TWAS hub - CYB561

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.423	0.0560	0.0e+00	0.657	0.523	0.663	0.029	0.047	6.2e-107	1.5e-74	1.2e-108	0.00015	1.8e-06
2	GTEx	Artery Aorta	0.071	0.0360	5.7e-03	0.043	NA	0.057	NA	0.031	2.1e-03	NA	4.6e-04	NA	7.8e-03
3	GTEx	Brain Caudate basal ganglia	0.319	0.0850	1.9e-08	0.327	NA	0.257	NA	0.308	3.8e-10	NA	5.1e-08	NA	1.5e-09
4	GTEx	Brain Cortex	0.524	0.0930	1.0e-13	0.474	NA	0.484	NA	0.488	7.9e-15	NA	3.0e-15	NA	2.1e-15
5	GTEx	Brain Frontal Cortex BA9	0.443	0.0913	6.0e-12	0.459	NA	0.418	NA	0.149	9.6e-14	NA	2.6e-12	NA	9.5e-05
6	GTEx	Brain Hippocampus	0.326	0.0860	1.7e-06	0.239	NA	0.272	NA	0.238	2.5e-06	NA	4.3e-07	NA	2.7e-06
7	GTEx	Brain Hypothalamus	0.243	0.0980	5.6e-04	0.220	NA	0.083	NA	0.024	6.8e-06	NA	5.6e-03	NA	9.1e-02
8	GTEx	Brain Nucleus accumbens basal ganglia	0.416	0.0970	2.2e-10	0.391	NA	0.357	NA	0.057	1.6e-11	NA	1.9e-10	NA	1.2e-02
9	GTEx	Brain Putamen basal ganglia	0.296	0.0810	1.8e-06	0.284	NA	0.269	NA	0.125	1.8e-07	NA	4.2e-07	NA	7.0e-04
10	GTEx	Cells Transformed fibroblasts	0.103	0.0400	1.6e-06	0.135	NA	0.117	NA	0.124	2.6e-10	NA	4.8e-09	NA	1.6e-09
11	GTEx	Heart Atrial Appendage	0.191	0.0990	1.5e-03	0.008	NA	0.059	NA	0.020	1.3e-01	NA	1.3e-03	NA	4.3e-02
12	YFS	Blood	0.015	0.0088	7.9e-03	0.011	0.005	0.006	0.007	0.006	1.5e-04	5.2e-03	2.7e-03	0.00140	3.8e-03
13	TCGA	Colon Adenocarcinoma	0.169	0.0820	1.1e-03	0.009	0.058	0.081	NA	0.039	9.2e-02	2.9e-04	2.0e-05	NA	2.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Pack years of smoking	9.6	14.1	22.4	-4.1	-4.1	-4.4	-4.3	-4.1	-4.7	-3.9	-3.6	-4.2	-4.4	-2.4	-1.6	1.1
Chronotype (morning person)	9.4	21.8	29.7	-5.0	-5.3	-5.0	-4.9	-5.1	-4.4	-4.8	-5.3	-5.5	-4.9	-2.2	-3.5	-3.8
Pack years adult smoking proportion	8.4	12.9	19.7	-3.9	-4.0	-4.2	-4.1	-3.8	-4.4	-3.8	-3.5	-4.0	-4.2	-2.1	-1.2	1.1
Hand grip strength (right)	5.8	15.8	35.8	3.7	4.5	3.8	4.1	3.8	6.0	4.4	3.4	3.9	3.7	4.8	2.1	-1.4
Relative age voice broke	5.3	8.2	11.1	3.3	2.8	3.2	3.0	3.3	2.9	2.4	3.3	3.2	3.1	2.0	2.0	1.9
Major Depression (MDD)	4.9	6.0	8.7	2.6	2.6	2.7	2.7	2.6	2.1	2.0	2.4	2.3	2.8	2.7	2.9	0.0
Worrier / anxious feelings	4.8	9.1	15.0	-3.4	-3.7	-3.6	-3.3	-3.5	-2.0	-2.9	-3.7	-3.9	-3.4	0.0	-0.8	-1.4
Forced expiratory volume in 1-second (FEV1)	4.7	15.7	41.6	3.3	5.0	3.4	3.7	3.3	5.5	4.9	2.7	3.4	3.4	6.5	2.2	-1.6
Forced vital capacity (FVC), Best measure	4.7	17.3	50.8	3.3	5.2	3.3	3.7	3.3	6.0	5.3	2.7	3.3	3.3	7.1	2.3	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	4.6	14.7	38.9	3.2	4.5	3.3	3.7	3.2	5.1	4.8	2.9	3.3	3.3	6.2	2.4	-1.3
Medication: Aspirin	4.4	5.8	11.0	-2.2	-3.3	-2.3	-2.4	-2.4	-2.3	-2.9	-2.1	-2.5	-2.3	-2.1	-1.2	-2.5
Worry (Nagel 2018)	4.3	9.0	16.3	-3.1	-4.0	-3.2	-3.1	-3.1	-2.1	-2.9	-4.0	-3.7	-3.0	-0.2	-0.9	-2.9
Medication: Aspirin	4.3	5.6	11.7	-2.2	-3.4	-2.3	-2.4	-2.3	-2.2	-3.1	-2.0	-2.4	-2.3	-2.1	-1.0	-2.3
Pulse wave reflection index	4.2	5.1	12.3	-2.3	-3.5	-2.5	-2.3	-2.3	-2.4	-2.6	-2.1	-2.6	-2.5	-1.5	-0.7	-0.7
Glaucoma (self-reported)	4.1	4.8	8.3	2.4	1.9	2.4	2.6	2.7	1.9	2.4	2.9	2.5	2.5	0.7	1.2	1.2
Exposure to tobacco smoke outside home	4.1	5.4	15.5	-1.9	-3.3	-1.9	-1.9	-1.9	-2.9	-2.5	-1.9	-2.0	-1.9	-3.9	-1.8	0.1
Ever had hysterectomy (womb removed)	4.0	4.6	7.0	2.4	2.6	2.2	2.1	2.2	2.2	2.5	2.1	2.4	2.1	2.3	1.4	0.0
Vitamin and mineral supplements	4.0	5.4	8.0	-2.4	-2.5	-2.3	-2.3	-2.3	-2.1	-2.6	-2.7	-2.4	-2.3	-2.8	-2.1	-0.7
Breastfed as a baby	4.0	4.9	6.6	2.3	2.6	2.4	2.4	2.3	1.6	2.4	2.2	2.5	2.4	2.1	2.1	1.2
Chronic bronchitis/emphysema (mother)	3.7	4.3	6.9	-2.0	-2.6	-2.1	-2.3	-2.1	-2.1	-2.1	-2.4	-2.3	-1.9	-1.9	-1.3	-1.3
High blood pressure (siblings)	3.7	5.3	8.5	2.7	1.2	2.7	2.9	2.5	2.4	1.6	2.0	2.5	2.6	1.9	2.8	-1.3
Forced vital capacity (FVC)	3.6	14.0	52.1	2.5	5.2	2.5	2.9	2.5	5.6	4.8	1.9	2.5	2.6	7.2	1.6	-1.5
Medication: Ventolin 100micrograms inhaler	3.6	4.7	7.7	-2.3	-2.3	-2.4	-2.4	-2.4	-2.8	-1.6	-2.4	-2.5	-2.5	-1.7	-1.4	-0.4
Age started oral contraceptive pill	3.5	4.4	6.2	2.4	2.5	2.4	2.4	2.3	2.2	2.1	1.8	2.1	2.4	2.0	1.2	0.1
Neuroticism (2016)	3.4	4.9	7.8	-2.2	-2.8	-2.5	-2.3	-2.5	-1.8	-2.3	-2.7	-2.4	-2.4	-0.3	-0.8	-2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.4	7.1	12.6	2.6	2.9	2.8	2.9	2.8	3.4	3.6	2.1	2.6	2.9	2.6	1.8	0.1
Ever taken oral contraceptive pill	3.4	3.8	6.2	2.0	1.6	2.1	1.9	2.0	1.8	2.1	1.9	1.8	2.1	1.7	1.7	2.5
Forced expiratory volume in 1-second (FEV1), predicted	3.2	6.6	16.6	1.8	4.1	1.8	1.8	1.7	3.6	3.9	2.1	1.8	1.8	4.1	0.1	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	3.1	4.8	6.3	2.3	1.7	2.2	2.3	2.3	2.1	2.4	2.3	2.1	2.3	2.5	2.5	0.4
