TWAS hub - SLC4A1AP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0850	0.0300	6.5e-07	0.068	0.057	0.055	0.060	0.060	1.0e-08	1.6e-07	2.9e-07	8.8e-08	7.2e-08
2	GTEx	Muscle Skeletal	0.0360	0.0194	5.9e-03	0.016	NA	0.000	NA	0.014	9.2e-03	NA	2.9e-01	NA	1.5e-02
3	GTEx	Skin Sun Exposed Lower leg	0.0420	0.0240	7.5e-03	0.015	NA	0.005	NA	0.015	2.0e-02	NA	1.3e-01	NA	1.7e-02
4	ROSMAP	Brain Pre-frontal Cortex	0.0813	0.0307	6.3e-07	0.083	0.056	0.069	0.063	0.075	8.9e-11	8.6e-08	3.1e-09	1.5e-08	7.4e-10
5	YFS	Blood	0.0626	0.0197	1.5e-08	0.035	0.026	0.041	0.038	0.045	1.2e-11	5.2e-09	2.2e-13	1.8e-12	1.3e-14
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0227	0.0169	5.7e-03	0.026	0.024	0.024	NA	0.028	5.8e-04	8.4e-04	8.4e-04	NA	3.7e-04
7	TCGA	Skin Cutaneous Melanoma	0.1700	0.1090	3.6e-03	0.051	0.077	0.075	NA	0.072	1.7e-02	4.4e-03	4.7e-03	NA	5.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Triglycerides	39.7	65.0	171.6	-3.5	-2.2	-13.1	-0.7	-1.9	-11.2	-11.7
Gout (self-reported)	13.7	18.7	59.8	-2.5	-1.6	-7.7	-0.9	-3.4	-5.1	-5.0
High cholesterol (Self-reported)	12.2	21.6	48.7	-2.6	-2.6	-6.1	-1.4	-1.6	-7.0	-6.9
Had menopause	11.1	13.9	40.1	3.9	3.4	6.3	3.3	1.3	3.4	2.7
Medication: Allopurinol	9.4	12.6	36.0	-2.0	-0.8	-6.0	-0.5	-2.7	-4.4	-4.5
Pain all over the body in last month	8.3	8.9	12.7	-3.2	-3.4	-0.7	-3.6	-3.0	-2.8	-3.2
Medication: Cholesterol lowering	7.8	12.2	26.3	-2.6	-2.4	-3.8	-2.0	-1.6	-5.0	-5.1
Number of operations (self-reported)	7.8	11.5	15.5	-3.5	-3.9	-0.5	-3.8	-3.0	-3.7	-3.9
Medication: Paracetamol	7.6	12.7	20.1	-3.8	-3.4	-2.2	-3.8	-1.7	-4.5	-4.5
Fasting Glucose	7.2	8.6	34.9	-0.2	-0.3	5.9	-1.2	-1.2	3.2	3.4
Bilateral oophorectomy (both ovaries removed)	6.9	8.0	12.0	-2.9	-3.5	-1.8	-2.9	-2.3	-3.0	-3.2
Mouth/teeth dental problems: Bleeding gums	6.9	9.0	14.4	-2.9	-3.0	-1.9	-3.1	-2.2	-3.5	-3.8
Cardiovascular Disease	6.7	22.3	32.2	-4.6	-5.0	-4.6	-3.9	-3.1	-5.7	-5.6
Medication: Atorvastatin	6.7	8.2	19.1	-1.3	-1.1	-4.4	-0.5	0.0	-4.3	-4.0
Ulcerative Colitis	6.2	8.9	17.2	-2.9	-2.7	-2.4	-2.4	-1.4	-4.1	-4.0
Number of self-reported non-cancer illnesses	6.2	10.8	17.9	-2.9	-3.2	-3.0	-2.5	-2.9	-3.9	-4.2
Medication for pain relief, constipation, heartburn	6.0	10.3	15.0	3.4	3.9	2.9	3.1	1.7	3.7	3.4
Blood Platelet Count	5.9	68.7	179.6	-4.3	-3.3	-13.4	-1.8	-1.1	-11.7	-11.4
Alcohol intake frequency.	5.9	13.7	44.9	0.0	-0.6	-6.7	1.1	1.4	-4.8	-5.0
Blood White Count	5.8	42.8	106.1	-4.2	-4.4	-10.3	-2.5	-2.2	-8.7	-8.4
Medication: Paracetamol	5.7	8.8	15.0	-2.9	-2.9	-1.7	-3.1	-1.6	-3.8	-3.9
Number of treatments/medications taken	5.4	9.8	14.2	-3.0	-3.1	-3.8	-2.7	-1.6	-3.6	-3.6
Medication for cholesterol, blood pressure or diabetes	5.1	8.5	14.5	2.9	2.6	2.6	2.5	1.9	3.6	3.8
High blood pressure (siblings)	5.1	7.3	10.8	-2.8	-3.3	-2.1	-2.4	-2.6	-2.8	-2.8
Cholesterol lowering medication	5.0	7.3	14.4	-1.6	-2.1	-3.6	-0.8	-1.4	-3.8	-3.8
Vascular/heart problems diagnosed by doctor	4.9	13.3	17.3	3.9	4.1	2.2	3.8	3.0	3.9	4.2
Diabetes diagnosed by doctor	4.8	7.9	21.0	1.8	0.3	4.6	0.9	1.8	3.6	3.8
Diabetes (self-reported)	4.7	7.2	19.3	1.8	0.6	4.4	1.1	1.5	3.4	3.5
Overall health rating	4.7	10.2	17.1	-2.8	-3.7	-2.5	-3.0	-1.3	-4.1	-4.0
Systolic Blood Pressure	4.6	22.9	30.2	-5.5	-5.5	-3.3	-5.0	-3.2	-5.1	-5.2
High blood pressure	4.6	12.7	16.9	-4.0	-4.0	-2.1	-3.7	-2.7	-3.9	-4.1
