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chr16:71,349,498-72,845,749

Best TWAS P=1.1e-10 · Best GWAS P=3.17e-10 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DHX38	0.31	0.39	enet	41	0.41	3.2e-54	5.4	6.2	6.8e-10	0.73	0.32	0.68	FALSE
2	CommonMind	Brain Pre-frontal Cortex	HPR	0.72	0.60	lasso	7	0.61	6.9e-94	6.3	6.2	5.7e-10	1.00	0.00	1.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	TXNL4B	0.05	0.07	lasso	3	0.06	8.8e-08	6.3	5.5	3.5e-08	0.97	0.00	1.00	FALSE
4	GTEx	Artery Aorta	DHODH	0.21	0.15	enet	15	0.19	1.7e-10	-4.7	5.4	6.0e-08	0.63	0.67	0.33	FALSE
5	GTEx	Esophagus Muscularis	DHX38	0.09	0.07	lasso	7	0.05	4.2e-04	5.1	5.3	9.1e-08	0.69	0.20	0.70	FALSE
6	METSIM	Adipose	DHX38	0.08	0.06	lasso	7	0.09	4.5e-13	-5.9	6.2	6.6e-10	0.54	0.04	0.96	FALSE
7	NTR	Blood	DHX38	0.02	0.01	blup	355	0.02	6.5e-06	-5.1	5.4	6.7e-08	0.45	0.08	0.91	FALSE
8	The Cancer Genome Atlas	Glioblastoma Multiforme	HPR	0.82	0.49	lasso	3	0.47	3.4e-16	6.3	6.4	1.8e-10	1.00	0.00	1.00	FALSE
9	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HP	0.02	0.01	blup	53	0.02	5.9e-03	5.0	-5.7	1.0e-08	-0.56	0.02	0.79	FALSE
10	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HP	0.02	0.00	blup	53	0.02	1.5e-03	5.5	-5.6	1.7e-08	-0.55	0.05	0.86	FALSE
11	The Cancer Genome Atlas	Brain Lower Grade Glioma	DHX38	0.02	0.01	blup	62	0.01	1.7e-02	-5.1	6.0	2.3e-09	0.48	0.02	0.79	TRUE
12	The Cancer Genome Atlas	Brain Lower Grade Glioma	HP	0.60	0.42	lasso	5	0.41	3.8e-50	6.3	6.5	1.1e-10	1.00	0.00	1.00	TRUE
13	The Cancer Genome Atlas	Brain Lower Grade Glioma	HPR	0.75	0.56	lasso	4	0.56	6.1e-76	6.3	6.2	4.3e-10	1.00	0.00	1.00	FALSE
14	The Cancer Genome Atlas	Brain Lower Grade Glioma	TXNL4B	0.44	0.29	lasso	4	0.29	3.2e-33	6.3	6.5	1.1e-10	0.99	0.00	1.00	FALSE
15	The Cancer Genome Atlas	Lung Adenocarcinoma	HP	0.14	0.08	blup	53	0.11	1.4e-12	-6.0	-5.2	1.9e-07	-0.41	0.02	0.98	FALSE
16	The Cancer Genome Atlas	Prostate Adenocarcinoma	HP	0.05	0.04	blup	53	0.04	9.8e-05	5.4	-6.2	6.0e-10	-0.66	0.31	0.66	FALSE