.6 -2.1 0.8 -0.1 -0.2 -0.9
Hair Pigment 0.1 3.8 16.2 4.0 1.3 -0.1 -0.1 1.1
Tanning 0.9 10.8 13.8 -3.7 -3.7 -3.3 -2.8 2.9
Hand grip strength (left) 0.7 1.8 3.3 -0.1 -1.8 -1.6 -0.7 1.7
Number of treatments/medications taken 1.5 2.8 4.7 1.0 1.8 2.2 1.8 -1.3
Average weekly spirits intake 0.2 0.2 0.5 0.0 0.1 0.5 0.7 0.5
Sensitivity / hurt feelings 0.1 0.2 0.4 0.0 -0.4 0.3 -0.6 0.7
Frequency of depressed mood in last 2 weeks 0.6 0.9 1.8 1.4 -0.7 -0.7 -1.2 0.1
Hearing difficulty/problems: Yes 0.2 0.3 0.6 -0.8 -0.7 -0.2 -0.1 0.5
Relative age of first facial hair 0.8 1.6 4.2 2.1 0.9 1.6 0.1 -0.7
Other serious medical condition/disability diagnosed by doctor 1.1 1.4 3.2 1.8 0.7 1.5 1.0 -0.4
Ever used hormone-replacement therapy (HRT) 0.8 1.0 3.8 1.9 0.5 0.9 0.5 0.2
Ever had hysterectomy (womb removed) 0.3 0.4 1.0 1.0 -0.4 0.2 0.1 0.9
Systolic blood pressure, automated reading 1.4 4.0 6.1 2.3 2.0 2.5 1.9 -1.2
Eye problems/disorders: Diabetes related eye disease 1.9 2.1 3.9 -0.3 -1.3 -1.8 -2.0 1.2
Angina 0.8 1.0 1.7 0.2 1.0 0.8 1.3 -1.2
Medication for hormone replacement therapy 0.5 0.6 1.3 1.2 0.5 1.0 0.5 -0.2
Vitamin and mineral supplements 0.8 1.0 2.7 -0.1 0.5 1.6 0.9 -1.2
Supplements: Zinc 0.8 0.9 2.5 -0.4 -0.9 -0.6 -0.8 1.6
Medication: Co-codamol 1.3 1.5 2.4 1.6 1.3 1.4 0.8 -0.9
Medication: Metformin 0.1 0.2 0.4 0.5 0.7 0.2 -0.4 0.1
Diabetes (father) 0.4 0.5 1.3 1.1 0.2 0.1 0.3 1.1
Diabetes (mother) 0.4 0.6 1.2 1.1 1.0 0.6 0.1 -0.5
Severe depression (siblings) 3.3 3.7 6.4 -0.9 -2.5 -1.7 -2.4 1.5
Pack years adult smoking proportion 1.5 2.3 5.3 2.3 0.6 1.4 1.7 -1.1
Impedance of leg (right) 3.9 18.9 31.9 1.1 5.7 5.6 4.0 -3.7
Leg fat-free mass (left) 3.7 19.4 29.7 -2.0 -5.5 -5.2 -3.9 4.6
Trunk fat percentage 0.7 3.0 4.1 -1.5 -1.8 -2.0 -1.5 1.8
Hand grip strength (right) 1.2 3.2 6.8 0.4 -2.6 -1.9 -1.0 2.1
Townsend deprivation index at recruitment 1.0 1.5 4.5 2.1 -0.6 -0.5 -1.4 0.6
Current tobacco smoking 0.8 1.3 5.1 2.3 -0.4 0.5 0.4 -0.9
Average weekly fortified wine intake 0.9 1.1 2.0 0.5 -1.1 -0.6 -1.4 1.3
Maternal smoking around birth 0.4 0.6 1.3 0.2 -1.2 -0.6 -0.8 0.7
Fed-up feelings 0.5 0.9 3.2 1.8 -0.3 0.3 -0.9 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 3.1 4.1 6.1 0.4 -2.3 -2.2 -2.5 2.0
Relative age voice broke 0.2 0.3 0.5 0.3 -0.3 -0.7 -0.7 0.3
