Hub : Genes

TEX29

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.143 0.0455 1.6e-03 0.000 NA 0.009 NA 0.012 3.4e-01 NA 5.9e-02 NA 3.9e-02
2 GTEx Brain Cerebellum 0.251 0.0970 7.4e-03 0.083 NA 0.064 NA 0.079 1.9e-03 NA 5.9e-03 NA 2.5e-03
3 GTEx Brain Frontal Cortex BA9 0.452 0.1200 8.5e-04 0.095 NA 0.196 NA 0.243 1.7e-03 NA 6.6e-06 NA 4.2e-07
4 GTEx Skin Not Sun Exposed Suprapubic 0.143 0.0550 5.8e-03 0.060 NA 0.056 NA 0.078 3.3e-04 NA 4.8e-04 NA 4.3e-05
5 GTEx Testis 0.372 0.0700 4.6e-09 0.244 NA 0.324 NA 0.329 3.4e-11 NA 5.4e-15 NA 2.9e-15

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.5 0.8 1.8 0.6 -0.6 1.0 -0.8 -1.4
Bipolar Disorder or Schizophrenia 0.1 0.2 0.5 0.0 -0.1 -0.7 -0.2 -0.7
Depressed Affect (Nagel 2018) 0.2 0.4 0.9 -0.4 1.0 -0.6 0.9 0.0
Depression (Nagel 2018) 3.8 5.8 14.4 1.1 0.8 -3.8 2.4 2.6
Intelligence (Savage-Jansen 2018) 0.1 0.4 0.8 -0.8 -0.6 0.5 -0.9 0.1
Neuroticism (Nagel 2018) 0.4 0.9 2.6 -0.2 1.6 -0.6 1.3 -0.5
Schizophrenia (2018) 0.3 0.7 3.0 -0.5 0.3 -1.7 0.4 0.2
Schizophrenia vs Biploar Disorder 2.1 2.7 5.7 -0.3 1.4 -2.4 1.7 1.7
Worry (Nagel 2018) 0.2 0.5 2.2 0.2 1.5 -0.3 0.4 0.1
Alzheimer’s Disease (in mother) 0.8 0.9 3.1 0.5 -1.8 0.4 -1.0 -0.5
Alzheimer’s Disease (in father) 0.7 0.8 2.7 0.8 -0.4 -1.6 0.2 0.5
Alzheimer’s Disease (including proxy) 0.7 1.0 2.3 1.5 -1.4 -0.9 -0.0 -0.1
Crohns Disease (2017) 0.5 1.0 2.1 1.3 -0.3 -1.4 1.0 0.5
Irritable Bowel Disease (IBD) 0.4 0.9 1.8 1.2 -1.1 -1.3 0.4 0.3
Ulcerative Colitis (UC) 0.3 0.5 2.1 0.5 -1.4 -0.3 -0.5 -0.2
Major Depression (MDD) 1.6 2.0 5.6 0.3 0.7 -2.4 1.5 1.3
Reaction Time 3.0 5.6 14.0 -0.1 -0.4 3.7 -2.5 -2.7
Verbal and Numeric Reasoning (VNR) 0.2 0.6 2.2 -1.5 0.4 -0.6 -0.0 0.1
Breast Cancer 0.4 0.9 2.8 0.0 0.1 -1.3 1.7 0.4
Ovarian Cancer 0.1 0.2 0.9 1.0 -0.1 0.0 -0.0 0.2
Prostate Cancer 0.3 0.4 1.0 0.3 0.7 -0.4 1.0 0.2
Age at First Birth 0.9 1.3 3.2 -0.3 -1.8 0.2 -1.8 -0.1
Bipolar Disorder (2011) 1.2 1.2 4.4 0.5 -0.6 0.7 -0.6 -2.1
Body Mass Index (BMI) (2010) 1.4 1.9 4.0 0.1 1.1 -2.0 1.4 1.5
Coronary Artery Disease (CAD) 2.0 2.4 5.7 -0.3 -1.0 -2.4 -0.4 2.2
Crohns Disease (2012) 0.5 0.7 1.4 0.7 0.4 -1.2 1.0 -0.9
Mean Putamen Volume 1.9 2.2 4.1 0.4 0.8 -1.6 2.0 1.9
Fasting Glucose 2.1 2.5 7.8 0.6 1.0 -1.9 2.8 0.1
HbA1C 1.8 2.0 4.5 2.0 -0.0 -1.1 0.4 2.1
HDL Cholesterol 0.8 1.3 3.4 1.3 -1.8 0.8 -0.8 -0.4
LDL Cholesterol 0.2 0.3 0.8 -0.7 0.9 0.2 0.0 0.3
Lupus 0.2 0.3 0.8 -0.5 0.3 0.7 -0.2 -0.9
Neuroticism (2016) 0.6 0.9 1.9 -1.3 1.4 -0.4 0.4 -0.5