Medication: Simvastatin	4.5	6.7	13.6	-1.8	-2.4	-2.4	-1.4	-2.0	-3.5	-3.7
Birth weight of first child	4.5	8.2	15.2	2.9	2.5	1.2	2.8	1.7	3.9	3.9
Primary Biliary Cirrhosis	4.3	6.2	9.9	-2.3	-2.4	-2.2	-2.2	-2.2	-2.8	-3.2
Hypertension (Self-reported)	4.3	12.1	16.5	-4.0	-4.1	-2.2	-3.7	-2.6	-3.6	-3.7
Pain experienced in last month	4.3	7.2	10.1	2.7	3.2	1.8	3.1	2.0	2.7	2.9
Neck or shoulder pain in last month	4.2	6.0	9.4	-2.6	-2.6	-0.0	-3.1	-2.8	-2.2	-2.5
Qualifications: NVQ or HND or HNC or equivalent	4.2	5.1	8.3	-2.4	-2.3	-1.3	-2.4	-1.4	-2.9	-2.6
Lupus	3.9	6.0	9.4	-2.7	-2.0	-2.4	-2.3	-1.0	-3.0	-3.1
Medication: Metformin	3.9	5.5	10.7	1.8	0.3	3.3	0.8	1.6	3.2	3.3
Pulse rate, automated reading	3.9	12.6	28.3	-1.8	-1.4	-5.1	-0.7	-0.9	-5.2	-5.3
Type 2 Diabetes (T2D) (2018)	3.8	7.1	27.2	1.0	-0.5	5.2	-0.3	1.0	3.2	3.2
Angina	3.6	4.7	8.0	-1.6	-2.2	-1.5	-2.1	-2.8	-2.3	-2.5
Eye problems/disorders: Cataract	3.6	4.1	8.4	-1.8	-2.1	-2.9	-1.8	-0.4	-2.2	-2.2
Diabetes (father)	3.4	4.2	9.9	1.5	0.9	2.2	1.6	0.2	3.0	3.1
Medication: Ibuprofen (e.g. Nurofen)	3.3	4.2	5.4	-2.3	-2.0	-2.0	-2.2	-2.2	-1.9	-1.6
Schizophrenia vs Biploar Disorder	3.2	4.2	13.2	1.4	2.4	3.6	1.4	1.3	1.5	1.6
Back pain experienced in last month	3.2	4.6	10.0	-1.9	-3.2	-0.7	-2.7	-0.3	-2.2	-2.4
Systolic blood pressure, automated reading	3.1	9.0	13.5	-3.5	-3.7	-2.1	-3.3	-1.4	-3.1	-3.2
Ever had stillbirth, spontaneous miscarriage or termination	3.1	3.3	5.4	-1.7	-2.0	-1.7	-1.5	-0.8	-2.3	-2.2
Medication for cholesterol	3.1	4.7	9.9	1.7	1.6	2.3	1.1	1.1	3.1	3.1
Irritable Bowel Disease (IBD)	3.0	7.1	17.3	-1.8	-1.4	-4.2	-0.8	-2.1	-3.4	-3.2
Ever used hormone-replacement therapy (HRT)	3.0	3.9	13.4	2.0	0.8	3.7	1.4	0.0	2.1	1.6
Hayfever, allergic rhinitis or eczema	3.0	6.5	18.1	-2.4	-1.9	-4.2	-1.4	-2.1	-2.5	-2.4
Diverticular disease/diverticulitis (self-reported)	2.9	3.5	8.6	-1.9	-2.0	-2.9	-1.7	-1.5	-1.0	-1.3
Vitamin and mineral supplements	2.8	3.8	7.5	1.9	1.6	2.7	1.8	1.2	2.1	2.0
Illnesses of siblings	2.8	4.0	5.5	2.2	2.3	1.9	1.7	1.2	2.3	2.0
Angina (self-reported)	2.8	3.6	6.7	-1.4	-1.9	-1.3	-1.8	-2.6	-2.0	-2.1
Schizophrenia (2014)	2.7	6.0	12.7	2.8	3.6	2.6	2.3	2.8	1.1	0.6
Allergy or Eczema	2.7	7.0	19.0	-2.3	-1.7	-4.4	-1.3	-2.2	-2.8	-2.6
Taking other prescription medications	2.7	4.2	7.2	-1.9	-2.3	-1.9	-1.8	-0.8	-2.4	-2.7
Trunk fat-free mass	2.7	15.5	35.9	-0.3	-1.7	5.3	-2.5	-1.0	6.0	5.8
Alcohol intake versus 10 years previously	2.7	4.1	17.5	-0.3	-0.3	-4.2	0.5	-0.1	-2.3	-2.4
Pulse rate	2.7	4.5	9.8	-1.5	-1.9	-3.1	-1.3	-0.7	-2.5	-2.7
Trunk predicted mass	2.7	15.7	37.0	-0.2	-1.6	5.4	-2.5	-0.9	6.1	5.9
Arm fat-free mass (right)	2.7	13.9	29.9	-0.3	-1.8	5.5	-2.6	-0.6	5.4	5.3
Medication: Omeprazole (e.g. Zanprol)	2.7	3.3	6.7	-1.6	-2.6	-0.6	-1.5	-2.4	-1.5	-1.6
Schizophrenia (2018)	2.6	5.3	9.1	2.5	2.8	3.0	2.0	2.9	1.1	0.8
Arm predicted mass (right)	2.6	13.4	28.0	-0.5	-2.0	5.2	-2.8	-0.8	5.3	5.2
Whole body water mass	2.6	14.6	33.4	-0.6	-1.9	5.0	-2.7	-0.9	5.8	5.6
Ever had prostate specific antigen (PSA) test	2.6	3.1	6.1	-2.5	-1.3	0.4	-2.4	-1.4	-1.7	-1.7
Ulcerative Colitis (UC)	2.5	4.6	8.8	-1.9	-1.9	-2.2	-1.4	-1.5	-3.0	-2.7
Hearing difficulty/problems: Yes	2.5	3.8	7.1	-1.9	-1.5	-0.7	-1.9	-1.8	-2.5	-2.7
Allergy	2.5	5.9	8.1	2.5	2.5	2.2	1.9	2.0	2.9	2.8