Taking other prescription medications 2.2 3.4 5.7 0.7 2.1 2.4 1.9 -1.6
Age when periods started (menarche) 0.4 1.0 1.6 0.3 0.6 1.1 1.3 -1.2
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.5 0.7 -0.2 -0.1 -0.2 0.2
Heel bone mineral density (BMD) T-score, automated (left) 4.8 10.8 16.7 1.0 -3.1 -3.8 -4.1 3.5
Tinnitus: Yes, but not now, but have in the past 1.7 1.8 3.0 1.2 1.4 1.1 1.7 -1.2
Qualifications: CSEs or equivalent 0.1 0.1 0.2 0.1 -0.2 -0.2 0.4 -0.5
Serious illness, injury or assault to yourself 1.2 1.4 2.5 0.1 1.2 1.6 1.3 -1.1
High blood pressure 2.1 5.8 9.2 1.1 2.5 3.0 2.5 -2.5
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.8 -0.9 0.4 0.3 -0.3 -0.3
Multivitamins +/- minerals 3.0 3.8 7.4 0.2 -1.7 -2.7 -1.3 2.6
Stomach or abdominal pain in last month 0.3 0.4 0.6 0.8 -0.6 0.5 -0.2 0.7
Supplements: Glucosamine 1.9 2.5 5.2 -1.4 -1.4 -2.3 -1.0 1.6
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.2 -0.2 0.4 0.4 0.1 0.1
Medication: Atenolol 0.4 0.5 1.5 -0.7 0.5 0.3 0.5 -1.2
Medication: Levothyroxine sodium 0.1 0.2 0.3 0.5 -0.6 0.1 -0.2 0.4
Sitting height 0.7 5.2 14.8 0.0 -2.0 -1.5 -2.1 3.9
Chronic bronchitis/emphysema (father) 0.7 0.8 2.0 -1.4 -1.4 -0.3 -0.5 0.0
High blood pressure (mother) 5.0 7.1 8.9 1.4 3.0 3.0 2.6 -3.0
Body mass index (BMI) 0.9 3.7 7.7 -0.4 -2.8 -2.7 -1.2 1.4
Impedance of leg (left) 3.5 17.2 28.0 0.9 5.3 5.3 4.0 -3.7
Leg predicted mass (left) 3.8 19.9 30.7 -2.1 -5.5 -5.2 -4.0 4.6
Trunk fat mass 1.3 5.7 7.9 -1.5 -2.8 -2.8 -2.1 2.5
Waist circumference 0.7 2.5 5.7 -1.1 -2.4 -1.7 -1.0 1.2
Number of incorrect matches in round 0.6 1.0 2.0 -0.6 0.9 1.4 0.9 -1.0
Past tobacco smoking 3.5 6.4 8.5 1.8 2.9 2.7 2.8 -2.2
Alcohol usually taken with meals 0.1 0.2 0.6 -0.4 0.0 -0.3 -0.3 0.7
Nervous feelings 3.2 6.0 9.3 -1.4 2.6 2.8 2.1 -3.1
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.3 2.5 0.8 1.3 1.6 0.7 -1.2
Hearing difficulty/problems with background noise 1.3 2.1 3.4 0.9 1.5 1.8 1.3 -1.5
Hair/balding pattern: Pattern 2 0.1 0.1 0.2 -0.0 -0.5 -0.2 -0.3 -0.2
Had menopause 1.8 2.2 4.3 2.1 1.7 1.6 0.7 -0.8
Had other major operations 0.6 0.8 2.1 1.5 0.1 0.7 1.1 -0.0
Forced vital capacity (FVC) 1.0 4.0 7.7 1.8 2.0 2.8 2.0 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 7.9 18.1 27.0 0.6 -4.5 -5.1 -5.2 4.1
Ever unenthusiastic/disinterested for a whole week 3.3 4.1 6.0 -0.3 -2.3 -1.7 -2.4 2.5
