Best TWAS P=1.35e-10 · Best GWAS P=9.66e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ACE | 0.08 | 0.05 | lasso | 4 | 0.04 | 1.0e-05 | -4.4 | -5.1 | 2.7e-07 | 0.66 | 0.05 | 0.95 | FALSE |
| 2 | GTEx | Colon Transverse | ACE | 0.31 | 0.28 | lasso | 2 | 0.28 | 1.8e-13 | -6.0 | 6.2 | 5.7e-10 | -0.87 | 0.01 | 0.99 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ACE | 0.02 | 0.01 | enet | 3 | 0.01 | 1.3e-03 | -6.1 | -6.3 | 3.7e-10 | 0.98 | 0.00 | 0.99 | FALSE |
| 4 | The Cancer Genome Atlas | Colon Adenocarcinoma | ACE | 0.34 | 0.22 | lasso | 5 | 0.22 | 6.5e-13 | -6.1 | 6.4 | 1.3e-10 | -0.97 | 0.00 | 1.00 | TRUE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | CYB561 | 0.17 | 0.01 | enet | 6 | 0.08 | 2.0e-05 | -6.0 | 5.3 | 1.4e-07 | -0.66 | 0.00 | 0.82 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ACE | 0.16 | 0.08 | lasso | 2 | 0.07 | 5.8e-05 | -6.1 | 6.3 | 3.1e-10 | -0.96 | 0.00 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ACE | 0.13 | 0.14 | lasso | 1 | 0.10 | 6.6e-05 | -6.0 | 6.0 | 2.5e-09 | -0.84 | 0.00 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Rectum Adenocarcinoma | ACE | 0.16 | 0.14 | lasso | 6 | 0.13 | 5.1e-04 | -6.0 | 6.0 | 2.0e-09 | -0.80 | 0.01 | 0.73 | FALSE |
| 9 | The Cancer Genome Atlas | Stomach Adenocarcinoma | ACE | 0.06 | 0.03 | blup | 53 | 0.02 | 9.3e-03 | -6.0 | 5.2 | 2.5e-07 | -0.84 | 0.01 | 0.98 | FALSE |