Whole body fat-free mass	2.5	14.5	33.4	-0.5	-1.8	5.0	-2.6	-0.9	5.8	5.6
Arm fat-free mass (left)	2.5	12.7	28.4	-0.4	-1.6	4.9	-2.5	-0.9	5.3	5.1
Arm predicted mass (left)	2.5	12.8	29.5	-0.2	-1.6	4.9	-2.4	-0.6	5.4	5.2
Medication: Ventolin 100micrograms inhaler	2.4	3.1	5.9	-1.9	-1.8	-0.9	-1.6	-0.7	-2.4	-2.2
Crohns Disease (2017)	2.3	4.9	19.5	-0.7	0.1	-4.4	0.6	-1.9	-2.4	-2.2
Age when periods started (menarche)	2.3	5.4	12.1	3.5	2.2	2.3	2.6	1.0	2.3	1.7
High blood pressure (mother)	2.3	3.2	6.1	-1.5	-1.7	-2.5	-1.0	-2.4	-1.6	-1.4
Illnesses of mother	2.3	2.8	5.2	1.7	1.7	1.6	1.5	2.3	1.5	1.4
Heart disease (mother)	2.3	2.9	4.0	-2.0	-1.9	-1.4	-2.0	-0.4	-1.8	-1.8
Illnesses of father: High blood pressure	2.3	2.8	4.7	-2.2	-1.9	-1.0	-1.9	-0.5	-1.9	-1.8
Worrier / anxious feelings	2.2	4.1	6.1	-2.3	-2.5	-2.0	-2.2	-1.1	-1.8	-1.9
Medication: Blood pressure	2.2	3.9	6.2	-2.4	-2.2	-1.1	-2.5	-0.6	-2.1	-2.2
Illnesses of father: Heart disease	2.2	3.0	6.8	-1.5	-1.6	-1.0	-1.6	0.3	-2.4	-2.6
Mood swings	2.2	4.0	8.8	-1.7	-3.0	-1.7	-1.9	-0.7	-2.2	-2.1
Basal metabolic rate	2.2	12.2	27.5	-0.6	-1.8	4.6	-2.6	-0.7	5.2	5.1
Unable to work because of sickness or disability	2.2	2.8	5.4	2.3	1.0	2.0	1.7	1.8	1.3	1.2
HDL Cholesterol	2.1	3.5	6.0	1.9	1.4	0.9	1.4	2.0	2.4	2.5
Medication: Co-codamol	2.1	2.4	4.6	1.9	1.9	-0.8	2.1	1.7	0.8	0.9
Serious illness, injury or assault to yourself	2.1	2.5	4.3	-1.2	-1.3	-1.6	-1.2	-1.3	-2.1	-2.1
Had major operations	2.1	2.4	4.5	-1.5	-1.6	-0.1	-1.8	-0.9	-1.9	-2.1
Leg fat-free mass (left)	2.0	10.5	24.2	-0.6	-1.6	4.1	-2.3	-0.7	4.9	4.9
Leg predicted mass (left)	2.0	10.3	23.9	-0.7	-1.6	4.0	-2.3	-0.7	4.9	4.8
Heart attack	2.0	2.6	4.5	-1.5	-2.1	-1.5	-1.7	-1.6	-1.4	-1.4
Number of live births	2.0	2.8	6.2	-1.7	-2.5	-1.1	-1.6	-1.1	-1.6	-1.8
Impedance of arm (left)	2.0	9.1	17.0	1.6	3.5	-1.8	3.5	0.1	-4.1	-4.1
Irritability	2.0	3.4	5.1	-1.9	-1.6	-1.3	-1.6	-2.0	-2.3	-2.1
Impedance of whole body	2.0	10.0	17.7	2.1	3.7	-1.6	3.8	0.8	-4.2	-4.2
Stomach or abdominal pain in last month	1.9	2.4	9.2	-0.9	-1.0	-3.0	-0.8	-0.6	-1.6	-1.5
Hearing difficulty/problems with background noise	1.9	3.0	6.9	-1.7	-0.9	-0.3	-1.4	-1.4	-2.6	-2.6
Fluid intelligence score	1.9	4.0	9.5	1.3	1.6	1.4	1.7	1.2	2.7	3.1
Impedance of arm (right)	1.9	8.9	14.6	1.7	3.6	-2.3	3.5	0.7	-3.8	-3.8
Blood clot in the leg (DVT)	1.9	2.4	3.9	-1.7	-1.6	0.6	-2.0	-1.7	-1.3	-1.7
Leg fat-free mass (right)	1.9	9.9	22.8	-0.8	-1.7	3.8	-2.4	-0.7	4.8	4.7
Medication: Gliclazide	1.9	2.2	5.2	1.1	0.7	1.8	0.5	-0.5	2.3	2.1
Leg predicted mass (right)	1.9	10.1	23.1	-0.8	-1.7	3.8	-2.5	-0.8	4.8	4.7
Tinnitus: Yes, now most or all of the time	1.9	2.2	6.4	-1.7	-0.6	-0.9	-1.1	-2.5	-1.6	-1.4
Heart attack/myocardial infarction (self-reported)	1.9	2.5	4.1	-1.5	-2.0	-1.5	-1.6	-1.5	-1.4	-1.4
Blood Red Count	1.8	17.4	44.4	-5.4	-6.6	0.4	-6.7	-1.5	-1.2	-1.2
Had other major operations	1.8	2.2	4.0	-1.6	-1.8	0.5	-2.0	-0.6	-1.7	-1.5
Health satisfaction	1.8	2.3	7.7	-1.2	-0.6	-2.8	-1.0	0.4	-1.6	-1.7
Bipolar Disorder (2011)	1.7	1.6	4.5	-0.2	0.0	-2.1	-0.2	0.6	-1.7	-1.9
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	3.2	-1.6	-1.5	0.7	-1.8	-1.7	-1.1	-1.6
Major Depression (MDD)	1.6	1.9	5.5	1.6	2.0	2.3	1.0	0.1	-0.1	-0.4
Impedance of leg (left)	1.6	7.6	12.8	2.5	3.3	-0.8	3.6	1.6	-3.2	-3.2
Comparative height size at age 10	1.6	8.9	21.4	1.3	1.5	3.9	0.3	-0.9	4.6	4.6
