Hub : Genes

SLC27A4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Mucosa 0.1990 0.0560 1.1e-06 0.066 NA 0.116 NA 0.094 3.3e-05 NA 3.7e-08 NA 7.4e-07
2 GTEx Testis 0.6040 0.0660 4.6e-15 0.390 NA 0.453 NA 0.441 1.8e-18 NA 4.1e-22 NA 2.0e-21
3 TCGA Kidney Renal Clear Cell Carcinoma 0.0382 0.0266 3.8e-03 0.006 0.006 0.014 NA 0.004 5.5e-02 0.067 8.4e-03 NA 9.1e-02
4 TCGA Lung Squamous Cell Carcinoma 0.0191 0.0120 5.2e-03 0.016 0.006 0.003 NA 0.016 5.5e-03 0.061 1.5e-01 NA 5.2e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.4 2.2 5.4 -1.2 -2.3 -0.2 1.4
Bipolar Disorder or Schizophrenia 0.2 0.4 0.9 -0.8 -0.9 0.0 -0.0
Depressed Affect (Nagel 2018) 2.8 6.0 7.9 -1.8 -2.8 2.3 2.7
Depression (Nagel 2018) 1.8 2.7 6.1 -1.1 -1.4 2.5 1.2
Intelligence (Savage-Jansen 2018) 0.0 0.1 0.5 0.0 -0.7 0.1 0.4
Neuroticism (Nagel 2018) 1.1 2.7 5.1 -0.6 -1.7 2.3 1.5
Schizophrenia (2018) 0.2 0.5 1.3 -0.0 0.7 0.2 -1.2
Schizophrenia vs Biploar Disorder 0.2 0.3 0.6 -0.8 -0.1 -0.2 0.6
Worry (Nagel 2018) 0.5 1.1 1.9 1.1 0.9 0.8 -1.4
Alzheimer’s Disease (in mother) 0.3 0.3 1.0 1.0 0.1 0.3 -0.2
Alzheimer’s Disease (in father) 1.2 1.3 2.4 1.6 1.1 -0.9 -0.8
Alzheimer’s Disease (including proxy) 0.3 0.4 1.4 1.2 0.4 0.3 0.1
Crohns Disease (2017) 0.1 0.2 0.4 -0.1 -0.2 0.4 0.7
Irritable Bowel Disease (IBD) 0.1 0.2 0.5 -0.0 -0.3 0.4 0.7
Ulcerative Colitis (UC) 0.5 0.9 1.7 -0.5 -1.0 0.9 1.3
Major Depression (MDD) 1.1 1.3 3.4 -0.3 -1.8 1.2 0.7
Reaction Time 0.2 0.5 0.7 0.5 0.4 0.8 -0.8
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.4 0.1 -0.6 -0.5 -0.1
Breast Cancer 0.4 1.0 2.2 1.5 0.9 0.9 -0.5
Ovarian Cancer 0.5 0.7 2.2 0.7 0.0 1.5 -0.0
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.8 1.1 2.5 1.0 0.8 -0.8 -1.6
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 9.6 13.2 17.8 -4.2 -3.4 2.7 4.0
Coronary Artery Disease (CAD) 1.3 1.5 2.2 -1.5 -1.1 0.9 1.3
Crohns Disease (2012) 2.6 4.1 5.2 -1.2 -2.2 2.3 2.2
Mean Putamen Volume 2.2 2.6 4.8 -1.2 -2.2 0.0 2.0
Fasting Glucose 0.0 0.0 0.0 0.2 0.1 0.1 0.0
HbA1C 0.5 0.6 1.0 -0.2 0.7 -0.9 -1.0
HDL Cholesterol 0.5 0.9 3.3 -0.2 -0.3 1.8 0.2
LDL Cholesterol 0.4 0.7 1.3 1.1 0.5 -0.6 -0.8
Lupus 0.2 0.3 0.7 0.9 0.4 0.2 -0.6
Neuroticism (2016) 0.9 1.3 4.0 -0.5 0.2 2.0 0.9
Primary Biliary Cirrhosis 0.9 1.3 1.9 -1.2 -1.1 0.8 1.4
Rheumatoid Arthritis 3.7 5.1 9.1 -3.0 -2.5 0.5 2.2
Schizophrenia (2014) 0.1 0.2 0.4 -0.7 -0.4 -0.4 -0.3
Triglycerides 0.5 0.8 1.7 -1.3 -0.8 0.0 1.0
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.4 -1.1 0.2 -0.4 1.2
Ulcerative Colitis 1.2 1.8 3.2 -0.9 -1.8 0.4 1.7
Blood Eosinophil Count 0.4 3.5 5.3 -1.3 -2.3 1.3 2.3
