Hub : Genes

DCAF12

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.0836 0.0326 0.00046 0.012 NA 0.016 NA -0.002 4.7e-02 NA 2.3e-02 NA 4.5e-01
2 GTEx Ovary 0.3660 0.1100 0.00210 0.008 NA 0.098 NA -0.012 2.0e-01 NA 2.2e-03 NA 8.4e-01
3 GTEx Testis 0.1740 0.0620 0.00024 0.134 NA 0.103 NA 0.126 1.6e-06 NA 2.6e-05 NA 3.4e-06
4 GTEx Thyroid 0.1000 0.0380 0.00110 0.006 NA 0.027 NA 0.023 1.0e-01 NA 3.4e-03 NA 6.5e-03
5 TCGA Kidney Renal Clear Cell Carcinoma 0.0469 0.0257 0.00600 0.000 0.003 0.002 NA 0.003 2.9e-01 0.14 1.8e-01 NA 1.5e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 2.8 4.4 15.1 1.0 1.3 -1.3 1.6 -3.9
Bipolar Disorder or Schizophrenia 2.4 5.8 20.0 1.4 2.2 -1.3 0.4 -4.5
Depressed Affect (Nagel 2018) 0.3 0.6 1.7 0.2 1.3 0.9 -0.8 0.1
Depression (Nagel 2018) 0.5 0.7 1.6 1.3 0.6 0.2 0.6 -1.1
Intelligence (Savage-Jansen 2018) 1.3 4.1 10.6 -2.8 1.3 -3.3 -0.1 0.6
Neuroticism (Nagel 2018) 0.5 1.1 1.7 0.6 1.3 1.0 -1.2 -1.0
Schizophrenia (2018) 1.2 2.4 6.9 0.9 1.9 -0.7 -0.8 -2.6
Schizophrenia vs Biploar Disorder 2.0 2.7 9.0 -0.8 0.1 0.4 -3.0 1.9
Worry (Nagel 2018) 0.8 1.7 4.3 1.2 -0.3 2.1 -1.6 0.0
Alzheimer’s Disease (in mother) 0.9 1.1 4.2 -1.1 -0.2 0.3 0.0 2.0
Alzheimer’s Disease (in father) 0.2 0.2 0.8 -0.3 0.2 -0.1 0.3 0.9
Alzheimer’s Disease (including proxy) 0.6 0.9 3.1 -0.9 -0.5 0.4 -0.3 1.8
Crohns Disease (2017) 0.2 0.5 1.8 -0.0 -0.2 -0.7 -1.3 0.5
Irritable Bowel Disease (IBD) 0.5 1.2 1.6 -1.1 1.1 -1.3 -1.2 0.9
Ulcerative Colitis (UC) 0.6 1.2 2.4 -1.5 1.2 -0.8 -0.5 1.0
Major Depression (MDD) 0.2 0.2 1.1 1.0 -0.0 -0.2 -0.2 -0.2
Reaction Time 1.2 2.3 4.2 1.4 -2.0 2.1 1.0 0.6
Verbal and Numeric Reasoning (VNR) 1.1 2.7 5.7 -2.4 -0.0 -2.1 -0.3 1.8
Breast Cancer 0.7 1.6 2.9 -1.6 -1.2 -1.0 0.2 1.7
Ovarian Cancer 2.1 2.8 5.8 0.1 1.1 -1.2 2.3 -2.4
Prostate Cancer 2.0 2.8 10.0 -1.6 -0.9 -0.9 -0.1 3.2
Age at First Birth 1.1 1.6 2.8 -1.7 -1.3 0.2 -1.0 1.6
Bipolar Disorder (2011) 2.1 2.1 6.5 0.5 1.1 -1.5 0.3 -2.5
Body Mass Index (BMI) (2010) 4.0 5.5 13.8 3.7 -0.6 3.3 0.5 -1.4
Coronary Artery Disease (CAD) 1.3 1.6 5.2 1.4 2.3 0.3 -0.6 -0.7
Crohns Disease (2012) 0.8 1.3 4.6 -0.2 -2.1 -0.5 -0.9 1.0
Mean Putamen Volume 1.0 1.2 1.8 -1.4 -1.2 -1.0 1.2 0.4
Fasting Glucose 0.9 1.1 3.5 0.8 1.0 -0.3 1.9 -0.5
HbA1C 3.2 3.5 7.3 2.7 2.1 0.1 -1.2 -2.1
HDL Cholesterol 0.4 0.7 2.4 -0.9 -0.2 -0.4 -0.1 1.5
LDL Cholesterol 0.2 0.3 0.9 -0.5 0.9 -0.5 0.1 0.5
Lupus 0.3 0.5 0.7 -0.8 0.7 -0.7 -0.4 -0.7
Neuroticism (2016) 0.6 0.9 3.0 0.5 0.2 0.8 -1.7 -0.7
Primary Biliary Cirrhosis 0.3 0.4 1.1 -0.7 1.0 -0.3 -0.3 0.6
Rheumatoid Arthritis 0.2 0.3 0.7 0.6 -0.1 0.3 -0.3 0.8
Schizophrenia (2014) 1.2 2.6 7.5 0.2 1.7 -1.6 -0.5 -2.7
Triglycerides 3.1 5.1 10.0 3.2 2.4 0.7 -0.1 -3.0
Type 2 Diabetes (T2D) (2012) 2.3 2.6 8.1 0.6 1.8 -0.9 -0.6 -2.9
