Hub : Genes

NR1H3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Hypothalamus	0.2510	0.0860	6.9e-04	0.175	NA	0.047	NA	0.098	6.6e-05	NA	3.0e-02	NA	2.7e-03
2	GTEx	Breast Mammary Tissue (Female)	0.2956	0.1308	2.1e-02	-0.010	NA	-0.002	NA	-0.008	9.5e-01	NA	3.9e-01	NA	7.0e-01
3	GTEx	Nerve Tibial	0.0993	0.0516	2.0e-03	0.004	NA	0.076	NA	0.028	1.6e-01	NA	4.7e-06	NA	4.3e-03
4	GTEx	Testis	0.1020	0.0550	3.8e-03	0.099	NA	0.060	NA	0.076	3.7e-05	NA	1.2e-03	NA	2.9e-04
5	METSIM	Adipose	0.0270	0.0147	7.5e-04	0.034	0.026	0.026	0.027	0.035	5.6e-06	6.3e-05	6.8e-05	5.8e-05	4.7e-06
6	ROSMAP	Brain Pre-frontal Cortex	0.0643	0.0280	1.6e-06	0.007	0.036	0.018	0.036	0.011	4.0e-02	1.5e-05	2.1e-03	1.6e-05	1.1e-02
7	YFS	Blood	0.3370	0.0578	0.0e+00	0.153	0.237	0.237	0.236	0.232	1.3e-47	3.3e-76	3.1e-76	6.6e-76	1.0e-74

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.1	1.8	3.9	1.8	-0.0	1.0	-1.5	-0.3	1.3	-2.0
Bipolar Disorder or Schizophrenia	0.9	2.2	5.5	1.0	1.7	-0.0	-1.2	-2.1	2.3	0.5
Depressed Affect (Nagel 2018)	7.6	15.9	53.0	-2.5	-3.4	3.7	2.8	-7.3	-4.2	-1.4
Depression (Nagel 2018)	3.2	4.7	12.0	0.2	-3.5	3.0	0.2	-2.7	-1.4	-1.8
Intelligence (Savage-Jansen 2018)	3.2	9.8	25.9	3.6	-1.7	5.1	-2.9	0.2	1.6	-4.0
Neuroticism (Nagel 2018)	6.8	16.1	48.1	-2.9	-3.8	3.7	3.1	-6.9	-4.3	-0.6
Schizophrenia (2018)	1.4	2.9	6.0	-0.2	2.2	-0.9	-0.4	-2.5	1.9	2.3
Schizophrenia vs Biploar Disorder	2.1	2.8	9.2	0.0	3.0	-1.5	-0.5	-0.7	1.7	2.1
Worry (Nagel 2018)	4.4	9.3	29.5	-1.3	-2.9	4.1	1.4	-5.4	-2.5	-0.8
Alzheimer’s Disease (in mother)	1.8	2.1	7.3	-1.6	0.3	0.4	1.2	-2.7	0.0	1.8
Alzheimer’s Disease (in father)	0.8	0.9	2.1	1.2	0.7	-0.2	-1.1	0.7	0.8	-1.4
Alzheimer’s Disease (including proxy)	1.7	2.5	13.8	-0.6	-0.4	1.7	0.5	-3.7	-0.4	0.1
Crohns Disease (2017)	0.5	1.1	2.5	0.0	-1.5	-1.0	-0.2	-0.4	-1.3	1.6
Irritable Bowel Disease (IBD)	0.2	0.5	1.1	0.6	-1.0	0.5	-0.7	0.3	-0.7	0.7
Ulcerative Colitis (UC)	0.2	0.3	1.2	0.2	-0.3	1.1	-0.3	0.6	0.1	0.5
Major Depression (MDD)	0.9	1.1	3.5	-0.4	-0.8	1.1	0.8	-1.9	0.3	1.0
Reaction Time	4.2	8.0	20.0	2.1	4.1	-1.9	-2.3	1.3	4.5	1.9
Verbal and Numeric Reasoning (VNR)	4.1	9.8	25.3	3.5	-2.0	5.0	-2.8	0.1	1.6	-4.1
Breast Cancer	2.3	5.4	17.9	-2.5	-0.4	1.9	2.5	-4.2	-1.6	1.1
Ovarian Cancer	1.7	2.3	6.5	1.6	0.1	0.7	-1.4	2.6	0.6	-2.0
Prostate Cancer	1.5	2.1	5.9	-1.0	-2.4	1.9	1.1	-1.4	-1.0	-0.3
Age at First Birth	0.2	0.3	1.1	-0.4	-0.7	-0.1	0.3	-0.7	-1.0	0.1
Bipolar Disorder (2011)	0.3	0.3	0.8	0.5	-0.4	0.8	-0.3	-0.5	0.9	-0.3
Body Mass Index (BMI) (2010)	5.2	7.1	24.9	-2.2	1.3	-5.0	2.1	1.5	0.2	3.4
Coronary Artery Disease (CAD)	0.9	1.1	2.9	-1.3	-0.4	-1.7	1.2	-0.8	-0.4	1.0
Crohns Disease (2012)	0.4	0.7	3.0	0.3	0.1	-1.7	-0.3	0.2	-0.4	1.2
Mean Putamen Volume	1.7	2.0	6.2	-0.5	1.4	-2.5	0.7	-0.6	0.6	2.0
Fasting Glucose	19.4	23.2	48.2	5.5	3.4	-2.3	-5.2	6.9	5.5	-3.1
HbA1C	0.9	1.0	5.0	0.8	0.3	-0.0	-0.6	0.5	-0.8	-2.2
HDL Cholesterol	23.4	39.0	64.1	7.8	2.4	5.3	-8.0	4.6	6.4	-7.2
LDL Cholesterol	2.5	4.0	12.9	-1.3	-3.6	2.2	1.1	-1.1	-2.4	-0.4
Lupus	3.0	4.5	8.4	2.7	-0.4	2.1	-2.7	1.7	1.1	-2.9
Neuroticism (2016)	4.3	6.2	12.7	-0.4	-3.2	3.2	0.8	-3.6	-2.6	-1.6
Primary Biliary Cirrhosis	1.7	2.4	4.7	1.6	1.8	0.6	-2.2	0.5	1.9	-1.6
Rheumatoid Arthritis	0.4	0.6	1.7	-0.5	-0.6	0.2	0.9	1.3	0.0	0.9
Schizophrenia (2014)	1.8	4.0	11.1	1.1	3.3	-0.4	-1.4	-1.6	3.1	1.1