Blood Platelet Count 0.2 2.5 4.7 -1.9 -0.5 2.2 1.2
Blood Red Count 1.3 12.2 22.2 -2.8 -4.1 1.4 4.7
Blood White Count 0.6 4.4 8.1 -2.0 -1.9 1.3 2.8
Heel T-Score 0.9 7.2 8.1 -2.7 -2.7 2.5 2.9
BMI 3.7 21.7 31.9 -4.8 -5.7 0.5 5.6
Height 0.7 14.4 18.9 2.0 4.3 -4.3 -4.0
Waist Hip Ratio (WHR) 0.1 0.5 1.2 -0.1 -1.1 0.4 0.8
Systolic Blood Pressure 1.6 8.2 13.8 -2.5 -2.3 3.7 2.6
Smoking Status 1.6 3.9 5.1 -1.1 -2.3 2.2 2.1
Allergy or Eczema 1.7 4.6 6.7 -1.4 -2.6 2.5 1.9
Cardiovascular Disease 0.7 2.3 3.1 -1.4 -1.8 1.0 1.8
Hypothyroidism (self reported) 0.4 0.8 3.2 -0.2 0.1 -1.8 -0.0
Respiratory disease 1.5 3.3 5.6 -1.6 -2.4 0.9 2.0
Type 2 Diabetes (T2D) (2018) 0.1 0.1 0.3 -0.1 -0.4 -0.3 0.5
Lung FEV1/FVC ratio 0.3 1.5 3.0 0.3 1.3 -1.7 -1.1
Lung FVC 0.4 1.8 2.9 -1.7 -0.9 1.4 1.3
Neuroticism 0.3 0.7 2.1 -0.3 -0.6 1.4 0.7
Chronotype (morning person) 0.1 0.3 0.5 0.5 0.7 0.4 -0.7
Hair Pigment 0.1 1.9 5.4 -0.7 -0.6 2.3 1.1
Tanning 0.1 1.3 3.2 -0.2 1.8 -0.2 -1.4
Hand grip strength (left) 1.0 2.6 4.3 -2.0 -1.4 0.3 2.1
Number of treatments/medications taken 2.1 3.8 5.8 -1.7 -2.4 2.1 1.6
Average weekly spirits intake 0.9 1.1 2.2 -1.1 -1.5 0.4 0.9
Sensitivity / hurt feelings 0.5 0.9 3.0 -0.2 -0.3 1.7 0.7
Frequency of depressed mood in last 2 weeks 4.0 5.6 12.1 -1.1 -2.1 3.5 2.2
Hearing difficulty/problems: Yes 2.0 3.1 4.8 -1.1 -1.8 2.2 1.8
Relative age of first facial hair 1.5 3.1 4.8 1.5 2.0 -1.1 -2.2
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 1.8 -0.5 -1.3 1.2 1.2
Ever used hormone-replacement therapy (HRT) 0.7 0.9 2.2 -0.4 -0.9 1.5 0.7
Ever had hysterectomy (womb removed) 6.5 7.3 10.4 -2.4 -3.2 2.4 2.7
Systolic blood pressure, automated reading 1.4 4.0 8.3 -1.5 -1.6 2.9 1.7
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.6 0.6 -0.3 -0.8 0.5
Angina 0.2 0.3 0.6 -0.8 -0.4 0.1 0.5
Medication for hormone replacement therapy 3.3 3.7 7.8 -2.8 -1.1 1.5 1.9
Vitamin and mineral supplements 2.6 3.5 4.3 -1.4 -2.1 1.9 2.1
Supplements: Zinc 1.2 1.3 2.4 0.6 0.4 -1.6 -1.4
Medication: Co-codamol 1.5 1.7 4.4 -2.1 -1.3 -0.5 0.8
Medication: Metformin 0.5 0.7 1.8 1.3 0.8 -0.2 -0.5
Diabetes (father) 2.7 3.3 6.0 -1.6 -2.1 0.5 2.5
Diabetes (mother) 4.8 6.2 9.6 -3.1 -2.6 1.1 2.7
Severe depression (siblings) 1.3 1.5 3.8 2.0 1.0 0.2 -1.1
Pack years adult smoking proportion 0.2 0.3 0.5 0.6 -0.1 0.7 -0.3
Impedance of leg (right) 0.4 1.8 4.3 0.6 2.1 0.8 -1.4
Leg fat-free mass (left) 0.5 2.6 3.6 -1.5 -1.6 -1.9 1.4
Trunk fat percentage 1.1 4.3 8.9 -3.0 -1.8 -0.7 2.1
Hand grip strength (right) 0.6 1.6 3.4 -1.5 -0.8 0.3 1.8
Townsend deprivation index at recruitment 0.2 0.2 0.7 0.0 0.5 0.8 -0.0