Hand grip strength (left)	3.0	7.8	19.4	2.7	3.1	2.7	2.9	2.7	4.4	3.3	2.5	2.8	2.6	2.9	0.9	-1.1
Relative age of first facial hair	2.9	6.0	9.3	2.9	2.2	2.9	2.6	2.9	3.0	2.0	2.8	2.9	2.8	1.2	0.8	1.3
Chronic bronchitis/emphysema (father)	2.9	3.5	5.1	-2.1	-2.0	-2.1	-2.2	-2.1	-2.2	-1.9	-1.6	-2.0	-2.1	-1.3	-0.9	0.2
Ever had prostate specific antigen (PSA) test	2.9	3.4	6.9	-1.7	-2.4	-1.6	-1.8	-1.7	-1.3	-2.2	-1.7	-1.7	-1.7	-2.6	-2.0	-0.8
Tinnitus: Yes, but not now, but have in the past	2.8	3.0	5.7	2.2	1.6	2.2	1.9	2.0	1.1	0.7	2.4	2.3	2.0	0.2	1.0	0.9
Alzheimer’s Disease (including proxy)	2.7	3.9	6.2	-2.4	-1.5	-2.4	-2.2	-2.2	-2.1	-1.8	-1.7	-1.9	-2.5	-0.9	0.4	2.5
Breast cancer (self-reported)	2.7	3.2	5.2	-2.1	-2.2	-2.0	-1.7	-1.9	-1.0	-1.6	-1.7	-1.8	-2.0	-2.3	-1.6	-0.2
Miserableness	2.4	4.2	8.2	2.1	1.0	2.0	1.9	2.1	2.1	2.3	2.2	1.9	2.1	2.9	2.5	0.1
Type 2 Diabetes (T2D) (2012)	2.3	2.7	9.1	-1.4	-2.5	-1.3	-1.5	-1.2	-2.0	-1.8	-1.1	-1.3	-1.1	-3.0	-0.7	0.4
Depression (self-reported)	2.3	2.7	4.2	1.9	1.7	2.0	1.9	1.9	2.0	1.5	1.4	1.9	2.0	0.1	0.7	0.5
Medication: Seretide 50 evohaler	2.3	2.7	5.1	1.7	1.8	1.8	1.6	1.8	0.4	1.5	1.8	1.9	1.9	-0.4	1.2	2.3
Suffer from ‘nerves’	2.3	3.6	7.1	-1.9	-2.7	-2.1	-1.9	-1.9	-2.3	-1.8	-2.2	-2.3	-2.1	0.6	1.2	-0.4
Eye problems/disorders: Glaucoma	2.3	2.7	6.0	1.8	1.4	1.8	1.9	2.0	1.1	1.6	2.5	2.0	1.8	-0.1	0.4	1.5
Unable to work because of sickness or disability	2.3	3.0	5.0	2.1	1.8	1.8	1.8	1.9	1.6	1.2	1.9	2.1	1.8	-0.5	0.3	2.2
Medication: Omeprazole (e.g. Zanprol)	2.3	2.8	6.6	-1.6	-1.7	-1.6	-1.7	-1.6	-2.4	-2.6	-1.2	-1.3	-1.5	-2.0	-0.7	-1.3
Reaction Time	2.2	4.2	8.8	2.0	2.6	2.0	2.0	2.0	1.9	1.5	2.2	2.5	1.8	1.6	0.9	3.0
Maternal smoking around birth	2.2	3.2	9.3	-1.7	-3.0	-1.6	-1.8	-1.7	-1.6	-1.8	-2.1	-2.0	-1.4	-1.8	-0.8	-0.3
Standing height	2.2	22.1	110.2	1.1	8.1	1.3	1.8	1.1	6.7	7.3	0.9	1.2	1.4	10.5	0.3	-0.2
Eye problems/disorders: None of the above	2.2	2.6	5.4	-2.0	-0.8	-1.9	-1.9	-1.9	-0.7	-1.1	-2.3	-2.0	-1.9	0.6	-1.0	-1.3
Supplements: Vitamin C	2.2	2.6	5.6	1.6	2.4	1.7	1.8	1.6	1.1	1.7	1.8	1.8	1.6	1.5	1.2	0.9
Fasting Glucose	2.1	2.5	4.3	-1.1	-1.7	-1.1	-1.0	-1.3	-1.8	-2.0	-2.1	-1.5	-1.3	-2.0	-1.0	-1.9
Mouth/teeth dental problems	2.1	3.2	4.5	2.0	2.1	2.1	2.1	2.1	2.0	1.6	1.8	2.0	2.1	0.3	-0.3	-1.4
Illnesses of siblings	2.1	3.0	5.2	-2.2	-0.9	-2.1	-2.1	-1.9	-1.4	-1.2	-1.7	-2.1	-1.9	-0.9	-2.3	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.4	5.6	1.7	1.2	1.5	1.4	1.7	2.4	1.4	2.0	1.9	1.5	1.2	0.9	0.9
Risk taking	2.1	3.1	9.1	1.5	2.3	1.7	1.5	1.7	0.4	1.5	2.2	2.1	1.8	0.1	1.2	3.0
Headache pain in last month	2.0	3.5	6.2	2.4	1.6	2.2	2.1	2.3	1.3	1.3	2.2	2.5	2.2	1.0	1.4	-0.5
Medication: Atorvastatin	2.0	2.4	6.7	-1.2	-1.7	-1.1	-1.1	-1.1	-1.8	-1.7	-1.3	-1.2	-1.1	-2.6	-1.0	-2.3
Lupus	1.9	2.8	5.2	-1.5	-2.3	-1.5	-1.8	-1.6	-1.6	-1.7	-2.0	-1.7	-1.5	-1.7	-1.1	-1.4
Height	1.9	35.9	207.4	-0.4	11.1	-0.2	0.6	-0.5	6.9	9.3	0.2	0.0	-0.1	14.4	-0.7	0.9
Medication for cholesterol, blood pressure or diabetes	1.9	3.1	27.7	0.6	2.5	0.6	0.6	0.7	0.4	1.0	0.4	1.1	0.5	1.2	0.1	5.3
Depressed Affect (Nagel 2018)	1.8	3.8	5.5	2.2	1.2	2.2	2.0	2.4	1.8	1.9	1.9	2.0	2.3	1.9	2.2	0.7
Nervous feelings	1.8	3.4	6.8	-1.8	-2.4	-2.0	-1.9	-2.0	-1.5	-2.0	-2.6	-2.2	-2.1	-0.4	-0.9	0.2
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	6.4	1.3	1.4	1.3	1.4	1.4	1.1	1.7	1.7	1.6	1.2	1.7	2.5	-0.2
Pulse wave peak to peak time	1.7	2.0	5.1	1.4	2.3	1.5	1.4	1.4	1.9	1.3	1.1	1.7	1.5	0.7	-0.4	0.0
Medication: Allopurinol	1.7	2.3	3.7	-1.9	-1.5	-1.9	-1.7	-1.8	-1.3	-1.1	-1.9	-1.9	-1.9	-0.3	-0.8	-0.7
Long-standing illness, disability or infirmity	1.7	2.5	7.2	1.8	0.8	1.8	1.9	1.7	0.8	0.9	1.8	1.7	1.8	0.7	2.7	1.0
Ovarian Cancer	1.6	2.1	3.8	-1.4	-1.9	-1.6	-1.4	-1.3	-1.9	-1.6	-1.5	-1.6	-1.5	-1.2	-0.5	-0.2
Severe depression (siblings)	1.6	1.8	5.8	1.2	1.6	1.0	1.1	1.2	1.8	1.2	0.8	1.0	1.0	2.4	1.4	-0.2
Father’s age at death	1.6	2.1	4.2	1.4	1.6	1.4	1.5	1.3	2.0	1.7	1.3	1.6	1.2	2.1	0.7	0.1
Pulse wave Arterial Stiffness index	1.6	1.8	3.4	-1.5	-1.8	-1.7	-1.5	-1.5	-1.5	-0.9	-1.2	-1.9	-1.6	0.2	0.3	-0.3
Blood clot in the leg (DVT)	1.6	2.0	6.7	1.2	1.3	1.2	1.3	1.3	1.0	1.4	1.4	1.4	1.1	1.7	2.6	-0.4
Systolic Blood Pressure	1.5	7.3	17.1	2.9	1.0	2.8	2.8	2.9	3.7	2.3	2.0	2.3	2.8	2.1	2.0	-4.1
Medication for hormone replacement therapy	1.5	1.6	4.0	1.4	1.3	1.5	1.4	1.4	2.0	0.6	1.5	1.6	1.4	0.3	-0.2	0.2
Hair/balding pattern: Pattern 2	1.5	1.9	4.5	-1.2	-1.1	-1.2	-1.2	-1.2	-1.8	-1.6	-1.5	-1.2	-1.2	-2.1	-1.5	-0.7
