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chr10:64,195,778-66,034,105

Best TWAS P=6.25e-11 · Best GWAS P=2.36e-11 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Brain Frontal Cortex BA9	NRBF2	0.25	0.17	lasso	6	0.16	6.1e-05	-6.2	6.5	6.3e-11	0.96	0.02	0.97	TRUE
1	CommonMind	Brain Pre-frontal Cortex	REEP3	0.05	0.05	lasso	3	0.04	5.9e-06	-6.1	-6.5	6.7e-11	-0.95	0.02	0.98	FALSE
15	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NRBF2	0.04	0.04	enet	5	0.03	1.3e-04	-6.2	6.4	1.2e-10	0.91	0.00	0.99	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NRBF2	0.10	0.06	lasso	7	0.08	3.5e-09	5.5	6.4	1.2e-10	0.86	0.01	0.99	FALSE
11	ROSMAP	Brain Pre-frontal Cortex	NRBF2	0.34	0.46	lasso	5	0.46	3.1e-66	-6.2	6.4	1.3e-10	0.94	0.06	0.94	FALSE
9	GTEx	Testis	NRBF2	0.14	0.08	lasso	12	0.09	6.7e-05	-6.1	6.4	1.6e-10	0.92	0.07	0.92	FALSE
3	GTEx	Brain Cortex	NRBF2	0.30	0.26	enet	24	0.21	1.4e-06	5.6	6.4	1.8e-10	0.95	0.02	0.97	FALSE
23	The Cancer Genome Atlas	Prostate Adenocarcinoma	NRBF2	0.08	0.09	lasso	6	0.08	9.7e-09	-6.2	6.4	2.0e-10	0.91	0.00	1.00	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	JMJD1C	0.04	0.01	blup	88	0.01	9.7e-03	-6.2	6.2	7.2e-10	0.80	0.01	0.90	FALSE
6	GTEx	Esophagus Mucosa	NRBF2	0.14	0.11	lasso	10	0.11	6.4e-08	-6.1	6.1	1.0e-09	0.89	0.07	0.93	FALSE
17	The Cancer Genome Atlas	Brain Lower Grade Glioma	NRBF2	0.08	0.08	enet	6	0.08	4.3e-09	-6.2	6.1	1.0e-09	0.90	0.00	1.00	FALSE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	NRBF2	0.05	0.06	lasso	2	0.06	5.5e-12	-6.2	6.1	1.1e-09	0.89	0.00	1.00	FALSE
21	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NRBF2	0.18	0.13	enet	11	0.08	2.5e-04	-6.2	6.0	1.8e-09	0.82	0.00	0.99	FALSE
8	GTEx	Stomach	NRBF2	0.09	0.04	lasso	6	0.03	1.6e-02	4.1	5.8	4.9e-09	0.78	0.06	0.55	FALSE
24	The Cancer Genome Atlas	Thyroid Carcinoma	NRBF2	0.14	0.10	enet	16	0.09	8.1e-09	-6.2	5.8	5.1e-09	0.86	0.00	1.00	FALSE
12	ROSMAP	Brain Pre-frontal Cortex	REEP3	0.10	0.11	lasso	8	0.09	7.2e-12	5.3	-5.8	7.8e-09	-0.75	0.86	0.14	FALSE
7	GTEx	Nerve Tibial	NRBF2	0.08	0.09	enet	11	0.06	5.0e-05	-6.1	5.7	1.2e-08	0.88	0.05	0.95	FALSE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	REEP3	0.04	0.04	blup	59	0.05	1.8e-06	5.1	-5.5	4.4e-08	-0.80	0.06	0.93	FALSE
5	GTEx	Cells Transformed fibroblasts	JMJD1C	0.09	0.01	enet	18	0.07	8.6e-06	4.9	5.4	7.5e-08	0.61	0.13	0.68	FALSE
20	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NRBF2	0.09	0.02	enet	6	0.04	1.4e-05	2.7	5.4	7.8e-08	0.74	0.06	0.91	FALSE
2	GTEx	Adipose Subcutaneous	REEP3	0.10	0.03	lasso	3	0.03	7.2e-04	5.4	-5.3	1.2e-07	-0.64	0.37	0.36	FALSE
19	The Cancer Genome Atlas	Lung Adenocarcinoma	NRBF2	0.09	0.06	enet	8	0.07	2.7e-08	-6.2	5.2	1.7e-07	0.82	0.00	1.00	FALSE
10	NTR	Blood	NRBF2	0.03	0.01	bslmm	386	0.01	3.4e-05	-2.5	-5.2	2.1e-07	-0.51	0.12	0.42	FALSE
14	The Cancer Genome Atlas	Glioblastoma Multiforme	JMJD1C	0.11	0.02	blup	87	0.05	1.4e-02	-6.2	5.2	2.6e-07	0.79	0.01	0.71	FALSE