Current tobacco smoking 0.6 1.0 1.4 -0.8 -0.8 1.2 1.1
Average weekly fortified wine intake 0.1 0.1 0.4 -0.4 0.7 -0.1 -0.0
Maternal smoking around birth 0.4 0.6 1.0 1.0 0.6 0.9 0.2
Fed-up feelings 2.6 4.7 6.6 -1.2 -2.4 2.2 2.6
Frequency of unenthusiasm / disinterest in last 2 weeks 3.5 4.7 7.6 -1.3 -2.1 2.8 2.3
Relative age voice broke 3.6 5.5 7.7 2.5 2.8 -1.5 -2.5
Taking other prescription medications 0.4 0.6 1.6 0.4 -0.8 1.3 -0.1
Age when periods started (menarche) 5.4 12.9 16.2 3.9 4.0 -2.2 -4.0
Bilateral oophorectomy (both ovaries removed) 7.8 9.0 12.1 -2.5 -3.5 2.8 3.1
Heel bone mineral density (BMD) T-score, automated (left) 3.2 7.2 8.5 -2.5 -2.5 2.9 2.9
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.4 -0.6 0.0 0.2 0.4
Qualifications: CSEs or equivalent 1.2 1.6 2.7 -1.3 -1.4 0.4 1.6
Serious illness, injury or assault to yourself 0.3 0.3 1.2 0.3 0.2 1.1 -0.2
High blood pressure 1.2 3.5 5.4 -2.3 -2.1 1.1 1.8
Hayfever, allergic rhinitis or eczema 0.8 1.8 3.9 -0.6 -1.4 2.0 1.0
Multivitamins +/- minerals 3.1 3.9 4.5 2.0 1.8 -2.1 -2.1
Stomach or abdominal pain in last month 3.6 4.5 6.4 -1.7 -2.5 1.7 2.4
Supplements: Glucosamine 0.6 0.7 1.7 -0.9 -1.3 -0.6 0.2
Diverticular disease/diverticulitis (self-reported) 1.7 2.0 3.5 -0.9 -1.9 1.0 1.7
Medication: Atenolol 1.5 1.8 2.7 -1.6 -1.6 0.7 1.3
Medication: Levothyroxine sodium 0.2 0.3 1.1 0.0 -0.4 -1.0 0.1
Sitting height 0.2 1.2 3.9 -2.0 -0.3 -0.7 0.6
Chronic bronchitis/emphysema (father) 1.9 2.2 3.9 1.1 2.0 -1.0 -1.6
High blood pressure (mother) 8.7 12.2 18.9 -4.3 -3.7 1.8 3.6
Body mass index (BMI) 2.6 11.3 17.0 -3.6 -3.9 0.4 4.1
Impedance of leg (left) 0.4 1.8 3.9 0.9 2.0 0.8 -1.3
Leg predicted mass (left) 0.5 2.6 3.2 -1.6 -1.6 -1.8 1.5
Trunk fat mass 1.1 4.8 9.3 -3.0 -1.9 -1.3 2.1
Waist circumference 2.2 8.0 12.3 -3.0 -3.5 0.3 3.3
Number of incorrect matches in round 0.8 1.3 3.8 -0.2 -0.7 1.9 1.0
Past tobacco smoking 0.7 1.2 2.2 0.8 1.5 -0.8 -1.2
Alcohol usually taken with meals 0.8 1.3 1.9 1.2 1.1 -1.4 -0.9
Nervous feelings 0.2 0.3 0.5 0.7 0.3 0.7 -0.3
Frequency of tenseness / restlessness in last 2 weeks 1.7 2.7 5.8 -0.3 -1.5 2.4 1.7
Hearing difficulty/problems with background noise 3.1 4.9 6.1 -1.9 -2.3 2.2 2.5
Hair/balding pattern: Pattern 2 1.7 2.1 3.6 1.3 1.4 -1.9 -1.1
Had menopause 0.3 0.4 0.9 0.3 -0.6 1.0 0.3
Had other major operations 0.1 0.2 0.4 -0.4 -0.6 0.2 0.4
Forced vital capacity (FVC) 0.2 0.9 1.8 -1.1 -0.5 0.6 1.4
Heel bone mineral density (BMD) T-score, automated (right) 1.4 3.2 4.2 -2.0 -1.6 1.5 2.0
Ever unenthusiastic/disinterested for a whole week 1.9 2.3 2.8 -0.9 -1.7 1.7 1.7