Supplements: Vitamin C	1.6	1.8	3.5	-1.7	-1.6	-0.3	-1.9	-0.9	-1.2	-1.2
Osteoporosis (self-reported)	1.6	2.0	6.8	-0.8	-0.9	-2.6	-0.4	-1.1	-1.4	-1.6
Neuroticism	1.5	3.5	5.4	-1.6	-1.8	-2.2	-1.4	-1.5	-2.3	-2.1
Ever had hysterectomy (womb removed)	1.5	1.7	4.3	-1.0	-1.3	0.0	-1.0	-0.6	-1.8	-2.1
Impedance of leg (right)	1.5	7.4	14.1	2.7	3.3	-0.4	3.8	1.6	-2.9	-2.9
Sitting height	1.5	10.8	31.1	1.0	0.8	5.6	-0.5	-0.0	4.7	4.5
Length of working week for main job	1.5	1.6	3.2	1.5	0.8	0.6	1.4	0.4	1.6	1.8
Headache pain in last month	1.5	2.5	8.5	-1.2	-1.6	-2.9	-1.0	0.2	-1.5	-1.4
Body Mass Index (BMI) (2010)	1.4	1.9	4.0	1.2	1.9	1.0	0.9	-0.1	2.0	1.5
Relative age of first facial hair	1.4	2.9	8.2	2.0	1.6	-2.9	2.3	0.3	0.5	-0.1
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	3.7	-1.4	-1.5	-1.2	-1.4	-1.2	-1.7	-1.9
Noisy workplace	1.4	1.7	4.5	1.4	1.7	0.6	1.4	2.1	0.0	0.3
Medication: Omeprazole	1.4	1.7	4.6	-1.2	-2.2	-0.0	-1.4	-1.3	-0.9	-1.1
Ever taken oral contraceptive pill	1.4	1.5	3.6	-1.9	-1.0	-0.4	-1.5	-1.9	-0.4	-0.3
Medication: Blood pressure	1.4	2.7	3.9	-1.5	-1.6	-1.5	-1.2	-1.8	-1.8	-2.0
Verbal and Numeric Reasoning (VNR)	1.3	3.1	7.0	1.1	1.8	1.6	1.6	0.5	2.3	2.6
Mean Putamen Volume	1.3	1.4	3.4	1.5	1.8	-0.1	1.6	1.4	0.3	0.3
Frequency of depressed mood in last 2 weeks	1.3	1.8	4.1	-0.7	-1.1	-1.7	-0.5	-2.0	-1.4	-1.5
Diabetes (mother)	1.3	1.6	4.5	0.6	0.8	1.1	0.3	0.4	2.1	2.1
Alcohol usually taken with meals	1.3	2.1	3.6	-1.4	-0.3	-1.8	-0.7	-1.5	-1.9	-1.7
Weight	1.3	6.2	14.2	-0.4	-0.9	3.5	-1.8	-0.1	3.8	3.6
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	3.6	-1.4	-1.7	-0.9	-1.3	-1.1	-1.9	-1.6
Breastfed as a baby	1.3	1.6	2.4	1.3	1.5	1.4	1.4	1.0	1.2	1.1
Leg pain on walking	1.3	1.7	3.9	-0.8	-2.0	1.1	-1.7	0.9	-0.9	-1.2
Miserableness	1.3	2.3	3.4	-1.2	-1.8	-1.9	-0.9	-1.1	-1.7	-1.6
Bipolar Disorder (2018)	1.2	1.8	5.2	-0.3	-0.9	-1.7	-0.5	-0.2	-1.9	-2.3
Height	1.2	23.5	70.2	2.8	3.0	8.4	1.0	-0.0	6.3	6.0
Sensitivity / hurt feelings	1.2	2.1	3.9	-1.5	-2.0	-0.4	-1.6	-1.9	-1.0	-1.1
Townsend deprivation index at recruitment	1.2	1.7	3.2	1.3	0.8	1.0	0.8	-1.6	1.8	1.4
Relative age voice broke	1.2	1.8	7.6	0.8	0.8	-2.8	1.4	1.1	-0.2	-0.5
Standing height	1.2	11.9	40.7	1.6	1.7	6.4	0.2	-1.3	4.4	4.1
Eye problems/disorders: None of the above	1.2	1.4	4.8	0.7	1.1	2.2	1.0	-0.5	1.0	1.1
Medication: Ibuprofen	1.2	1.4	3.0	-1.1	-1.3	-1.7	-1.1	-1.1	-0.9	-0.8
Family relationship satisfaction	1.2	1.4	3.4	0.9	0.2	1.8	0.2	1.2	1.6	1.3
Ever had bowel cancer screening	1.2	1.4	3.3	-1.1	0.0	-1.3	-0.9	-1.1	-1.4	-1.8
Hearing aid user	1.2	1.4	2.1	-0.8	-1.2	-1.4	-1.0	-1.1	-1.2	-1.4
Commuting to job workplace: Public transport	1.2	1.4	2.7	1.0	1.3	1.2	1.6	-0.6	0.9	1.3
Diastolic blood pressure, automated reading	1.2	3.6	7.4	-2.5	-2.7	-0.3	-2.7	0.0	-1.5	-1.5
Ovarian Cancer	1.1	1.5	5.1	-1.0	-0.9	-2.3	-0.8	-1.6	-0.2	-0.2
Multivitamins +/- minerals	1.1	1.5	4.6	-0.9	-0.8	-2.1	-0.7	-0.4	-1.4	-1.2
Number of incorrect matches in round	1.1	1.8	6.0	1.2	2.5	0.3	1.6	1.5	0.5	0.4
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	3.7	-1.3	-0.9	-0.8	-0.9	-1.3	-1.9	-1.7
Fractured/broken bones in last 5 years	1.1	1.4	6.1	-0.9	-0.9	-2.5	-0.6	-1.3	-0.1	-0.3
Depression (Nagel 2018)	1.0	1.5	3.8	-0.4	-0.9	-1.3	-0.1	-1.2	-1.6	-1.9
Hair Pigment	1.0	29.9	59.4	-4.5	-6.0	-7.7	-3.9	-2.2	-6.2	-5.9
