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chr11:67,968,724-70,179,848

Best TWAS P=1.21e-10 · Best GWAS P=4.24e-13 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MRPL21	0.47	0.67	lasso	4	0.67	4.2e-110	5.2	-5.3	1.2e-07	-0.06	0.27	0.73	FALSE
2	GTEx	Adipose Subcutaneous	IGHMBP2	0.42	0.44	lasso	16	0.45	3.2e-40	5.2	5.7	1.3e-08	0.06	0.29	0.71	FALSE
3	GTEx	Adipose Subcutaneous	MRPL21	0.38	0.56	lasso	2	0.56	5.2e-54	5.2	-5.2	1.7e-07	-0.06	0.30	0.70	FALSE
4	GTEx	Adipose Visceral Omentum	IGHMBP2	0.36	0.37	enet	23	0.39	9.8e-22	5.2	6.2	5.2e-10	0.05	0.23	0.77	FALSE
5	GTEx	Adipose Visceral Omentum	MRPL21	0.34	0.38	lasso	8	0.38	8.3e-21	5.2	-5.3	1.3e-07	-0.06	0.32	0.68	FALSE
6	GTEx	Adrenal Gland	IGHMBP2	0.25	0.10	enet	25	0.18	5.1e-07	5.2	5.3	9.4e-08	0.04	0.20	0.74	FALSE
7	GTEx	Adrenal Gland	MRPL21	0.38	0.34	lasso	6	0.31	6.8e-12	5.2	-5.2	2.2e-07	-0.06	0.36	0.64	FALSE
8	GTEx	Artery Aorta	IGHMBP2	0.32	0.32	lasso	5	0.36	5.1e-21	5.2	5.8	4.9e-09	0.06	0.35	0.65	FALSE
9	GTEx	Artery Aorta	ORAOV1	0.13	0.07	lasso	3	0.04	2.0e-03	7.2	6.1	1.2e-09	0.88	0.00	0.98	TRUE
10	GTEx	Artery Coronary	MRPL21	0.39	0.53	lasso	2	0.52	1.8e-20	5.2	-5.2	1.5e-07	-0.06	0.33	0.67	FALSE
11	GTEx	Artery Tibial	IGHMBP2	0.31	0.16	enet	24	0.25	3.0e-19	6.0	5.9	3.8e-09	0.08	0.01	0.99	FALSE
12	GTEx	Artery Tibial	MRPL21	0.47	0.57	lasso	4	0.56	6.7e-53	5.2	-5.2	1.7e-07	-0.06	0.30	0.70	FALSE
13	GTEx	Brain Caudate basal ganglia	IGHMBP2	0.31	0.25	lasso	5	0.30	2.0e-09	6.0	5.6	1.7e-08	0.09	0.02	0.98	FALSE
14	GTEx	Brain Caudate basal ganglia	MRPL21	0.33	0.27	lasso	3	0.28	1.3e-08	5.2	-5.2	2.0e-07	-0.06	0.22	0.77	FALSE
15	GTEx	Brain Cerebellar Hemisphere	IGHMBP2	0.23	0.22	lasso	3	0.16	8.4e-05	4.5	5.4	7.8e-08	0.06	0.04	0.82	FALSE
16	GTEx	Brain Cerebellum	IGHMBP2	0.31	0.11	enet	17	0.17	1.2e-05	-4.9	6.1	1.3e-09	0.03	0.18	0.74	FALSE
17	GTEx	Brain Cerebellum	MRPL21	0.65	0.63	lasso	5	0.63	1.7e-23	5.2	-5.2	1.9e-07	-0.06	0.29	0.71	FALSE
18	GTEx	Brain Cortex	MRPL21	0.70	0.59	lasso	9	0.59	9.5e-20	5.2	-5.4	5.4e-08	-0.07	0.28	0.72	FALSE
19	GTEx	Brain Frontal Cortex BA9	MRPL21	0.44	0.25	lasso	4	0.18	1.2e-05	5.2	-5.3	1.1e-07	-0.06	0.25	0.70	FALSE
20	GTEx	Brain Hippocampus	MRPL21	0.44	0.34	lasso	11	0.32	3.4e-08	5.2	-5.3	1.1e-07	-0.06	0.20	0.79	FALSE
21	GTEx	Brain Putamen basal ganglia	MRPL21	0.43	0.37	lasso	8	0.36	2.0e-09	5.2	-5.3	1.1e-07	-0.06	0.26	0.72	FALSE
22	GTEx	Breast Mammary Tissue	IGHMBP2	0.49	0.47	enet	28	0.50	8.1e-29	5.2	5.7	1.5e-08	0.06	0.34	0.66	FALSE