Triglycerides	4.5	7.4	15.1	-3.5	-1.9	0.6	3.9	-2.2	-2.6	2.9
Type 2 Diabetes (T2D) (2012)	1.0	1.2	4.1	0.1	2.0	-1.0	-0.3	0.7	1.3	0.9
Ulcerative Colitis	0.1	0.1	0.4	-0.0	0.0	-0.1	0.4	0.5	-0.1	0.7
Blood Eosinophil Count	0.5	4.1	7.3	-2.4	2.7	-1.5	2.5	-1.8	-1.8	0.7
Blood Platelet Count	2.7	31.7	65.8	6.9	3.8	6.1	-8.1	-1.0	2.2	-7.1
Blood Red Count	0.2	2.1	8.1	-0.6	1.7	-0.1	-0.2	2.8	-0.2	-1.7
Blood White Count	1.9	13.8	22.1	-4.5	3.5	-4.2	4.7	1.3	-3.1	3.5
Heel T-Score	8.9	71.0	116.6	8.3	10.8	-4.5	-10.3	7.8	10.6	-3.5
BMI	5.3	30.8	95.5	-4.3	3.1	-9.8	4.7	2.1	0.9	8.1
Height	3.5	67.8	132.2	10.7	0.7	6.2	-11.5	3.2	7.0	-11.4
Waist Hip Ratio (WHR)	1.6	7.0	10.6	2.9	1.4	3.1	-3.2	1.0	3.0	-3.0
Systolic Blood Pressure	7.3	36.4	116.6	-5.4	-1.8	1.8	5.6	-10.8	-8.5	-0.3
Smoking Status	1.9	4.5	7.7	2.1	2.3	0.9	-2.4	-0.1	2.8	-2.7
Allergy or Eczema	0.6	1.7	6.6	-1.6	0.1	0.1	1.1	-2.6	-0.6	1.0
Cardiovascular Disease	9.2	30.4	64.8	-7.0	0.0	-2.5	6.6	-8.1	-4.7	5.2
Hypothyroidism (self reported)	1.3	3.1	11.3	-0.7	3.4	-3.1	0.2	0.5	-0.4	0.1
Respiratory disease	0.5	1.0	3.9	-0.5	0.2	0.9	0.4	-2.0	-1.2	-0.7
Type 2 Diabetes (T2D) (2018)	1.1	2.1	4.2	-1.0	0.8	-1.6	1.5	1.2	1.6	2.0
Lung FEV1/FVC ratio	0.3	1.3	5.9	-0.9	-2.4	-0.4	0.9	0.8	-0.8	0.4
Lung FVC	0.7	3.5	7.5	2.7	0.5	0.6	-2.6	1.5	0.9	-2.5
Neuroticism	5.1	12.3	37.3	-1.4	-3.6	3.9	1.5	-6.1	-3.7	-1.6
Chronotype (morning person)	5.2	12.0	29.6	-3.6	2.5	-5.1	2.6	-1.7	-0.4	5.4
Hair Pigment	0.9	26.2	45.6	6.7	3.0	3.1	-6.8	3.7	4.8	-6.1
Tanning	0.1	1.5	4.3	0.8	0.9	1.8	-1.3	-2.1	0.5	-0.2
Hand grip strength (left)	1.9	5.1	16.0	2.0	-0.2	2.4	-2.6	-1.4	-1.0	-4.0
Number of treatments/medications taken	2.0	3.7	6.1	-2.0	-2.5	-1.3	1.8	-1.9	-2.4	1.1
Average weekly spirits intake	0.3	0.4	0.9	0.4	0.6	0.5	-0.8	0.2	-1.0	-0.7
Sensitivity / hurt feelings	2.6	4.5	12.0	-2.1	-3.5	0.5	2.2	-1.6	-2.4	1.2
Frequency of depressed mood in last 2 weeks	4.1	5.8	12.2	-0.1	-3.5	3.2	0.3	-3.2	-2.1	-1.8
Hearing difficulty/problems: Yes	0.5	0.8	1.6	1.3	-0.1	1.3	-0.8	0.6	0.7	-0.9
Relative age of first facial hair	0.7	1.4	2.6	1.5	0.5	-0.2	-1.4	0.4	1.6	-1.6
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	3.7	1.6	0.1	-1.7	-1.9	1.2	-0.0	-1.2
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.8	-0.8	-0.5	-1.5	1.1	1.1	-1.7	0.6
Ever had hysterectomy (womb removed)	0.5	0.6	1.7	-0.8	-0.0	0.1	1.0	0.9	-1.3	0.2
Systolic blood pressure, automated reading	4.0	11.6	35.3	-3.0	-1.1	-0.6	3.1	-5.9	-5.1	0.5
Eye problems/disorders: Diabetes related eye disease	3.2	3.5	7.1	-2.0	1.9	-2.7	1.6	0.9	-0.1	2.5
Angina	1.0	1.3	4.1	-1.5	-0.2	-0.8	2.0	-0.8	-1.0	0.6
Medication for hormone replacement therapy	2.6	2.9	4.8	2.0	1.8	0.2	-1.9	2.2	1.8	-1.3
Vitamin and mineral supplements	1.1	1.5	5.4	-1.1	-0.7	0.3	1.4	-2.3	-0.4	1.0
Supplements: Zinc	0.9	1.0	2.0	1.2	1.0	0.0	-1.2	0.9	1.4	-0.7
Medication: Co-codamol	0.0	0.0	0.1	0.0	-0.3	0.1	0.2	0.0	0.2	0.1
Medication: Metformin	2.8	4.0	11.3	-0.3	1.9	-3.4	0.6	2.2	2.1	1.9
Diabetes (father)	1.5	1.9	7.2	-1.2	-0.4	-2.7	0.9	0.2	-1.2	1.4
Diabetes (mother)	0.6	0.8	3.2	0.5	-0.2	-0.2	0.1	1.8	1.2	-0.5
Severe depression (siblings)	0.6	0.7	1.6	1.0	-0.2	0.4	-1.0	-0.8	1.3	0.3
Pack years adult smoking proportion	0.5	0.8	3.0	1.0	0.9	-0.2	-1.0	-0.2	1.7	0.2
Impedance of leg (right)	2.0	9.5	49.5	-0.1	-0.2	7.0	0.9	-3.4	-0.8	-2.1