Ulcerative Colitis 1.0 1.4 2.7 -1.3 1.3 -1.6 -0.6 0.8
Blood Eosinophil Count 0.4 3.2 7.0 -0.7 1.6 -2.6 1.0 -2.2
Blood Platelet Count 0.4 4.1 12.3 1.6 -1.9 3.5 -0.8 1.3
Blood Red Count 1.3 12.5 24.8 0.6 4.9 -3.6 -0.5 -5.0
Blood White Count 0.4 2.9 8.0 0.3 2.8 0.2 0.5 -2.5
Heel T-Score 0.4 2.9 12.5 0.5 1.3 0.1 -0.1 -3.5
BMI 2.2 13.0 35.2 5.9 0.8 4.7 -0.1 -2.8
Height 0.7 13.9 28.0 -5.3 -2.8 -4.7 2.6 2.2
Waist Hip Ratio (WHR) 0.7 3.1 10.2 -0.3 0.9 -1.1 3.2 -1.8
Systolic Blood Pressure 1.5 7.5 24.3 4.9 0.3 2.9 0.5 -2.1
Smoking Status 0.7 1.8 5.7 -1.2 2.4 0.4 -0.2 1.2
Allergy or Eczema 0.8 2.0 7.5 0.3 1.2 -0.9 2.7 -0.6
Cardiovascular Disease 1.9 6.2 16.8 4.1 2.0 1.6 0.4 -2.8
Hypothyroidism (self reported) 0.7 1.6 2.5 1.6 -0.2 1.0 1.4 -1.6
Respiratory disease 1.5 3.3 9.8 1.4 1.4 0.3 3.1 -1.7
Type 2 Diabetes (T2D) (2018) 1.0 1.9 5.6 0.9 0.3 1.3 2.4 -1.2
Lung FEV1/FVC ratio 1.3 6.8 15.7 3.4 0.5 2.4 -4.0 -1.1
Lung FVC 0.7 3.3 7.9 -2.8 -0.9 -2.8 -0.3 -0.5
Neuroticism 0.9 2.2 3.9 1.3 1.7 1.5 -2.0 -0.6
Chronotype (morning person) 2.5 5.7 18.5 4.3 0.8 2.1 -0.2 -2.2
Hair Pigment 0.0 0.9 3.0 -1.1 0.5 1.7 -0.3 -0.1
Tanning 0.3 3.6 10.7 1.8 -1.3 3.3 0.8 1.3
Hand grip strength (left) 0.4 1.1 2.3 -0.2 0.7 -1.5 -0.6 1.4
Number of treatments/medications taken 2.4 4.3 7.9 2.5 2.2 1.3 0.4 -2.8
Average weekly spirits intake 0.5 0.7 1.8 0.7 1.4 0.2 0.9 0.1
Sensitivity / hurt feelings 2.6 4.5 8.9 2.1 2.7 1.0 -1.1 -3.0
Frequency of depressed mood in last 2 weeks 0.3 0.4 0.9 1.0 0.7 0.6 0.0 -0.4
Hearing difficulty/problems: Yes 0.4 0.7 1.8 -0.0 1.3 0.0 1.2 -0.2
Relative age of first facial hair 0.5 1.1 1.7 -0.9 1.1 -1.2 1.3 0.6
Other serious medical condition/disability diagnosed by doctor 2.2 2.9 5.3 2.3 1.6 0.9 0.8 -2.3
Ever used hormone-replacement therapy (HRT) 2.3 3.0 6.5 -1.0 2.6 -2.1 0.2 -1.7
Ever had hysterectomy (womb removed) 0.1 0.1 0.5 0.1 0.7 -0.3 -0.1 0.1
Systolic blood pressure, automated reading 3.8 11.0 32.9 5.7 0.8 3.9 -0.9 -2.2
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.8 -0.6 0.1 -0.5 0.9 -0.3
Angina 0.6 0.8 2.2 1.1 0.1 1.5 -0.8 0.1
Medication for hormone replacement therapy 0.7 0.8 1.8 0.6 1.3 -0.8 0.3 -1.0
Vitamin and mineral supplements 2.9 3.9 6.7 1.0 -2.6 2.1 -0.8 2.6
Supplements: Zinc 2.5 2.7 10.6 0.8 3.3 0.3 -1.0 -1.2
Medication: Co-codamol 1.5 1.8 4.2 2.0 -0.2 2.0 -0.8 0.3
Medication: Metformin 0.9 1.3 1.7 1.3 1.1 1.3 1.2 -0.9
Diabetes (father) 1.0 1.3 1.9 0.9 -1.3 1.4 1.3 0.5
Diabetes (mother) 0.5 0.6 1.3 1.1 -0.1 0.5 0.6 -1.1
Severe depression (siblings) 0.9 1.1 4.6 -0.3 -0.6 0.4 -2.1 0.2
Pack years adult smoking proportion 0.8 1.2 3.1 -1.7 -0.1 0.4 0.2 1.8
Impedance of leg (right) 2.0 9.9 21.1 -4.6 -1.9 -4.1 0.4 2.8
Leg fat-free mass (left) 0.9 4.6 10.6 3.3 0.9 2.5 0.9 -2.1
Trunk fat percentage 0.4 1.6 2.3 1.4 1.0 1.5 -1.5 -0.6