Primary Biliary Cirrhosis 1.0 1.5 3.8 -1.5 -0.8 -0.2 -1.9 0.9
Rheumatoid Arthritis 0.9 1.2 1.8 1.2 -0.3 -1.3 0.9 1.4
Schizophrenia (2014) 0.4 0.8 3.7 0.1 0.1 -1.9 0.5 0.1
Triglycerides 0.1 0.2 0.4 -0.3 0.4 0.2 0.2 0.6
Type 2 Diabetes (T2D) (2012) 1.0 1.1 2.1 1.4 1.0 -1.0 1.1 0.6
Ulcerative Colitis 0.2 0.3 1.0 0.3 -0.5 -1.0 0.2 0.0
Blood Eosinophil Count 0.3 2.4 6.2 -0.9 -1.8 0.6 -2.5 1.2
Blood Platelet Count 0.0 0.1 0.6 -0.3 -0.2 -0.7 -0.2 -0.0
Blood Red Count 0.3 3.0 6.2 2.5 -1.2 -2.1 1.4 0.9
Blood White Count 0.1 1.0 2.2 -0.4 -1.5 -0.7 -1.0 1.0
Heel T-Score 0.2 1.2 2.4 1.4 -0.6 1.5 -0.2 -1.2
BMI 3.9 22.4 56.0 0.7 2.8 -7.5 5.2 4.5
Height 0.1 1.4 3.4 0.1 -1.1 1.8 -1.6 0.0
Waist Hip Ratio (WHR) 0.2 0.7 1.5 0.3 -0.8 1.2 -0.3 -1.0
Systolic Blood Pressure 0.5 2.7 6.1 0.9 2.1 -1.4 2.5 0.0
Smoking Status 1.7 4.0 11.2 -2.8 3.3 0.7 1.0 0.2
Allergy or Eczema 0.5 1.3 3.5 1.0 -1.0 -1.9 0.1 1.0
Cardiovascular Disease 1.5 4.9 12.5 1.9 1.6 -2.3 3.5 0.6
Hypothyroidism (self reported) 0.3 0.6 1.6 0.7 -0.6 -1.3 0.6 -0.4
Respiratory disease 0.5 1.2 2.0 0.4 -1.4 -1.3 -0.6 1.3
Type 2 Diabetes (T2D) (2018) 1.2 2.2 4.4 0.4 1.8 -1.5 2.1 1.0
Lung FEV1/FVC ratio 0.4 2.2 7.9 -0.2 2.8 -0.4 1.7 -0.3
Lung FVC 0.6 3.0 5.2 0.2 2.3 0.7 2.1 -2.1
Neuroticism 0.1 0.3 1.0 -0.8 1.0 -0.3 -0.1 0.2
Chronotype (morning person) 0.5 1.1 2.9 -1.3 0.5 -1.7 0.7 0.1
Hair Pigment 0.0 0.7 1.4 -0.3 1.2 -0.5 1.2 -0.4
Tanning 0.2 2.1 7.5 0.4 0.5 -2.7 1.2 1.1
Hand grip strength (left) 0.0 0.1 0.1 0.4 0.2 0.4 -0.2 -0.2
Number of treatments/medications taken 2.7 4.8 12.3 1.9 1.1 -3.5 2.5 0.7
Average weekly spirits intake 1.6 2.0 4.7 -2.2 2.0 -0.7 0.7 -0.7
Sensitivity / hurt feelings 0.3 0.5 1.1 0.5 0.1 -0.9 1.0 -0.5
Frequency of depressed mood in last 2 weeks 3.4 4.8 11.5 0.9 0.2 -3.4 1.7 2.9
Hearing difficulty/problems: Yes 0.3 0.5 1.3 1.2 0.7 -0.1 0.7 0.5
Relative age of first facial hair 0.3 0.7 1.9 -0.0 1.4 0.3 1.2 -0.2
Other serious medical condition/disability diagnosed by doctor 2.5 3.3 9.7 1.6 -0.5 -3.1 1.8 0.7
Ever used hormone-replacement therapy (HRT) 1.5 1.9 3.4 -1.6 -0.2 -1.7 -0.7 1.9
Ever had hysterectomy (womb removed) 0.8 0.9 2.5 1.3 0.3 -0.5 1.6 0.0
Systolic blood pressure, automated reading 0.8 2.4 4.3 0.7 1.8 -1.8 2.1 0.8
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 5.1 0.5 -0.4 -0.6 0.4 2.2
Angina 3.4 4.5 7.8 2.5 -1.8 -2.8 1.8 1.4
Medication for hormone replacement therapy 1.2 1.3 3.5 -1.1 0.4 1.9 -1.1 -0.8
Vitamin and mineral supplements 1.1 1.5 3.3 -0.5 -1.3 1.1 -1.1 1.8
Supplements: Zinc 0.5 0.6 1.1 0.4 0.3 -0.9 1.0 -0.8
