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chr15:90,712,555-92,135,418

Best TWAS P=2.52e-20 · Best GWAS P=4.82e-17 conditioned to 0.543

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FURIN	0.12	0.14	lasso	2	0.13	1.2e-15	-6.4	6.4	1.7e-10	0.82	0.95	0.05	FALSE
2	GTEx	Adipose Visceral Omentum	FES	0.21	0.09	lasso	5	0.05	1.3e-03	7.2	-7.3	2.7e-13	-0.68	0.42	0.17	FALSE
3	GTEx	Artery Tibial	FES	0.16	0.04	lasso	5	0.05	4.8e-05	7.0	-7.8	6.7e-15	-0.71	0.26	0.71	FALSE
4	GTEx	Cells Transformed fibroblasts	FES	0.28	0.17	enet	21	0.20	2.8e-15	7.2	-8.4	3.7e-17	-0.87	0.02	0.98	FALSE
5	GTEx	Lung	FES	0.24	0.07	lasso	6	0.05	5.1e-05	7.0	-8.0	1.7e-15	-0.77	0.09	0.90	FALSE
6	GTEx	Skin Sun Exposed Lower leg	FES	0.09	0.04	lasso	5	0.04	1.4e-04	7.2	-6.8	1.4e-11	-0.63	0.13	0.47	FALSE
7	GTEx	Thyroid	FES	0.33	0.19	lasso	6	0.18	4.3e-14	7.2	-7.2	6.5e-13	-0.69	0.96	0.04	FALSE
8	METSIM	Adipose	FES	0.08	0.06	lasso	3	0.05	6.8e-08	6.9	-7.0	2.1e-12	-0.64	0.94	0.06	FALSE
9	YFS	Blood	FES	0.31	0.11	enet	77	0.22	1.2e-68	7.2	-7.0	2.3e-12	-0.66	0.04	0.96	FALSE
10	YFS	Blood	FURIN	0.11	0.03	enet	37	0.06	8.3e-19	-6.4	-5.6	2.2e-08	-0.68	0.00	1.00	FALSE
11	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FES	0.06	0.05	blup	46	0.06	1.9e-05	8.2	-7.3	2.3e-13	-0.80	0.01	0.99	FALSE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	FES	0.06	0.05	blup	46	0.07	7.4e-14	7.2	-9.2	2.5e-20	-0.88	0.01	0.99	TRUE
13	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FES	0.06	0.02	blup	46	0.02	2.4e-02	7.2	-7.4	1.1e-13	-0.76	0.01	0.73	FALSE
14	The Cancer Genome Atlas	Colon Adenocarcinoma	FES	0.08	0.07	blup	46	0.06	3.4e-04	8.4	-8.3	1.2e-16	-0.91	0.00	0.99	FALSE
15	The Cancer Genome Atlas	Glioblastoma Multiforme	FES	0.12	0.06	enet	6	0.06	5.7e-03	8.3	-7.5	4.7e-14	-0.92	0.00	0.92	FALSE
16	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FES	0.06	0.03	blup	46	0.05	5.6e-06	8.3	-7.4	1.0e-13	-0.80	0.01	0.99	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FES	0.10	0.07	enet	5	0.05	2.8e-06	8.3	-8.2	3.3e-16	-0.95	0.00	1.00	FALSE
18	The Cancer Genome Atlas	Lung Adenocarcinoma	FES	0.05	0.04	lasso	2	0.04	2.2e-05	7.2	-8.3	1.4e-16	-0.86	0.01	0.99	FALSE
19	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FES	0.08	0.07	enet	7	0.08	4.2e-09	7.2	-7.9	2.7e-15	-0.79	0.10	0.90	FALSE
20	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FES	0.13	0.16	lasso	2	0.14	6.1e-10	7.2	-7.3	3.2e-13	-0.69	0.54	0.46	FALSE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	FES	0.12	0.09	lasso	5	0.08	4.1e-09	7.2	-8.0	9.9e-16	-0.77	0.20	0.80	FALSE
22	The Cancer Genome Atlas	Stomach Adenocarcinoma	FES	0.04	0.01	blup	46	0.02	1.7e-02	8.2	-7.5	8.7e-14	-0.78	0.01	0.68	FALSE
23	The Cancer Genome Atlas	Testicular Germ Cell Tumors	FES	0.32	0.26	lasso	2	0.25	2.0e-09	7.4	-7.5	9.2e-14	-0.70	0.45	0.54	FALSE
24	The Cancer Genome Atlas	Thyroid Carcinoma	FES	0.30	0.30	lasso	7	0.32	1.3e-31	7.4	-8.3	8.1e-17	-0.83	0.87	0.13	FALSE