Best TWAS P=8.22e-11 · Best GWAS P=2.42e-10 conditioned to 0.384
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | DOCK7 | 0.14 | 0.08 | lasso | 4 | 0.09 | 1.2e-05 | -6.2 | 6.5 | 8.2e-11 | -0.92 | 0.04 | 0.95 | TRUE |
| 2 | GTEx | Artery Tibial | DOCK7 | 0.07 | 0.07 | enet | 20 | 0.07 | 3.5e-06 | -6.3 | 6.0 | 2.0e-09 | -0.98 | 0.04 | 0.96 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | DOCK7 | 0.23 | 0.21 | lasso | 5 | 0.28 | 4.9e-21 | -5.3 | 5.5 | 3.1e-08 | -0.95 | 0.13 | 0.87 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | DOCK7 | 0.17 | 0.01 | lasso | 2 | 0.00 | 2.5e-01 | -6.1 | 6.1 | 8.5e-10 | -0.99 | 0.06 | 0.63 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | DOCK7 | 0.09 | 0.10 | lasso | 3 | 0.10 | 2.7e-08 | -6.1 | 6.2 | 7.7e-10 | -1.00 | 0.06 | 0.94 | FALSE |
| 6 | GTEx | Whole Blood | DOCK7 | 0.06 | 0.00 | lasso | 6 | 0.00 | 1.6e-01 | -5.3 | 5.7 | 9.5e-09 | -0.98 | 0.06 | 0.88 | FALSE |
| 7 | GTEx | Whole Blood | USP1 | 0.05 | 0.02 | lasso | 1 | 0.02 | 1.0e-02 | -6.3 | 6.3 | 3.5e-10 | -1.00 | 0.04 | 0.92 | FALSE |
| 8 | NTR | Blood | DOCK7 | 0.02 | 0.00 | blup | 647 | 0.01 | 1.5e-03 | -6.2 | 5.5 | 4.1e-08 | -0.84 | 0.05 | 0.94 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | DOCK7 | 0.06 | 0.06 | lasso | 6 | 0.06 | 3.7e-08 | -6.1 | -5.6 | 2.0e-08 | 0.93 | 0.05 | 0.95 | FALSE |
| 10 | YFS | Blood | DOCK7 | 0.05 | 0.04 | lasso | 8 | 0.05 | 1.3e-14 | -6.1 | 6.0 | 1.8e-09 | -0.97 | 0.04 | 0.96 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DOCK7 | 0.01 | 0.01 | blup | 85 | 0.01 | 1.1e-03 | -6.2 | 6.2 | 6.0e-10 | -0.99 | 0.05 | 0.92 | FALSE |
| 12 | The Cancer Genome Atlas | Colon Adenocarcinoma | DOCK7 | 0.07 | 0.06 | blup | 83 | 0.06 | 2.1e-04 | -6.3 | 6.0 | 2.7e-09 | -0.95 | 0.04 | 0.94 | FALSE |
| 13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DOCK7 | 0.12 | 0.05 | lasso | 8 | 0.07 | 9.2e-09 | -6.2 | 5.2 | 2.0e-07 | -0.90 | 0.07 | 0.93 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ANGPTL3 | 0.04 | 0.04 | lasso | 2 | 0.04 | 3.0e-05 | -6.3 | 6.2 | 4.5e-10 | -0.94 | 0.02 | 0.97 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DOCK7 | 0.04 | 0.01 | enet | 11 | 0.04 | 5.6e-05 | -6.2 | 5.8 | 8.5e-09 | -0.70 | 0.04 | 0.90 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | DOCK7 | 0.06 | 0.07 | blup | 86 | 0.07 | 1.0e-04 | -6.3 | 6.0 | 2.4e-09 | -0.98 | 0.05 | 0.95 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Adenocarcinoma | DOCK7 | 0.04 | 0.01 | enet | 3 | 0.02 | 3.0e-03 | -6.2 | 6.2 | 7.0e-10 | -0.98 | 0.04 | 0.70 | FALSE |
| 18 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | DOCK7 | 0.08 | 0.05 | enet | 29 | 0.10 | 7.8e-05 | -6.3 | 6.1 | 8.1e-10 | -0.91 | 0.05 | 0.94 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | DOCK7 | 0.05 | 0.03 | blup | 86 | 0.02 | 1.6e-03 | -4.3 | 5.9 | 2.9e-09 | -0.94 | 0.07 | 0.89 | FALSE |