Hand grip strength (right) 0.8 2.1 5.0 -1.5 -0.4 -2.2 0.7 1.6
Townsend deprivation index at recruitment 0.8 1.1 1.8 1.1 0.6 1.2 1.3 -0.7
Current tobacco smoking 0.6 1.0 3.3 -0.8 0.9 0.4 0.3 1.8
Average weekly fortified wine intake 1.8 2.1 4.3 0.1 2.1 -1.8 -0.7 -1.6
Maternal smoking around birth 1.2 1.7 4.3 -2.1 0.4 -1.9 0.7 -0.1
Fed-up feelings 0.2 0.4 0.8 -0.8 0.9 0.3 -0.6 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.1 1.7 1.2 1.0 1.3 0.9 -0.8
Relative age voice broke 0.1 0.1 0.3 0.3 0.5 -0.3 0.3 -0.3
Taking other prescription medications 1.8 2.7 3.3 1.8 1.8 1.6 1.7 -1.4
Age when periods started (menarche) 0.4 1.0 1.9 -0.1 -1.3 -1.1 1.4 0.6
Bilateral oophorectomy (both ovaries removed) 0.7 0.9 2.7 0.4 1.0 0.6 1.6 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 2.8 -0.7 1.7 -0.7 0.2 -1.3
Tinnitus: Yes, but not now, but have in the past 0.9 0.9 2.2 0.8 1.5 0.2 0.1 -1.4
Qualifications: CSEs or equivalent 1.1 1.5 3.8 -1.9 0.2 -1.1 -1.4 0.7
Serious illness, injury or assault to yourself 1.1 1.3 2.2 0.6 1.5 -0.4 -1.4 -1.3
High blood pressure 3.1 8.6 20.9 4.6 2.1 2.3 0.5 -3.5
Hayfever, allergic rhinitis or eczema 0.7 1.5 6.1 -0.3 0.5 -1.0 2.5 0.3
Multivitamins +/- minerals 3.2 4.1 9.0 -0.7 2.4 -1.8 1.4 -3.0
Stomach or abdominal pain in last month 0.2 0.3 1.0 0.0 -0.1 -1.0 0.5 -0.3
Supplements: Glucosamine 1.1 1.4 3.4 1.7 -0.3 1.8 -0.8 -0.0
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.5 0.6 0.5 0.7 -0.6 -0.5
Medication: Atenolol 0.1 0.2 0.5 0.1 0.3 0.4 -0.7 0.3
Medication: Levothyroxine sodium 1.1 1.9 4.9 2.2 0.5 1.2 1.2 -1.3
Sitting height 0.5 3.4 9.7 -1.8 -0.6 -3.1 1.9 -0.4
Chronic bronchitis/emphysema (father) 1.3 1.5 5.8 -0.4 2.4 -0.5 0.4 -1.1
High blood pressure (mother) 1.0 1.4 4.6 1.1 2.1 -0.3 0.7 -1.0
Body mass index (BMI) 1.9 8.3 19.4 4.4 2.0 3.5 -0.6 -2.3
Impedance of leg (left) 2.4 11.6 25.8 -5.1 -1.9 -3.9 -0.1 3.6
Leg predicted mass (left) 0.9 4.7 10.9 3.3 0.8 2.5 1.0 -2.1
Trunk fat mass 0.5 2.2 4.6 2.1 1.3 1.6 -0.7 -1.3
Waist circumference 1.2 4.5 7.1 2.7 1.9 2.1 0.7 -2.6
Number of incorrect matches in round 1.2 2.1 6.2 1.0 0.4 -0.8 1.5 -2.5
Past tobacco smoking 0.8 1.4 3.2 1.8 -1.8 0.9 -0.4 0.2
Alcohol usually taken with meals 0.2 0.3 1.0 -0.3 -0.1 -1.0 -0.1 0.5
Nervous feelings 0.2 0.3 0.8 0.1 0.8 0.5 -0.9 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 1.5 0.4 -0.2 1.1 0.8 1.2
Hearing difficulty/problems with background noise 0.8 1.3 3.3 0.4 1.6 0.2 0.4 -1.8
Hair/balding pattern: Pattern 2 2.3 2.9 6.1 2.5 -0.8 1.9 0.3 -2.0
Had menopause 0.4 0.5 1.7 0.5 0.4 -0.7 0.2 -1.3
Had other major operations 0.3 0.4 1.6 -0.4 -0.3 -0.3 1.3 -0.2
Forced vital capacity (FVC) 1.5 5.8 13.7 -3.7 -1.1 -3.5 1.2 0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.4 -0.5 1.2 -0.0 -0.4 -0.7