Leg fat-free mass (left)	1.6	8.7	23.2	2.4	0.8	-4.8	-3.2	3.6	2.9	-0.4
Trunk fat percentage	4.8	19.1	54.0	-3.4	3.3	-7.3	3.8	1.6	1.5	6.2
Hand grip strength (right)	1.1	3.1	10.4	1.0	-0.0	1.5	-1.4	-2.1	-1.2	-3.2
Townsend deprivation index at recruitment	1.1	1.5	3.7	0.9	-1.5	1.1	-1.1	-1.9	0.1	-1.2
Current tobacco smoking	2.3	3.8	10.0	1.7	0.8	2.8	-1.7	-0.8	1.3	-3.2
Average weekly fortified wine intake	1.0	1.2	3.0	1.4	-0.7	0.6	-1.0	1.1	-0.1	-1.7
Maternal smoking around birth	1.9	2.8	5.3	-1.0	2.3	-2.3	0.6	-2.3	-0.1	1.6
Fed-up feelings	4.7	8.6	23.8	-2.2	-2.6	1.5	2.5	-4.9	-3.9	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	3.0	3.9	11.0	0.4	-3.3	2.6	-0.5	-1.9	-1.8	-1.6
Relative age voice broke	1.0	1.5	3.2	1.2	0.6	-1.8	-1.4	0.9	0.8	-1.5
Taking other prescription medications	0.9	1.3	4.5	0.5	1.5	-2.1	-0.9	0.9	0.6	-0.4
Age when periods started (menarche)	3.3	8.0	34.6	0.8	-2.6	5.9	-0.9	-1.9	-1.2	-2.9
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.5	-0.9	-0.2	-0.0	1.2	-0.7	-0.7	0.5
Heel bone mineral density (BMD) T-score, automated (left)	6.3	14.4	24.0	3.7	4.4	-2.6	-4.9	3.5	4.8	-1.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.2	-0.2	0.2	-0.2	0.1	-0.3	-1.1	-0.7
Qualifications: CSEs or equivalent	0.2	0.3	0.8	-0.2	-0.7	-0.9	0.6	0.0	0.1	0.3
Serious illness, injury or assault to yourself	0.4	0.5	1.2	0.6	0.8	-1.0	-0.5	1.1	0.3	-0.4
High blood pressure	15.6	43.5	91.0	-8.0	-2.6	-0.8	8.0	-9.5	-7.2	5.2
Hayfever, allergic rhinitis or eczema	0.8	1.7	7.5	-1.4	0.0	0.5	1.1	-2.7	-0.8	0.7
Multivitamins +/- minerals	0.8	1.0	2.2	0.8	0.3	1.3	-1.1	1.0	-0.8	-1.5
Stomach or abdominal pain in last month	0.4	0.5	1.1	0.8	-1.1	0.5	-0.8	-0.6	0.5	-0.3
Supplements: Glucosamine	1.1	1.5	5.6	1.2	0.8	-0.3	-1.3	2.4	0.9	0.1
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	3.8	0.6	1.2	-0.7	-0.5	1.9	1.3	-1.3
Medication: Atenolol	1.8	2.2	6.8	-1.7	0.5	0.2	1.2	-2.6	-0.9	1.8
Medication: Levothyroxine sodium	1.3	2.3	9.5	-1.3	0.8	-3.1	1.2	0.3	-1.6	0.1
Sitting height	1.9	13.5	32.8	4.8	0.4	1.6	-5.5	-0.7	2.3	-5.7
Chronic bronchitis/emphysema (father)	0.6	0.8	1.6	0.7	1.3	-0.6	-0.9	-0.6	1.2	-0.3
High blood pressure (mother)	4.3	6.0	12.7	-2.7	-2.3	-1.0	2.3	-3.6	-3.2	1.0
Body mass index (BMI)	4.2	18.1	63.0	-3.3	2.0	-7.9	3.4	1.9	0.3	5.8
Impedance of leg (left)	1.7	8.1	40.6	-0.2	0.5	6.4	0.9	-3.3	-0.5	-1.9
Leg predicted mass (left)	1.6	8.6	24.5	2.3	0.8	-4.9	-3.0	3.6	2.8	-0.3
Trunk fat mass	3.3	14.1	49.6	-2.1	3.0	-7.0	2.2	2.0	2.1	4.8
Waist circumference	1.8	6.5	23.5	-1.2	1.3	-4.9	1.3	2.3	1.4	3.1
Number of incorrect matches in round	1.0	1.7	5.1	0.5	1.2	-0.7	-0.8	2.3	1.5	1.2
Past tobacco smoking	0.7	1.3	2.1	-1.2	-1.2	0.6	1.3	-0.2	-1.4	1.4
Alcohol usually taken with meals	0.4	0.6	0.9	-0.8	-0.5	0.5	0.9	0.9	-0.9	-0.8
Nervous feelings	4.9	9.2	21.6	-2.5	-3.8	2.4	2.8	-4.6	-2.8	0.8
Frequency of tenseness / restlessness in last 2 weeks	2.3	3.6	10.7	0.2	-2.0	3.3	-0.1	-2.7	-1.2	-1.3
Hearing difficulty/problems with background noise	3.4	5.5	11.2	-0.6	-2.8	2.9	1.3	-2.5	-3.3	-1.7
Hair/balding pattern: Pattern 2	1.0	1.3	3.4	0.8	0.5	1.9	-1.4	-0.8	0.5	-1.3
Had menopause	1.1	1.3	2.7	1.6	1.0	0.4	-1.4	1.0	1.0	-1.2
Had other major operations	1.1	1.3	5.0	0.6	0.9	2.2	-0.6	1.1	0.7	-0.8
