[Hub]/) : Traits : Medication: Cholesterol lowering : ← →

chr2:26,883,355-28,414,302

Best TWAS P=3.72e-15 · Best GWAS P=4.58e-15 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Esophagus Mucosa AC074117.10 0.12 0.14 lasso 8 0.14 2.1e-09 -5.0 5.2 1.9e-07 0.74 0.94 0.06 FALSE
2 GTEx Esophagus Muscularis NRBP1 0.07 0.04 lasso 6 0.04 1.3e-03 -5.0 6.5 9.9e-11 0.82 0.01 0.97 FALSE
3 GTEx Ovary AC074117.10 0.16 0.04 enet 9 0.05 2.0e-02 -3.8 5.8 5.9e-09 0.77 0.04 0.80 FALSE
4 GTEx Testis NRBP1 0.16 0.09 lasso 3 0.06 1.8e-03 -5.0 6.1 9.5e-10 0.80 0.03 0.96 FALSE
5 GTEx Testis AC074117.10 0.14 0.08 lasso 6 0.12 4.5e-06 -4.0 6.1 1.2e-09 0.85 0.05 0.94 FALSE
6 GTEx Thyroid FNDC4 0.24 0.10 enet 23 0.16 2.2e-12 -2.6 -5.6 2.8e-08 -0.69 0.67 0.33 FALSE
7 The Cancer Genome Atlas Breast Invasive Carcinoma GPN1 0.06 0.02 lasso 6 0.02 7.2e-05 6.5 6.0 1.6e-09 0.54 0.00 0.98 FALSE
8 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma FNDC4 0.13 0.06 lasso 2 0.05 1.1e-03 7.8 -7.9 3.7e-15 -0.99 0.00 0.96 TRUE
9 The Cancer Genome Atlas Skin Cutaneous Melanoma SLC4A1AP 0.17 0.05 blup 26 0.08 4.4e-03 6.5 -5.1 2.8e-07 -0.47 0.01 0.72 FALSE
10 The Cancer Genome Atlas Thyroid Carcinoma FNDC4 0.24 0.09 enet 9 0.17 1.9e-16 -3.0 -5.7 1.1e-08 -0.70 0.41 0.59 FALSE
11 The Cancer Genome Atlas Thyroid Carcinoma GCKR 0.18 0.08 enet 5 0.13 1.7e-12 -2.6 -5.2 2.4e-07 -0.64 0.91 0.09 FALSE