Ever unenthusiastic/disinterested for a whole week 1.0 1.3 2.5 -1.1 1.6 -1.2 -0.2 1.0
Qualifications: None of the above 0.8 1.7 4.7 2.2 -0.4 1.7 -0.5 -0.7
Financial difficulties in last 2 years 0.7 0.9 1.8 -0.8 -0.9 1.3 -0.1 1.1
Mouth/teeth dental problems 0.8 1.2 3.7 -0.1 -1.9 -0.1 1.4 0.5
Heart attack 0.3 0.4 0.7 -0.7 -0.7 -0.8 0.1 0.5
Allergy 0.7 1.6 7.6 -0.5 0.1 0.1 -2.8 -0.1
Pain all over the body in last month 0.7 0.7 1.8 0.5 -0.9 1.3 0.3 0.9
Diabetes (self-reported) 0.7 1.0 2.1 0.9 -0.3 1.4 1.1 -0.9
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.8 0.5 -0.1 0.2 1.4 0.1
Medication: Ramipril 0.2 0.3 0.8 0.9 -0.3 0.8 0.0 -0.0
Medication: Simvastatin 1.2 1.7 3.0 1.5 1.7 0.8 -1.6 -0.2
Fluid intelligence score 1.4 2.9 7.8 -2.8 -0.3 -1.7 -1.0 1.7
Illnesses of siblings 1.2 1.7 3.3 -1.8 -1.2 -1.7 0.4 1.0
Neuroticism score 0.3 0.6 1.0 0.5 1.0 0.9 -0.8 -0.3
Weight 0.7 3.4 8.1 2.8 1.4 1.9 0.3 -1.8
Impedance of arm (right) 1.8 8.6 24.6 -5.0 -0.6 -4.0 -0.8 1.3
Arm fat percentage (right) 1.3 5.2 8.8 3.0 2.3 2.1 -1.1 -2.5
Trunk fat-free mass 0.5 2.8 5.4 2.3 0.8 0.9 2.0 -1.7
Hip circumference 0.6 2.7 5.1 2.3 1.5 2.0 -0.8 -1.4
Time employed in main current job 0.6 0.7 1.9 -0.6 1.1 -1.4 -0.4 0.1
Alcohol intake versus 10 years previously 0.7 1.0 2.8 1.3 -0.5 1.7 -0.0 -0.5
Father’s age at death 1.0 1.3 4.7 -0.2 -0.9 -0.5 2.2 -0.9
Worrier / anxious feelings 0.6 1.1 2.6 1.0 0.7 1.6 -1.2 0.3
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 1.6 0.3 0.1 0.4 1.3 -0.1
Falls in the last year 1.4 1.9 3.4 1.8 1.1 0.7 1.9 -0.9
Hair/balding pattern: Pattern 3 2.7 4.0 9.5 -3.1 -0.3 -0.9 1.2 2.9
Number of live births 1.6 2.2 6.9 2.6 -1.3 0.9 0.1 -1.3
Forced expiratory volume in 1-second (FEV1) 1.1 3.7 10.5 -2.7 -0.8 -3.2 0.0 -0.4
Pulse rate 1.0 1.7 5.8 -1.1 2.4 -0.4 -1.1 -0.6
Happiness 0.3 0.4 1.4 -0.5 -0.4 -0.0 1.2 -0.0
Noisy workplace 0.3 0.4 0.8 0.4 0.0 0.7 -0.9 -0.7
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.1 -1.0 0.2 -1.0 -0.5 0.8
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.6 2.2 -0.1 0.7 -0.6 1.5 -0.5
Mouth/teeth dental problems: Dentures 2.4 4.0 9.5 3.1 1.7 2.4 0.1 -1.4
Asthma 0.7 1.5 5.7 0.7 0.6 -0.2 2.4 -0.9
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 3.4 -0.1 0.6 -0.8 1.8 -1.1
Medication: Cholesterol lowering 1.2 1.8 3.4 1.8 0.2 1.3 -1.9 -0.7
Depression (self-reported) 0.4 0.4 1.2 -0.7 1.1 -0.6 -0.2 0.3
Medication: Lansoprazole 1.3 1.5 3.5 0.4 -1.9 1.4 0.4 1.3
Prospective memory result 2.8 3.4 8.6 2.9 -0.7 2.7 -0.6 -0.6
Lung cancer (father) 1.7 2.0 5.2 1.9 -0.5 2.3 -0.7 0.6
Illnesses of mother 0.5 0.6 1.0 -0.6 -1.0 -0.2 0.8 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 3.0 7.8 -2.3 -1.3 -2.8 0.0 -0.7
Pulse wave Arterial Stiffness index 0.4 0.5 1.0 -0.9 1.0 -0.5 -0.1 -0.5
Impedance of arm (left) 2.1 9.8 27.3 -5.2 -1.8 -3.2 -1.3 2.6