Qualifications: None of the above 0.5 1.1 3.8 2.0 0.2 0.7 0.8 -0.6
Financial difficulties in last 2 years 1.3 1.8 7.1 2.7 0.8 1.1 0.0 -0.1
Mouth/teeth dental problems 0.7 1.1 1.6 -0.4 -1.2 -1.3 -1.1 1.0
Heart attack 0.5 0.7 1.3 -0.6 -1.0 0.2 -0.7 1.1
Allergy 0.4 0.9 1.6 0.7 -1.0 -1.0 -0.5 1.2
Pain all over the body in last month 0.7 0.7 2.2 1.5 0.5 0.8 0.8 -0.3
Diabetes (self-reported) 1.0 1.5 3.3 0.7 1.8 0.9 0.8 -1.6
Hayfever/allergic rhinitis (self-reported) 0.0 0.1 0.2 0.1 0.0 -0.2 -0.4 0.2
Medication: Ramipril 0.7 0.8 1.7 0.7 0.7 1.3 0.6 -1.0
Medication: Simvastatin 6.3 9.3 13.3 1.2 3.3 3.6 3.1 -3.3
Fluid intelligence score 1.0 2.0 3.8 1.8 1.1 2.0 0.6 -1.3
Illnesses of siblings 4.1 5.7 11.2 -1.5 -2.1 -3.4 -2.0 2.6
Neuroticism score 0.3 0.7 2.0 0.3 0.6 1.4 0.1 -0.9
Weight 2.3 11.1 18.9 -1.4 -4.3 -3.9 -2.7 3.5
Impedance of arm (right) 0.3 1.2 2.6 -1.0 1.6 1.3 -0.8 0.3
Arm fat percentage (right) 0.8 3.3 5.7 -0.8 -2.1 -2.4 -1.7 1.7
Trunk fat-free mass 2.2 12.5 20.6 -1.3 -4.5 -4.0 -3.0 3.8
Hip circumference 1.6 7.0 13.7 -1.2 -3.7 -3.0 -2.0 2.6
Time employed in main current job 0.2 0.3 0.5 -0.4 -0.4 -0.6 -0.2 0.7
Alcohol intake versus 10 years previously 1.8 2.7 4.6 0.7 2.1 1.8 1.6 -1.7
Father’s age at death 0.4 0.5 1.7 -1.3 0.3 -0.7 -0.4 0.5
Worrier / anxious feelings 0.6 1.1 2.4 -0.2 1.4 1.5 0.9 -0.7
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 3.8 2.0 0.8 1.0 0.0 -0.3
Falls in the last year 0.4 0.5 2.1 1.4 0.4 0.4 0.2 -0.2
Hair/balding pattern: Pattern 3 0.5 0.8 1.9 1.0 -0.5 -0.8 -1.4 -0.0
Number of live births 0.4 0.6 2.3 -1.5 -0.8 -0.1 0.2 0.4
Forced expiratory volume in 1-second (FEV1) 0.2 0.5 0.8 0.8 0.8 0.9 0.7 -0.1
Pulse rate 0.3 0.6 0.9 -0.3 0.7 0.9 0.7 -0.9
Happiness 0.4 0.5 0.8 0.8 0.9 0.6 0.4 -0.6
Noisy workplace 0.4 0.4 0.7 -0.8 -0.7 -0.6 -0.6 0.5
Qualifications: A levels/AS levels or equivalent 0.3 0.7 1.6 -0.6 1.0 0.1 1.3 -0.8
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.6 -0.8 -0.1 0.2 0.2 -0.4
Mouth/teeth dental problems: Dentures 0.3 0.5 1.1 -1.1 0.8 -0.1 -0.0 -0.9
Asthma 1.4 2.8 4.0 0.8 1.8 2.0 1.9 -1.6
Medication: Ibuprofen (e.g. Nurofen) 3.4 4.3 7.5 -1.1 -2.4 -2.7 -2.0 1.9
Medication: Cholesterol lowering 0.4 0.6 1.2 0.0 1.1 0.9 0.5 -0.8
Depression (self-reported) 0.4 0.4 1.1 -0.5 -1.0 -0.5 -0.7 0.3
Medication: Lansoprazole 8.4 9.6 15.6 4.0 2.9 3.2 2.9 -2.3