Birth weight of first child	1.5	2.8	4.0	1.8	1.6	1.9	2.0	1.8	2.0	1.7	1.2	1.9	2.0	1.4	1.3	-0.1
Illnesses of father: None of the above (group 1)	1.5	1.9	4.9	1.4	2.2	1.3	1.4	1.3	1.8	1.2	0.7	1.3	1.5	1.7	0.5	0.3
Coronary Artery Disease (CAD)	1.4	1.7	2.5	-1.5	-1.2	-1.5	-1.6	-1.5	-0.7	-1.3	-1.4	-1.3	-1.6	-1.0	-1.5	0.0
Lung FVC	1.4	7.0	15.4	2.4	2.9	2.4	2.5	2.3	3.4	3.8	1.9	2.3	2.3	3.9	2.0	-0.3
Multivitamins +/- minerals	1.4	1.8	4.8	1.4	0.9	1.2	1.1	1.3	1.3	1.3	1.5	1.3	1.2	2.2	1.7	-0.2
Leg fat percentage (right)	1.4	5.0	16.1	-1.5	-3.8	-1.6	-1.9	-1.6	-2.5	-3.0	-0.8	-1.4	-1.7	-4.0	-0.7	-1.5
Mean time to correctly identify matches	1.4	2.7	8.0	1.2	2.8	1.2	1.1	1.1	1.2	1.6	1.7	1.6	1.0	2.3	0.5	2.3
Arm predicted mass (right)	1.4	7.0	28.8	1.2	4.2	1.2	1.5	1.1	3.5	4.2	1.6	1.4	1.2	5.4	1.4	0.7
Family relationship satisfaction	1.4	1.7	2.5	-1.5	-1.3	-1.5	-1.6	-1.6	-0.9	-1.3	-1.2	-1.5	-1.5	-0.3	-1.3	-0.4
Back pain experienced in last month	1.4	2.0	3.0	1.7	1.5	1.5	1.6	1.6	0.5	1.0	1.7	1.6	1.6	0.4	1.3	1.6
Leg predicted mass (right)	1.4	7.4	32.0	1.2	4.3	1.1	1.5	1.1	3.7	4.1	1.9	1.6	1.2	5.7	1.0	0.9
Medication: Lisinopril	1.4	1.9	7.8	-1.1	-1.6	-1.2	-1.0	-1.2	-1.6	-1.5	-1.1	-1.2	-1.2	-0.2	0.0	-2.8
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	3.9	1.4	0.8	1.3	1.3	1.3	0.6	0.8	1.0	1.1	1.4	1.3	2.0	-1.6
Time employed in main current job	1.3	1.5	2.8	-1.4	-1.1	-1.6	-1.3	-1.5	-1.4	-1.1	-1.5	-1.7	-1.6	0.3	-0.5	-0.0
Lung cancer (father)	1.3	1.5	2.7	-1.3	0.2	-1.3	-1.5	-1.4	-1.6	0.1	-1.5	-1.6	-1.4	1.1	0.2	1.0
Trunk predicted mass	1.3	7.3	35.8	0.5	4.6	0.6	0.9	0.4	3.7	4.6	0.9	0.7	0.6	6.0	0.4	0.4
Exposure to tobacco smoke at home	1.3	1.5	6.5	-0.9	-0.8	-0.8	-1.0	-1.0	-2.6	-0.9	-0.9	-1.0	-0.9	-1.9	-0.9	1.0
Hair/balding pattern: Pattern 4	1.3	3.2	6.0	1.7	2.0	1.7	2.0	1.7	2.1	1.6	1.3	1.6	1.8	2.4	1.9	0.9
Medication for pain relief, constipation, heartburn	1.3	2.3	8.1	1.2	2.8	1.4	1.3	1.3	1.6	2.3	0.9	1.4	1.4	0.8	-0.6	1.3
Medication: Blood pressure	1.3	2.3	26.8	0.2	-1.6	0.2	-0.0	0.1	-0.2	-0.4	0.2	-0.2	0.3	-0.9	0.0	-5.2
Leg fat-free mass (right)	1.3	7.2	31.7	1.1	4.2	1.1	1.4	1.0	3.7	4.0	1.8	1.5	1.2	5.6	1.0	1.0
Whole body water mass	1.3	7.2	33.4	0.8	4.4	0.8	1.2	0.7	3.8	4.3	1.3	1.1	0.9	5.8	0.7	0.6
Arm fat-free mass (left)	1.3	6.6	27.7	1.2	4.0	1.2	1.5	1.1	3.5	4.1	1.6	1.4	1.1	5.3	1.2	0.6
Cardiovascular Disease	1.2	4.1	40.3	0.4	-3.0	0.5	0.5	0.3	0.1	-0.8	0.2	-0.2	0.6	-1.4	0.2	-6.3
Stomach or abdominal pain in last month	1.2	1.5	3.0	1.1	1.7	1.1	1.4	1.1	1.0	1.3	0.9	1.1	1.1	1.7	1.2	-0.4
Sitting height	1.2	8.7	52.6	0.2	4.3	0.4	0.9	0.1	4.2	4.6	-0.3	-0.1	0.5	7.2	1.1	-0.8
Trunk fat-free mass	1.2	7.1	35.4	0.4	4.5	0.5	0.8	0.3	3.6	4.5	0.8	0.6	0.5	6.0	0.3	0.4
Hair/balding pattern: Pattern 3	1.2	1.9	7.4	0.8	1.8	0.7	0.4	0.8	1.9	1.8	1.1	0.7	0.6	2.7	0.3	1.6
Gout (self-reported)	1.2	1.7	3.1	-1.5	-1.4	-1.5	-1.5	-1.5	-0.7	-0.6	-1.8	-1.7	-1.4	-0.5	-1.3	-0.3
Arm fat-free mass (right)	1.2	6.2	28.5	0.9	4.1	0.9	1.2	0.8	3.4	3.9	1.3	1.1	0.9	5.3	1.1	0.7
Whole body fat-free mass	1.2	7.1	33.8	0.7	4.4	0.7	1.1	0.6	3.7	4.3	1.3	1.0	0.8	5.8	0.6	0.7
Medication for cholesterol	1.2	1.8	4.8	-1.6	0.6	-1.6	-1.6	-1.5	-0.9	0.2	-1.3	-1.4	-1.5	0.8	-1.0	2.2
Bipolar Disorder (2011)	1.1	1.1	3.0	-1.4	-0.1	-1.2	-1.3	-1.3	-0.5	-0.6	-0.9	-1.0	-1.1	-0.7	-1.7	0.0
Current tobacco smoking	1.1	1.8	3.2	-1.4	-0.9	-1.4	-1.7	-1.5	-1.8	-1.4	-1.2	-1.5	-1.4	-0.9	-0.3	1.4
Qualifications: None of the above	1.1	2.4	4.5	-1.3	-1.6	-1.3	-1.3	-1.3	-2.1	-1.5	-1.3	-1.1	-1.5	-2.1	-1.1	-2.1
Medication: Ramipril	1.1	1.4	8.1	-0.6	-0.7	-0.7	-0.8	-0.7	-1.4	-1.0	-0.3	-0.8	-0.7	-1.7	-0.9	-2.9
Knee pain experienced in last month	1.1	1.7	5.5	-1.1	-1.7	-1.2	-1.2	-1.3	-2.4	-1.5	-1.4	-1.3	-1.2	-0.6	0.6	0.7
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.8	-1.0	-0.8	-0.9	-0.9	-1.1	-1.5	-1.5	-1.0	-0.8	-1.1	-1.5	-1.7	0.8
Smoking status: Current	1.1	1.7	3.2	-1.3	-0.9	-1.4	-1.7	-1.4	-1.8	-1.5	-1.3	-1.4	-1.4	-1.0	-0.4	0.9
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.5	0.8	1.6	0.6	1.0	0.8	1.9	1.0	1.1	1.1	0.6	1.8	0.9	-0.3
Supplements: Fish oil (including cod liver oil)	1.1	1.4	6.2	0.9	2.0	0.8	0.9	0.9	1.0	1.5	0.8	1.0	0.8	2.5	-0.2	-0.3
Medication: Paracetamol	1.1	1.6	4.5	1.4	0.3	1.3	1.4	1.4	0.9	0.3	1.6	1.5	1.3	1.2	2.1	-0.3
Leg fat percentage (left)	1.1	4.1	13.4	-1.3	-3.5	-1.4	-1.7	-1.4	-2.6	-2.8	-0.6	-1.2	-1.5	-3.7	-0.3	-0.8
Vascular/heart problems diagnosed by doctor	1.1	3.1	28.1	0.6	2.2	0.5	0.5	0.7	1.3	1.2	0.3	0.9	0.5	1.2	0.1	5.3
Arm predicted mass (left)	1.1	5.7	24.5	1.0	3.7	1.0	1.3	0.9	3.0	3.9	1.5	1.2	1.0	5.0	1.2	0.6