Arm fat mass (right) 1.3 5.2 10.9 3.3 1.9 2.5 -0.5 -2.2
Trunk predicted mass 0.5 2.8 5.3 2.3 0.9 0.9 2.0 -1.8
Standing height 0.5 5.4 10.8 -3.3 -1.4 -3.1 1.9 1.0
Length of working week for main job 1.5 1.6 4.8 -1.3 2.2 -0.7 0.6 -0.9
Exposure to tobacco smoke at home 0.4 0.5 1.3 0.8 -0.6 1.1 -0.3 -0.3
Breastfed as a baby 1.3 1.7 5.0 -1.0 0.4 -2.2 -1.1 -1.0
Tense / ‘highly strung’ 0.5 0.8 2.2 1.1 -0.2 1.5 -0.6 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 2.8 4.2 9.4 -1.1 3.1 -2.0 1.1 -2.4
Hair/balding pattern: Pattern 4 0.6 1.4 2.8 1.6 1.1 -0.3 -0.2 -1.7
Birth weight of first child 0.2 0.3 1.1 -0.3 -1.1 0.1 0.1 0.4
Peak expiratory flow (PEF) 2.5 5.7 17.4 -2.6 0.7 -4.2 1.9 -0.5
Pulse wave reflection index 0.3 0.4 1.0 0.6 -1.0 0.1 0.7 0.1
Ever highly irritable/argumentative for 2 days 0.7 0.9 3.2 0.3 1.8 -0.6 0.9 -0.1
Loud music exposure frequency 1.5 1.7 3.9 1.6 -0.6 0.7 2.0 -1.0
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 3.2 0.3 0.4 0.6 -1.8 1.2
Mouth/teeth dental problems: Bleeding gums 1.3 1.6 4.5 -2.1 -0.4 -1.4 -0.5 1.1
Blood clot in the leg (DVT) 0.7 0.9 1.6 -0.9 -0.8 -0.6 1.3 -1.2
Medication: Paracetamol 0.8 1.3 3.9 0.0 -2.0 0.7 -1.3 0.8
Headache pain in last month 0.6 1.0 3.4 -1.0 0.5 -1.8 -0.1 -0.5
Medication for cholesterol, blood pressure or diabetes 1.2 2.1 6.2 -2.5 0.2 -1.6 0.3 1.2
Glaucoma (self-reported) 2.1 2.4 4.3 1.2 -1.3 2.1 -1.7 1.4
Gout (self-reported) 3.0 4.1 9.8 3.1 1.2 1.7 0.1 -2.5
Hypothyroidism/myxoedema (self-reported) 1.3 2.6 6.5 2.5 0.3 1.5 1.2 -1.5
Medication: Amlodipine 0.8 1.2 3.4 1.9 0.2 1.5 -0.0 -0.3
Medication: Ventolin 100micrograms inhaler 0.9 1.2 3.1 0.5 1.8 -0.5 0.4 -1.4
Birth weight 2.2 4.7 14.5 -1.6 -2.3 0.4 0.9 3.8
Chronic bronchitis/emphysema (mother) 1.4 1.7 2.2 1.3 -1.4 1.5 -1.3 1.0
High blood pressure (siblings) 1.1 1.6 2.9 1.7 1.0 1.3 0.9 -1.4
Forced vital capacity (FVC), Best measure 1.6 6.0 14.4 -3.8 -1.6 -3.5 0.7 -0.1
Body fat percentage 0.6 2.3 3.6 1.9 1.5 1.7 -1.2 -1.1
Leg fat percentage (right) 0.9 3.3 8.2 2.9 1.7 1.8 -0.5 -1.5
Arm fat-free mass (right) 0.5 2.8 7.5 2.7 0.3 1.7 1.5 -1.1
Exposure to tobacco smoke outside home 0.7 1.0 2.1 0.3 1.4 -0.7 -0.6 -1.5
Comparative body size at age 10 1.3 3.7 7.8 2.8 -0.8 2.5 0.4 -1.8
Number of full brothers 0.7 0.9 1.9 1.1 1.4 -0.0 -0.8 -0.9
Worry too long after embarrassment 1.4 2.3 7.1 0.4 2.7 -0.7 0.5 -1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.7 4.5 0.6 1.2 -0.8 2.1 -1.2
Wheeze or whistling in the chest in last year 1.4 2.5 9.0 0.7 1.6 -0.2 3.0 -0.5
Number of children fathered 0.7 0.8 3.0 -0.2 0.3 -1.7 -0.7 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 2.0 1.4 -0.2 0.9 0.8 -0.9
Age at first live birth 2.5 4.4 9.3 -0.4 -3.1 2.2 0.1 2.8
Pulse wave peak to peak time 0.4 0.5 1.3 0.7 -1.1 0.4 0.3 0.6