23	GTEx	Breast Mammary Tissue	MRPL21	0.40	0.44	lasso	4	0.44	7.9e-25	5.2	-5.2	1.5e-07	-0.06	0.30	0.70	FALSE
24	GTEx	Breast Mammary Tissue (Male)	IGHMBP2	0.43	0.24	lasso	5	0.23	4.5e-06	5.2	5.2	2.3e-07	0.06	0.25	0.74	FALSE
25	GTEx	Breast Mammary Tissue (Male)	MRPL21	0.41	0.33	lasso	6	0.30	1.2e-07	5.2	-5.4	5.9e-08	-0.06	0.21	0.73	FALSE
26	GTEx	Breast Mammary Tissue (Female)	MRPL21	0.40	0.33	lasso	2	0.30	1.5e-09	5.2	-5.3	1.2e-07	-0.06	0.26	0.74	FALSE
27	GTEx	Cells EBV-transformed lymphocytes	IGHMBP2	0.54	0.62	enet	27	0.64	2.0e-26	5.4	5.2	1.9e-07	0.04	0.21	0.79	FALSE
28	GTEx	Cells Transformed fibroblasts	IGHMBP2	0.27	0.37	enet	10	0.37	5.0e-29	5.2	5.6	1.8e-08	0.06	0.28	0.72	FALSE
29	GTEx	Cells Transformed fibroblasts	MRPL21	0.44	0.52	lasso	2	0.52	6.4e-45	5.2	-5.2	1.7e-07	-0.06	0.30	0.70	FALSE
30	GTEx	Colon Sigmoid	MRPL21	0.63	0.61	lasso	7	0.60	3.2e-26	5.2	-5.6	2.1e-08	-0.05	0.33	0.67	FALSE
31	GTEx	Colon Transverse	MRPL21	0.48	0.49	lasso	2	0.49	5.4e-26	5.2	-5.2	1.7e-07	-0.06	0.34	0.66	FALSE
32	GTEx	Esophagus Mucosa	IGHMBP2	0.37	0.47	enet	33	0.49	1.8e-36	5.2	5.4	6.7e-08	0.07	0.25	0.75	FALSE
33	GTEx	Esophagus Mucosa	MRPL21	0.47	0.57	lasso	6	0.57	2.2e-45	5.2	-5.2	1.7e-07	-0.06	0.34	0.66	FALSE
34	GTEx	Esophagus Muscularis	IGHMBP2	0.12	0.06	enet	17	0.06	9.4e-05	5.1	5.6	2.7e-08	0.08	0.22	0.75	FALSE
35	GTEx	Esophagus Muscularis	MRPL21	0.47	0.59	lasso	1	0.58	3.7e-43	5.2	-5.2	1.5e-07	-0.06	0.30	0.70	FALSE
36	GTEx	Heart Atrial Appendage	IGHMBP2	0.26	0.27	lasso	4	0.26	3.9e-12	6.0	6.4	1.5e-10	0.07	0.01	0.99	FALSE
37	GTEx	Heart Atrial Appendage	MRPL21	0.20	0.18	lasso	1	0.19	7.8e-09	5.2	-5.2	1.5e-07	-0.06	0.24	0.75	FALSE
38	GTEx	Heart Left Ventricle	IGHMBP2	0.14	0.15	lasso	7	0.14	6.2e-08	5.2	5.3	1.3e-07	0.05	0.23	0.77	FALSE
39	GTEx	Heart Left Ventricle	MRPL21	0.33	0.31	lasso	3	0.30	2.7e-16	5.2	-5.2	2.5e-07	-0.06	0.30	0.69	FALSE
40	GTEx	Liver	IGHMBP2	0.40	0.40	lasso	4	0.37	2.2e-11	5.3	5.5	5.0e-08	0.05	0.24	0.76	FALSE
41	GTEx	Lung	IGHMBP2	0.40	0.51	lasso	6	0.50	3.7e-44	5.2	5.4	5.9e-08	0.06	0.29	0.71	FALSE
42	GTEx	Lung	MRPL21	0.27	0.40	lasso	2	0.39	2.0e-31	5.2	-5.2	1.7e-07	-0.06	0.31	0.69	FALSE
43	GTEx	Nerve Tibial	IGHMBP2	0.45	0.47	enet	44	0.48	2.0e-38	5.2	6.2	7.0e-10	0.08	0.32	0.68	FALSE
44	GTEx	Nerve Tibial	MRPL21	0.52	0.62	lasso	4	0.61	7.7e-54	5.2	-5.3	1.3e-07	-0.06	0.30	0.70	FALSE
45	GTEx	Ovary	IGHMBP2	0.41	0.43	lasso	10	0.36	8.9e-10	5.2	5.3	1.0e-07	0.06	0.22	0.77	FALSE