Alzheimer’s Disease (in father)	1.0	1.1	4.4	-0.8	-0.7	-0.7	-0.7	-0.7	-2.1	-0.6	-0.8	-0.9	-0.7	-1.0	1.0	1.8
Age at First Birth	1.0	1.4	2.6	-1.4	0.6	-1.5	-1.1	-1.2	-0.0	-0.3	-1.5	-1.3	-1.6	1.6	-1.3	-0.5
Sensitivity / hurt feelings	1.0	1.7	5.6	-1.2	-2.4	-1.3	-1.3	-1.3	-0.3	-1.6	-1.2	-1.4	-1.3	-0.6	-1.2	-0.5
High blood pressure	1.0	2.7	29.8	-0.1	-2.0	-0.1	-0.0	-0.2	-0.8	-0.7	-0.1	-0.5	-0.1	-0.4	0.5	-5.5
Medication: Atenolol	1.0	1.2	1.9	1.2	1.2	1.3	1.3	1.1	0.2	1.0	1.1	1.1	1.3	1.1	1.4	-0.3
Alcohol usually taken with meals	1.0	1.6	4.2	1.5	0.4	1.4	1.8	1.4	2.1	1.0	1.2	1.6	1.4	-0.4	-0.1	-0.7
Financial difficulties in last 2 years	1.0	1.3	5.2	1.2	0.1	1.2	1.0	1.2	0.3	0.8	1.4	1.0	1.2	0.2	2.3	1.1
Fluid intelligence score	1.0	2.1	5.2	-1.5	-1.0	-1.5	-1.7	-1.7	-0.3	-0.3	-2.3	-2.1	-1.3	2.1	-0.2	-0.3
Pulse rate	1.0	1.7	2.7	1.6	1.0	1.6	1.4	1.5	0.9	1.5	1.2	1.3	1.6	0.2	1.6	0.3
Peak expiratory flow (PEF)	1.0	2.3	12.8	0.8	0.1	0.9	1.2	0.8	2.6	1.2	0.1	0.6	0.9	2.1	0.8	-3.6
Number of full brothers	1.0	1.2	2.2	1.1	1.5	1.1	1.1	1.2	0.8	0.6	1.0	1.3	1.1	1.3	1.2	-0.8
Pulse rate, automated reading	1.0	3.2	4.5	2.1	1.2	2.0	2.0	2.1	1.7	2.0	1.8	1.7	1.9	1.3	2.0	0.6
Comparative height size at age 10	1.0	5.7	29.5	-1.0	4.4	-0.8	-0.5	-1.0	2.9	3.3	-0.7	-0.7	-0.7	5.4	-1.2	0.1
Financial situation satisfaction	1.0	1.2	1.9	1.3	0.3	1.3	1.2	1.3	1.4	0.7	1.2	1.2	1.3	0.3	1.1	1.0
Basal metabolic rate	1.0	5.4	26.9	0.6	3.7	0.6	0.9	0.5	3.3	3.7	1.2	0.9	0.6	5.2	0.6	0.3
Type 2 Diabetes (T2D) (2018)	0.9	1.8	4.7	1.5	-0.3	1.5	1.5	1.4	1.4	0.3	1.3	1.1	1.5	0.4	1.3	-2.2
Leg fat-free mass (left)	0.9	4.9	24.1	0.6	3.5	0.6	0.9	0.5	3.3	3.4	1.3	1.0	0.7	4.9	0.5	0.1
Average weekly fortified wine intake	0.9	1.1	2.9	-1.4	-0.9	-1.1	-1.3	-1.3	-0.1	-0.6	-1.7	-1.5	-1.1	0.2	-0.5	-0.3
Leg predicted mass (left)	0.9	4.9	23.6	0.6	3.5	0.6	0.9	0.5	3.3	3.3	1.4	1.1	0.7	4.9	0.5	0.2
Had menopause	0.9	1.1	4.0	-0.8	-1.1	-0.7	-0.7	-0.8	-0.4	-1.1	-1.1	-0.7	-0.7	-1.1	-1.5	-2.0
Mouth/teeth dental problems: Dentures	0.9	1.5	2.3	-1.2	-1.4	-1.3	-1.2	-1.3	-1.5	-1.0	-1.4	-1.3	-1.3	-1.0	-0.4	-1.0
Loud music exposure frequency	0.9	0.9	3.5	0.8	1.9	1.0	0.6	0.8	0.5	1.4	1.2	1.1	1.0	0.0	-0.3	0.6
Wheeze or whistling in the chest in last year	0.9	1.7	5.1	-1.0	-1.3	-1.2	-1.2	-1.1	-2.0	-2.2	-1.2	-1.1	-1.3	-1.2	0.3	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	2.0	-1.1	-0.5	-1.3	-1.3	-1.2	-1.2	0.0	-1.1	-1.4	-1.2	0.7	-0.5	-0.5
Qualifications: College or University degree	0.9	2.8	9.3	1.1	2.9	1.2	1.1	1.0	2.4	1.8	1.1	1.2	1.2	3.0	0.7	0.8
Hypertension (Self-reported)	0.9	2.4	27.3	0.1	-1.6	0.1	0.2	0.0	-0.5	-0.5	0.2	-0.2	0.2	-0.4	0.3	-5.2
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	3.0	0.8	1.7	0.9	0.8	0.9	0.8	1.3	1.1	0.8	1.0	0.5	0.4	0.7
Commuting to job workplace: Walk	0.9	0.9	2.5	1.1	0.5	0.8	1.0	0.9	0.9	1.2	0.9	0.8	0.8	1.6	1.1	0.3
Intelligence (Savage-Jansen 2018)	0.8	2.5	5.6	-1.9	-0.8	-1.8	-2.0	-2.0	0.1	-0.4	-2.4	-2.2	-1.8	1.6	-0.4	-0.3
Alzheimer’s Disease (in mother)	0.8	1.0	2.2	-1.2	-0.8	-1.3	-1.3	-1.1	-0.4	-0.9	-0.7	-0.7	-1.3	-0.3	0.2	1.5
Number of treatments/medications taken	0.8	1.5	9.5	-0.5	-2.1	-0.6	-0.5	-0.7	-0.9	-1.3	-0.2	-0.6	-0.7	-0.5	0.8	-3.1
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	5.0	0.7	0.9	0.8	1.1	0.8	-0.2	0.2	1.3	1.3	1.0	0.5	2.2	0.7
Tense / ‘highly strung’	0.8	1.4	2.1	1.5	-0.3	1.2	1.4	1.5	1.2	1.0	1.0	1.1	1.3	1.3	1.3	-0.9
Shortness of breath walking on level ground	0.8	1.0	3.5	-0.6	-1.0	-0.7	-0.7	-0.6	-1.5	-1.1	-0.5	-0.5	-0.8	-1.9	0.1	1.3
Medication: Omeprazole	0.8	1.0	2.9	-0.7	-0.6	-0.7	-0.8	-0.7	-1.5	-1.5	-0.3	-0.4	-0.6	-1.7	-0.3	-1.5
Wears glasses or contact lenses	0.8	0.9	2.8	-0.6	-0.1	-0.6	-0.6	-0.5	-0.5	-1.1	-1.0	-0.6	-0.6	-1.5	-1.7	-1.4
Cholesterol lowering medication	0.8	1.2	6.4	-0.1	-1.7	-0.1	-0.1	-0.2	-1.8	-1.5	-0.3	-0.4	-0.3	-2.5	0.1	-1.1
Primary Biliary Cirrhosis	0.7	1.0	2.2	-0.8	-0.7	-0.9	-1.0	-0.9	-1.5	-1.1	-0.8	-0.8	-0.9	-1.4	-0.1	1.2
Blood White Count	0.7	5.3	19.9	-1.4	-4.5	-1.6	-1.2	-1.3	-2.5	-2.8	-1.2	-2.0	-1.5	-3.6	-0.1	-2.5
Townsend deprivation index at recruitment	0.7	1.0	5.7	1.0	0.2	0.9	0.9	0.9	-0.0	0.4	0.8	1.0	0.8	-0.1	1.1	2.4
Serious illness, injury or assault to yourself	0.7	0.8	1.9	1.1	1.0	1.0	0.9	1.1	0.2	-0.2	1.3	1.4	0.9	-0.8	-0.1	0.8
High blood pressure (mother)	0.7	1.0	8.5	0.9	-0.0	0.7	0.9	0.8	0.2	0.3	0.3	0.8	0.7	0.4	0.6	-2.9
Medication: Cholesterol lowering	0.7	1.1	9.1	-0.4	-1.6	-0.4	-0.4	-0.4	-0.1	-0.7	0.0	-0.6	-0.3	-0.9	0.0	-3.0
Illnesses of mother	0.7	0.9	2.4	-0.9	-0.6	-0.9	-0.8	-0.9	0.7	-0.8	-0.7	-0.9	-0.9	-0.2	-1.5	1.5