Medication: Co-codamol 0.6 0.6 1.7 0.3 1.0 1.3 0.6 -0.2
Medication: Metformin 1.4 2.0 2.8 1.2 1.3 -1.5 1.7 1.3
Diabetes (father) 0.5 0.7 1.3 0.3 -1.1 1.1 -0.4 0.6
Diabetes (mother) 1.4 1.8 5.2 1.1 -0.7 -1.2 0.9 2.3
Severe depression (siblings) 0.5 0.5 1.9 0.7 -0.2 -1.4 -0.5 0.3
Pack years adult smoking proportion 0.7 1.1 2.9 -0.1 1.1 -1.7 1.0 -0.5
Impedance of leg (right) 0.7 3.5 6.3 1.0 -2.4 2.0 -2.5 -0.5
Leg fat-free mass (left) 1.7 8.8 19.6 -0.8 2.2 -4.4 2.9 3.3
Trunk fat percentage 2.4 9.5 27.1 0.8 1.5 -5.2 3.0 2.9
Hand grip strength (right) 0.1 0.4 0.8 0.9 0.4 -0.7 0.7 0.2
Townsend deprivation index at recruitment 0.6 0.8 2.0 -0.8 -0.2 -1.4 0.2 1.1
Current tobacco smoking 1.8 2.9 3.9 -1.7 1.9 -1.9 0.8 2.0
Average weekly fortified wine intake 0.2 0.2 0.9 -0.9 -0.0 0.4 -0.2 -0.3
Maternal smoking around birth 0.1 0.2 0.3 -0.6 0.6 -0.2 0.2 0.3
Fed-up feelings 0.3 0.5 1.2 -0.2 0.4 -1.1 0.9 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 2.7 3.6 7.5 1.6 -0.9 -2.4 1.2 2.7
Relative age voice broke 0.8 1.2 3.1 -1.5 1.8 -0.1 0.4 0.6
Taking other prescription medications 3.8 5.9 15.4 -0.5 1.2 -3.9 1.7 3.1
Age when periods started (menarche) 0.2 0.6 2.2 -1.5 0.3 -0.2 0.3 -0.6
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 3.3 1.8 -0.7 -0.2 0.6 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 2.5 1.6 -0.3 -0.8 0.4 -1.2
Tinnitus: Yes, but not now, but have in the past 0.2 0.3 0.5 0.4 0.6 0.4 -0.4 -0.7
Qualifications: CSEs or equivalent 0.2 0.3 1.0 0.3 -0.2 0.5 -0.4 -1.0
Serious illness, injury or assault to yourself 0.8 1.0 2.8 0.2 -0.6 -1.7 0.9 0.8
High blood pressure 0.5 1.3 4.6 0.8 1.0 -0.2 2.2 -0.1
Hayfever, allergic rhinitis or eczema 0.5 1.1 2.6 1.1 -1.6 -1.1 -0.4 0.6
Multivitamins +/- minerals 1.6 2.0 3.8 0.4 1.9 -1.7 1.3 -1.2
Stomach or abdominal pain in last month 1.6 2.0 7.5 -0.2 -0.4 -1.5 -0.2 2.7
Supplements: Glucosamine 0.6 0.8 2.2 0.7 0.6 0.7 0.8 -1.5
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 2.1 0.4 -0.8 -1.4 0.4 0.6
Medication: Atenolol 0.2 0.2 0.6 0.1 0.8 -0.5 0.4 -0.1
Medication: Levothyroxine sodium 0.3 0.5 1.1 0.5 -0.2 -1.0 0.9 0.3
Sitting height 0.2 1.2 4.3 -0.1 -0.6 -1.1 0.4 2.1
Chronic bronchitis/emphysema (father) 1.1 1.3 2.9 0.6 0.8 -1.4 1.7 -0.7
High blood pressure (mother) 1.9 2.7 5.5 -0.8 2.3 1.2 0.8 -2.3
Body mass index (BMI) 3.4 14.5 40.0 0.8 2.1 -6.3 4.2 3.1
Impedance of leg (left) 0.8 4.0 7.3 0.9 -2.5 2.3 -2.7 -0.7
Leg predicted mass (left) 1.7 8.7 20.4 -0.7 2.1 -4.5 2.8 3.2
Trunk fat mass 2.7 11.6 32.6 0.6 1.9 -5.7 3.4 3.2