Prospective memory result 0.6 0.7 1.3 -0.8 0.0 -1.2 -1.1 0.7
Lung cancer (father) 0.9 1.1 2.5 -0.2 -0.8 -1.3 -1.6 0.8
Illnesses of mother 6.4 7.9 9.3 -3.0 -3.0 -2.7 -2.4 2.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 0.5 0.7 -0.2 0.0 0.1 0.6
Pulse wave Arterial Stiffness index 0.4 0.4 0.8 0.9 0.6 0.5 -0.1 -0.9
Impedance of arm (left) 0.2 1.1 2.4 -1.1 1.6 1.1 -0.8 0.1
Arm fat mass (right) 1.5 6.1 9.8 -1.1 -3.1 -3.0 -2.0 2.5
Trunk predicted mass 2.2 12.4 20.3 -1.4 -4.5 -4.1 -3.0 3.8
Standing height 1.5 14.6 26.4 -2.4 -4.1 -3.2 -3.7 5.1
Length of working week for main job 0.7 0.8 2.1 0.2 -1.4 -1.2 -0.2 0.4
Exposure to tobacco smoke at home 0.5 0.6 1.9 -0.1 -0.8 -0.5 -0.4 1.4
Breastfed as a baby 0.5 0.6 1.4 0.1 0.3 0.9 1.2 -0.9
Tense / ‘highly strung’ 0.2 0.4 1.4 -1.2 0.5 0.4 -0.0 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 4.4 -2.1 -1.0 -0.4 -1.5 0.4
Hair/balding pattern: Pattern 4 1.5 3.6 5.8 -1.2 -1.9 -2.4 -1.4 2.4
Birth weight of first child 2.0 3.6 8.2 -2.9 -1.6 -2.4 -0.9 0.7
Peak expiratory flow (PEF) 0.8 2.0 3.3 1.7 -0.8 -1.8 -1.0 1.4
Pulse wave reflection index 1.1 1.3 3.3 0.8 1.8 0.8 0.6 -1.3
Ever highly irritable/argumentative for 2 days 1.3 1.5 3.2 -0.6 -1.2 -0.9 -1.8 1.4
Loud music exposure frequency 0.4 0.5 1.8 1.3 0.5 0.4 -0.1 -0.2
Qualifications: O levels/GCSEs or equivalent 1.0 1.5 3.9 -0.2 2.0 0.6 0.7 -1.7
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.5 0.7 0.3 0.4 0.4 -0.1
Blood clot in the leg (DVT) 1.3 1.7 4.0 -2.0 -0.8 -1.2 -1.4 0.4
Medication: Paracetamol 0.2 0.3 0.8 0.2 0.7 0.4 0.9 -0.2
Headache pain in last month 0.3 0.4 0.8 0.9 0.8 -0.1 0.8 -0.3
Medication for cholesterol, blood pressure or diabetes 1.3 2.2 3.0 -0.3 -1.6 -1.7 -1.5 1.7
Glaucoma (self-reported) 0.3 0.3 0.8 0.9 -0.1 0.9 0.1 0.0
Gout (self-reported) 0.3 0.4 0.8 0.9 -0.6 -0.3 0.3 0.9
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 2.3 0.5 -1.5 -0.5 -0.3 1.1
Medication: Amlodipine 0.9 1.3 1.7 1.2 1.1 0.8 1.3 -1.2
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.3 0.6 0.3 0.1 0.5 0.4
Birth weight 2.8 6.2 10.7 -2.0 -2.4 -3.3 -2.3 2.3
Chronic bronchitis/emphysema (mother) 4.7 5.4 9.5 -0.7 -2.6 -1.7 -3.1 2.7
High blood pressure (siblings) 5.9 8.4 14.3 1.7 2.8 3.8 2.9 -3.0
Forced vital capacity (FVC), Best measure 0.4 1.4 2.9 1.4 0.9 1.7 1.2 -0.2