Mouth/teeth dental problems: Loose teeth	0.7	0.9	3.1	-0.9	-0.6	-0.9	-1.1	-1.0	-0.7	-0.6	-0.8	-0.9	-0.9	0.6	0.4	1.8
Had major operations	0.7	0.8	1.6	-1.1	-1.0	-0.8	-0.8	-1.0	-0.5	-1.3	-0.7	-0.4	-1.0	-1.2	-1.2	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	3.5	-0.6	-1.0	-0.7	-0.9	-0.6	-0.8	-1.4	0.2	-0.3	-0.5	-1.9	-1.1	0.9
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.8	-1.2	-0.1	-1.2	-1.2	-1.4	-0.2	-0.3	-1.1	-1.1	-1.1	1.7	-0.9	0.8
Number of self-reported non-cancer illnesses	0.7	1.3	4.4	-0.7	-1.4	-0.6	-0.6	-0.6	-1.7	-1.3	-0.2	-0.7	-0.6	-2.1	0.1	-1.7
Guilty feelings	0.7	1.0	4.6	-0.4	0.3	-0.7	-0.7	-0.6	-0.6	-0.1	-0.8	-0.5	-0.7	1.9	1.0	2.1
Medication: Blood pressure	0.7	1.3	11.8	0.7	-0.8	0.7	1.0	0.6	0.2	-0.2	0.6	0.5	0.6	-0.0	1.1	-3.4
High cholesterol (Self-reported)	0.7	1.3	10.1	0.1	-2.0	0.0	0.1	-0.0	-0.6	-0.7	-0.2	-0.4	0.1	-1.1	0.9	-3.2
Illnesses of father: High blood pressure	0.7	0.9	5.9	0.8	0.1	0.7	0.7	0.7	0.8	1.0	0.9	0.6	0.7	0.2	-0.1	-2.4
Verbal and Numeric Reasoning (VNR)	0.6	1.5	3.4	-1.3	-0.2	-1.2	-1.4	-1.4	-0.6	0.1	-1.8	-1.8	-1.1	1.6	0.1	1.2
Body Mass Index (BMI) (2010)	0.6	0.8	2.4	0.8	-1.1	0.7	0.9	0.9	-0.4	-0.3	0.6	0.7	0.7	-1.1	1.6	-0.6
Diabetes (self-reported)	0.6	0.9	3.6	-0.6	-1.9	-0.7	-0.7	-0.8	-0.9	-1.1	-0.5	-1.1	-0.7	0.1	1.0	-1.0
Medication: Simvastatin	0.6	0.9	6.4	-0.3	-1.4	-0.4	-0.3	-0.4	-0.7	-1.1	-0.1	-0.5	-0.4	-1.0	-0.1	-2.5
Arm fat percentage (right)	0.6	2.3	8.3	-0.8	-2.9	-0.9	-1.1	-0.8	-1.5	-2.2	0.1	-0.5	-1.0	-2.6	-0.7	-1.7
Asthma	0.6	1.1	2.7	1.3	-0.1	1.2	1.3	1.2	-0.1	0.3	0.8	1.2	1.0	-1.2	1.6	-1.1
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	4.0	-0.2	-1.2	-0.3	-0.3	-0.3	-0.9	-0.7	0.1	-0.2	-0.3	0.2	1.6	2.0
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.9	1.0	0.6	1.1	1.0	1.0	0.7	0.3	1.2	1.4	1.0	0.2	0.4	-0.2
Osteoarthritis (self-reported)	0.6	0.8	4.8	-0.5	-0.5	-0.6	-0.5	-0.6	-1.2	-1.2	-0.6	-0.5	-0.6	-0.4	0.7	2.2
Hearing aid user	0.6	0.7	1.7	0.8	0.7	0.8	0.8	1.0	0.5	0.2	1.3	1.2	0.7	-1.1	-0.4	0.2
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.6	-0.8	-0.6	-0.7	-0.9	-0.8	-1.3	-0.9	-1.0	-0.8	-0.7	-1.2	-0.4	-0.6
Crohns Disease (2017)	0.5	1.1	1.4	-1.1	-0.9	-1.1	-0.8	-1.1	-1.2	-0.7	-1.2	-1.1	-1.1	-1.2	-1.2	0.1
Breast Cancer	0.5	1.2	2.8	1.1	0.7	1.0	1.2	1.1	0.2	1.1	1.4	1.0	0.9	1.7	1.4	0.9
LDL Cholesterol	0.5	0.9	7.5	0.0	-1.2	0.2	-0.2	-0.1	-0.1	-0.7	-1.0	-0.5	-0.1	-0.7	0.2	-2.7
BMI	0.5	2.8	14.7	-0.5	-3.8	-0.7	-0.6	-0.5	-1.6	-2.1	0.3	-0.3	-0.7	-3.4	0.4	-1.3
Lung FEV1/FVC ratio	0.5	2.6	5.3	1.8	-0.0	2.1	2.0	2.0	0.6	0.6	2.3	2.3	2.0	-0.7	1.4	0.8
Systolic blood pressure, automated reading	0.5	1.6	7.2	1.2	-0.2	1.2	1.1	1.2	1.7	0.9	0.6	0.8	1.2	0.8	1.0	-2.7
Fed-up feelings	0.5	0.8	4.7	0.6	-1.1	0.4	0.5	0.6	-0.6	0.3	0.3	0.2	0.4	1.2	2.2	-1.3
Heart attack	0.5	0.6	3.6	-0.3	-0.6	-0.2	-0.3	-0.2	-1.2	-1.3	0.2	-0.2	-0.2	-1.9	0.2	-0.3
Alcohol intake versus 10 years previously	0.5	0.8	4.5	0.9	-0.3	0.7	0.9	0.8	-0.3	0.2	0.7	0.6	0.7	0.9	2.1	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	5.9	0.8	0.5	0.7	0.6	0.7	-0.1	-0.3	0.7	0.6	0.7	1.0	2.4	0.7
Medication: Lansoprazole	0.5	0.6	1.9	-0.6	-1.3	-0.5	-0.4	-0.6	-0.8	-1.4	-0.6	-0.4	-0.6	-0.8	-0.5	0.1
Birth weight	0.5	1.1	5.5	0.6	2.4	0.6	0.6	0.7	1.0	1.3	0.6	1.0	0.6	0.8	-0.9	1.2
Emphysema/chronic bronchitis	0.5	0.5	1.0	-0.6	-0.8	-0.7	-0.6	-0.6	-1.0	-1.0	-0.7	-0.7	-0.8	-0.3	0.7	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	3.3	-0.0	-0.7	0.1	0.0	-0.1	-0.9	-1.1	-0.3	-0.2	0.1	-1.1	0.4	-1.8
Asthma (self-reported)	0.5	0.9	2.0	1.1	-0.2	1.0	1.1	1.0	-0.3	0.1	0.5	1.0	0.8	-1.4	1.4	-1.4
Commuting to job workplace: Public transport	0.5	0.6	4.0	0.4	0.6	0.3	0.6	0.5	0.9	0.6	-0.3	0.0	0.4	2.0	1.0	-0.6
Average weekly beer plus cider intake	0.5	0.7	5.4	0.3	-0.3	0.2	0.1	0.2	-1.4	0.4	-0.1	-0.3	0.2	1.0	2.3	-0.7
Schizophrenia (2018)	0.4	0.9	4.9	0.6	2.2	0.7	0.3	0.6	0.6	1.6	0.8	0.7	0.7	1.0	0.0	0.0
Prostate Cancer	0.4	0.6	5.2	-0.1	0.1	-0.0	-0.4	-0.0	-1.2	-0.2	0.4	0.2	-0.1	-0.4	0.2	2.3
HbA1C	0.4	0.5	1.6	-0.5	-0.9	-0.6	-0.4	-0.7	-0.9	-1.3	-0.9	-0.5	-0.5	-0.2	0.3	-0.6
Heel T-Score	0.4	3.3	5.5	2.3	0.7	2.2	2.0	2.2	-0.7	1.6	2.3	1.8	2.1	-1.1	2.4	0.7
Smoking Status	0.4	1.0	3.9	-0.8	-0.5	-0.9	-1.1	-0.9	-1.8	-0.6	-0.3	-0.8	-0.9	-1.0	-0.2	2.0
Respiratory disease	0.4	0.8	3.8	0.8	-0.8	0.7	0.8	0.8	-0.1	-0.1	0.3	0.7	0.5	-1.9	1.3	-1.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.7	0.3	-1.3	0.3	0.5	0.3	1.0	0.0	0.7	0.2	0.3	-0.9	0.4	-0.6
Taking other prescription medications	0.4	0.6	1.9	0.1	-1.2	0.1	0.2	-0.0	-1.4	-1.4	-0.2	0.1	-0.0	-0.9	1.1	-1.0