Waist circumference 2.6 9.5 25.8 0.6 1.7 -5.1 3.4 2.6
Number of incorrect matches in round 0.3 0.5 0.9 0.9 -0.7 -0.9 -0.3 0.4
Past tobacco smoking 1.5 2.8 6.2 2.3 -2.5 -1.1 -0.7 0.8
Alcohol usually taken with meals 0.6 1.0 2.3 -1.5 -0.5 0.5 -1.5 0.1
Nervous feelings 0.8 1.5 3.1 0.1 -0.8 1.7 -1.8 -0.8
Frequency of tenseness / restlessness in last 2 weeks 3.6 5.6 13.3 0.4 1.4 -3.7 2.4 2.5
Hearing difficulty/problems with background noise 0.6 1.0 2.5 1.0 -1.6 -0.7 -0.8 0.3
Hair/balding pattern: Pattern 2 0.2 0.3 0.6 0.8 0.3 -0.3 0.6 -0.6
Had menopause 0.6 0.7 1.9 -1.1 0.5 -0.5 0.1 1.4
Had other major operations 0.4 0.5 0.6 -0.7 -0.5 -0.7 -0.8 0.7
Forced vital capacity (FVC) 0.7 2.6 6.6 0.0 2.5 -0.2 2.6 -0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.3 3.2 1.8 -0.2 -1.1 0.9 -1.0
Ever unenthusiastic/disinterested for a whole week 1.1 1.3 2.7 1.2 0.9 -1.6 1.3 0.4
Qualifications: None of the above 0.4 0.9 2.3 -0.7 1.5 0.3 0.1 -1.3
Financial difficulties in last 2 years 2.3 3.0 10.4 -1.7 0.1 -1.3 -0.1 3.2
Mouth/teeth dental problems 0.7 1.0 2.5 -0.8 0.4 -1.2 1.6 -0.5
Heart attack 1.6 2.0 4.8 -0.3 -2.2 -0.3 -1.8 1.4
Allergy 1.0 2.4 6.3 -0.6 2.5 1.2 1.4 -1.3
Pain all over the body in last month 0.2 0.2 0.6 0.3 -0.5 -0.8 0.4 0.0
Diabetes (self-reported) 0.7 1.1 3.3 1.8 0.9 -0.1 1.1 0.1
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.5 0.4 -0.3 -0.5 0.1 0.7
Medication: Ramipril 0.4 0.6 1.5 1.0 -1.2 -0.1 -0.1 -0.6
Medication: Simvastatin 1.5 2.2 6.2 0.7 0.8 -2.5 1.6 1.2
Fluid intelligence score 0.3 0.6 1.9 -1.4 -0.1 -0.5 -0.7 0.3
Illnesses of siblings 1.2 1.6 4.0 -0.6 -0.4 2.0 -1.6 -1.0
Neuroticism score 0.0 0.0 0.1 -0.2 0.3 -0.1 -0.1 -0.2
Weight 2.7 13.4 36.3 0.7 1.9 -6.0 3.7 3.6
Impedance of arm (right) 1.3 6.1 15.2 -0.6 -1.6 3.9 -3.2 -1.6
Arm fat percentage (right) 2.3 9.1 24.2 0.3 2.1 -4.9 3.2 2.6
Trunk fat-free mass 0.8 4.5 11.2 0.2 1.3 -3.3 2.4 2.0
Hip circumference 3.0 12.8 35.6 1.1 1.5 -6.0 3.8 3.3
Time employed in main current job 5.4 6.2 10.6 0.7 3.3 1.9 2.4 -3.3
Alcohol intake versus 10 years previously 0.8 1.1 2.1 -0.5 1.1 -1.4 1.1 1.0
Father’s age at death 2.5 3.3 10.3 -3.2 2.3 0.6 0.5 -0.6
Worrier / anxious feelings 0.5 0.9 2.4 -0.4 1.6 -0.9 1.1 0.3
Frequency of tiredness / lethargy in last 2 weeks 1.9 3.1 9.8 1.0 -0.3 -3.1 0.9 2.0
Falls in the last year 2.4 3.2 6.9 -0.6 1.1 -2.6 0.8 2.6
Hair/balding pattern: Pattern 3 0.7 1.1 2.1 -1.5 1.4 0.1 1.0 -0.7
Number of live births 0.8 1.2 4.4 2.1 -0.9 0.6 0.4 -0.1