Body fat percentage 0.4 1.5 2.6 -0.9 -1.4 -1.6 -0.9 1.2
Leg fat percentage (right) 0.0 0.2 0.7 0.2 0.2 0.2 0.8 -0.3
Arm fat-free mass (right) 2.0 10.3 17.7 -1.2 -4.2 -3.9 -2.4 3.4
Exposure to tobacco smoke outside home 0.7 0.9 1.3 0.5 -0.9 -1.0 -1.2 1.1
Comparative body size at age 10 0.0 0.1 0.4 0.6 -0.3 0.1 0.5 -0.0
Number of full brothers 0.1 0.2 0.7 0.2 0.1 0.3 0.2 -0.8
Worry too long after embarrassment 0.2 0.3 1.0 -1.0 -0.3 -0.4 -0.0 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.9 -0.2 0.1 0.9 0.0 -0.7
Wheeze or whistling in the chest in last year 0.2 0.3 0.7 0.9 0.1 0.5 0.7 -0.4
Number of children fathered 2.0 2.3 3.9 -1.2 -2.0 -1.6 -1.0 1.5
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.5 -0.5 0.7 0.2 0.4 0.7
Age at first live birth 0.7 1.3 3.8 -1.9 -0.5 -1.4 -0.5 0.3
Pulse wave peak to peak time 0.9 1.1 2.1 -1.1 -1.1 -0.9 -0.4 1.4
Health satisfaction 0.2 0.3 0.6 0.4 0.7 0.3 0.8 -0.4
Shortness of breath walking on level ground 0.3 0.3 0.8 0.4 0.7 0.4 0.2 -0.9
Qualifications: College or University degree 0.1 0.5 1.1 -0.3 -0.7 -0.5 -0.5 1.0
Eye problems/disorders: None of the above 0.6 0.7 3.2 -1.8 0.2 -0.2 -0.3 -0.3
Mouth/teeth dental problems: Loose teeth 0.9 1.1 2.8 -0.2 -1.7 -0.3 -0.8 1.4
Emphysema/chronic bronchitis 2.6 2.9 4.4 2.1 1.4 1.8 1.3 -1.7
Medication for pain relief, constipation, heartburn 0.4 0.6 1.1 -0.6 0.9 0.9 0.3 -1.1
Neck or shoulder pain in last month 8.6 12.3 13.5 3.6 3.6 3.5 3.7 -3.2
Medication: Blood pressure 0.9 1.6 2.2 -0.8 1.3 1.2 1.3 -1.5
Angina (self-reported) 0.9 1.2 2.0 0.2 1.1 1.0 1.4 -1.3
Migraine (self-reported) 1.2 1.5 4.1 1.2 2.0 1.0 0.3 -1.0
Medication: Ibuprofen 2.8 3.4 5.9 -1.2 -2.2 -2.4 -1.5 1.6
Medication: Allopurinol 0.0 0.1 0.1 0.2 -0.2 -0.1 0.3 0.1
Medication: Omeprazole 0.9 1.0 3.4 1.9 0.0 1.2 0.2 0.5
Medication: Seretide 50 evohaler 0.5 0.6 1.3 -0.4 0.8 0.9 1.2 -0.3
Mean time to correctly identify matches 0.2 0.3 0.9 -0.5 -0.1 -0.2 -1.0 0.5
Heart disease (mother) 3.5 4.3 5.2 2.1 2.0 2.3 2.1 -1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 0.5 0.7 -0.7 -0.6 -0.5 0.4
Whole body fat mass 1.0 4.1 6.4 -1.2 -2.5 -2.5 -1.5 2.1
Leg fat mass (right) 0.4 1.7 3.2 -0.7 -1.8 -1.7 -0.6 1.3
Arm predicted mass (right) 1.9 9.5 17.7 -1.1 -4.2 -3.7 -2.2 3.2
Pulse rate, automated reading 0.7 2.3 4.0 0.8 2.0 1.7 1.3 -1.6