Body mass index (BMI)	0.4	1.7	6.6	-0.7	-2.6	-0.8	-0.9	-0.8	-1.7	-1.7	0.2	-0.4	-0.9	-2.2	0.1	-0.6
Waist circumference	0.4	1.4	2.7	-1.3	-1.6	-1.3	-1.7	-1.4	-1.5	-1.1	-0.4	-1.1	-1.4	-1.0	-0.2	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	4.8	0.3	-0.8	0.1	0.1	0.2	-0.0	0.1	0.2	0.1	0.2	1.2	2.2	0.6
Hearing difficulty/problems with background noise	0.4	0.6	1.3	-0.8	0.5	-0.8	-1.1	-0.8	-0.2	-0.7	-0.8	-0.9	-1.0	0.2	-0.7	0.8
Body fat percentage	0.4	1.7	6.4	-0.6	-2.5	-0.7	-0.9	-0.6	-1.2	-1.9	0.1	-0.4	-0.8	-2.1	-0.2	-1.8
Worry too long after embarrassment	0.4	0.6	5.2	-0.4	0.9	-0.6	-0.5	-0.5	0.3	0.2	-0.5	-0.4	-0.5	2.3	-0.5	0.5
Number of children fathered	0.4	0.4	1.8	-0.2	-0.3	-0.2	-0.1	-0.1	0.2	-0.1	0.1	-0.1	-0.2	-1.3	-1.2	-1.3
Angina (self-reported)	0.4	0.5	1.7	0.6	0.6	0.6	0.5	0.6	-0.2	0.3	1.2	0.6	0.6	-0.8	0.7	1.3
Heart disease (mother)	0.4	0.5	1.8	0.6	0.4	0.7	0.8	0.7	-0.4	0.1	0.9	0.7	0.7	-0.1	1.3	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	2.9	-0.2	-0.3	-0.2	-0.3	-0.1	0.1	-0.8	0.1	0.1	-0.3	-1.2	-0.8	-1.7
Illnesses of father: Heart disease	0.4	0.6	4.0	0.2	-1.6	0.1	0.2	0.1	-0.3	-0.8	0.4	0.2	-0.1	-2.0	0.1	-0.3
Arm fat percentage (left)	0.4	1.7	6.9	-0.5	-2.6	-0.6	-0.8	-0.6	-1.2	-2.0	0.3	-0.3	-0.8	-2.4	-0.5	-1.5
Ever had bowel cancer screening	0.4	0.5	2.4	-0.7	0.4	-0.6	-0.6	-0.8	-0.3	0.2	-0.9	-0.7	-0.6	0.5	-0.1	-1.6
Mineral and other dietary supplements	0.4	0.5	2.3	-0.4	-0.9	-0.4	-0.5	-0.4	-0.3	-0.8	-0.5	-0.6	-0.4	-1.5	-0.1	0.7
Average weekly champagne plus white wine intake	0.4	0.5	1.1	0.9	-0.4	0.9	0.8	0.8	1.0	0.5	0.3	0.5	0.9	0.7	0.9	-0.3
Mother’s age at death	0.4	0.5	1.1	-0.8	0.6	-0.8	-0.6	-0.7	-0.3	-0.4	-1.0	-0.8	-0.6	0.6	-0.9	0.8
Medication: Bendroflumethiazide	0.4	0.6	4.4	0.6	-0.5	0.5	0.6	0.5	0.7	0.2	0.3	0.5	0.4	0.5	0.6	-2.1
Basal cell carcinoma (self-reported)	0.4	0.5	1.1	-0.8	-0.3	-0.9	-1.0	-0.9	-1.1	0.0	-0.5	-0.9	-0.8	0.4	-0.0	-0.3
Heart disease (siblings)	0.4	0.5	0.9	0.7	0.8	0.7	0.5	0.5	0.3	0.6	0.9	0.9	0.5	0.9	1.0	0.5
Bipolar Disorder (2018)	0.3	0.5	0.9	-0.9	-0.5	-1.0	-0.8	-0.8	-1.0	-0.7	-0.2	-0.6	-1.0	-0.6	-0.6	0.0
Neuroticism (Nagel 2018)	0.3	0.8	2.9	-0.7	-1.7	-0.7	-0.8	-0.6	0.1	-0.5	-1.3	-1.0	-0.6	1.3	0.5	-0.3
Mean Putamen Volume	0.3	0.4	2.8	-0.0	0.2	0.1	0.1	0.0	0.1	-0.1	0.0	-0.1	0.1	0.8	1.7	1.1
HDL Cholesterol	0.3	0.5	4.7	-0.3	0.1	-0.3	-0.2	-0.3	-0.4	-0.0	-0.6	-0.5	-0.4	0.8	0.6	-2.2
Schizophrenia (2014)	0.3	0.6	3.9	0.4	2.0	0.5	0.2	0.5	0.7	1.3	0.6	0.6	0.5	0.9	-0.1	0.0
Blood Eosinophil Count	0.3	2.0	4.8	-1.2	-1.7	-1.2	-0.9	-1.1	-2.0	-2.2	-1.5	-1.1	-1.2	-1.9	-0.8	-0.9
Allergy or Eczema	0.3	0.8	1.6	0.9	0.8	1.0	1.0	1.1	0.2	0.2	1.2	1.3	1.1	-0.6	0.8	0.3
Neuroticism	0.3	0.7	2.9	-0.4	-1.7	-0.7	-0.8	-0.5	-0.3	-0.3	-1.1	-1.0	-0.5	1.1	0.4	-0.9
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.1	0.5	0.5	0.6	0.7	0.6	1.0	0.2	0.4	0.9	0.7	0.3	-0.5	-0.7
Angina	0.3	0.4	2.3	0.4	0.5	0.4	0.3	0.4	-0.3	-0.0	1.0	0.4	0.4	-1.0	0.5	1.5
Supplements: Zinc	0.3	0.3	0.9	0.5	0.9	0.4	0.6	0.7	0.7	0.2	0.6	0.7	0.5	0.6	-0.3	0.2
Medication: Metformin	0.3	0.4	1.7	-0.6	-1.0	-0.7	-0.7	-0.7	0.0	-1.3	-0.3	-0.6	-0.7	0.0	-0.0	0.3
Impedance of leg (right)	0.3	1.3	3.9	-0.7	-1.4	-0.5	-0.8	-0.6	-1.0	-1.4	-1.4	-1.1	-0.6	-2.0	-0.9	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.5	-0.3	-1.2	-0.4	-0.3	-0.2	-1.1	-0.5	-0.2	-0.4	-0.4	-0.1	1.2	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	2.8	-0.2	-1.6	-0.6	-0.6	-0.3	-1.7	-0.4	-0.1	-0.8	-0.7	-0.8	0.2	-1.4
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.3	0.8	0.6	0.9	0.9	0.9	0.5	-0.1	1.1	1.1	0.9	-0.6	0.7	0.6
Past tobacco smoking	0.3	0.6	2.2	0.6	0.7	0.6	0.6	0.6	1.5	0.6	0.3	0.6	0.5	1.2	0.4	-0.8
Hayfever/allergic rhinitis (self-reported)	0.3	0.5	4.3	0.1	-0.2	0.1	0.0	0.1	-0.4	-0.5	0.2	0.0	0.1	-2.1	-0.5	0.9
Happiness	0.3	0.4	1.5	0.4	0.2	0.4	0.4	0.4	0.6	0.9	0.3	0.1	0.5	1.2	0.7	0.8
Medication: Paracetamol	0.3	0.5	2.5	0.7	-0.9	0.5	0.6	0.5	-0.0	-0.8	0.7	0.6	0.4	0.4	1.6	-0.1
Medication: Amlodipine	0.3	0.5	4.5	0.3	-0.9	0.1	0.0	0.1	-0.0	0.7	0.1	-0.2	0.1	0.3	0.4	-2.1
Comparative body size at age 10	0.3	1.0	3.6	-1.1	-0.1	-1.2	-1.2	-1.1	-0.7	-0.6	-0.7	-0.7	-1.1	-0.1	-0.7	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.3	0.5	0.6	0.5	0.5	0.6	0.3	-0.0	0.6	0.5	0.6	1.1	1.1	-0.3
Alcohol intake frequency.	0.3	0.8	1.9	1.1	0.8	1.0	1.0	1.0	-0.0	-0.1	0.9	1.4	1.0	-0.1	1.1	0.3
Number of full sisters	0.3	0.3	1.6	0.3	0.2	0.4	0.3	0.4	0.6	0.1	0.6	0.3	0.3	-1.0	-0.3	-1.3
Overall health rating	0.3	0.6	3.1	0.7	-0.7	0.5	0.7	0.7	-0.5	-0.7	0.2	0.6	0.5	0.0	1.8	-1.0