Hand grip strength (left)	1.0	2.7	5.3	1.4	0.9	2.3	1.1	0.3	2.3	2.2
Average weekly spirits intake	1.0	1.2	3.8	0.8	1.2	0.2	1.1	1.9	-1.0	-0.7
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.7	-0.7	-0.6	-1.1	-0.8	-0.5	-1.6	-1.9
Medication: Levothyroxine sodium	1.0	1.7	3.2	-1.5	-1.8	-0.6	-1.6	-0.5	-1.1	-1.2
Neuroticism score	1.0	2.2	4.8	-1.1	-2.2	-1.6	-1.2	-0.9	-1.6	-1.4
Commuting to job workplace: Car/motor vehicle	1.0	1.2	2.3	-0.8	-0.6	-0.2	-1.2	1.1	-1.4	-1.5
Age started oral contraceptive pill	1.0	1.2	2.9	1.2	1.5	-0.2	1.7	-0.8	0.8	0.9
Tanning	0.9	10.6	22.7	2.2	1.8	4.2	1.3	1.5	4.8	4.7
Hand grip strength (right)	0.9	2.4	5.2	1.0	0.5	2.3	0.7	-0.1	2.2	2.2
Supplements: Glucosamine	0.9	1.2	2.1	1.4	1.1	0.5	1.1	0.2	1.4	1.3
Falls in the last year	0.9	1.2	3.3	-0.6	-0.0	-1.2	-0.5	-0.6	-1.8	-1.7
Hair/balding pattern: Pattern 3	0.9	1.4	2.9	1.1	0.8	1.7	0.9	0.5	1.4	1.5
Pulse wave reflection index	0.9	1.1	3.2	0.6	0.7	1.8	0.4	0.7	1.0	1.4
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.3	-1.1	-1.0	-1.2	-1.5	-0.9	-0.5	-0.8
Number of full brothers	0.9	1.2	1.8	1.3	1.1	1.1	1.0	-0.1	1.4	1.0
Eye problems/disorders: Glaucoma	0.9	1.0	1.9	1.4	1.2	0.3	1.0	0.6	1.1	1.1
Risk taking	0.9	1.3	2.8	1.5	1.1	0.3	1.0	1.7	0.8	0.9
Commuting to job workplace: Cycle	0.9	1.0	2.0	1.0	-0.1	0.5	0.6	1.3	1.4	1.4
Bipolar Disorder or Schizophrenia	0.8	2.0	4.3	1.7	1.6	1.3	1.2	2.1	-0.3	-0.8
Crohns Disease (2012)	0.8	1.3	5.1	0.5	1.0	-2.2	1.4	-0.7	-0.7	-0.5
Hypothyroidism (self reported)	0.8	1.7	3.7	-1.6	-1.9	-0.6	-1.8	-0.2	-1.0	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.5	0.9	1.4	1.2	1.0	-0.9	1.9	1.7
Mouth/teeth dental problems	0.8	1.2	2.9	0.9	1.7	-0.3	1.4	0.8	1.0	1.0
Peak expiratory flow (PEF)	0.8	2.0	4.0	-1.5	-2.0	-0.0	-1.8	-1.4	-1.2	-0.9
Glaucoma (self-reported)	0.8	1.0	1.7	1.3	1.2	0.2	1.0	-0.1	1.2	1.1
Comparative body size at age 10	0.8	2.1	13.8	-0.7	-0.7	-3.7	0.0	-0.0	-0.2	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	5.1	1.2	0.6	2.3	0.6	-0.0	0.5	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.6	-0.7	-1.3	-0.8	-0.7	-1.0	-1.0	-1.0
Loneliness, isolation	0.8	1.1	2.0	0.0	-1.2	-1.4	-0.5	-0.6	-1.2	-1.4
Qualifications: nursing, teaching	0.8	1.3	3.5	-1.9	-0.2	-0.9	-1.1	-0.1	-1.6	-1.0
Average weekly beer plus cider intake	0.8	1.2	2.5	1.4	0.6	1.6	0.8	1.0	0.9	0.9
Depressed Affect (Nagel 2018)	0.7	1.5	2.6	-0.8	-1.5	-1.5	-0.8	-0.5	-1.5	-1.6
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.2	-0.8	-1.5	0.4	-1.2	0.4	0.6	0.6
Severe depression (siblings)	0.7	0.8	2.0	0.5	0.9	-0.5	0.5	0.5	1.4	1.3
Chronic bronchitis/emphysema (father)	0.7	0.8	2.4	-0.5	0.5	-0.2	-0.4	-0.6	-1.4	-1.6
Hip circumference	0.7	3.0	8.0	-0.5	-0.9	1.4	-1.6	-0.2	2.8	2.7
Hair/balding pattern: Pattern 4	0.7	1.8	5.8	-0.7	-1.2	2.4	-1.1	-1.6	-0.5	-0.8
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.7	-0.7	-1.3	-0.3	-1.1	-0.6	-1.0	-0.9
Birth weight	0.7	1.4	3.6	-1.6	-1.5	-0.1	-1.9	-0.9	-0.5	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.1	0.6	0.7	1.5	0.3	0.2	1.1	1.2
Medication: Lisinopril	0.7	0.9	1.7	-1.3	-1.1	0.0	-1.2	-0.2	-1.1	-0.7
Intelligence (Savage-Jansen 2018)	0.6	2.0	5.5	0.9	1.3	0.6	1.4	0.4	1.9	2.3
Coronary Artery Disease (CAD)	0.6	0.8	1.7	0.1	1.2	-1.3	0.7	-1.2	-0.2	-0.2
Rheumatoid Arthritis	0.6	0.8	1.4	0.5	1.2	0.2	0.8	-0.8	1.1	1.0
