Best TWAS P=5.85e-18 · Best GWAS P=3.56e-51 conditioned to 7.9e-19
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | EPOR | 0.11 | 0.04 | lasso | 7 | 0.04 | 3.8e-04 | -7.4 | -7.1 | 1.6e-12 | 0.48 | 0.52 | 0.38 | TRUE |
| 2 | GTEx | Esophagus Mucosa | SMARCA4 | 0.18 | 0.03 | enet | 15 | 0.09 | 8.2e-07 | -4.0 | 5.6 | 2.7e-08 | -0.36 | 0.95 | 0.00 | FALSE |
| 3 | GTEx | Muscle Skeletal | SLC44A2 | 0.19 | 0.18 | lasso | 5 | 0.19 | 5.1e-18 | -5.6 | -5.5 | 3.1e-08 | 0.21 | 1.00 | 0.00 | TRUE |
| 4 | GTEx | Pancreas | LDLR | 0.19 | -0.01 | enet | 5 | 0.01 | 9.7e-02 | 1.7 | -6.8 | 1.4e-11 | 0.50 | 0.02 | 0.71 | TRUE |
| 5 | NTR | Blood | SMARCA4 | 0.07 | 0.06 | lasso | 11 | 0.06 | 9.0e-18 | -5.9 | 5.8 | 5.4e-09 | -0.38 | 1.00 | 0.00 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | C19orf80 | 0.08 | 0.04 | enet | 17 | 0.05 | 3.1e-07 | 3.8 | 8.6 | 5.8e-18 | -0.41 | 0.65 | 0.33 | TRUE |
| 7 | YFS | Blood | SMARCA4 | 0.02 | 0.01 | enet | 3 | 0.00 | 9.2e-03 | -4.0 | 5.8 | 4.9e-09 | -0.39 | 0.15 | 0.07 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C19orf52 | 0.04 | 0.04 | blup | 27 | 0.03 | 1.7e-04 | -5.5 | 5.4 | 8.6e-08 | -0.37 | 0.00 | 1.00 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SPC24 | 0.06 | 0.00 | enet | 15 | 0.01 | 1.4e-02 | -12.0 | 8.2 | 3.0e-16 | -0.35 | 0.00 | 0.55 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | C19orf52 | 0.05 | 0.06 | lasso | 4 | 0.06 | 2.5e-06 | -4.5 | 5.2 | 2.1e-07 | -0.36 | 0.01 | 0.99 | FALSE |