46	GTEx	Ovary	MRPL21	0.38	0.36	lasso	3	0.29	7.5e-08	5.2	-5.7	1.5e-08	-0.07	0.09	0.90	FALSE
47	GTEx	Pancreas	IGHMBP2	0.36	0.42	lasso	8	0.40	4.4e-18	5.1	5.2	2.3e-07	0.06	0.37	0.63	FALSE
48	GTEx	Pituitary	IGHMBP2	0.46	0.40	lasso	14	0.34	2.0e-09	5.2	5.2	1.6e-07	0.06	0.24	0.76	FALSE
49	GTEx	Pituitary	MRPL21	0.73	0.53	lasso	8	0.51	6.3e-15	5.2	-5.3	1.1e-07	-0.06	0.29	0.71	FALSE
50	GTEx	Prostate	MRPL21	0.45	0.52	lasso	6	0.52	3.2e-15	5.1	-5.2	2.5e-07	-0.06	0.31	0.69	FALSE
51	GTEx	Skin Not Sun Exposed Suprapubic	IGHMBP2	0.44	0.37	lasso	7	0.43	1.9e-25	5.2	5.8	6.1e-09	0.05	0.27	0.73	FALSE
52	GTEx	Skin Not Sun Exposed Suprapubic	MRPL21	0.44	0.46	lasso	3	0.49	1.7e-30	5.2	-5.2	1.7e-07	-0.06	0.34	0.66	FALSE
53	GTEx	Skin Sun Exposed Lower leg	IGHMBP2	0.35	0.38	lasso	6	0.38	6.1e-33	5.2	5.7	1.5e-08	0.06	0.27	0.73	FALSE
54	GTEx	Skin Sun Exposed Lower leg	MRPL21	0.39	0.51	lasso	3	0.50	1.4e-47	5.2	-5.2	1.7e-07	-0.06	0.30	0.70	FALSE
55	GTEx	Small Intestine Terminal Ileum	MRPL21	0.38	0.28	lasso	3	0.25	2.5e-06	5.2	-5.2	1.5e-07	-0.06	0.15	0.75	FALSE
56	GTEx	Spleen	IGHMBP2	0.51	0.52	lasso	5	0.56	3.7e-17	5.4	5.3	9.3e-08	0.05	0.19	0.81	FALSE
57	GTEx	Stomach	IGHMBP2	0.15	0.06	enet	14	0.03	9.1e-03	5.2	5.5	3.9e-08	0.09	0.22	0.70	FALSE
58	GTEx	Testis	MRPL21	0.47	0.60	lasso	2	0.59	5.9e-32	5.2	-5.2	1.6e-07	-0.06	0.31	0.69	FALSE
59	GTEx	Thyroid	IGHMBP2	0.32	0.40	enet	23	0.42	5.7e-35	5.2	5.8	4.9e-09	0.06	0.29	0.71	FALSE
60	GTEx	Thyroid	MRPL21	0.50	0.56	lasso	3	0.57	1.3e-52	5.2	-5.2	1.8e-07	-0.06	0.30	0.70	FALSE
61	GTEx	Uterus	MRPL21	0.53	0.50	lasso	7	0.57	3.9e-14	5.2	-5.3	1.4e-07	-0.06	0.24	0.76	FALSE
62	GTEx	Vagina	IGHMBP2	0.34	-0.01	enet	34	0.16	2.0e-04	4.5	5.5	3.6e-08	0.08	0.06	0.41	FALSE
63	GTEx	Vagina	MRPL21	0.52	0.48	lasso	6	0.51	1.2e-13	5.2	-5.4	7.9e-08	-0.06	0.15	0.85	FALSE
64	GTEx	Whole Blood	IGHMBP2	0.44	0.49	enet	16	0.51	1.3e-54	5.4	5.3	9.3e-08	0.05	0.20	0.80	FALSE
65	GTEx	Whole Blood	MRPL21	0.17	0.12	enet	21	0.12	2.5e-11	5.2	-5.2	1.9e-07	-0.05	0.31	0.69	FALSE
66	METSIM	Adipose	IGHMBP2	0.21	0.31	enet	28	0.33	3.8e-50	5.4	5.7	1.6e-08	0.06	0.25	0.75	FALSE
67	METSIM	Adipose	MRPL21	0.10	0.12	lasso	10	0.12	4.7e-17	5.4	-5.4	6.5e-08	-0.05	0.27	0.73	FALSE
68	NTR	Blood	IGHMBP2	0.02	0.02	lasso	7	0.02	5.9e-06	5.2	5.5	4.5e-08	0.07	0.12	0.88	FALSE
69	NTR	Blood	MRPL21	0.06	0.07	enet	19	0.07	7.0e-23	5.4	-5.3	8.8e-08	-0.05	0.23	0.77	FALSE
70	NTR	Blood	ORAOV1	0.04	0.02	lasso	2	0.02	2.3e-07	-6.4	6.4	1.6e-10	0.31	0.54	0.46	TRUE