Forced vital capacity (FVC)	4.2	16.2	32.8	5.3	0.4	2.7	-5.7	2.5	2.5	-5.7
Heel bone mineral density (BMD) T-score, automated (right)	7.4	17.0	31.0	4.4	4.4	-1.9	-5.6	4.0	5.0	-2.0
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	4.1	1.6	1.0	-0.2	-2.0	0.9	1.6	-0.7
Qualifications: None of the above	1.3	2.7	7.3	-1.9	0.4	1.0	1.9	-2.7	-0.7	1.8
Financial difficulties in last 2 years	1.1	1.4	2.6	0.4	-1.5	1.4	-0.6	-1.6	-1.4	-0.8
Mouth/teeth dental problems	3.3	5.0	13.2	2.2	-2.0	1.0	-2.4	2.1	-1.4	-3.6
Heart attack	0.2	0.3	0.6	0.3	0.6	0.1	-0.5	0.7	0.5	-0.7
Allergy	0.5	1.0	5.4	0.8	-0.7	0.3	-0.7	2.3	0.3	-0.0
Pain all over the body in last month	0.5	0.5	1.6	0.2	0.5	-1.3	-0.4	0.7	0.5	0.8
Diabetes (self-reported)	1.3	2.0	6.9	-0.9	0.1	-2.6	1.2	1.5	0.8	1.3
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.4	-0.9	0.1	1.2	1.3	-1.5	-1.4	-0.7
Medication: Ramipril	3.0	3.8	12.6	-1.8	-1.2	-1.0	1.7	-3.6	-1.7	1.5
Medication: Simvastatin	1.3	2.0	3.0	-1.7	-0.1	-1.3	1.5	-1.7	-1.6	1.2
Fluid intelligence score	3.5	7.3	18.5	2.8	-1.6	4.3	-2.5	-0.2	1.7	-3.6
Illnesses of siblings	3.1	4.3	8.0	1.8	-1.7	1.7	-2.4	2.7	0.4	-2.8
Neuroticism score	4.9	10.2	30.0	-1.2	-3.5	3.5	1.2	-5.5	-3.3	-1.8
Weight	1.5	7.2	29.9	0.4	1.7	-5.5	-0.8	2.7	2.6	1.7
Impedance of arm (right)	0.3	1.2	2.6	-0.8	1.6	0.8	1.0	-0.3	1.0	1.6
Arm fat percentage (right)	6.5	25.5	72.1	-4.2	3.4	-8.5	4.4	1.9	0.9	7.3
Trunk fat-free mass	2.3	13.2	33.1	4.8	-0.2	-0.3	-5.8	2.9	3.3	-4.1
Hip circumference	2.4	10.2	37.4	-2.5	-0.3	-6.1	2.8	1.7	-0.3	4.1
Time employed in main current job	1.0	1.2	2.7	1.4	0.8	0.6	-1.3	1.0	1.6	0.4
Alcohol intake versus 10 years previously	1.4	2.1	6.4	-1.3	1.2	-1.4	1.0	0.9	1.1	2.5
Father’s age at death	1.6	2.2	4.6	-1.3	-2.1	1.3	1.9	-1.0	-1.5	0.8
Worrier / anxious feelings	1.1	2.0	8.2	-0.8	-1.3	1.6	0.6	-2.9	-0.6	0.2
Frequency of tiredness / lethargy in last 2 weeks	2.8	4.6	15.5	0.2	-3.9	2.9	-0.1	-1.6	-1.9	-1.5
Falls in the last year	0.6	0.9	1.6	1.2	0.1	0.5	-1.2	-1.2	-0.3	-1.1
Hair/balding pattern: Pattern 3	3.9	5.8	13.8	-2.9	-1.4	-1.8	3.3	-0.9	-1.4	3.7
Number of live births	0.9	1.2	6.0	-0.4	2.5	-1.0	0.3	-1.1	0.2	0.3
Forced expiratory volume in 1-second (FEV1)	2.6	8.7	19.9	3.7	-0.9	2.0	-4.0	2.2	1.1	-4.5
Pulse rate	2.9	4.8	10.3	2.7	0.6	-1.0	-2.6	3.2	1.4	-2.4
Happiness	0.4	0.4	1.0	0.2	-0.8	0.1	0.1	-1.0	-0.8	-0.8
Noisy workplace	0.7	0.8	2.6	-0.2	1.6	-1.0	-0.5	-1.1	0.3	0.7
Qualifications: A levels/AS levels or equivalent	0.8	1.8	5.5	0.8	-2.3	2.0	-0.5	1.0	-0.4	-1.0
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	4.4	-0.5	-2.1	1.0	0.4	-1.5	-1.2	0.6
Mouth/teeth dental problems: Dentures	0.9	1.5	4.1	1.2	1.5	1.2	-0.9	0.4	2.0	-0.7
Asthma	1.0	2.0	5.6	-0.7	-1.1	0.5	1.1	-2.4	-2.0	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.9	0.1	-0.1	1.4	0.3	1.0	-0.1	-1.2
Medication: Cholesterol lowering	0.8	1.3	2.9	-1.2	0.9	-1.7	1.1	-1.3	-0.1	1.2
Depression (self-reported)	1.0	1.2	2.9	1.5	-0.6	0.7	-1.5	-0.7	0.1	-1.7
Medication: Lansoprazole	0.3	0.4	0.9	-0.5	-0.9	0.3	0.9	-0.7	-0.0	0.1
Prospective memory result	2.8	3.4	11.7	-1.3	0.9	-2.6	1.1	-1.1	-0.1	3.4
Lung cancer (father)	2.1	2.5	5.6	1.7	0.4	2.4	-1.9	-0.5	1.9	-1.1
Illnesses of mother	1.8	2.2	9.1	1.5	0.5	0.1	-1.3	3.0	1.3	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	3.4	10.8	20.8	4.2	-0.9	2.2	-4.6	2.8	1.9	-4.5