BMI	0.6	3.5	8.1	-1.8	-2.6	1.4	-2.9	0.1	1.6	1.4
Waist Hip Ratio (WHR)	0.6	2.5	6.5	0.0	-0.9	2.5	-0.4	0.3	-2.2	-2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.7	-0.1	-0.9	-1.1	-0.1	-1.6	-0.5	-0.8
Waist circumference	0.6	2.2	5.4	-0.1	-0.9	2.3	-1.3	0.7	1.9	1.8
Past tobacco smoking	0.6	1.0	5.9	0.6	-0.1	0.4	0.5	2.4	0.2	0.7
Father’s age at death	0.6	0.8	1.6	-1.2	-0.6	-0.2	-0.9	-0.7	-1.3	-1.0
Mouth/teeth dental problems: Dentures	0.6	1.0	2.7	0.5	-0.7	1.0	-0.1	0.6	1.6	1.7
Wheeze or whistling in the chest in last year	0.6	1.1	1.6	-1.2	-1.2	-1.0	-1.2	-0.8	-0.9	-0.8
Pulse wave peak to peak time	0.6	0.7	1.5	0.8	0.6	0.3	1.2	-0.6	1.1	1.1
Migraine (self-reported)	0.6	0.7	2.6	-0.3	-0.2	0.1	-0.2	-0.1	-1.6	-1.4
Mean time to correctly identify matches	0.6	1.1	4.4	-1.0	-0.3	-1.1	-0.5	-2.1	-0.5	-0.6
Chest pain or discomfort	0.6	0.8	3.0	-0.3	-0.6	-1.7	-0.2	-1.4	-0.5	-0.5
Illnesses of siblings: Diabetes	0.6	0.8	2.1	-1.2	-1.4	0.5	-1.3	0.2	-0.0	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.8	1.7	0.8	0.2	-1.3	1.0	0.6	-0.9	-0.8
Mother’s age at death	0.6	0.7	2.6	0.3	0.4	1.3	0.6	-1.6	0.5	0.2
Supplements: Calcium	0.6	0.7	2.3	-0.4	-0.0	-0.2	-0.2	-0.7	-1.3	-1.5
Neuroticism (Nagel 2018)	0.5	1.1	2.2	-0.7	-1.5	-0.7	-0.9	-1.1	-1.0	-1.1
Alzheimer’s Disease (in mother)	0.5	0.6	1.8	-0.7	-0.3	-0.3	0.0	-0.8	-1.4	-1.1
Reaction Time	0.5	0.9	3.4	-0.7	-0.2	-1.8	0.1	-1.5	-0.3	-0.0
Age at First Birth	0.5	0.8	3.5	0.4	1.9	-1.0	0.7	0.5	-0.1	-0.2
Medication for hormone replacement therapy	0.5	0.6	1.0	-0.4	-0.8	1.0	-0.6	0.7	-0.9	-0.9
Maternal smoking around birth	0.5	0.7	1.7	-0.5	-0.8	0.8	-0.8	-0.6	-0.8	-1.3
Fed-up feelings	0.5	0.9	2.8	-0.5	-1.3	-1.7	-0.8	-0.5	-0.4	-0.4
Medication: Atenolol	0.5	0.6	2.4	-0.5	-0.9	-0.5	-0.5	-1.5	0.2	0.2
Body mass index (BMI)	0.5	2.3	4.2	-1.2	-1.8	0.6	-2.0	0.5	1.9	1.8
Hair/balding pattern: Pattern 2	0.5	0.7	1.2	0.9	1.1	-1.1	0.9	0.6	0.6	0.4
Medication: Ramipril	0.5	0.7	1.6	-1.2	-0.1	-0.6	-1.1	-0.7	-0.7	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.3	-0.7	0.0	0.6	-0.4	-1.5	-0.8	-0.3
Pulse wave Arterial Stiffness index	0.5	0.6	1.7	-0.7	-0.5	0.3	-1.3	0.4	-0.8	-0.8
Arm fat mass (right)	0.5	2.2	4.1	-0.8	-1.0	1.7	-1.7	0.2	2.0	1.9
Tense / ‘highly strung’	0.5	0.8	2.3	-0.0	-0.2	-0.7	-0.1	-0.4	-1.5	-1.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.8	-1.3	-1.1	-1.3	-0.5	0.2	-0.0	0.6
Medication: Amlodipine	0.5	0.8	1.1	-0.8	-0.5	-0.7	-0.9	1.0	-1.0	-1.1
Worry too long after embarrassment	0.5	0.8	2.5	-0.8	-1.1	-1.6	-0.4	-1.0	-0.0	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.8	-0.4	-0.7	-1.4	-0.3	0.1	-1.0	-0.8
Leg fat mass (right)	0.5	2.1	4.9	-0.5	-0.8	2.2	-1.6	0.7	1.8	1.6
Age at last live birth	0.5	0.7	2.3	0.7	1.5	0.1	0.8	1.2	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.8	0.4	0.3	1.7	0.0	-1.0	1.4	1.3
Arm fat mass (left)	0.5	2.1	3.6	-0.9	-1.2	1.7	-1.7	0.2	1.9	1.8
Average weekly champagne plus white wine intake	0.5	0.7	2.0	-0.9	-0.5	0.4	-1.1	-1.4	0.3	0.4
Heart disease (siblings)	0.5	0.6	1.7	0.2	-0.1	-1.1	0.6	-0.1	-1.3	-1.1
Leg fat mass (left)	0.5	2.1	4.1	-0.7	-0.9	2.0	-1.7	0.6	1.8	1.7
Smoking Status	0.4	1.0	5.1	-0.2	0.8	-0.8	0.2	-2.3	-0.6	-0.8
Pack years adult smoking proportion	0.4	0.6	2.5	-0.5	-1.6	0.3	-0.9	-0.1	-0.6	-0.7
Current tobacco smoking	0.4	0.7	2.5	0.5	-0.3	-1.2	0.6	-1.6	-0.1	-0.1