Illnesses of siblings: Diabetes	0.3	0.3	2.3	0.0	-0.8	-0.1	-0.1	-0.2	-0.7	-0.1	0.1	0.0	-0.1	0.1	1.5	-1.0
Mood swings	0.3	0.5	1.5	0.9	-0.3	0.8	0.8	0.9	0.4	0.4	0.3	0.6	0.9	0.8	1.2	-0.3
Medication: Gliclazide	0.3	0.4	0.6	0.7	0.4	0.7	0.7	0.7	0.7	0.2	0.8	0.5	0.5	0.4	0.6	-0.5
Alcohol drinker status: Never	0.3	0.3	1.4	-0.1	1.2	0.1	-0.2	-0.0	-0.3	-0.5	-0.0	0.3	0.1	-1.1	-0.9	0.5
Ever smoked	0.3	0.5	3.9	0.3	0.1	0.3	0.2	0.4	-0.8	0.1	0.5	0.3	0.4	-1.1	0.1	2.0
Myopia	0.3	0.4	3.5	-0.1	0.2	0.1	-0.2	-0.0	-0.0	0.6	-0.2	-0.3	0.1	-0.5	-0.7	-1.9
Pain experienced in last month	0.3	0.5	2.8	0.3	0.8	0.4	0.4	0.5	1.7	0.4	0.4	0.4	0.5	1.0	-0.5	-0.3
Supplements: Calcium	0.3	0.3	1.0	0.4	1.0	0.4	0.5	0.6	0.8	0.1	0.4	0.6	0.5	-0.0	-0.4	-0.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	2.9	-0.0	-0.1	0.1	-0.0	0.0	-0.7	-1.0	0.5	0.1	0.0	-1.7	0.1	-0.3
Ulcerative Colitis (UC)	0.2	0.5	2.2	0.4	1.5	0.6	0.4	0.4	0.8	0.3	-0.4	0.4	0.7	1.0	-0.0	0.5
Waist Hip Ratio (WHR)	0.2	0.7	5.5	0.6	0.3	0.6	-0.1	0.6	-0.7	-0.1	0.7	0.5	0.6	-0.7	0.7	2.4
Hypothyroidism (self reported)	0.2	0.5	3.6	-0.3	0.1	-0.2	-0.5	-0.4	0.2	0.3	-0.7	-0.4	-0.1	1.1	-0.9	-1.9
Hearing difficulty/problems: Yes	0.2	0.4	1.3	-0.2	0.8	-0.3	-0.6	-0.3	0.4	-0.7	-0.2	-0.0	-0.6	-1.0	-1.2	0.2
Medication: Co-codamol	0.2	0.3	0.9	-0.3	-0.1	-0.4	-0.4	-0.3	-0.7	-0.9	0.3	-0.1	-0.5	-0.8	-0.5	0.8
Diabetes (mother)	0.2	0.2	1.5	-0.2	-0.1	-0.2	-0.2	-0.3	-0.6	-0.5	-0.1	-0.3	-0.2	1.2	0.5	-0.1
Trunk fat percentage	0.2	0.8	3.2	-0.3	-1.7	-0.3	-0.5	-0.2	-0.4	-1.2	0.4	0.0	-0.5	-1.2	-0.2	-1.8
Age when periods started (menarche)	0.2	0.5	4.4	0.5	-0.2	0.5	0.3	0.5	0.6	-0.1	0.6	0.4	0.4	0.1	0.1	-2.1
Supplements: Glucosamine	0.2	0.3	1.1	0.4	0.4	0.3	0.3	0.3	-0.2	0.6	0.3	0.3	0.3	1.0	1.0	-0.3
Pain all over the body in last month	0.2	0.2	1.3	0.0	-0.9	0.1	0.0	0.1	-0.2	-0.4	-0.3	-0.0	0.1	-0.0	1.2	0.7
Neuroticism score	0.2	0.5	2.2	-0.1	-1.5	-0.4	-0.3	-0.1	0.2	0.0	-0.7	-0.7	-0.3	1.4	1.0	-0.4
Weight	0.2	1.0	6.6	-0.2	1.2	-0.3	-0.1	-0.3	1.4	1.5	0.6	0.1	-0.3	2.6	0.2	-0.5
Noisy workplace	0.2	0.3	1.3	-0.0	-0.4	-0.1	-0.1	0.0	0.0	-1.1	0.2	0.4	-0.3	-1.2	-0.1	0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.4	2.4	-0.4	1.0	-0.3	-0.4	-0.3	0.6	-0.4	-0.3	-0.1	-0.1	0.1	-1.5	0.6
Prospective memory result	0.2	0.3	2.6	-0.1	-0.4	-0.1	-0.1	-0.1	-0.4	-0.4	-0.1	0.2	-0.1	-1.6	-0.5	-0.4
Length of working week for main job	0.2	0.2	1.1	-0.2	-0.4	-0.2	-0.1	-0.2	-0.7	-0.1	0.1	-0.1	-0.3	-0.9	0.3	1.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	2.0	-0.1	1.1	-0.0	-0.1	-0.0	0.7	0.5	0.4	-0.0	0.1	1.4	-0.0	0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	3.1	-0.3	0.1	-0.2	-0.5	-0.4	0.3	0.3	-0.5	-0.2	-0.1	0.8	-0.8	-1.8
Neck or shoulder pain in last month	0.2	0.3	1.6	0.3	0.8	0.2	0.1	0.2	-0.5	-0.2	0.5	0.8	0.1	0.6	0.7	1.2
Leg fat mass (right)	0.2	0.7	2.1	-0.8	-1.4	-0.8	-1.0	-0.9	-0.7	-1.0	-0.0	-0.6	-0.9	-0.9	0.0	-1.0
Leg pain on walking	0.2	0.2	1.2	0.1	-0.0	-0.1	0.0	-0.0	1.0	-0.3	0.4	0.4	-0.0	0.1	0.1	1.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.8	-0.5	0.1	-0.4	-0.3	-0.5	0.8	0.2	-0.7	-0.5	-0.3	0.9	-0.7	-0.7
Smoking status: Previous	0.2	0.3	0.9	-0.5	-0.6	-0.5	-0.4	-0.5	-1.0	-0.2	-0.0	-0.4	-0.5	-0.7	-0.6	0.4
Average weekly red wine intake	0.2	0.3	1.8	0.3	0.3	0.3	0.5	0.4	1.3	0.7	0.2	0.4	0.2	0.8	-0.1	0.6
Loneliness, isolation	0.2	0.2	1.3	0.2	-1.0	-0.0	0.1	0.2	0.0	0.2	0.0	-0.1	0.1	-0.6	0.3	1.2
Diabetes diagnosed by doctor	0.2	0.3	0.9	0.5	-0.8	0.5	0.4	0.3	0.7	-0.3	0.5	0.0	0.4	0.5	0.9	-0.9
Friendships satisfaction	0.2	0.3	0.8	-0.5	-0.9	-0.5	-0.4	-0.4	0.5	-0.4	-0.3	-0.6	-0.5	-0.4	-0.8	-0.4
Osteoporosis (self-reported)	0.2	0.2	0.9	-0.6	0.7	-0.3	-0.3	-0.4	-0.2	0.1	-0.3	-0.2	-0.1	-0.3	-0.9	0.2
Number of operations (self-reported)	0.2	0.3	1.2	-0.3	0.1	-0.2	-0.0	-0.2	-0.6	-1.1	-0.0	0.0	-0.3	-0.8	-1.0	0.6
Irritability	0.2	0.4	1.8	0.5	-0.5	0.4	0.1	0.5	1.3	0.8	-0.1	-0.0	0.6	1.2	0.3	0.6
Fractured/broken bones in last 5 years	0.2	0.3	1.6	-0.1	0.7	0.0	0.2	0.1	1.3	-0.0	0.1	0.3	-0.0	-0.3	-0.9	-0.6
Diastolic blood pressure, automated reading	0.2	0.7	5.4	-0.1	-0.9	-0.2	-0.1	-0.1	0.9	0.1	-0.9	-0.6	-0.1	1.2	0.3	-2.3
Alcohol drinker status: Previous	0.2	0.2	0.7	0.6	0.0	0.3	0.5	0.5	0.1	-0.3	0.2	0.7	0.1	0.7	0.9	0.4
Bipolar Disorder or Schizophrenia	0.1	0.3	2.2	-0.1	1.5	-0.1	-0.3	-0.0	-0.2	0.8	0.4	0.1	-0.1	0.3	-0.4	0.0
Depression (Nagel 2018)	0.1	0.1	0.6	0.1	-0.4	-0.0	-0.1	0.2	-0.1	-0.1	0.2	0.3	0.1	-0.2	0.7	-0.7
Schizophrenia vs Biploar Disorder	0.1	0.1	0.4	-0.3	0.4	-0.2	-0.4	-0.3	-0.6	-0.0	-0.5	-0.4	-0.1	0.6	0.2	0.0