Forced expiratory volume in 1-second (FEV1) 1.1 3.6 9.4 0.3 3.1 -0.4 2.9 -0.2
Pulse rate 0.6 1.1 4.2 -0.9 0.4 -0.5 0.0 2.0
Happiness 0.4 0.5 1.5 1.2 -0.3 -0.8 0.6 -0.1
Noisy workplace 0.3 0.4 1.5 -0.1 -0.3 0.0 -0.3 1.2
Qualifications: A levels/AS levels or equivalent 0.9 2.0 6.2 -0.1 -2.5 -0.5 -1.7 0.7
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 0.8 -0.9 0.9 0.4 0.5 0.9
Mouth/teeth dental problems: Dentures 0.5 0.9 1.4 1.0 -1.1 0.8 -1.2 0.4
Asthma 1.3 2.6 6.1 -0.3 -2.5 0.5 -2.3 1.1
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 1.6 1.3 -0.1 -1.1 0.9 0.4
Medication: Cholesterol lowering 0.4 0.7 3.2 -0.1 0.2 -1.8 0.3 -0.1
Depression (self-reported) 0.7 0.8 2.6 0.0 0.3 -1.6 0.1 1.2
Medication: Lansoprazole 1.2 1.3 2.7 0.0 -0.3 -1.7 1.4 1.4
Prospective memory result 0.9 1.1 4.0 -0.4 -0.6 1.1 -2.0 0.1
Lung cancer (father) 0.7 0.8 2.9 1.7 -0.4 -0.2 0.4 0.8
Illnesses of mother 0.3 0.4 0.7 0.8 -0.8 0.2 -0.2 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.6 6.5 1.7 1.8 0.2 2.5 -0.6
Pulse wave Arterial Stiffness index 2.0 2.3 5.9 1.4 1.7 -0.5 2.4 0.8
Impedance of arm (left) 0.9 4.3 12.5 -0.9 -0.7 3.5 -2.5 -1.2
Arm fat mass (right) 2.9 12.0 34.0 0.2 1.9 -5.8 3.3 3.4
Trunk predicted mass 0.8 4.6 11.1 0.2 1.3 -3.3 2.4 2.1
Standing height 0.0 0.4 1.6 -0.1 -0.5 0.2 -0.5 1.3
Length of working week for main job 3.6 4.0 9.7 -0.3 3.1 -2.0 2.4 0.6
Exposure to tobacco smoke at home 1.1 1.2 2.7 -0.3 -0.8 1.6 -1.6 -0.2
Breastfed as a baby 0.4 0.5 1.1 0.7 -1.1 0.5 0.6 -0.5
Tense / ‘highly strung’ 0.3 0.4 1.1 0.4 -0.0 0.4 -0.8 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 3.9 0.4 0.4 -1.5 1.0 2.0
Hair/balding pattern: Pattern 4 0.3 0.8 2.3 1.5 -0.9 -1.0 -0.1 0.3
Birth weight of first child 0.7 1.2 2.3 -0.4 1.4 1.5 -0.6 -1.1
Peak expiratory flow (PEF) 0.9 2.1 4.4 0.6 2.1 -0.2 1.9 -1.5
Pulse wave reflection index 2.3 2.9 8.2 1.6 1.7 -0.7 2.9 -0.2
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.5 -0.2 0.4 -0.1 -0.7 -0.3
Loud music exposure frequency 1.4 1.5 4.8 -0.9 2.2 -0.3 1.3 -0.2
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 1.8 -0.6 -1.4 -0.6 -0.8 0.9
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 1.3 -0.0 -0.4 0.3 -1.1 -0.1
Blood clot in the leg (DVT) 1.6 2.1 4.9 0.9 0.6 -2.1 2.2 -0.2
Medication: Paracetamol 2.0 3.2 5.0 1.8 1.7 -0.5 2.2 -2.2
Headache pain in last month 1.2 2.0 5.3 2.3 -0.2 -1.5 0.9 1.3
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.6 -0.7 0.8 0.7 0.1 0.7
Glaucoma (self-reported) 1.5 1.8 3.0 -1.7 -0.5 1.0 -1.6 1.4