71	ROSMAP	Brain Pre-frontal Cortex	IGHMBP2	0.19	0.19	enet	17	0.20	3.9e-25	5.3	5.2	2.4e-07	0.06	0.24	0.76	FALSE
72	ROSMAP	Brain Pre-frontal Cortex	MRPL21	0.46	0.61	bslmm	401	0.61	2.3e-99	5.3	-5.4	7.0e-08	-0.07	0.22	0.78	FALSE
73	YFS	Blood	IGHMBP2	0.23	0.41	enet	31	0.42	1.2e-150	5.3	5.3	9.8e-08	0.06	0.29	0.71	FALSE
74	YFS	Blood	MRPL21	0.14	0.18	enet	38	0.19	3.6e-60	5.3	-5.6	1.8e-08	-0.07	0.28	0.72	FALSE
75	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MRPL21	0.07	0.06	blup	45	0.07	1.4e-06	5.2	-6.1	8.6e-10	-0.06	0.12	0.88	FALSE
76	The Cancer Genome Atlas	Breast Invasive Carcinoma	MRPL21	0.10	0.17	blup	45	0.17	1.2e-33	5.4	-5.5	3.2e-08	-0.06	0.09	0.91	FALSE
77	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MRPL21	0.16	0.17	blup	45	0.19	8.5e-10	5.4	-6.0	2.3e-09	-0.04	0.09	0.91	FALSE
78	The Cancer Genome Atlas	Colon Adenocarcinoma	IGHMBP2	0.07	0.09	lasso	6	0.08	1.6e-05	5.2	5.2	1.7e-07	0.06	0.02	0.98	FALSE
79	The Cancer Genome Atlas	Colon Adenocarcinoma	MRPL21	0.23	0.30	blup	45	0.32	4.8e-19	5.2	-6.0	2.7e-09	-0.05	0.10	0.90	FALSE
80	The Cancer Genome Atlas	Glioblastoma Multiforme	IGHMBP2	0.35	0.16	blup	60	0.20	1.4e-06	5.1	6.4	1.2e-10	0.05	0.02	0.97	TRUE
81	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MRPL21	0.06	0.05	lasso	2	0.04	1.0e-05	5.1	-5.1	2.7e-07	-0.06	0.13	0.86	FALSE
82	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IGHMBP2	0.21	0.22	lasso	5	0.22	2.2e-24	5.3	5.2	1.6e-07	0.07	0.02	0.98	FALSE
83	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MRPL21	0.32	0.36	blup	45	0.39	3.4e-47	5.2	-5.2	1.6e-07	-0.06	0.12	0.88	FALSE
84	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	IGHMBP2	0.27	0.30	blup	60	0.32	1.1e-18	5.4	5.3	1.2e-07	0.06	0.02	0.98	FALSE
85	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MRPL21	0.47	0.32	lasso	4	0.32	5.7e-19	5.2	-5.1	3.0e-07	-0.06	0.12	0.88	FALSE
86	The Cancer Genome Atlas	Brain Lower Grade Glioma	IGHMBP2	0.30	0.16	lasso	6	0.18	5.9e-20	5.1	5.1	3.0e-07	0.07	0.03	0.97	FALSE
87	The Cancer Genome Atlas	Brain Lower Grade Glioma	MRPL21	0.55	0.59	enet	21	0.60	1.3e-85	5.2	-5.4	6.9e-08	-0.06	0.12	0.87	FALSE
88	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MRPL21	0.11	0.07	enet	3	0.07	2.9e-04	5.4	-5.4	5.7e-08	-0.06	0.09	0.88	FALSE
89	The Cancer Genome Atlas	Lung Adenocarcinoma	MRPL21	0.14	0.22	lasso	5	0.22	7.5e-25	5.1	-5.2	2.2e-07	-0.06	0.14	0.86	FALSE
