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chr1:62,207,254-63,844,736

Best TWAS P=8.22e-11 · Best GWAS P=2.42e-10 conditioned to 0.384

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Aorta	DOCK7	0.14	0.08	lasso	4	0.09	1.2e-05	-6.2	6.5	8.2e-11	-0.92	0.04	0.95	TRUE
7	GTEx	Whole Blood	USP1	0.05	0.02	lasso	1	0.02	1.0e-02	-6.3	6.3	3.5e-10	-1.00	0.04	0.92	FALSE
14	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ANGPTL3	0.04	0.04	lasso	2	0.04	3.0e-05	-6.3	6.2	4.5e-10	-0.94	0.02	0.97	FALSE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	DOCK7	0.01	0.01	blup	85	0.01	1.1e-03	-6.2	6.2	6.0e-10	-0.99	0.05	0.92	FALSE
17	The Cancer Genome Atlas	Lung Adenocarcinoma	DOCK7	0.04	0.01	enet	3	0.02	3.0e-03	-6.2	6.2	7.0e-10	-0.98	0.04	0.70	FALSE
5	GTEx	Skin Sun Exposed Lower leg	DOCK7	0.09	0.10	lasso	3	0.10	2.7e-08	-6.1	6.2	7.7e-10	-1.00	0.06	0.94	FALSE
18	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DOCK7	0.08	0.05	enet	29	0.10	7.8e-05	-6.3	6.1	8.1e-10	-0.91	0.05	0.94	FALSE
4	GTEx	Skin Not Sun Exposed Suprapubic	DOCK7	0.17	0.01	lasso	2	0.00	2.5e-01	-6.1	6.1	8.5e-10	-0.99	0.06	0.63	FALSE
10	YFS	Blood	DOCK7	0.05	0.04	lasso	8	0.05	1.3e-14	-6.1	6.0	1.8e-09	-0.97	0.04	0.96	FALSE
2	GTEx	Artery Tibial	DOCK7	0.07	0.07	enet	20	0.07	3.5e-06	-6.3	6.0	2.0e-09	-0.98	0.04	0.96	FALSE
16	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DOCK7	0.06	0.07	blup	86	0.07	1.0e-04	-6.3	6.0	2.4e-09	-0.98	0.05	0.95	FALSE
12	The Cancer Genome Atlas	Colon Adenocarcinoma	DOCK7	0.07	0.06	blup	83	0.06	2.1e-04	-6.3	6.0	2.7e-09	-0.95	0.04	0.94	FALSE
19	The Cancer Genome Atlas	Thyroid Carcinoma	DOCK7	0.05	0.03	blup	86	0.02	1.6e-03	-4.3	5.9	2.9e-09	-0.94	0.07	0.89	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DOCK7	0.04	0.01	enet	11	0.04	5.6e-05	-6.2	5.8	8.5e-09	-0.70	0.04	0.90	FALSE
6	GTEx	Whole Blood	DOCK7	0.06	0.00	lasso	6	0.00	1.6e-01	-5.3	5.7	9.5e-09	-0.98	0.06	0.88	FALSE
9	ROSMAP	Brain Pre-frontal Cortex	DOCK7	0.06	0.06	lasso	6	0.06	3.7e-08	-6.1	-5.6	2.0e-08	0.93	0.05	0.95	FALSE
3	GTEx	Cells Transformed fibroblasts	DOCK7	0.23	0.21	lasso	5	0.28	4.9e-21	-5.3	5.5	3.1e-08	-0.95	0.13	0.87	FALSE
8	NTR	Blood	DOCK7	0.02	0.00	blup	647	0.01	1.5e-03	-6.2	5.5	4.1e-08	-0.84	0.05	0.94	FALSE
13	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DOCK7	0.12	0.05	lasso	8	0.07	9.2e-09	-6.2	5.2	2.0e-07	-0.90	0.07	0.93	FALSE