Alcohol intake frequency. 1.8 4.3 8.1 0.9 2.8 1.9 1.8 -2.3
Comparative height size at age 10 1.9 10.6 19.3 -1.4 -3.1 -3.2 -3.5 4.4
Number of full sisters 0.7 0.8 1.8 -1.1 -1.4 -0.4 -0.9 -0.1
Suffer from ‘nerves’ 0.9 1.4 2.7 -0.2 0.9 1.6 1.0 -1.6
Overall health rating 0.7 1.5 2.6 1.6 1.0 1.5 1.1 -0.7
Chest pain or discomfort 1.0 1.4 2.8 1.7 1.5 1.1 0.9 -0.4
Had major operations 0.3 0.3 0.7 -0.8 -0.5 0.6 -0.4 -0.5
Age at last live birth 1.4 2.1 4.8 -2.2 -0.9 -1.8 -1.0 0.6
Family relationship satisfaction 0.1 0.1 0.2 -0.2 -0.1 -0.2 -0.4 0.3
Leg pain on walking 0.3 0.3 1.1 -0.0 0.3 0.1 0.6 -1.1
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.2 0.3 -0.4 0.3 -0.5 0.2
Commuting to job workplace: Car/motor vehicle 1.1 1.3 2.9 -0.2 -1.7 -1.4 -0.7 0.9
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 2.0 -1.4 -0.4 -1.0 -0.1 0.8
Medication: Aspirin 0.2 0.2 0.6 0.6 0.8 0.3 0.1 0.1
Supplements: Vitamin C 0.3 0.4 1.6 -1.3 0.2 -0.1 -0.3 0.3
Knee pain experienced in last month 1.6 2.4 4.3 -0.5 -1.7 -1.3 -1.7 2.1
Hypertension (Self-reported) 1.8 5.1 8.1 0.8 2.5 2.8 2.3 -2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.0 3.5 5.6 1.8 -1.9 -0.7 -2.3 2.4
Illnesses of father: Heart disease 0.1 0.1 0.3 0.1 0.4 0.0 0.5 -0.5
Illnesses of siblings: Diabetes 0.1 0.1 0.4 0.6 -0.0 -0.1 0.0 0.5
Smoking status: Previous 1.6 2.3 4.0 -2.0 -1.4 -1.4 -1.4 1.2
Forced expiratory volume in 1-second (FEV1), predicted 1.8 3.8 10.1 0.6 -2.2 -1.2 -1.4 3.2
Whole body fat-free mass 2.7 15.7 25.1 -1.7 -5.0 -4.7 -3.4 4.2
Leg fat-free mass (right) 4.2 22.5 35.6 -2.1 -6.0 -5.6 -4.2 4.8
Arm fat percentage (left) 0.8 3.2 5.9 -0.9 -2.1 -2.4 -1.6 1.6
Average weekly red wine intake 3.8 5.6 9.0 -2.2 -1.9 -2.4 -3.0 2.2
Handedness (chirality/laterality): Left-handed 0.8 1.0 1.4 1.2 0.9 1.2 -0.1 -1.1
Mood swings 0.8 1.4 5.8 2.4 -0.1 1.0 -0.3 0.1
Loneliness, isolation 0.3 0.5 1.6 1.3 0.5 -0.0 -0.6 -0.5
Long-standing illness, disability or infirmity 1.3 2.0 3.9 2.0 1.4 1.8 0.8 -0.8
Ever had bowel cancer screening 0.1 0.2 0.6 -0.8 0.4 -0.2 0.1 0.1
Diabetes diagnosed by doctor 0.7 1.1 2.2 1.5 1.5 0.6 0.4 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 2.6 1.6 0.2 0.7 0.5 -0.4
Friendships satisfaction 0.7 0.9 1.9 -0.7 -0.6 -0.8 -1.0 1.4
Qualifications: nursing, teaching 0.1 0.1 0.4 0.6 0.3 0.3 -0.0 0.2
Commuting to job workplace: Walk 5.2 5.6 9.2 1.5 3.0 2.7 1.9 -2.4