Health satisfaction 0.2 0.3 0.7 -0.5 0.7 -0.2 0.0 0.8
Shortness of breath walking on level ground 0.8 0.9 3.0 -0.2 1.7 -1.0 0.1 -0.8
Qualifications: College or University degree 0.1 0.4 1.0 -0.6 1.0 -0.1 1.0 0.0
Eye problems/disorders: None of the above 0.9 1.0 2.1 -1.4 -0.5 -0.8 1.3 0.7
Mouth/teeth dental problems: Loose teeth 0.1 0.2 0.3 -0.4 -0.5 0.1 -0.2 0.6
Emphysema/chronic bronchitis 0.5 0.6 1.4 -0.0 0.1 0.6 1.2 1.0
Medication for pain relief, constipation, heartburn 1.1 1.9 4.7 -2.2 -0.3 -1.8 1.0 0.5
Neck or shoulder pain in last month 0.2 0.3 1.2 0.2 -0.1 0.2 -1.1 0.1
Medication: Blood pressure 2.5 4.5 11.9 3.5 1.1 1.0 1.3 -2.6
Angina (self-reported) 0.4 0.5 1.7 0.8 -0.2 1.3 -0.4 0.2
Migraine (self-reported) 1.7 2.1 5.2 -1.5 0.2 -2.3 0.5 -1.6
Medication: Ibuprofen 3.2 3.8 7.3 0.1 1.9 -1.7 2.7 -2.3
Medication: Allopurinol 3.0 4.0 10.0 3.2 1.6 1.4 0.2 -2.3
Medication: Omeprazole 0.6 0.7 1.6 1.3 -0.1 1.2 -0.6 -0.4
Medication: Seretide 50 evohaler 1.0 1.1 3.0 1.4 0.4 -0.4 0.5 -1.7
Mean time to correctly identify matches 1.7 3.2 7.4 2.7 -0.8 2.4 1.4 -0.5
Heart disease (mother) 0.2 0.2 0.7 0.3 -0.8 -0.2 -0.1 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.4 2.6 1.6 1.1 1.2 1.1 -0.7
Whole body fat mass 0.7 3.0 6.2 2.5 1.6 1.7 -0.2 -1.7
Leg fat mass (right) 1.3 5.0 12.6 3.5 1.7 2.4 0.1 -2.0
Arm predicted mass (right) 0.7 3.5 9.9 3.1 0.4 2.0 1.4 -1.2
Pulse rate, automated reading 0.3 0.9 1.8 -1.0 1.4 -0.2 -1.0 -0.7
Alcohol intake frequency. 0.4 0.8 2.2 1.2 -0.2 0.5 -0.4 -1.5
Comparative height size at age 10 0.1 0.4 1.0 -1.0 0.4 -0.7 -0.4 -0.5
Number of full sisters 1.1 1.3 2.9 1.6 -1.7 0.8 0.4 0.3
Suffer from ‘nerves’ 1.4 2.3 3.7 -0.0 -1.3 1.9 -1.6 1.8
Overall health rating 0.8 1.7 4.2 0.8 1.8 -0.0 0.6 -2.1
Chest pain or discomfort 0.4 0.6 1.5 0.4 0.2 0.8 0.7 1.2
Had major operations 0.2 0.2 0.5 0.3 -0.7 0.5 -0.2 -0.4
Age at last live birth 0.9 1.3 2.8 1.1 -1.7 1.5 0.2 -0.0
Family relationship satisfaction 0.7 0.8 1.7 -0.4 0.9 -1.0 0.7 -1.3
Leg pain on walking 1.8 2.3 10.4 -0.0 3.2 -0.3 0.1 -1.1
Qualifications: NVQ or HND or HNC or equivalent 1.8 2.2 3.9 1.5 1.7 0.6 1.3 -2.0
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.2 1.1 1.0 0.7 0.5 -0.7
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.2 -1.1 -0.2 -0.5 -0.8 1.0
Medication: Aspirin 0.9 1.2 3.8 0.9 0.1 2.0 -1.0 0.3
Supplements: Vitamin C 0.8 0.9 1.4 1.0 1.0 0.7 -1.2 0.9
Knee pain experienced in last month 0.6 0.9 1.9 0.5 1.4 0.5 1.4 0.2
Hypertension (Self-reported) 3.3 9.1 22.5 4.7 2.1 2.0 0.8 -3.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 2.8 1.7 -0.4 1.0 0.4 -0.3
Illnesses of father: Heart disease 0.5 0.6 2.5 0.0 -0.8 -0.0 -1.6 0.1
Illnesses of siblings: Diabetes 2.4 3.0 7.4 2.7 1.3 1.8 -0.5 -1.5
Smoking status: Previous 0.6 0.9 2.0 -0.8 1.4 -0.3 -0.6 -1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.6 4.0 -0.5 -1.2 -1.2 2.0 0.8