Pulse wave Arterial Stiffness index	0.2	0.2	0.3	0.2	0.5	0.3	-0.4	-0.3	-0.5	-0.6
Impedance of arm (left)	0.3	1.3	3.4	-0.8	1.8	0.3	1.1	-0.1	1.1	1.6
Arm fat mass (right)	4.0	16.3	59.9	-2.6	2.7	-7.7	2.5	2.3	1.3	5.2
Trunk predicted mass	2.3	13.1	32.6	4.8	-0.1	-0.4	-5.7	2.9	3.3	-4.1
Standing height	3.6	36.1	74.3	7.7	0.2	4.5	-8.6	2.0	5.2	-8.3
Length of working week for main job	1.8	2.0	4.7	2.2	0.5	-0.1	-1.8	1.7	1.4	-1.1
Exposure to tobacco smoke at home	2.8	3.1	6.5	-2.5	-0.9	-0.7	2.1	-1.6	-1.0	2.5
Breastfed as a baby	4.4	5.5	12.7	3.4	-0.2	0.6	-3.6	1.4	1.6	-3.0
Tense / ‘highly strung’	2.3	3.7	13.7	-1.7	-1.0	0.9	1.7	-3.7	-2.1	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	4.3	0.5	-1.4	0.9	-0.1	-2.1	0.4	-0.4
Hair/balding pattern: Pattern 4	0.9	2.1	5.9	-1.4	-0.1	-2.4	2.1	-0.1	-1.5	-0.2
Birth weight of first child	1.8	3.3	8.7	2.0	0.1	0.8	-2.2	2.9	1.1	-2.0
Peak expiratory flow (PEF)	1.5	3.4	10.4	1.9	-1.3	1.2	-2.5	0.6	0.1	-3.2
Pulse wave reflection index	1.2	1.5	2.8	-1.7	0.3	-0.0	1.4	-1.5	-1.3	1.3
Ever highly irritable/argumentative for 2 days	1.6	1.9	4.1	1.7	0.9	-0.5	-1.7	1.3	1.0	-2.0
Loud music exposure frequency	2.8	3.0	7.5	-2.0	0.7	-2.4	1.8	-0.2	-0.3	2.7
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.8	0.4	-0.8	0.9	-0.3	0.8	0.1	-0.6
Mouth/teeth dental problems: Bleeding gums	9.1	11.8	31.5	-4.1	0.6	-2.3	4.1	-3.4	-0.4	5.6
Blood clot in the leg (DVT)	4.1	5.3	12.4	1.9	3.4	-0.2	-1.5	2.1	3.5	-1.6
Medication: Paracetamol	0.2	0.4	1.8	0.2	0.2	0.3	-0.5	1.3	-0.0	-0.6
Headache pain in last month	0.9	1.5	7.0	-0.4	-1.1	2.6	0.2	-1.2	-0.4	-0.8
Medication for cholesterol, blood pressure or diabetes	3.0	5.0	11.8	2.6	0.6	1.5	-2.6	3.4	2.0	-1.8
Glaucoma (self-reported)	4.1	4.8	9.8	2.7	-0.1	1.7	-2.6	1.7	2.0	-3.1
Gout (self-reported)	0.6	0.8	3.6	-0.8	-0.8	-0.1	0.6	-1.9	-0.6	0.2
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	8.1	-1.6	1.8	-2.8	1.4	-0.8	-1.4	0.5
Medication: Amlodipine	4.3	6.1	13.8	-2.8	-0.7	-0.9	2.6	-3.7	-2.4	2.7
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.6	0.5	1.3	0.6	-0.4	-0.0	0.5	-0.8
Birth weight	2.1	4.5	9.8	2.2	-0.4	2.6	-3.0	-0.9	0.3	-3.1
Chronic bronchitis/emphysema (mother)	1.2	1.3	6.0	1.0	2.4	-0.5	-0.9	0.1	1.2	-0.3
High blood pressure (siblings)	5.4	7.9	20.4	-3.2	0.9	-1.5	2.9	-4.5	-2.4	2.6
Forced vital capacity (FVC), Best measure	4.7	17.1	36.1	5.6	0.4	2.5	-6.0	2.6	3.1	-5.4
Body fat percentage	5.0	19.8	51.7	-3.8	3.1	-7.2	4.3	1.1	1.0	6.5
Leg fat percentage (right)	4.2	15.1	35.2	-4.2	2.0	-5.1	4.8	-0.2	-0.2	5.9
Arm fat-free mass (right)	1.5	7.9	17.3	3.6	0.5	-1.1	-4.2	2.4	2.7	-3.2
Exposure to tobacco smoke outside home	1.2	1.6	4.0	-1.3	-1.2	-0.2	1.8	-0.9	-0.5	2.0
Comparative body size at age 10	5.6	15.5	59.4	-1.9	3.6	-7.7	1.5	2.5	0.7	4.8
Number of full brothers	0.4	0.5	1.7	-0.2	0.3	-1.1	0.4	-1.3	0.0	0.2
Worry too long after embarrassment	0.7	1.1	3.6	-0.2	-0.9	0.8	-0.1	-1.9	-1.4	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.1	1.4	-0.2	0.5	-1.4	-0.0	0.5	-0.8
Wheeze or whistling in the chest in last year	0.7	1.3	6.3	0.2	2.5	0.2	-0.2	-0.8	0.7	-1.2
Number of children fathered	1.4	1.6	3.3	-0.4	1.7	-1.8	0.3	1.0	1.5	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	2.0	0.3	-0.4	-1.4	-0.3	-0.4	0.1	0.4
Age at first live birth	0.8	1.4	3.6	1.0	-1.0	0.6	-1.0	1.9	-1.1	-1.3