Eye problems/disorders: Cataract 0.3 0.4 0.7 0.9 -0.4 -0.4 0.5 0.7
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 2.5 0.5 1.2 1.1 1.6 -0.8
Medication for cholesterol 4.7 7.1 10.0 -1.3 -3.0 -3.2 -2.9 2.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 2.4 -0.5 -1.1 -1.1 -1.6 1.0
Back pain experienced in last month 1.3 1.8 2.5 1.3 1.6 1.6 0.8 -1.4
Mineral and other dietary supplements 0.6 0.8 2.2 -0.1 0.3 1.5 0.0 -1.2
Breast cancer (self-reported) 0.1 0.1 0.2 -0.2 -0.2 0.0 -0.4 -0.4
Asthma (self-reported) 1.1 2.2 3.0 0.9 1.6 1.7 1.7 -1.2
Osteoporosis (self-reported) 3.5 4.3 8.5 1.0 2.2 2.9 2.2 -1.6
Osteoarthritis (self-reported) 0.5 0.6 2.7 1.6 0.2 -0.4 0.1 0.0
Medication: Aspirin 0.4 0.6 1.3 0.8 1.1 0.7 0.6 -0.1
Medication: Gliclazide 0.2 0.2 0.5 0.7 -0.2 -0.2 -0.6 0.0
Illnesses of father: None of the above (group 1) 0.2 0.3 1.0 -0.4 1.0 0.2 0.4 -0.2
Smoking status: Current 0.6 1.0 3.6 1.9 -1.1 -0.2 -0.2 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.5 3.1 5.0 1.2 1.5 2.2 2.1 -1.7
Whole body water mass 2.9 16.5 26.1 -1.8 -5.1 -4.8 -3.4 4.3
Leg predicted mass (right) 4.2 22.2 35.2 -2.1 -5.9 -5.5 -4.2 4.8
Arm fat mass (left) 1.5 6.1 9.8 -1.2 -3.1 -3.1 -2.0 2.5
Number of self-reported non-cancer illnesses 2.1 3.6 6.3 1.9 1.8 2.5 1.6 -1.5
Average weekly champagne plus white wine intake 0.5 0.6 1.7 -0.5 -0.6 -1.3 -0.5 0.8
Miserableness 0.5 0.9 3.4 1.8 0.1 0.9 -0.5 0.2
Guilty feelings 0.3 0.5 1.0 -0.4 -0.6 -0.4 -0.8 1.0
Wears glasses or contact lenses 0.2 0.3 1.0 1.0 0.4 0.1 -0.3 0.0
Ever taken oral contraceptive pill 0.4 0.4 1.2 -0.5 0.3 1.1 0.5 -0.7
Hearing aid user 0.6 0.7 2.7 1.6 0.1 0.6 0.6 0.3
Mother’s age at death 0.6 0.8 2.0 -1.4 -0.8 -0.8 -0.5 0.3
Financial situation satisfaction 0.4 0.4 1.0 -0.6 0.6 -0.0 -0.7 -1.0
Tinnitus: Yes, now most or all of the time 0.6 0.8 1.4 -0.9 0.8 0.2 1.2 -0.9
Commuting to job workplace: Public transport 0.9 1.1 3.7 1.9 0.7 1.1 -0.0 -0.3
Eye problems/disorders: Glaucoma 1.1 1.3 2.5 0.8 1.1 1.6 1.1 -0.9
Medication: Blood pressure 3.1 6.0 9.4 0.9 3.1 3.0 2.2 -2.5
Pain type(s) experienced in last month: Hip pain 0.4 0.5 0.9 -0.1 0.5 0.9 0.9 -0.7
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.2 -0.8 -0.7 -1.5 -0.2 0.8
High cholesterol (Self-reported) 6.8 12.1 17.1 1.8 4.1 4.1 3.3 -3.4
