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chr16:3,462,595-5,510,848

Best TWAS P=4.96e-11 · Best GWAS P=3.73e-10 conditioned to 0.00128

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Tibial ZNF500 0.19 0.18 lasso 5 0.17 1.8e-13 -5.0 -5.3 8.9e-08 0.92 0.02 0.98 FALSE
2 GTEx Brain Hypothalamus MGRN1 0.28 0.15 lasso 7 0.15 2.8e-04 -5.1 5.1 2.7e-07 -0.89 0.12 0.64 FALSE
3 GTEx Breast Mammary Tissue ZNF500 0.18 0.10 lasso 3 0.10 5.0e-06 -4.7 -5.2 1.8e-07 0.87 0.30 0.70 FALSE
4 GTEx Breast Mammary Tissue (Female) ZNF500 0.14 0.10 lasso 3 0.05 1.7e-02 -5.0 -5.1 2.9e-07 0.84 0.06 0.78 FALSE
5 GTEx Heart Atrial Appendage MGRN1 0.33 0.30 enet 13 0.32 7.1e-15 -4.2 5.8 6.8e-09 -0.71 0.82 0.17 FALSE
6 GTEx Heart Left Ventricle MGRN1 0.32 0.10 enet 18 0.33 3.6e-18 3.2 6.6 5.0e-11 -0.56 0.50 0.49 TRUE
7 GTEx Muscle Skeletal MGRN1 0.16 0.06 lasso 7 0.15 1.1e-14 3.6 6.2 6.0e-10 -0.51 0.83 0.16 FALSE
8 GTEx Spleen MGRN1 0.55 0.45 lasso 3 0.42 4.3e-12 -5.1 5.2 2.5e-07 -0.89 0.13 0.87 FALSE
9 GTEx Testis NUDT16L1 0.38 0.49 enet 16 0.38 5.9e-18 -4.7 -5.3 1.2e-07 0.89 0.27 0.73 FALSE
10 GTEx Thyroid MGRN1 0.30 0.24 enet 32 0.33 6.8e-26 -4.1 5.3 9.7e-08 -0.78 0.85 0.15 FALSE
11 METSIM Adipose NUDT16L1 0.06 0.03 bslmm 392 0.04 2.2e-06 -4.5 -6.0 1.9e-09 0.84 0.01 0.99 FALSE
12 The Cancer Genome Atlas Breast Invasive Carcinoma C16orf71 0.01 0.01 blup 52 0.01 3.1e-03 -5.2 -5.2 2.6e-07 0.88 0.06 0.69 FALSE
13 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma TRAP1 0.11 0.01 blup 43 0.05 9.4e-04 -3.1 5.2 1.7e-07 0.01 0.00 0.01 TRUE