Pulse wave peak to peak time	0.1	0.1	0.6	0.1	-0.5	0.2	-0.0	0.1	0.8	0.0
Health satisfaction	0.4	0.5	2.6	-0.4	-0.2	-0.4	0.4	-1.6	-0.5	-0.2
Shortness of breath walking on level ground	0.1	0.1	0.4	-0.1	-0.4	0.1	0.6	-0.3	-0.1	0.4
Qualifications: College or University degree	0.4	1.4	3.5	0.9	-0.8	-0.4	-0.8	1.6	-1.1	-1.9
Eye problems/disorders: None of the above	0.9	1.1	2.7	-0.2	-1.3	1.6	0.3	-1.1	-0.9	-1.1
Mouth/teeth dental problems: Loose teeth	0.6	0.8	1.9	-0.5	1.2	-0.4	0.6	-1.4	0.7	0.8
Emphysema/chronic bronchitis	0.4	0.5	1.3	0.2	1.1	-0.6	-0.4	-0.8	0.9	0.1
Medication for pain relief, constipation, heartburn	0.9	1.5	4.0	2.0	0.4	0.5	-1.9	0.6	0.6	-1.3
Neck or shoulder pain in last month	1.4	2.0	7.7	0.9	-0.4	1.9	-1.3	0.3	-0.6	-2.8
Medication: Blood pressure	7.1	12.5	28.7	-4.0	-1.7	-1.9	3.9	-5.4	-4.0	2.1
Angina (self-reported)	0.7	0.9	2.9	-1.3	-0.1	-0.7	1.7	-0.5	-0.9	0.4
Migraine (self-reported)	4.9	6.1	16.3	2.9	-0.3	2.7	-3.1	1.1	0.6	-4.0
Medication: Ibuprofen	0.3	0.4	1.6	-0.2	-0.7	0.3	0.5	1.3	-0.2	-0.6
Medication: Allopurinol	1.5	2.0	4.4	-1.4	-2.1	-0.7	1.1	-1.6	-1.8	0.4
Medication: Omeprazole	0.3	0.4	1.5	0.3	-0.6	-0.6	-0.5	1.2	0.2	-0.0
Medication: Seretide 50 evohaler	0.4	0.4	0.9	0.7	0.4	-0.6	-0.6	-0.5	1.0	0.5
Mean time to correctly identify matches	4.1	7.8	22.2	2.2	3.8	-1.8	-2.3	1.2	4.7	2.0
Heart disease (mother)	1.4	1.7	4.7	-1.1	1.2	-0.4	0.8	-2.2	-0.8	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.0	-1.2	0.6	-0.6	1.4	-1.2	-1.4	-0.7
Whole body fat mass	3.2	13.4	47.1	-2.3	2.7	-6.9	2.4	1.7	1.6	4.7
Leg fat mass (right)	2.8	10.7	36.4	-2.3	2.2	-6.0	2.5	1.4	1.0	4.4
Arm predicted mass (right)	1.6	8.2	17.7	3.7	0.6	-1.4	-4.2	2.5	2.9	-3.0
Pulse rate, automated reading	3.1	9.9	19.0	4.0	0.3	-1.2	-3.8	4.4	3.0	-3.0
Alcohol intake frequency.	2.0	4.8	11.5	-0.1	3.2	-2.3	-0.1	3.4	2.2	1.3
Comparative height size at age 10	3.8	21.0	46.8	5.8	2.3	1.8	-6.8	2.3	4.5	-5.6
Number of full sisters	0.3	0.3	0.8	-0.9	0.5	-0.1	0.6	-0.2	-0.4	0.7
Suffer from ‘nerves’	7.9	12.4	29.7	1.2	-4.0	5.5	-0.8	-4.1	-2.0	-4.2
Overall health rating	0.5	1.2	3.3	0.4	-0.2	0.0	-0.6	-1.8	-1.1	-1.8
Chest pain or discomfort	2.4	3.4	8.6	1.6	0.8	2.9	-1.1	-1.9	1.0	-2.5
Had major operations	0.5	0.5	1.5	0.2	-1.2	0.7	0.1	-0.3	-0.8	-0.9
Age at last live birth	1.4	2.0	6.9	1.2	-0.8	1.4	-1.5	0.4	-0.7	-2.6
Family relationship satisfaction	0.7	0.8	1.4	0.9	1.1	0.6	-0.9	-0.8	0.6	-1.2
Leg pain on walking	0.8	1.0	2.6	0.9	0.8	1.2	-0.7	-0.9	-0.4	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.5	0.2	0.1	-0.2	-0.7	1.6	1.6	0.5
Commuting to job workplace: Car/motor vehicle	1.8	2.1	3.7	1.4	1.7	-0.2	-1.5	1.9	1.8	-0.7
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.9	-0.1	1.4	-0.2	0.4	1.7	0.7	0.3
Medication: Aspirin	1.1	1.5	4.1	-1.2	0.5	-1.1	1.4	-2.0	-0.9	0.8
Supplements: Vitamin C	0.8	0.9	1.2	1.1	1.1	0.2	-1.0	1.0	1.0	-0.8
Knee pain experienced in last month	2.1	3.3	5.7	2.4	-1.4	2.3	-2.2	0.1	1.8	-1.5
Hypertension (Self-reported)	14.7	40.8	86.5	-7.7	-2.4	-1.4	7.7	-9.3	-6.7	5.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.4	9.4	1.3	-1.3	3.1	-0.8	-0.6	1.3	-1.2
Illnesses of father: Heart disease	0.4	0.6	1.8	-0.1	-0.7	-1.2	0.3	-1.4	-0.4	0.3
Illnesses of siblings: Diabetes	1.8	2.2	6.0	-0.9	0.2	-2.5	1.6	1.1	0.7	2.1