Medication: Bendroflumethiazide 0.6 0.8 3.2 -1.8 0.5 0.2 0.8 -0.3
Medication: Paracetamol 0.1 0.1 0.2 -0.4 0.2 -0.0 0.5 0.0
Medication: Lisinopril 1.0 1.3 2.5 1.2 1.6 0.9 0.9 -0.9
Medication: Atorvastatin 2.0 2.5 4.3 0.8 1.5 2.1 1.7 -1.5
Illnesses of father: High blood pressure 0.2 0.2 0.4 0.2 -0.6 0.4 0.7 0.3
Alcohol drinker status: Never 0.2 0.3 0.7 0.2 -0.5 -0.8 -0.6 0.2
Ever smoked 2.1 3.6 5.2 -1.4 -2.2 -2.3 -2.1 1.4
Basal metabolic rate 2.9 16.1 25.9 -1.8 -5.1 -4.7 -3.4 4.2
Leg fat percentage (left) 0.0 0.1 0.3 -0.1 -0.3 -0.3 0.5 -0.2
Arm fat-free mass (left) 1.9 9.7 17.9 -1.0 -4.2 -3.7 -2.3 3.2
Number of operations (self-reported) 0.2 0.3 1.1 0.3 0.2 1.0 0.5 0.0
Average weekly beer plus cider intake 1.2 1.8 2.8 1.2 0.8 1.2 1.6 -1.7
Irritability 0.1 0.1 0.2 0.2 0.4 0.4 -0.4 -0.1
Risk taking 2.6 3.9 6.2 0.0 -2.5 -2.5 -1.8 2.0
Ever had prostate specific antigen (PSA) test 1.9 2.1 3.7 -1.0 -1.4 -1.9 -1.1 1.7
Fractured/broken bones in last 5 years 1.1 1.4 2.5 1.2 1.6 1.3 1.0 -0.7
Age started oral contraceptive pill 1.1 1.3 2.5 -0.9 1.6 0.8 1.4 -1.0
Diastolic blood pressure, automated reading 1.5 4.6 8.7 2.5 1.6 3.0 2.0 -1.3
Ever depressed for a whole week 0.5 0.6 1.5 -0.5 -0.4 -0.4 -1.2 0.9
Unable to work because of sickness or disability 0.6 0.8 1.6 1.1 0.4 0.9 1.3 -0.4
Commuting to job workplace: Cycle 1.6 1.9 7.4 -2.7 -0.5 -1.3 0.3 0.1
Myopia 0.1 0.2 0.4 0.6 0.4 0.2 -0.2 -0.4
Vascular/heart problems diagnosed by doctor 1.8 5.0 7.8 -1.3 -2.3 -2.8 -2.3 2.2
Cholesterol lowering medication 14.6 21.5 26.7 2.2 5.2 5.1 5.0 -5.0
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 2.0 1.4 -0.1 1.0 0.2 0.3
Pain experienced in last month 0.3 0.4 0.7 -0.8 -0.7 -0.5 -0.8 0.3
Supplements: Calcium 0.2 0.3 0.5 0.4 0.6 -0.3 -0.5 0.7
Basal cell carcinoma (self-reported) 0.4 0.5 0.7 -0.8 0.8 0.4 0.6 -0.8
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.0 -0.7 -1.0 0.3 -0.6 1.0
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 3.3 -1.8 -0.5 -0.8 -1.0 0.3
Heart disease (siblings) 0.2 0.3 1.0 -1.0 -0.1 0.6 -0.2 -0.3
Alcohol drinker status: Previous 1.1 1.3 2.8 -0.4 1.7 0.9 0.9 -1.3
Pack years of smoking 1.4 2.1 5.8 2.4 0.4 1.3 1.4 -0.9
Impedance of whole body 1.3 6.8 15.0 -0.0 3.9 3.5 1.7 -1.9
Leg fat mass (left) 0.5 1.8 3.6 -0.8 -1.9 -1.7 -0.6 1.1
Arm predicted mass (left) 2.0 10.3 17.5 -1.4 -4.2 -3.9 -2.4 3.3