Qualifications: None of the above 0.1 0.3 0.8 0.1 0.3 -0.9 -0.3
Financial difficulties in last 2 years 0.1 0.1 0.3 0.0 -0.3 0.3 0.6
Mouth/teeth dental problems 0.6 0.9 1.6 0.7 0.8 -1.3 -0.9
Heart attack 0.2 0.3 0.9 -1.0 0.2 0.0 0.4
Allergy 0.6 1.4 2.5 0.4 1.6 -1.4 -1.0
Pain all over the body in last month 0.6 0.6 1.6 0.7 -0.6 -1.3 0.3
Diabetes (self-reported) 0.1 0.1 0.2 0.5 0.4 0.2 0.2
Hayfever/allergic rhinitis (self-reported) 0.7 1.0 1.7 1.3 0.5 1.1 -0.8
Medication: Ramipril 0.6 0.7 2.5 0.2 -0.1 -1.6 -0.6
Medication: Simvastatin 0.2 0.4 1.0 -1.0 -0.3 0.6 -0.1
Fluid intelligence score 1.1 2.3 3.8 -1.1 -1.9 1.6 1.3
Illnesses of siblings 6.4 9.0 11.7 3.4 3.1 -2.1 -3.2
Neuroticism score 0.4 0.9 2.6 0.1 -0.5 1.6 0.8
Weight 1.3 6.2 9.5 -3.1 -2.6 -1.1 2.7
Impedance of arm (right) 1.4 6.6 13.0 1.9 2.9 -1.0 -3.6
Arm fat percentage (right) 1.5 5.8 10.3 -3.2 -2.6 -0.6 2.4
Trunk fat-free mass 0.2 1.0 3.2 -0.8 -0.2 -1.8 0.4
Hip circumference 1.5 6.7 9.8 -3.1 -3.0 -0.5 2.8
Time employed in main current job 0.2 0.2 0.4 -0.6 -0.1 0.6 -0.0
Alcohol intake versus 10 years previously 2.1 3.1 6.1 -1.1 -1.5 2.5 1.8
Father’s age at death 1.8 2.4 4.0 0.9 1.8 -1.2 -2.0
Worrier / anxious feelings 0.1 0.1 0.2 0.3 0.4 0.2 -0.4
Frequency of tiredness / lethargy in last 2 weeks 4.0 6.5 8.6 -1.5 -2.7 2.9 2.9
Falls in the last year 0.1 0.1 0.2 -0.0 -0.5 0.1 -0.2
Hair/balding pattern: Pattern 3 0.4 0.6 0.9 -0.7 -0.9 0.5 1.0
Number of live births 0.2 0.3 0.6 0.8 0.5 -0.0 -0.6
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.4 -0.9 -0.3 -0.0 1.2
Pulse rate 0.9 1.5 3.6 -0.3 -1.9 0.5 1.5
Happiness 0.5 0.6 2.2 0.4 0.2 1.5 -0.2
Noisy workplace 0.5 0.6 1.6 -0.5 -0.8 -0.2 1.3
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.6 -0.7 0.4 -0.0 0.4
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.3 2.1 -1.4 -1.2 0.8 1.1
Mouth/teeth dental problems: Dentures 0.5 0.8 1.1 -0.8 -0.8 1.1 0.8
Asthma 1.1 2.1 3.9 -1.2 -2.0 0.9 1.6
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 1.5 -0.3 -0.3 1.2 1.0
Medication: Cholesterol lowering 0.1 0.1 0.3 -0.6 0.3 0.1 -0.0
Depression (self-reported) 4.2 5.1 6.6 -1.2 -2.6 2.5 2.4
Medication: Lansoprazole 0.4 0.4 0.9 0.1 -0.7 1.0 0.5
Prospective memory result 2.1 2.6 3.9 1.3 1.5 -2.0 -1.5
Lung cancer (father) 0.1 0.1 0.3 -0.3 -0.2 -0.4 0.5
Illnesses of mother 8.7 10.7 13.9 3.5 3.7 -1.6 -3.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.4 -0.5 0.6 -0.6 0.3
Pulse wave Arterial Stiffness index 1.4 1.7 2.3 -1.5 -1.4 -0.0 1.5
Impedance of arm (left) 1.6 7.2 13.0 2.3 3.0 -1.3 -3.6
Arm fat mass (right) 1.9 7.9 11.9 -3.5 -3.0 -0.5 3.2