Smoking status: Previous	0.6	0.8	2.5	0.5	0.8	-1.6	-0.7	0.8	1.2	0.2
Forced expiratory volume in 1-second (FEV1), predicted	4.4	9.1	21.3	3.8	-0.1	1.0	-4.6	1.8	1.7	-4.6
Whole body fat-free mass	1.7	9.9	22.5	3.8	0.2	-2.2	-4.7	3.2	3.1	-2.7
Leg fat-free mass (right)	1.8	9.4	25.3	2.5	0.9	-5.0	-3.3	3.6	2.9	-0.6
Arm fat percentage (left)	6.9	27.7	80.5	-4.4	3.3	-9.0	4.7	2.0	0.7	7.5
Average weekly red wine intake	0.5	0.8	2.1	-0.3	-1.2	-1.5	0.3	0.8	-1.0	-0.6
Handedness (chirality/laterality): Left-handed	0.4	0.4	0.9	-0.5	-1.0	-0.8	0.8	-0.2	0.3	0.7
Mood swings	7.2	13.1	45.9	-3.0	-2.9	2.9	2.7	-6.8	-3.6	0.2
Loneliness, isolation	3.8	5.3	13.7	0.5	-2.7	3.7	-0.3	-3.4	-1.0	-1.8
Long-standing illness, disability or infirmity	1.1	1.7	4.0	1.8	1.2	-0.6	-2.0	-0.5	1.0	-1.4
Ever had bowel cancer screening	1.2	1.4	4.7	0.3	0.5	-0.7	-0.0	2.2	2.0	0.8
Diabetes diagnosed by doctor	1.5	2.4	6.9	0.2	0.9	-2.6	0.1	2.5	1.6	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.5	-0.1	0.0	1.2	0.2	0.0	0.6	-0.4
Friendships satisfaction	2.0	2.5	8.0	2.0	0.5	0.9	-2.0	-0.3	0.5	-2.8
Qualifications: nursing, teaching	0.5	0.7	2.3	-0.4	-0.3	-1.5	0.5	-0.2	-1.3	0.7
Commuting to job workplace: Walk	0.8	0.8	2.4	-0.5	-0.7	1.1	0.9	-1.6	-0.6	0.2
Eye problems/disorders: Cataract	1.1	1.2	3.7	0.5	1.4	-1.9	-0.5	1.1	0.8	0.7
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	5.0	-0.7	0.9	-1.3	0.8	-0.4	0.0	2.2
Medication for cholesterol	3.7	5.6	9.6	3.1	0.0	1.3	-3.0	2.5	1.6	-3.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.2	3.7	12.7	-1.4	0.6	-3.6	1.3	0.2	0.8	3.0
Back pain experienced in last month	1.8	2.6	7.9	-0.6	-1.3	2.8	0.3	-0.8	-2.4	-1.2
Mineral and other dietary supplements	0.4	0.5	2.8	0.2	-0.5	-0.3	-0.0	-1.7	0.7	0.0
Breast cancer (self-reported)	0.1	0.1	0.2	0.2	0.3	-0.3	-0.5	0.5	-0.2	0.3
Asthma (self-reported)	0.9	1.8	5.7	-0.6	-0.8	0.7	0.8	-2.4	-1.9	-1.0
Osteoporosis (self-reported)	0.8	1.0	2.7	-0.2	-1.2	1.6	0.2	-0.3	-1.6	-0.5
Osteoarthritis (self-reported)	0.5	0.7	1.7	0.6	-1.2	0.6	-0.8	0.3	-0.5	-1.3
Medication: Aspirin	1.1	1.5	3.1	-1.3	0.5	-1.6	1.2	-1.8	-0.7	1.0
Medication: Gliclazide	2.0	2.3	4.6	0.7	1.8	-2.1	-0.5	1.9	1.8	0.6
Illnesses of father: None of the above (group 1)	2.1	2.6	5.4	1.5	1.4	1.4	-1.4	2.1	2.3	-0.4
Smoking status: Current	2.1	3.4	8.7	1.5	0.7	2.6	-1.5	-1.1	1.4	-2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.8	-0.1	0.4	-0.8	0.1	1.3	0.3	0.3
Whole body water mass	1.8	10.2	22.8	3.9	0.3	-2.2	-4.8	3.3	3.2	-2.8
Leg predicted mass (right)	1.7	9.2	24.9	2.5	0.9	-5.0	-3.3	3.6	2.9	-0.6
Arm fat mass (left)	3.8	15.8	58.7	-2.2	3.0	-7.7	2.2	2.6	1.6	4.9
Number of self-reported non-cancer illnesses	1.4	2.4	7.1	-0.8	-1.0	0.7	0.8	-2.7	-2.4	-1.3
Average weekly champagne plus white wine intake	0.9	1.2	2.8	-0.3	0.5	1.7	0.5	-1.3	1.6	0.9
Miserableness	10.0	17.2	44.2	-3.1	-4.5	3.6	3.2	-6.7	-4.7	-1.0
Guilty feelings	2.6	3.8	15.5	-1.4	-1.1	1.1	1.4	-3.9	-2.2	-0.6
Wears glasses or contact lenses	0.2	0.2	1.0	0.0	0.4	-1.0	0.1	-0.5	-0.1	0.4
Ever taken oral contraceptive pill	4.5	5.0	9.4	1.9	-3.1	2.3	-2.0	1.9	-0.5	-2.9
Hearing aid user	2.0	2.3	5.9	-1.4	0.6	-2.4	1.5	-0.2	-0.1	2.3
Mother’s age at death	1.4	1.7	4.5	-0.6	-2.0	2.1	0.7	-1.0	-1.0	0.8
Financial situation satisfaction	1.3	1.7	3.8	1.9	-0.1	0.9	-1.8	0.1	0.3	-1.9