Whole body fat-free mass 0.6 3.5 8.0 2.8 0.9 1.5 1.6 -1.9
Leg fat-free mass (right) 0.7 4.0 9.1 3.0 0.9 2.5 0.8 -1.8
Arm fat percentage (left) 1.3 5.1 9.7 3.1 1.7 2.6 -1.3 -2.1
Average weekly red wine intake 0.3 0.4 0.8 0.2 -0.7 0.7 0.3 0.9
Handedness (chirality/laterality): Left-handed 0.3 0.4 1.1 -0.2 0.5 -0.8 0.2 -1.1
Mood swings 0.4 0.8 1.4 1.1 0.4 1.2 -0.9 0.5
Loneliness, isolation 0.2 0.3 0.7 -0.7 0.2 0.0 0.8 -0.4
Long-standing illness, disability or infirmity 1.9 3.0 7.0 1.3 2.7 0.3 2.0 -1.5
Ever had bowel cancer screening 0.1 0.2 0.3 0.3 -0.3 0.4 0.4 -0.5
Diabetes diagnosed by doctor 1.0 1.6 4.4 1.1 -0.3 2.1 1.4 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 3.9 0.3 0.9 -0.4 -0.1 -2.0
Friendships satisfaction 0.9 1.1 3.5 -0.9 -0.3 -1.9 0.7 -0.6
Qualifications: nursing, teaching 1.3 2.1 6.5 -1.1 1.4 -2.5 0.2 -0.8
Commuting to job workplace: Walk 1.2 1.3 3.5 -1.4 -0.6 -1.9 -0.8 -0.2
Eye problems/disorders: Cataract 0.4 0.5 1.1 1.1 0.0 1.0 -0.6 -0.0
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 1.9 -1.2 1.3 -1.4 -1.0 -0.7
Medication for cholesterol 1.9 2.8 5.6 -2.4 -1.8 -1.1 0.4 2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 3.3 1.8 0.5 0.9 0.3 -1.6
Back pain experienced in last month 1.0 1.5 4.4 -0.2 0.8 -0.8 2.1 -1.4
Mineral and other dietary supplements 1.3 1.7 3.5 -1.1 -1.5 0.2 1.2 1.9
Breast cancer (self-reported) 0.4 0.5 1.3 -1.1 0.0 0.5 0.7 -0.6
Asthma (self-reported) 0.7 1.4 4.8 1.0 0.2 0.1 2.2 -1.1
Osteoporosis (self-reported) 1.3 1.6 5.9 0.3 2.4 1.1 -0.7 -0.5
Osteoarthritis (self-reported) 0.8 1.0 1.9 0.6 0.8 0.5 1.3 -1.4
Medication: Aspirin 0.7 0.9 3.4 0.7 -0.1 1.8 -0.6 0.2
Medication: Gliclazide 0.6 0.7 2.3 0.8 0.7 1.5 0.0 -0.3
Illnesses of father: None of the above (group 1) 1.2 1.5 2.9 0.8 -1.7 1.7 -0.8 0.5
Smoking status: Current 0.8 1.2 3.8 -1.1 0.8 0.3 0.5 2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 3.2 -1.3 -1.8 -0.3 -1.2 -0.1
Whole body water mass 0.6 3.6 8.2 2.9 0.9 1.7 1.6 -1.9
Leg predicted mass (right) 0.8 4.0 9.1 3.0 1.0 2.5 0.7 -1.8
Arm fat mass (left) 1.2 4.9 10.7 3.3 1.5 2.6 -0.5 -2.1
Number of self-reported non-cancer illnesses 1.6 2.8 4.9 1.9 0.7 1.4 2.2 -1.8
Average weekly champagne plus white wine intake 1.1 1.4 4.3 2.1 0.5 -0.1 1.1 -1.2
Miserableness 0.2 0.4 1.7 -0.2 1.3 0.4 -0.4 -0.2
Guilty feelings 0.4 0.6 1.7 1.0 0.3 0.6 -0.1 -1.3
Wears glasses or contact lenses 0.7 0.8 1.6 -1.1 0.8 -0.6 1.3 0.3
Ever taken oral contraceptive pill 0.5 0.6 1.8 -0.4 0.8 0.0 -0.4 1.4
Hearing aid user 3.2 3.6 6.8 2.1 2.2 1.3 2.6 -0.5
Mother’s age at death 0.1 0.1 0.3 -0.2 -0.2 0.1 -0.4 0.5
Financial situation satisfaction 0.5 0.6 1.4 -1.2 1.0 -0.7 0.0 0.3
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.1 -1.0 0.8 -0.9 0.1 0.1
