Best TWAS P=7.28e-11 · Best GWAS P=1.77e-11 conditioned to 3.88e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | VCL | 0.17 | 0.06 | lasso | 9 | 0.09 | 7.9e-06 | 5.6 | -5.6 | 2.1e-08 | -0.46 | 0.06 | 0.93 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | VCL | 0.07 | 0.02 | enet | 10 | 0.04 | 8.0e-04 | 5.6 | -5.2 | 2.1e-07 | -0.29 | 0.02 | 0.93 | FALSE |
| 3 | GTEx | Heart Atrial Appendage | ADK | 0.12 | 0.12 | lasso | 4 | 0.10 | 2.8e-05 | 5.6 | -5.6 | 2.3e-08 | -0.41 | 0.26 | 0.66 | FALSE |
| 4 | GTEx | Heart Left Ventricle | ADK | 0.21 | 0.11 | enet | 14 | 0.12 | 8.0e-07 | 5.5 | -5.6 | 2.1e-08 | -0.40 | 0.71 | 0.28 | FALSE |
| 5 | GTEx | Muscle Skeletal | AP3M1 | 0.14 | 0.06 | lasso | 5 | 0.06 | 1.3e-06 | 5.5 | 5.7 | 1.5e-08 | 0.42 | 0.36 | 0.64 | FALSE |
| 6 | GTEx | Whole Blood | VCL | 0.08 | 0.03 | lasso | 2 | 0.01 | 8.9e-02 | 5.6 | -5.4 | 5.4e-08 | -0.42 | 0.18 | 0.30 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | VCL | 0.12 | 0.12 | lasso | 9 | 0.12 | 1.2e-15 | 5.5 | -6.1 | 1.4e-09 | -0.43 | 0.03 | 0.97 | FALSE |
| 8 | YFS | Blood | VCL | 0.07 | 0.03 | blup | 251 | 0.06 | 2.3e-18 | 5.6 | -6.5 | 7.3e-11 | -0.48 | 0.26 | 0.74 | TRUE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | VCL | 0.02 | 0.00 | blup | 57 | 0.01 | 5.7e-04 | 5.0 | -5.8 | 5.1e-09 | -0.50 | 0.03 | 0.54 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | VCL | 0.08 | 0.02 | blup | 57 | 0.05 | 7.6e-06 | 5.6 | -5.8 | 7.3e-09 | -0.47 | 0.01 | 0.98 | FALSE |