Trunk predicted mass 0.2 1.0 3.3 -0.8 -0.2 -1.8 0.4
Standing height 0.7 6.7 12.9 0.7 2.5 -3.6 -2.7
Length of working week for main job 1.0 1.1 3.4 0.7 0.7 -1.8 -0.3
Exposure to tobacco smoke at home 1.4 1.6 2.3 1.3 0.9 -1.5 -1.3
Breastfed as a baby 2.3 2.8 4.3 1.4 2.1 -0.8 -2.0
Tense / ‘highly strung’ 0.5 0.9 1.9 1.4 -0.1 1.2 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 1.6 1.2 -0.4 1.3 0.0
Hair/balding pattern: Pattern 4 0.7 1.6 2.4 1.1 1.6 0.5 -1.6
Birth weight of first child 1.3 2.4 6.6 -2.6 -0.7 -0.4 1.5
Peak expiratory flow (PEF) 2.5 5.9 10.3 -2.6 -2.3 1.0 3.2
Pulse wave reflection index 0.1 0.1 0.3 -0.5 -0.0 0.1 0.4
Ever highly irritable/argumentative for 2 days 4.1 5.0 7.0 -1.5 -2.6 2.1 2.5
Loud music exposure frequency 0.9 1.0 2.0 -1.1 -0.8 0.4 1.4
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.3 -0.1 0.5 -0.2 -0.4
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.9 -1.0 -0.1 -0.4 0.3
Blood clot in the leg (DVT) 0.2 0.2 0.5 -0.3 -0.7 -0.5 0.2
Medication: Paracetamol 3.1 5.1 7.9 -1.8 -2.8 1.4 2.7
Headache pain in last month 1.8 3.1 6.9 -0.7 -2.6 0.6 2.1
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.5 0.7 0.3 -0.5 -0.4
Glaucoma (self-reported) 0.4 0.4 1.5 -0.2 0.4 -1.2 -0.2
Gout (self-reported) 2.9 4.0 7.0 -1.4 -1.9 2.6 1.9
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.9 0.4 -0.2 -0.9 0.1
Medication: Amlodipine 0.1 0.2 0.3 0.2 -0.4 -0.6 -0.4
Medication: Ventolin 100micrograms inhaler 0.4 0.6 1.3 -0.9 -1.1 0.1 0.4
Birth weight 0.8 1.6 4.2 -2.0 -0.4 -1.4 0.3
Chronic bronchitis/emphysema (mother) 3.9 4.6 6.4 -0.9 -2.4 2.3 2.5
High blood pressure (siblings) 4.9 7.1 13.1 -3.6 -2.7 0.6 2.8
Forced vital capacity (FVC), Best measure 0.1 0.3 0.6 -0.8 0.4 -0.2 0.5
Body fat percentage 1.5 6.1 11.0 -3.3 -2.4 -0.3 2.7
Leg fat percentage (right) 3.0 10.9 17.6 -4.2 -3.5 0.6 3.7
Arm fat-free mass (right) 0.5 2.3 4.0 -1.5 -1.3 -1.1 2.0
Exposure to tobacco smoke outside home 0.2 0.2 0.5 0.6 0.1 -0.7 -0.3
Comparative body size at age 10 0.6 1.7 3.2 -1.8 -0.8 -1.3 1.1
Number of full brothers 3.1 3.9 5.8 -2.3 -2.0 0.6 2.4
Worry too long after embarrassment 0.9 1.4 4.2 0.2 -0.2 2.0 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.7 3.0 1.7 1.5 -0.2 -1.3
Wheeze or whistling in the chest in last year 2.7 4.9 7.6 -1.3 -2.5 2.1 2.8
Number of children fathered 0.7 0.8 2.6 -1.6 -0.2 -0.4 0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 1.4 1.2 -0.1 0.4 -0.1
Age at first live birth 0.8 1.5 2.2 1.5 0.9 -0.9 -1.5
Pulse wave peak to peak time 1.2 1.5 2.2 1.3 1.4 -0.1 -1.5
Health satisfaction 0.9 1.2 2.2 -0.6 -1.3 1.5 0.6
