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chr1:108,854,166-110,733,794

Best TWAS P=4.36e-32 · Best GWAS P=9.27e-32 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CELSR2	0.03	0.00	lasso	10	0.01	1.5e-02	-8.699	7.0	2.0e-12	-0.63	0.08	0.43	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PSRC1	0.20	0.04	lasso	8	0.13	4.8e-16	2.829	-7.2	4.3e-13	0.59	0.03	0.97	FALSE
3	GTEx	Cells Transformed fibroblasts	GPSM2	0.12	0.00	enet	24	0.01	5.6e-02	-0.009	5.7	9.4e-09	-0.38	0.05	0.44	FALSE
4	GTEx	Esophagus Mucosa	PSRC1	0.18	0.14	lasso	3	0.14	2.4e-09	-11.513	-11.3	1.7e-29	0.95	0.01	0.99	FALSE
5	GTEx	Liver	CELSR2	0.39	0.36	lasso	1	0.35	1.0e-10	-11.513	-11.5	1.1e-30	0.96	0.01	0.99	FALSE
6	GTEx	Liver	ATXN7L2	0.39	0.04	lasso	12	0.21	1.3e-06	-1.518	-7.5	5.4e-14	0.70	0.08	0.79	FALSE
7	GTEx	Muscle Skeletal	CELSR2	0.41	0.31	lasso	4	0.30	2.4e-30	-11.513	-11.4	4.7e-30	0.95	0.02	0.98	FALSE
8	GTEx	Skin Sun Exposed Lower leg	CELSR2	0.18	0.05	lasso	6	0.06	8.1e-06	-9.180	-8.6	5.5e-18	0.72	0.01	0.97	FALSE
9	GTEx	Whole Blood	PSRC1	0.14	0.04	lasso	3	0.03	6.9e-04	-11.646	-11.8	4.4e-32	0.98	0.00	1.00	TRUE
10	ROSMAP	Brain Pre-frontal Cortex	PSRC1	0.33	0.21	bslmm	430	0.26	1.2e-32	-11.513	-9.6	9.0e-22	0.80	0.01	0.99	FALSE
11	ROSMAP	Brain Pre-frontal Cortex	CELSR2	0.25	0.21	lasso	6	0.23	4.9e-29	-11.513	-11.4	6.2e-30	0.96	0.00	1.00	FALSE
12	YFS	Blood	PSRC1	0.25	0.18	enet	32	0.24	1.6e-76	-11.513	-10.1	4.2e-24	0.85	0.00	1.00	FALSE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	PSRC1	0.03	0.00	blup	49	0.02	5.7e-05	-9.180	-8.8	9.5e-19	0.81	0.00	0.97	FALSE
14	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PSRC1	0.14	0.04	enet	13	0.07	2.7e-04	-11.185	-8.2	3.6e-16	0.72	0.01	0.69	FALSE
15	The Cancer Genome Atlas	Colon Adenocarcinoma	CELSR2	0.12	0.00	enet	21	0.04	3.0e-03	-11.646	-6.9	7.0e-12	0.54	0.01	0.65	FALSE
16	The Cancer Genome Atlas	Colon Adenocarcinoma	PSRC1	0.07	0.06	lasso	1	0.04	1.8e-03	-9.180	-9.2	4.3e-20	0.79	0.01	0.86	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PSRC1	0.14	0.05	enet	6	0.08	7.5e-09	1.165	-5.8	5.6e-09	0.50	0.16	0.60	FALSE
18	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSRC1	0.12	0.11	lasso	4	0.09	4.5e-06	-11.423	-11.3	1.6e-29	0.96	0.01	0.99	FALSE
19	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MYBPHL	0.09	0.07	blup	46	0.06	5.7e-04	-0.610	-6.5	6.4e-11	0.55	0.03	0.46	FALSE
20	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PSRC1	0.16	0.20	lasso	3	0.19	3.7e-09	-11.727	-11.5	8.3e-31	0.99	0.00	1.00	FALSE
21	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SORT1	0.23	0.16	lasso	4	0.16	4.6e-08	-11.646	-11.4	6.0e-30	0.93	0.00	1.00	FALSE
22	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PSRC1	0.07	0.03	enet	8	0.05	3.4e-04	-11.185	-8.3	7.5e-17	0.76	0.01	0.92	FALSE
23	The Cancer Genome Atlas	Soft Tissue Sarcoma	PSRC1	0.09	0.00	blup	49	0.02	3.1e-02	-6.951	-8.2	2.2e-16	0.67	0.01	0.37	FALSE
24	The Cancer Genome Atlas	Stomach Adenocarcinoma	CELSR2	0.08	0.00	blup	62	0.02	8.1e-03	-2.052	-6.2	4.3e-10	0.49	0.01	0.23	FALSE
25	The Cancer Genome Atlas	Stomach Adenocarcinoma	PSRC1	0.12	0.03	enet	6	0.08	1.5e-06	-11.513	-9.1	1.5e-19	0.71	0.01	0.97	FALSE
26	The Cancer Genome Atlas	Stomach Adenocarcinoma	SORT1	0.04	0.01	blup	60	0.03	4.4e-03	-11.513	-7.5	6.8e-14	0.66	0.01	0.70	FALSE