Gout (self-reported) 0.8 1.1 3.2 -1.8 1.0 -0.4 -0.4 1.0
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 1.0 0.6 0.4 -1.0 1.0 -0.3
Medication: Amlodipine 0.3 0.5 1.1 -0.3 0.8 1.0 0.7 -0.2
Medication: Ventolin 100micrograms inhaler 0.8 1.0 2.8 -1.5 -0.1 0.3 -0.2 1.7
Birth weight 0.8 1.7 5.2 -0.2 1.2 -1.1 2.3 0.6
Chronic bronchitis/emphysema (mother) 0.5 0.5 2.1 -0.2 0.3 0.6 -0.3 -1.4
High blood pressure (siblings) 0.5 0.7 1.9 1.3 -0.1 -0.2 1.4 0.1
Forced vital capacity (FVC), Best measure 0.4 1.5 4.0 1.0 1.3 0.4 2.0 -0.7
Body fat percentage 2.8 11.1 31.3 1.1 1.7 -5.6 3.5 2.8
Leg fat percentage (right) 3.6 13.0 36.2 1.7 1.5 -6.0 3.8 3.1
Arm fat-free mass (right) 1.7 8.7 22.9 0.3 1.5 -4.8 3.0 3.1
Exposure to tobacco smoke outside home 0.8 1.0 1.9 1.4 0.3 -1.0 0.9 1.1
Comparative body size at age 10 0.6 1.6 4.1 -0.4 0.9 -2.0 1.7 0.1
Number of full brothers 0.6 0.8 2.0 0.8 -1.4 -0.9 0.4 -0.6
Worry too long after embarrassment 0.2 0.4 0.8 0.5 -0.7 0.6 -0.9 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 2.3 0.1 -0.2 -1.5 0.4 1.3
Wheeze or whistling in the chest in last year 2.3 4.2 8.3 -1.5 1.3 -2.9 1.5 2.6
Number of children fathered 2.0 2.2 5.1 0.2 2.2 1.6 0.9 -1.6
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 0.7 -0.6 0.6 0.8 -0.6 -0.2
Age at first live birth 1.0 1.7 3.9 -0.8 -1.1 1.6 -2.0 0.2
Pulse wave peak to peak time 2.0 2.3 6.0 -1.2 -1.8 0.5 -2.5 -0.6
Health satisfaction 2.4 3.1 7.2 1.6 1.2 -2.7 2.0 0.6
Shortness of breath walking on level ground 0.9 1.1 3.4 -0.9 1.8 1.0 0.3 0.2
Qualifications: College or University degree 0.3 1.0 3.5 0.4 -1.9 0.1 -1.1 0.1
Eye problems/disorders: None of the above 0.4 0.5 1.0 -1.0 -0.3 0.6 -0.6 -0.8
Mouth/teeth dental problems: Loose teeth 0.8 0.9 1.8 -1.4 0.5 0.2 -1.2 1.0
Emphysema/chronic bronchitis 2.7 3.0 6.6 -0.0 1.2 -2.5 2.6 0.8
Medication for pain relief, constipation, heartburn 1.8 3.1 6.7 -2.6 -0.7 1.1 -1.7 2.0
Neck or shoulder pain in last month 1.3 1.9 3.1 1.1 1.3 -1.8 1.7 0.7
Medication: Blood pressure 0.2 0.4 0.8 0.9 -0.8 0.5 0.2 -0.6
Angina (self-reported) 3.6 4.7 7.5 2.6 -1.8 -2.7 1.9 1.5
Migraine (self-reported) 0.8 0.9 3.4 0.6 0.8 -0.2 1.8 0.5
Medication: Ibuprofen 0.6 0.7 1.6 1.3 0.1 -0.9 1.1 0.3
Medication: Allopurinol 0.3 0.4 1.1 -1.1 0.7 0.0 -0.5 0.2
Medication: Omeprazole 0.5 0.6 1.4 0.5 0.9 -0.7 1.2 -0.1
Medication: Seretide 50 evohaler 0.3 0.4 1.3 -0.4 -1.1 -0.1 -0.4 0.5
Mean time to correctly identify matches 3.9 7.4 17.4 0.6 -0.1 4.2 -1.9 -4.0