Tinnitus: Yes, now most or all of the time	1.3	1.6	4.6	-1.0	0.6	2.1	0.9	-1.9	0.0	0.9
Commuting to job workplace: Public transport	0.5	0.6	2.3	-0.7	-0.4	0.1	0.7	-1.0	-1.5	0.1
Eye problems/disorders: Glaucoma	7.7	9.2	15.2	3.9	1.0	2.0	-3.7	2.6	3.4	-3.4
Medication: Blood pressure	9.3	17.7	29.9	-5.5	-1.1	-1.1	5.3	-5.1	-3.8	4.7
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.8	0.3	-0.8	1.1	-1.1	-0.7	-1.4	-1.2
Supplements: Fish oil (including cod liver oil)	0.8	1.0	4.3	0.0	0.4	-1.6	-0.2	2.1	-0.2	0.4
High cholesterol (Self-reported)	1.4	2.4	7.1	-1.8	1.0	-0.9	1.6	-2.7	-0.9	1.3
Medication: Bendroflumethiazide	8.5	12.8	29.5	-4.4	-1.4	-0.7	4.4	-5.4	-3.9	2.1
Medication: Paracetamol	0.7	1.1	5.9	0.4	0.4	-0.6	-0.7	2.4	0.5	-0.6
Medication: Lisinopril	6.2	8.0	18.0	-3.5	-0.6	-1.0	4.2	-3.7	-2.4	2.1
Medication: Atorvastatin	1.2	1.5	5.2	-1.2	0.0	-2.3	1.2	-0.6	0.2	1.3
Illnesses of father: High blood pressure	4.4	5.5	21.4	-2.2	0.2	-0.3	2.1	-4.6	-2.3	1.5
Alcohol drinker status: Never	1.3	1.5	3.3	-0.9	1.8	-1.0	1.5	1.0	0.9	1.3
Ever smoked	0.9	1.6	5.4	1.4	0.7	0.7	-1.3	-0.7	0.9	-2.3
Basal metabolic rate	1.4	8.0	14.2	3.0	0.7	-3.2	-3.8	3.2	3.1	-1.5
Leg fat percentage (left)	4.6	16.8	37.1	-4.2	2.6	-5.8	4.7	-0.0	-0.0	6.1
Arm fat-free mass (left)	1.4	6.9	16.2	3.4	0.1	-1.2	-4.0	2.3	2.5	-2.8
Number of operations (self-reported)	0.9	1.3	4.3	1.3	0.7	0.6	-0.7	2.1	1.3	-0.1
Average weekly beer plus cider intake	1.5	2.1	4.1	2.0	1.4	0.9	-1.8	-0.9	1.8	-0.8
Irritability	0.4	0.7	2.7	-0.5	-1.2	0.6	0.6	-1.6	-0.3	-0.4
Risk taking	1.5	2.1	5.8	2.0	1.2	0.3	-2.4	1.2	1.4	-0.4
Ever had prostate specific antigen (PSA) test	0.4	0.5	2.1	0.7	-1.4	0.5	-0.1	0.3	-0.6	-0.4
Fractured/broken bones in last 5 years	1.8	2.3	7.0	-0.5	-1.8	2.6	0.7	-1.6	-1.5	-0.2
Age started oral contraceptive pill	0.7	0.9	3.7	-0.4	-0.6	1.9	0.5	-0.4	-0.2	1.2
Diastolic blood pressure, automated reading	3.8	11.8	37.7	-3.6	-0.2	-0.5	3.5	-6.1	-4.4	0.6
Ever depressed for a whole week	0.4	0.5	1.2	0.5	-0.6	-1.1	-0.6	0.6	1.1	-0.3
Unable to work because of sickness or disability	0.7	0.9	2.7	1.3	-0.2	-0.6	-1.6	-0.5	0.6	-1.0
Commuting to job workplace: Cycle	0.8	1.0	2.9	-0.9	-1.5	-0.6	0.6	-0.2	-1.7	0.3
Myopia	3.3	4.7	9.6	3.1	0.6	1.8	-2.9	0.2	2.9	-1.7
Vascular/heart problems diagnosed by doctor	12.6	34.4	70.6	7.2	2.0	0.8	-7.2	8.4	6.2	-4.7
Cholesterol lowering medication	2.8	4.1	8.0	-2.8	0.3	-1.4	2.7	-2.0	-1.4	2.4
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	1.1	0.0	-0.4	-0.5	-0.2	1.0	0.3	0.1
Pain experienced in last month	1.6	2.7	11.4	0.1	2.0	-3.4	-0.2	1.2	1.0	0.9
Supplements: Calcium	2.0	2.2	3.7	1.9	-0.8	1.9	-1.7	1.0	0.3	-1.8
Basal cell carcinoma (self-reported)	1.3	1.6	3.2	-1.3	-0.0	-0.7	0.9	-1.5	-1.8	1.6
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.2	0.6	1.1	0.2	-0.8	0.7	0.8	-1.0
Deep venous thrombosis (DVT) (self-reported)	3.9	5.0	12.7	1.7	3.6	-0.6	-1.5	1.9	3.3	-1.4
Heart disease (siblings)	1.0	1.2	3.8	1.2	1.6	-0.2	-0.8	0.4	2.0	-0.1
Alcohol drinker status: Previous	0.3	0.4	0.9	-0.3	0.6	-0.7	0.3	-0.5	0.9	0.7
Pack years of smoking	0.8	1.2	4.2	1.1	1.2	-0.2	-1.1	-0.0	2.1	0.4
Impedance of whole body	0.6	3.2	13.2	-0.9	1.1	3.6	1.4	-2.2	-0.0	-0.1
Leg fat mass (left)	3.0	11.9	42.2	-2.1	2.7	-6.5	2.2	1.7	1.3	4.4
Arm predicted mass (left)	1.2	6.2	14.3	3.2	0.2	-1.0	-3.8	2.1	2.6	-2.6