Trunk fat mass	0.4	1.8	5.7	0.0	0.1	2.4	-0.8	0.6	1.8	1.7
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.7	-0.1	-0.4	-1.0	0.3	-1.3	0.3	0.6
Medication: Lansoprazole	0.4	0.4	1.0	-0.5	-1.0	-0.3	-0.9	0.5	-0.5	-0.4
Prospective memory result	0.4	0.5	1.7	0.7	1.1	0.3	0.6	1.3	0.0	0.2
Exposure to tobacco smoke outside home	0.4	0.5	1.8	-0.5	-1.3	-0.1	-0.8	0.8	0.1	0.4
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.0	-0.5	-0.8	-0.1	-0.7	-1.0	-0.5	-0.8
Emphysema/chronic bronchitis	0.4	0.5	1.9	-0.3	-0.0	0.9	-0.3	-1.4	0.6	0.4
Whole body fat mass	0.4	1.5	3.9	-0.4	-0.4	2.0	-1.1	0.4	1.6	1.5
Medication: Aspirin	0.4	0.6	3.0	0.4	-0.3	-1.7	0.8	0.5	-0.1	0.0
Knee pain experienced in last month	0.4	0.6	1.2	-0.3	-0.4	0.9	-0.3	-0.5	-1.1	-1.1
Smoking status: Previous	0.4	0.6	2.2	-0.7	0.3	-0.0	-0.7	-1.5	-0.4	-1.0
Commuting to job workplace: Walk	0.4	0.4	1.1	0.6	0.5	-0.0	0.9	-0.3	0.8	1.0
Osteoarthritis (self-reported)	0.4	0.5	0.8	-0.7	-0.4	0.6	-0.9	-0.0	-0.8	-0.8
Medication: Aspirin	0.4	0.6	3.5	0.3	-0.1	-1.9	0.6	0.1	-0.1	-0.1
Illnesses of father: None of the above (group 1)	0.4	0.5	1.8	0.2	0.1	-0.7	0.3	0.0	1.1	1.4
Smoking status: Current	0.4	0.6	2.4	0.6	0.0	-0.9	0.8	-1.6	0.0	0.1
Medication: Bendroflumethiazide	0.4	0.6	1.1	-0.5	-0.9	-0.5	-0.5	-1.1	-0.7	-0.9
Alcohol drinker status: Never	0.4	0.5	1.7	0.5	-0.6	-0.2	-0.1	1.3	-0.5	-0.9
Ever smoked	0.4	0.7	3.5	0.2	0.6	-0.7	0.3	-1.9	0.3	-0.1
Myopia	0.4	0.5	1.2	0.8	0.7	0.3	0.7	1.1	0.6	0.6
Worry (Nagel 2018)	0.3	0.7	1.5	-0.6	-1.1	-0.5	-0.7	0.2	-1.2	-1.1
Alzheimer’s Disease (including proxy)	0.3	0.4	1.1	-0.5	0.0	0.5	-0.1	-0.5	-1.0	-0.9
Breast Cancer	0.3	0.7	1.5	1.1	0.5	-0.0	1.1	1.2	0.8	0.6
HbA1C	0.3	0.3	0.8	0.4	0.2	0.5	0.8	0.1	0.6	0.9
LDL Cholesterol	0.3	0.4	1.0	0.6	0.8	-0.6	1.0	0.3	-0.5	-0.6
Neuroticism (2016)	0.3	0.4	2.2	0.5	-1.5	0.6	0.3	0.2	-0.1	-0.0
Blood Eosinophil Count	0.3	2.6	7.8	-1.7	-2.0	-2.8	-1.4	-0.8	0.3	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.1	0.2	0.8	1.4	0.4	-0.9	0.5	0.5
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.1	0.9	0.3	0.5	0.8	1.0	-0.1	-0.0
Asthma	0.3	0.7	1.7	-0.7	-0.7	0.6	-0.7	0.0	-1.1	-1.3
Depression (self-reported)	0.3	0.3	1.3	0.8	0.4	0.1	1.1	0.2	-0.1	0.3
Number of children fathered	0.3	0.4	1.9	0.4	-0.6	1.4	-0.2	-0.5	0.1	0.2
Shortness of breath walking on level ground	0.3	0.3	0.9	0.9	0.3	0.1	0.4	-0.0	0.9	0.6
Number of full sisters	0.3	0.3	1.3	-0.4	-1.1	0.1	-0.5	-0.8	-0.2	-0.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.7	-0.2	0.6	0.6	0.0	1.3	0.3	0.1
Average weekly red wine intake	0.3	0.4	0.7	-0.7	-0.7	0.8	-0.7	-0.8	0.1	-0.1
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.1	0.2	0.8	1.0	0.3	-0.7	0.3	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.3	-0.8	-1.1	-0.5	-0.9	-0.4	-0.7	-0.6
Supplements: Fish oil (including cod liver oil)	0.3	0.3	0.9	-0.5	0.4	-0.9	-0.7	0.0	-0.4	-0.7
Basal cell carcinoma (self-reported)	0.3	0.4	0.9	-0.9	-0.5	-0.4	-0.7	-0.4	-0.8	-0.4
Pack years of smoking	0.3	0.4	1.3	-0.2	-1.1	0.9	-0.6	-0.2	-0.2	-0.5
Alzheimer’s Disease (in father)	0.2	0.2	0.6	-0.7	-0.5	0.0	-0.8	-0.1	-0.4	-0.6
Prostate Cancer	0.2	0.3	0.6	0.4	0.4	0.6	0.4	0.7	-0.6	-0.8
Type 2 Diabetes (T2D) (2012)	0.2	0.2	1.0	-0.5	-0.1	1.0	-0.5	-0.2	-0.1	-0.0
Heel T-Score	0.2	1.4	2.9	0.9	1.4	1.7	0.6	-0.5	1.4	1.2
Respiratory disease	0.2	0.5	1.0	-0.6	-0.5	0.0	-0.5	-0.8	-0.8	-1.0