90	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MRPL21	0.12	0.19	blup	45	0.20	8.2e-22	5.2	-5.6	2.7e-08	-0.05	0.11	0.89	FALSE
91	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	IGHMBP2	0.15	0.14	enet	20	0.13	5.0e-09	5.4	5.2	1.7e-07	0.06	0.02	0.98	FALSE
92	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MRPL21	0.19	0.23	lasso	4	0.23	9.6e-16	5.1	-5.2	2.7e-07	-0.06	0.13	0.87	FALSE
93	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	IGHMBP2	0.18	0.18	lasso	4	0.19	1.9e-08	5.1	5.3	1.2e-07	0.05	0.02	0.98	FALSE
94	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MRPL21	0.43	0.39	enet	17	0.39	1.1e-17	5.2	-5.8	6.0e-09	-0.06	0.11	0.89	FALSE
95	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	MRPL21	0.39	0.46	lasso	9	0.45	1.2e-19	5.4	-5.3	1.1e-07	-0.05	0.10	0.90	FALSE
96	The Cancer Genome Atlas	Prostate Adenocarcinoma	IGHMBP2	0.18	0.09	enet	10	0.17	1.2e-17	5.3	5.1	3.1e-07	0.07	0.02	0.98	FALSE
97	The Cancer Genome Atlas	Prostate Adenocarcinoma	MRPL21	0.45	0.54	blup	45	0.55	3.1e-69	5.2	-5.4	7.0e-08	-0.05	0.13	0.87	FALSE
98	The Cancer Genome Atlas	Rectum Adenocarcinoma	IGHMBP2	0.30	0.20	enet	9	0.26	9.9e-07	5.2	5.4	7.1e-08	0.06	0.03	0.95	FALSE
99	The Cancer Genome Atlas	Soft Tissue Sarcoma	IGHMBP2	0.10	0.09	blup	60	0.09	4.1e-06	5.1	6.1	1.2e-09	0.06	0.02	0.97	FALSE
100	The Cancer Genome Atlas	Soft Tissue Sarcoma	MRPL21	0.31	0.31	lasso	3	0.30	3.7e-18	5.2	-5.3	1.3e-07	-0.06	0.10	0.90	FALSE
101	The Cancer Genome Atlas	Skin Cutaneous Melanoma	MRPL21	0.30	0.18	lasso	1	0.14	1.2e-04	5.3	-5.3	1.0e-07	-0.05	0.05	0.71	FALSE
102	The Cancer Genome Atlas	Stomach Adenocarcinoma	IGHMBP2	0.06	0.06	lasso	4	0.06	7.5e-05	5.3	5.5	4.2e-08	0.04	0.01	0.98	FALSE
103	The Cancer Genome Atlas	Testicular Germ Cell Tumors	IGHMBP2	0.30	0.27	blup	60	0.22	2.8e-08	5.3	5.9	4.7e-09	0.06	0.02	0.98	FALSE
104	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MRPL21	0.21	0.28	enet	14	0.26	7.6e-10	5.1	-5.4	5.3e-08	-0.06	0.11	0.89	FALSE
105	The Cancer Genome Atlas	Thyroid Carcinoma	CCND1	0.05	0.03	lasso	2	0.02	8.8e-03	-6.5	6.2	6.6e-10	0.26	0.03	0.06	TRUE
106	The Cancer Genome Atlas	Thyroid Carcinoma	MRPL21	0.40	0.47	blup	45	0.50	3.4e-56	5.4	-5.2	1.8e-07	-0.05	0.08	0.92	FALSE
107	The Cancer Genome Atlas	Thyroid Carcinoma	ORAOV1	0.04	0.00	blup	49	0.03	1.2e-03	-3.2	6.1	9.8e-10	0.35	0.04	0.08	FALSE
108	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	MRPL21	0.19	0.10	lasso	3	0.14	1.2e-04	5.2	-5.5	3.4e-08	-0.07	0.07	0.86	FALSE