Heart disease (mother) 3.9 4.7 14.0 2.4 -3.7 -0.7 -1.8 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.7 0.3 0.1 -0.5 0.9 -0.5
Whole body fat mass 3.4 14.1 39.0 0.8 2.0 -6.2 3.8 3.5
Leg fat mass (right) 4.1 15.9 43.7 0.9 2.1 -6.6 4.0 3.8
Arm predicted mass (right) 1.7 8.9 22.8 0.3 1.5 -4.8 3.1 3.1
Pulse rate, automated reading 1.5 4.9 12.1 -1.2 1.5 -3.5 1.8 2.4
Alcohol intake frequency. 1.0 2.4 5.2 2.3 -0.6 -2.1 1.5 0.1
Comparative height size at age 10 0.2 1.1 2.3 0.5 -1.2 -0.0 -1.2 1.5
Number of full sisters 0.1 0.2 0.5 -0.2 0.0 0.2 -0.5 -0.7
Suffer from ‘nerves’ 0.1 0.2 0.8 0.9 0.1 0.4 -0.2 -0.1
Overall health rating 2.2 4.8 10.5 0.9 1.2 -3.2 2.1 2.7
Chest pain or discomfort 0.9 1.2 2.1 -0.5 0.5 -1.4 1.3 1.3
Had major operations 0.9 1.1 3.8 1.2 0.2 -2.0 0.5 -0.2
Age at last live birth 0.9 1.3 2.4 1.2 -1.6 0.7 -0.9 1.3
Family relationship satisfaction 0.3 0.4 0.8 -0.9 0.8 -0.4 -0.3 0.2
Leg pain on walking 1.8 2.2 5.6 2.4 -0.3 -1.6 1.5 0.8
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 1.6 -0.9 0.9 -1.3 0.8 1.1
Commuting to job workplace: Car/motor vehicle 2.7 3.1 6.4 0.7 1.5 -2.5 2.3 0.9
Illness, injury, bereavement, stress in last 2 years 2.7 3.3 12.3 0.9 -0.1 1.8 -0.3 -3.5
Medication: Aspirin 1.1 1.5 5.9 2.4 -0.9 -0.0 0.0 -0.9
Supplements: Vitamin C 0.8 1.0 2.2 -0.2 1.1 -0.7 1.5 -0.8
Knee pain experienced in last month 2.6 4.0 12.1 0.7 1.0 -3.5 0.8 2.4
Hypertension (Self-reported) 0.6 1.7 5.5 1.4 0.8 -0.7 2.3 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 3.6 -0.2 0.2 -1.9 0.8 1.6
Illnesses of father: Heart disease 1.9 2.6 4.5 1.6 -1.3 -2.1 -0.3 2.1
Illnesses of siblings: Diabetes 0.9 1.1 2.2 -1.5 0.4 -1.1 0.0 1.4
Smoking status: Previous 1.4 2.0 3.6 -1.3 1.8 1.9 0.5 -1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 1.9 1.4 -1.1 -0.9 0.6 1.2
Whole body fat-free mass 1.2 6.8 16.1 -0.2 1.7 -4.0 2.8 2.7
Leg fat-free mass (right) 1.4 7.3 15.3 -0.8 2.1 -3.9 2.7 3.0
Arm fat percentage (left) 2.7 10.7 27.7 0.1 2.4 -5.3 3.4 2.9
Average weekly red wine intake 0.7 1.1 4.0 -0.1 -2.0 0.8 -0.9 0.0
Handedness (chirality/laterality): Left-handed 0.3 0.3 1.2 -0.3 0.3 0.6 -0.1 -1.1
Mood swings 0.3 0.5 1.4 0.3 0.7 -0.7 1.2 0.0
Loneliness, isolation 0.6 0.8 2.9 -0.4 -0.1 -1.7 0.7 0.8
Long-standing illness, disability or infirmity 4.6 7.0 23.0 0.9 0.5 -4.8 2.5 2.2
Ever had bowel cancer screening 2.5 2.9 8.8 0.8 1.8 -1.4 3.0 -0.1
Diabetes diagnosed by doctor 1.0 1.6 1.8 1.2 1.3 -1.2 1.3 1.3
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 3.0 -0.1 0.5 -1.4 1.2 1.7
Friendships satisfaction 0.4 0.5 0.8 0.9 -0.7 -0.5 -0.3 -0.9