Lung FEV1/FVC ratio	0.2	1.2	4.8	0.2	-2.2	0.1	0.3	-1.0	0.9	1.2
Lung FVC	0.2	1.0	2.6	-0.5	0.3	-1.6	-0.4	-0.3	-1.4	-1.4
Supplements: Zinc	0.2	0.3	0.7	-0.8	-0.1	0.4	-0.7	-0.6	0.1	0.1
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.7	0.2	0.6	0.9	0.2	-0.1	0.0	0.2
Forced vital capacity (FVC)	0.2	1.0	1.8	0.9	1.0	1.3	0.6	0.1	1.1	1.2
Qualifications: None of the above	0.2	0.4	1.1	1.0	0.6	0.4	0.4	0.2	0.8	0.2
Financial difficulties in last 2 years	0.2	0.3	0.9	0.8	0.7	0.2	0.9	0.1	-0.1	0.2
Time employed in main current job	0.2	0.2	0.5	-0.3	0.1	-0.7	0.2	0.3	-0.6	-0.5
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.1	-1.0	-0.1	-0.8	-0.3	1.0	-0.4	0.1
Lung cancer (father)	0.2	0.2	0.7	-0.1	0.0	-0.8	-0.2	-0.5	-0.4	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.2	0.5	-0.4	1.0	0.3	0.4	0.9	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.9	0.5	0.9	0.7	0.7	-0.0	-0.3	-0.1
Loud music exposure frequency	0.2	0.2	0.5	-0.3	0.1	0.6	-0.7	-0.1	-0.4	-0.4
Forced vital capacity (FVC), Best measure	0.2	0.9	2.6	0.8	0.5	1.6	0.4	0.5	1.0	1.1
Qualifications: College or University degree	0.2	0.6	1.4	0.1	1.2	-0.9	0.7	1.0	-0.4	-0.0
Medication: Seretide 50 evohaler	0.2	0.2	0.4	0.1	0.4	0.6	0.2	0.2	0.4	0.7
Long-standing illness, disability or infirmity	0.2	0.3	0.9	0.2	-0.9	-0.9	-0.0	-0.4	-0.3	-0.5
Breast cancer (self-reported)	0.2	0.2	0.7	0.3	0.9	-0.2	0.4	0.7	-0.3	-0.3
Asthma (self-reported)	0.2	0.4	1.4	-0.5	-0.5	0.1	-0.4	0.2	-1.0	-1.2
Guilty feelings	0.2	0.3	0.9	-0.1	-0.9	-0.1	-0.2	-0.9	-0.2	0.0
Financial situation satisfaction	0.2	0.3	1.3	-0.1	-0.5	-0.5	-0.5	1.1	0.0	0.2
Pain type(s) experienced in last month: Hip pain	0.2	0.2	1.4	-0.1	-0.1	1.2	0.1	-0.1	-0.5	-0.2
Ever depressed for a whole week	0.2	0.2	0.8	0.3	0.3	0.6	-0.1	0.9	-0.2	-0.4
Alcohol drinker status: Previous	0.2	0.3	0.7	0.8	0.3	-0.6	0.9	0.2	0.0	-0.2
Chronotype (morning person)	0.1	0.3	0.8	0.3	-0.6	0.4	0.0	-0.1	0.7	0.9
Trunk fat percentage	0.1	0.2	0.7	0.1	0.6	0.8	0.1	0.9	0.1	0.0
Average weekly fortified wine intake	0.1	0.1	0.5	0.1	0.2	0.7	0.2	0.3	-0.0	-0.0
Qualifications: CSEs or equivalent	0.1	0.2	0.7	-0.1	-0.8	-0.2	-0.4	-0.3	0.4	0.1
Nervous feelings	0.1	0.2	0.6	-0.0	-0.5	-0.3	-0.1	0.5	-0.8	-0.7
Arm fat percentage (right)	0.1	0.4	1.1	-0.8	-0.6	-0.1	-1.1	0.6	0.4	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.7	0.4	-0.3	0.8	-0.0	-0.1	0.6	0.9
Happiness	0.1	0.2	0.6	-0.0	-0.1	-0.8	0.1	0.7	-0.1	0.2
Exposure to tobacco smoke at home	0.1	0.1	0.3	-0.5	0.3	0.1	-0.2	-0.2	-0.2	0.4
Leg fat percentage (right)	0.1	0.3	0.8	-0.2	-0.5	0.4	-0.7	0.9	0.3	0.1
Age at first live birth	0.1	0.3	1.0	-0.3	0.3	-1.0	-0.1	0.8	-0.3	-0.2
Suffer from ‘nerves’	0.1	0.2	0.4	0.3	-0.6	-0.2	0.1	-0.5	0.6	0.5
Arm fat percentage (left)	0.1	0.5	1.5	-0.9	-0.7	0.2	-1.2	0.4	0.2	0.1
Mineral and other dietary supplements	0.1	0.2	0.8	-0.3	-0.9	0.2	0.1	-0.3	-0.3	-0.0
Wears glasses or contact lenses	0.1	0.2	0.2	-0.5	-0.1	-0.2	-0.5	-0.5	-0.4	-0.4
Leg fat percentage (left)	0.1	0.3	1.1	-0.5	-0.6	0.1	-1.0	0.8	0.2	0.0
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.1	-0.2	-0.3	-0.1	-0.3	-0.1	-0.2	-0.3
Body fat percentage	0.0	0.2	0.7	-0.3	0.0	0.4	-0.5	0.8	-0.1	-0.2
Friendships satisfaction	0.0	0.0	0.1	0.1	0.0	-0.1	-0.1	0.3	-0.0	-0.1

Hub : Genes

SLC4A1AP

Models

Trait associations