Best TWAS P=7.27e-14 · Best GWAS P=1.73e-14 conditioned to 1.72e-14
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Frontal Cortex BA9 | TEX29 | 0.45 | 0.10 | lasso | 8 | 0.24 | 4.2e-07 | -6.2 | -7.5 | 7.3e-14 | -0.04 | 0.11 | 0.10 | TRUE |
| 2 | GTEx | Colon Transverse | ARHGEF7 | 0.21 | 0.24 | lasso | 4 | 0.23 | 3.1e-11 | -5.9 | 5.9 | 3.2e-09 | -0.08 | 0.98 | 0.02 | FALSE |
| 3 | GTEx | Muscle Skeletal | ARHGEF7 | 0.14 | 0.05 | enet | 49 | 0.06 | 1.3e-06 | -5.8 | 6.2 | 5.6e-10 | -0.05 | 0.83 | 0.05 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | TEX29 | 0.14 | 0.06 | lasso | 3 | 0.08 | 4.3e-05 | 3.6 | 5.2 | 1.6e-07 | -0.07 | 0.52 | 0.04 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ARHGEF7 | 0.09 | 0.07 | blup | 142 | 0.08 | 3.1e-09 | -6.6 | 7.3 | 3.2e-13 | -0.03 | 0.12 | 0.88 | TRUE |