Shortness of breath walking on level ground 2.7 3.2 5.8 -0.5 -1.9 2.4 1.7
Qualifications: College or University degree 0.7 2.3 2.7 1.6 1.2 -1.7 -1.5
Eye problems/disorders: None of the above 0.4 0.4 1.1 0.1 0.5 -0.7 -1.0
Mouth/teeth dental problems: Loose teeth 1.2 1.4 2.3 1.2 1.5 -0.5 -1.2
Emphysema/chronic bronchitis 0.3 0.3 0.8 0.6 -0.2 -0.9 -0.5
Medication for pain relief, constipation, heartburn 0.2 0.4 0.9 0.7 0.6 -0.1 -0.9
Neck or shoulder pain in last month 2.4 3.4 6.9 -2.6 -1.7 0.0 1.9
Medication: Blood pressure 0.7 1.3 2.6 -1.6 -1.3 0.2 0.9
Angina (self-reported) 0.4 0.5 0.9 -1.0 -0.7 -0.1 0.7
Migraine (self-reported) 2.6 3.3 6.1 -1.5 -2.5 1.4 1.7
Medication: Ibuprofen 1.9 2.3 3.8 -0.7 -1.2 1.8 2.0
Medication: Allopurinol 1.1 1.5 3.8 -0.5 -0.9 2.0 1.0
Medication: Omeprazole 2.0 2.4 3.8 -0.5 -2.0 1.4 1.8
Medication: Seretide 50 evohaler 0.2 0.2 0.4 -0.3 0.0 -0.5 -0.7
Mean time to correctly identify matches 0.5 1.0 1.7 0.7 0.9 0.9 -1.3
Heart disease (mother) 5.2 6.3 8.1 -2.0 -2.2 2.8 2.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 0.5 0.4 0.1 -0.7 -0.2
Whole body fat mass 1.5 6.2 11.2 -3.3 -2.4 -1.0 2.6
Leg fat mass (right) 2.7 10.5 16.0 -4.0 -3.5 -0.2 3.7
Arm predicted mass (right) 0.4 2.2 3.8 -1.5 -1.3 -1.1 2.0
Pulse rate, automated reading 0.2 0.7 2.3 0.3 -1.5 0.1 0.7
Alcohol intake frequency. 1.3 3.0 4.5 -0.9 -2.1 1.6 2.1
Comparative height size at age 10 0.2 1.1 3.4 -1.0 0.1 -1.8 -0.0
Number of full sisters 0.2 0.2 0.6 -0.1 -0.3 0.3 0.8
Suffer from ‘nerves’ 1.0 1.5 3.1 1.8 0.8 -0.6 -1.4
Overall health rating 1.9 4.0 6.0 -1.6 -2.4 1.9 1.9
Chest pain or discomfort 1.0 1.4 2.3 -1.5 -1.2 0.7 1.1
Had major operations 0.1 0.1 0.3 0.4 0.0 0.5 -0.0
Age at last live birth 0.8 1.2 2.1 0.9 1.1 -0.9 -1.5
Family relationship satisfaction 1.4 1.7 3.3 1.8 1.5 -0.4 -1.0
Leg pain on walking 0.3 0.4 0.9 -0.7 -0.9 -0.5 0.2
Qualifications: NVQ or HND or HNC or equivalent 5.8 6.9 10.1 -2.0 -1.9 3.2 3.1
Commuting to job workplace: Car/motor vehicle 4.6 5.2 7.6 -2.6 -2.8 0.3 2.6
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 1.6 -0.7 -0.9 -1.2 0.4
Medication: Aspirin 0.2 0.3 0.8 -0.7 0.2 -0.9 -0.1
Supplements: Vitamin C 1.6 1.9 3.0 1.4 1.7 -0.3 -1.7
Knee pain experienced in last month 0.3 0.5 1.2 0.0 -1.1 -0.3 0.8
Hypertension (Self-reported) 1.2 3.2 4.8 -2.2 -1.9 1.1 1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.2 2.6 4.7 -1.7 -2.2 0.3 1.7
Illnesses of father: Heart disease 1.2 1.7 3.0 -1.4 -1.7 0.8 1.1
Illnesses of siblings: Diabetes 2.2 2.7 4.4 0.1 -2.1 1.7 1.8
Smoking status: Previous 0.1 0.1 0.4 0.3 -0.6 0.0 0.2
