TWAS
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Medication for cholesterol
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chr11:99,859,184-101,559,718
Best TWAS P=7.05e-08 · Best GWAS P=1.85e-07 conditioned to 0.634
99.8M
100M
100.2M
100.4M
100.6M
100.8M
101M
101.2M
101.4M
101.6M
0
2
4
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Artery Tibial
TMEM133
0.26
0.25
enet
28
0.27
1.3e-21
5.2
5.4
7.1e-08
0.94
0
1
TRUE
1
GTEx
Artery Tibial
ARHGAP42
0.24
0.24
lasso
4
0.24
2.4e-18
5.2
5.2
2.3e-07
0.98
0
1
FALSE