Commuting to job workplace: Public transport 0.6 0.8 3.3 -0.0 0.2 -0.1 -1.8 0.7
Eye problems/disorders: Glaucoma 2.3 2.7 7.2 1.4 -0.6 2.7 -1.7 0.9
Medication: Blood pressure 1.5 2.9 7.2 2.7 0.9 2.2 -0.3 -1.3
Pain type(s) experienced in last month: Hip pain 1.4 1.7 5.1 1.0 2.3 0.1 0.0 -1.6
Supplements: Fish oil (including cod liver oil) 1.2 1.6 2.8 1.5 1.6 -0.5 -0.5 -1.7
High cholesterol (Self-reported) 1.9 3.3 6.3 2.5 2.2 0.4 -1.5 -1.7
Medication: Bendroflumethiazide 0.9 1.4 2.6 1.6 0.7 1.1 -1.2 -1.0
Medication: Paracetamol 0.7 1.1 1.9 1.0 -1.4 1.2 -0.8 0.8
Medication: Lisinopril 0.5 0.6 1.8 0.7 0.6 -0.4 1.4 -0.6
Medication: Atorvastatin 0.9 1.1 1.6 1.0 1.3 0.6 -1.2 -0.9
Illnesses of father: High blood pressure 1.4 1.7 8.1 0.2 0.2 -0.5 2.9 0.2
Alcohol drinker status: Never 3.2 3.8 8.8 3.0 1.8 1.7 1.9 -0.8
Ever smoked 0.6 1.1 2.2 -1.5 1.4 -0.6 0.4 0.8
Basal metabolic rate 0.6 3.6 8.4 2.9 1.1 1.8 1.3 -1.9
Leg fat percentage (left) 0.8 2.9 6.5 2.5 1.6 1.9 -0.8 -1.1
Arm fat-free mass (left) 0.7 3.5 7.8 2.8 1.2 1.2 1.7 -1.9
Number of operations (self-reported) 1.1 1.6 5.7 -0.0 1.3 -0.9 0.1 -2.4
Average weekly beer plus cider intake 1.2 1.7 3.4 -1.8 -1.0 -0.6 0.9 1.7
Irritability 0.1 0.2 0.8 -0.2 -0.9 0.2 0.4 -0.0
Risk taking 0.6 0.9 1.4 0.9 1.2 0.6 -0.9 -0.9
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.0 -1.0 -0.3 -1.0 1.0 -0.1
Fractured/broken bones in last 5 years 0.1 0.2 0.5 0.0 0.4 0.2 0.7 0.4
Age started oral contraceptive pill 1.1 1.3 4.5 0.9 1.0 -0.5 -0.2 -2.1
Diastolic blood pressure, automated reading 2.7 8.3 20.5 4.5 2.4 2.5 0.7 -2.9
Ever depressed for a whole week 1.8 2.3 5.6 -1.3 2.4 -2.0 0.1 0.1
Unable to work because of sickness or disability 0.7 0.9 1.7 1.1 0.0 1.3 0.9 -0.9
Commuting to job workplace: Cycle 0.9 1.1 2.5 0.9 1.6 -0.3 0.9 -1.1
Myopia 2.0 2.8 5.2 -1.3 1.4 -2.2 0.7 -2.3
Vascular/heart problems diagnosed by doctor 2.5 6.8 15.5 -3.9 -1.7 -2.2 -0.5 3.3
Cholesterol lowering medication 1.1 1.7 4.9 0.7 2.2 -0.2 -1.4 -1.0
Medication: Omeprazole (e.g. Zanprol) 1.1 1.4 3.7 1.9 -0.3 1.6 -0.5 -0.5
Pain experienced in last month 0.3 0.5 1.1 0.6 -0.8 0.6 -1.1 0.0
Supplements: Calcium 1.6 1.8 2.5 -1.3 1.5 -1.6 0.1 -1.5
Basal cell carcinoma (self-reported) 0.2 0.3 0.4 0.4 -0.6 0.6 0.7 0.2
Heart attack/myocardial infarction (self-reported) 0.6 0.8 1.1 -1.1 -1.0 -0.9 0.2 0.9
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 2.5 -0.8 -1.0 -0.5 1.6 -1.0
Heart disease (siblings) 1.5 1.9 4.2 2.1 0.2 1.9 -0.6 -1.0
Alcohol drinker status: Previous 0.6 0.6 1.2 -0.9 -1.1 -1.1 0.1 -0.3
Pack years of smoking 0.9 1.4 4.1 -2.0 0.0 0.0 0.1 1.7
Impedance of whole body 2.6 13.4 34.9 -5.9 -2.1 -4.0 -0.6 3.3
Leg fat mass (left) 1.2 4.7 11.6 3.4 1.7 2.5 -0.1 -1.7
Arm predicted mass (left) 0.7 3.4 7.5 2.7 1.3 1.2 1.8 -1.8