Forced expiratory volume in 1-second (FEV1), predicted 1.5 3.1 4.9 1.6 1.8 -2.2 -1.2
Whole body fat-free mass 0.3 1.7 3.2 -1.2 -1.0 -1.8 1.2
Leg fat-free mass (right) 0.5 2.6 3.1 -1.4 -1.7 -1.8 1.6
Arm fat percentage (left) 1.4 5.7 8.8 -3.0 -2.7 -0.6 2.6
Average weekly red wine intake 0.2 0.3 0.8 0.9 -0.1 0.5 0.2
Handedness (chirality/laterality): Left-handed 1.1 1.4 2.1 0.9 1.1 -1.1 -1.4
Mood swings 3.1 5.6 7.3 -1.6 -2.4 2.7 2.6
Loneliness, isolation 2.4 3.3 8.6 -0.2 -1.0 2.9 1.9
Long-standing illness, disability or infirmity 4.3 6.6 8.5 -1.3 -2.9 2.9 2.8
Ever had bowel cancer screening 1.3 1.6 3.2 1.8 1.0 0.4 -1.4
Diabetes diagnosed by doctor 0.3 0.5 1.1 -0.7 -0.4 0.5 1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.4 -0.1 -0.1 0.6 -0.1
Friendships satisfaction 0.2 0.3 0.4 0.7 0.0 0.6 0.4
Qualifications: nursing, teaching 0.2 0.3 0.4 -0.4 -0.6 0.5 0.5
Commuting to job workplace: Walk 1.7 1.8 3.0 -1.7 -1.1 1.2 1.3
Eye problems/disorders: Cataract 0.3 0.3 0.6 -0.4 -0.5 0.8 0.5
Mouth/teeth dental problems: Mouth ulcers 0.0 0.0 0.1 0.3 0.0 0.0 0.2
Medication for cholesterol 3.7 5.6 8.0 2.8 1.8 -2.6 -2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 1.1 -0.2 0.2 1.1 -0.1
Back pain experienced in last month 0.1 0.1 0.3 0.6 0.1 0.3 0.2
Mineral and other dietary supplements 0.8 1.1 2.2 -1.3 -0.2 0.7 1.5
Breast cancer (self-reported) 0.9 1.0 1.8 0.8 0.4 -1.4 -1.2
Asthma (self-reported) 0.8 1.6 2.9 -1.2 -1.7 0.6 1.3
Osteoporosis (self-reported) 0.4 0.5 1.5 1.2 -0.1 0.5 -0.3
Osteoarthritis (self-reported) 0.1 0.1 0.3 -0.5 -0.2 0.1 0.0
Medication: Aspirin 0.1 0.1 0.5 -0.7 -0.1 -0.1 0.2
Medication: Gliclazide 0.3 0.4 0.8 -0.4 -0.2 0.8 0.9
Illnesses of father: None of the above (group 1) 0.3 0.3 0.8 0.3 0.9 -0.3 -0.6
Smoking status: Current 0.7 1.2 2.0 -0.8 -0.7 1.4 1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.0 0.1 0.2 -0.4 -0.1 -0.3 0.3
Whole body water mass 0.3 1.8 3.1 -1.3 -1.0 -1.8 1.2
Leg predicted mass (right) 0.4 2.4 3.4 -1.3 -1.6 -1.8 1.4
Arm fat mass (left) 1.6 6.7 10.2 -3.2 -2.8 -0.9 2.9
Number of self-reported non-cancer illnesses 2.3 4.0 6.3 -1.3 -2.5 2.5 1.3
Average weekly champagne plus white wine intake 2.5 3.4 5.9 1.2 2.4 -1.8 -1.7
Miserableness 1.3 2.3 3.5 -0.9 -1.4 1.9 1.7
Guilty feelings 1.7 2.5 4.2 -1.0 -1.0 2.1 2.0
Wears glasses or contact lenses 0.1 0.1 0.3 -0.5 0.1 0.3 -0.5
Ever taken oral contraceptive pill 0.4 0.4 1.2 -0.2 -1.1 -0.4 0.6
Hearing aid user 1.7 1.9 2.7 -1.4 -1.6 0.7 1.6
Mother’s age at death 0.3 0.4 0.6 0.6 0.7 -0.3 -0.8
Financial situation satisfaction 2.0 2.5 3.8 -0.6 -1.9 2.0 1.4
Tinnitus: Yes, now most or all of the time 0.7 0.8 1.6 -0.7 -0.6 1.3 0.9
