Best TWAS P=3.29e-09 · Best GWAS P=4.84e-08 conditioned to 0.361
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Hypothalamus | NR1H3 | 0.25 | 0.18 | lasso | 5 | 0.10 | 2.7e-03 | -5.4 | -5.5 | 4.5e-08 | 0.99 | 0.02 | 0.87 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | ACP2 | 0.17 | 0.03 | lasso | 6 | 0.03 | 4.2e-02 | -5.1 | 5.9 | 3.3e-09 | -0.84 | 0.03 | 0.92 | TRUE |
| 3 | GTEx | Esophagus Mucosa | ACP2 | 0.07 | 0.04 | enet | 11 | 0.04 | 6.2e-04 | -4.9 | 5.4 | 5.6e-08 | -0.85 | 0.04 | 0.95 | FALSE |
| 4 | GTEx | Lung | ACP2 | 0.04 | 0.03 | lasso | 2 | 0.04 | 4.3e-04 | -5.1 | 5.6 | 2.2e-08 | -0.95 | 0.03 | 0.95 | FALSE |
| 5 | GTEx | Testis | NR1H3 | 0.10 | 0.10 | lasso | 6 | 0.08 | 2.9e-04 | -5.1 | 5.3 | 9.3e-08 | -0.95 | 0.02 | 0.97 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ACP2 | 0.03 | 0.03 | blup | 44 | 0.04 | 3.5e-05 | -5.1 | 5.5 | 3.8e-08 | -0.95 | 0.01 | 0.98 | FALSE |