Irritable Bowel Disease (IBD)	0.1	0.1	0.8	-0.3	0.4	-0.1	-0.1	-0.3	-0.2	-0.3	-0.9	-0.4	-0.0	-0.1	-0.6	0.2
Crohns Disease (2012)	0.1	0.1	0.8	0.0	-0.4	0.1	-0.0	-0.1	-0.4	0.3	-0.2	-0.2	-0.0	-0.9	-0.4	0.0
Rheumatoid Arthritis	0.1	0.1	0.4	-0.3	0.0	-0.3	-0.5	-0.3	-0.3	0.2	0.1	-0.2	-0.3	-0.1	-0.3	0.6
Triglycerides	0.1	0.2	0.4	-0.3	-0.6	-0.5	-0.4	-0.3	-0.2	-0.3	-0.6	-0.4	-0.4	-0.5	-0.7	-0.4
Ulcerative Colitis	0.1	0.1	0.6	-0.2	-0.1	0.1	-0.2	-0.3	0.6	-0.4	-0.8	-0.4	0.1	-0.2	-0.4	0.0
Blood Platelet Count	0.1	1.0	6.8	0.5	-1.6	0.4	0.7	0.6	-0.5	-1.1	0.6	0.4	0.2	-2.6	-0.1	-0.3
Blood Red Count	0.1	1.3	6.8	-0.5	-2.2	-0.6	0.0	-0.5	-0.3	-0.5	-1.0	-0.8	-0.6	-1.3	-0.1	-2.6
Tanning	0.1	0.7	6.9	-0.3	0.3	0.1	-0.1	-0.1	1.0	0.0	-0.3	-0.2	0.2	-0.4	-0.5	2.6
Frequency of depressed mood in last 2 weeks	0.1	0.2	1.2	0.1	-1.1	-0.0	0.1	0.2	-0.1	-0.3	0.2	0.2	0.0	-0.8	0.1	-0.2
Diabetes (father)	0.1	0.1	0.3	-0.3	-0.1	-0.3	-0.4	-0.3	-0.3	-0.3	0.1	-0.3	-0.3	-0.3	0.2	-0.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	1.1	0.2	0.6	0.1	0.0	-0.0	0.2	0.1	-0.0	0.4	-0.0	1.0	0.4	-0.2
Qualifications: CSEs or equivalent	0.1	0.2	1.1	0.2	-0.3	0.1	0.0	0.2	-0.2	-0.5	0.4	0.3	0.0	0.4	0.1	-1.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.5	-0.0	0.2	0.1	0.1	-0.0	0.5	0.4	0.2	-0.1	-0.0	0.6	0.6	0.7
Medication: Levothyroxine sodium	0.1	0.2	0.4	-0.3	-0.5	-0.1	-0.5	-0.4	-0.2	0.2	-0.3	-0.3	-0.1	-0.6	-0.7	-0.5
Impedance of leg (left)	0.1	0.3	1.5	-0.0	-0.7	0.0	-0.2	0.0	-0.8	-0.9	-0.8	-0.5	-0.0	-1.2	-0.1	-0.5
Trunk fat mass	0.1	0.3	2.0	-0.4	-0.6	-0.4	-0.5	-0.4	0.3	-0.2	0.3	-0.1	-0.5	0.3	-0.1	-1.4
Number of incorrect matches in round	0.1	0.2	0.6	-0.6	-0.1	-0.7	-0.3	-0.6	-0.8	-0.2	-0.0	-0.3	-0.8	-0.6	-0.4	-0.2
Had other major operations	0.1	0.1	0.6	0.4	0.3	0.3	0.5	0.4	-0.2	-0.3	0.0	0.5	0.3	-0.0	0.8	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	1.0	0.5	-0.1	0.4	0.3	0.6	-1.0	0.4	0.7	0.2	0.3	-0.5	0.6	0.1
Allergy	0.1	0.3	1.6	-0.1	0.4	-0.0	-0.2	-0.2	0.6	0.9	-0.3	-0.2	0.1	0.9	-1.3	0.5
Impedance of arm (right)	0.1	0.4	2.3	0.0	0.2	0.2	0.0	0.2	0.6	-0.5	-0.1	0.0	0.2	-0.2	-1.3	-1.5
Hip circumference	0.1	0.3	1.2	-0.3	-0.2	-0.3	-0.2	-0.4	1.0	0.6	0.4	0.0	-0.3	1.1	0.1	-0.9
Falls in the last year	0.1	0.1	0.7	-0.0	-0.3	-0.1	0.1	0.1	0.1	-0.4	0.3	0.1	-0.1	-0.8	-0.2	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	1.1	0.2	1.1	0.2	0.2	0.2	0.0	0.3	0.5	0.5	0.2	0.2	0.4	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.7	-0.2	-0.9	-0.2	-0.2	-0.2	-0.0	0.2	-0.3	-0.4	-0.2	0.5	0.8	0.4
Impedance of arm (left)	0.1	0.4	1.6	0.5	0.5	0.6	0.5	0.7	1.0	-0.2	0.2	0.4	0.6	0.0	-0.9	-1.3
Arm fat mass (right)	0.1	0.4	2.2	-0.3	-1.2	-0.4	-0.4	-0.3	-0.1	-0.6	0.5	-0.0	-0.5	-0.2	-0.0	-1.5
Ever highly irritable/argumentative for 2 days	0.1	0.2	1.1	-0.1	-0.7	0.0	-0.2	-0.1	-0.1	-0.2	0.1	-0.1	0.0	0.3	1.0	-0.5
Age at first live birth	0.1	0.1	0.7	0.3	0.8	0.3	0.3	0.4	0.2	0.3	0.4	0.3	0.4	0.0	0.4	0.4
Health satisfaction	0.1	0.1	0.4	0.1	0.0	0.0	-0.0	0.0	-0.4	0.7	0.6	0.1	0.0	-0.2	0.1	0.4
Migraine (self-reported)	0.1	0.1	0.5	0.3	0.1	0.2	0.3	0.3	-0.4	-0.2	-0.1	0.3	0.1	-0.7	-0.2	0.7
Medication: Ibuprofen	0.1	0.1	0.5	-0.1	-0.6	-0.0	0.1	-0.0	0.0	0.1	-0.1	-0.2	0.1	0.3	0.6	0.7
Whole body fat mass	0.1	0.3	2.3	-0.3	-0.9	-0.4	-0.5	-0.4	0.2	-0.3	0.4	-0.1	-0.5	-0.0	-0.1	-1.5
Chest pain or discomfort	0.1	0.2	1.1	0.3	-0.1	0.1	0.2	0.4	-0.2	-0.3	0.5	0.2	0.2	-1.1	0.3	0.6
Age at last live birth	0.1	0.1	0.6	-0.3	-0.7	-0.3	-0.2	-0.2	0.1	-0.7	-0.4	-0.6	-0.2	-0.3	0.2	0.1
Qualifications: nursing, teaching	0.1	0.2	1.0	-0.3	0.1	-0.3	-0.4	-0.5	0.3	-0.5	-0.7	-0.4	-0.3	0.0	-0.7	1.0
Eye problems/disorders: Cataract	0.1	0.1	0.8	-0.2	-0.9	-0.3	-0.4	-0.2	-0.5	-0.3	-0.1	-0.1	-0.2	-0.5	0.0	0.1
Arm fat mass (left)	0.1	0.2	1.2	-0.0	-0.9	-0.1	-0.1	-0.1	0.2	-0.2	0.8	0.3	-0.2	-0.1	0.2	-1.1
Ever depressed for a whole week	0.1	0.1	0.4	0.1	-0.4	-0.1	-0.2	-0.1	0.3	-0.3	-0.3	-0.3	-0.1	0.4	0.3	-0.6
Commuting to job workplace: Cycle	0.1	0.1	0.4	-0.3	0.2	-0.2	0.1	-0.2	0.6	-0.1	-0.1	-0.2	-0.3	0.5	-0.5	0.1
Impedance of whole body	0.1	0.3	1.0	0.3	-0.2	0.5	0.3	0.5	0.3	-0.6	-0.3	0.1	0.4	-0.7	-0.5	-1.0
Leg fat mass (left)	0.1	0.5	1.6	-0.7	-1.3	-0.7	-0.8	-0.7	-0.8	-0.8	0.2	-0.4	-0.8	-0.7	0.3	-0.6
Hair Pigment	0.0	1.1	4.1	1.1	1.3	0.9	0.8	0.9	-0.3	0.9	1.6	1.1	0.8	0.2	0.6	2.0
Average weekly spirits intake	0.0	0.0	0.1	0.1	-0.3	0.0	-0.0	0.1	-0.1	0.2	-0.3	0.0	0.1	0.2	0.3	0.3
Number of live births	0.0	0.0	0.1	0.1	0.3	0.1	-0.0	0.0	-0.1	-0.3	-0.3	-0.0	0.0	0.3	-0.3	-0.1

Hub : Genes

CYB561

Models

Trait associations