Commuting to job workplace: Public transport 5.4 6.4 10.9 2.5 3.3 -0.4 -2.9
Eye problems/disorders: Glaucoma 0.1 0.1 0.1 -0.4 -0.1 -0.2 0.3
Medication: Blood pressure 0.5 0.9 1.3 -1.1 -1.1 0.7 0.7
Pain type(s) experienced in last month: Hip pain 2.2 2.8 4.8 -1.3 -1.6 1.5 2.2
Supplements: Fish oil (including cod liver oil) 0.9 1.1 2.2 1.1 0.8 -0.6 -1.5
High cholesterol (Self-reported) 0.3 0.5 1.3 -0.7 -0.4 1.1 0.3
Medication: Bendroflumethiazide 1.2 1.8 2.9 -1.1 -1.4 1.7 0.9
Medication: Paracetamol 3.9 6.0 9.2 -2.1 -3.0 1.6 2.8
Medication: Lisinopril 0.3 0.4 1.3 -1.1 -0.1 0.4 0.3
Medication: Atorvastatin 1.1 1.4 2.7 -1.1 -0.6 1.6 1.1
Illnesses of father: High blood pressure 0.2 0.3 0.8 -0.6 -0.0 0.9 0.0
Alcohol drinker status: Never 0.9 1.0 1.6 -0.8 -1.2 0.6 1.2
Ever smoked 2.1 3.7 4.6 -1.8 -2.0 1.7 2.1
Basal metabolic rate 0.5 2.6 3.0 -1.7 -1.4 -1.6 1.6
Leg fat percentage (left) 3.0 10.8 15.3 -3.9 -3.6 0.6 3.8
Arm fat-free mass (left) 0.6 2.9 4.4 -2.0 -1.5 -0.9 2.1
Number of operations (self-reported) 0.8 1.2 2.8 -1.1 -1.7 0.3 0.9
Average weekly beer plus cider intake 0.6 0.8 1.2 -1.1 -0.3 0.9 1.0
Irritability 0.7 1.1 1.6 0.3 -1.2 1.2 1.1
Risk taking 0.7 1.1 2.2 -1.0 -1.5 0.2 1.0
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.6 -0.0 0.3 -1.3 -0.6
Fractured/broken bones in last 5 years 0.4 0.5 2.1 -1.5 0.1 -0.2 0.1
Age started oral contraceptive pill 2.5 3.1 4.8 2.2 1.6 -0.4 -2.2
Diastolic blood pressure, automated reading 0.6 1.9 3.2 -1.5 -1.8 0.5 1.4
Ever depressed for a whole week 2.0 2.4 2.9 -1.3 -1.7 1.6 1.6
Unable to work because of sickness or disability 1.0 1.3 4.0 -0.4 -2.0 0.4 1.0
Commuting to job workplace: Cycle 1.3 1.5 2.0 1.1 1.4 1.3 -1.2
Myopia 0.3 0.4 0.9 0.7 0.3 0.4 -0.9
Vascular/heart problems diagnosed by doctor 2.3 6.2 9.4 3.1 2.5 -1.6 -2.5
Cholesterol lowering medication 2.4 3.5 4.9 -1.7 -2.0 2.2 1.4
Medication: Omeprazole (e.g. Zanprol) 1.0 1.3 2.1 -0.7 -1.4 0.9 1.3
Pain experienced in last month 0.9 1.5 3.5 0.1 1.6 -0.3 -1.9
Supplements: Calcium 0.3 0.4 0.9 0.9 -0.0 -0.3 -0.7
Basal cell carcinoma (self-reported) 0.1 0.1 0.4 0.0 -0.2 0.6 -0.1
Heart attack/myocardial infarction (self-reported) 0.3 0.3 1.0 -1.0 0.5 0.1 0.3
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.8 -0.3 -0.9 -0.2 0.4
Heart disease (siblings) 4.2 5.1 7.4 -2.5 -1.9 1.7 2.7
Alcohol drinker status: Previous 0.4 0.4 1.4 0.3 -0.3 1.2 0.5
Pack years of smoking 0.1 0.2 0.3 0.5 0.1 0.5 -0.5
Impedance of whole body 1.0 5.2 8.9 1.9 3.0 -0.4 -2.9
Leg fat mass (left) 2.6 10.3 14.4 -3.8 -3.6 -0.3 3.7
Arm predicted mass (left) 0.6 2.9 4.2 -2.0 -1.6 -1.0 2.0