Qualifications: nursing, teaching 0.2 0.3 0.8 0.3 -0.4 -0.7 0.9 0.4
Commuting to job workplace: Walk 1.7 1.8 4.8 0.1 -2.2 1.3 -1.6 0.3
Eye problems/disorders: Cataract 1.1 1.3 3.2 1.8 -1.0 -0.7 0.4 1.2
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.6 0.4 0.4 0.4 0.8 0.2
Medication for cholesterol 0.7 1.0 2.3 0.1 -1.5 0.9 -1.4 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 2.2 -0.0 1.0 -1.5 0.6 0.7
Back pain experienced in last month 1.7 2.5 6.5 -0.3 1.2 -1.8 1.0 2.6
Mineral and other dietary supplements 1.4 1.9 7.0 -0.5 -1.0 -0.1 -1.1 2.6
Breast cancer (self-reported) 0.2 0.2 0.6 0.8 -0.2 -0.5 0.0 -0.5
Asthma (self-reported) 1.2 2.4 6.3 -0.1 -2.5 0.3 -2.1 1.1
Osteoporosis (self-reported) 0.5 0.6 1.1 0.6 0.9 0.2 0.7 -1.1
Osteoarthritis (self-reported) 0.5 0.6 2.3 0.5 0.0 -1.5 0.7 0.5
Medication: Aspirin 0.9 1.2 5.2 2.3 -0.7 -0.3 0.1 -0.5
Medication: Gliclazide 1.5 1.7 3.2 1.6 0.1 -1.8 1.0 1.2
Illnesses of father: None of the above (group 1) 0.2 0.2 0.5 -0.7 -0.1 0.6 -0.3 0.1
Smoking status: Current 1.8 2.9 3.8 -1.6 1.9 -1.9 0.9 1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.9 4.0 9.8 2.0 2.1 -0.4 3.1 -1.1
Whole body water mass 1.2 6.9 16.5 -0.3 1.7 -4.1 2.7 2.7
Leg predicted mass (right) 1.3 7.2 15.0 -0.9 2.1 -3.9 2.6 3.0
Arm fat mass (left) 3.5 14.2 38.9 0.5 2.1 -6.2 3.8 3.6
Number of self-reported non-cancer illnesses 2.9 5.1 13.5 1.3 0.8 -3.7 2.7 1.4
Average weekly champagne plus white wine intake 0.7 1.0 2.6 -1.6 0.8 1.2 -0.3 -0.5
Miserableness 0.5 0.8 1.4 -1.0 0.3 1.2 -0.6 -1.1
Guilty feelings 0.6 1.0 1.8 -0.6 0.8 -1.4 1.2 0.6
Wears glasses or contact lenses 0.3 0.4 1.2 0.1 -0.2 -1.1 0.8 -0.0
Ever taken oral contraceptive pill 1.5 1.6 3.2 0.9 0.4 -1.7 1.8 1.0
Hearing aid user 0.4 0.4 1.0 0.6 -0.6 1.0 -0.5 -0.3
Mother’s age at death 0.1 0.1 0.3 -0.1 0.1 -0.6 0.1 0.5
Financial situation satisfaction 0.7 0.8 1.6 -0.7 1.2 -0.6 0.5 1.3
Tinnitus: Yes, now most or all of the time 0.9 1.1 2.9 0.9 -1.7 0.1 -1.1 0.7
Commuting to job workplace: Public transport 0.2 0.2 0.4 0.4 -0.6 -0.3 -0.4 -0.4
Eye problems/disorders: Glaucoma 1.0 1.2 2.3 -1.4 0.5 1.5 -1.0 0.6
Medication: Blood pressure 1.0 2.0 5.5 1.0 1.6 -0.9 2.3 0.3
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.8 -0.9 0.6 -1.3 -0.0 0.4
Supplements: Fish oil (including cod liver oil) 0.6 0.7 3.3 0.5 0.1 -0.1 0.2 -1.8
High cholesterol (Self-reported) 0.9 1.6 4.5 0.3 1.4 -1.2 2.1 -0.2
Medication: Bendroflumethiazide 0.9 1.4 2.6 0.5 0.4 -1.5 1.6 1.3
Medication: Paracetamol 1.1 1.6 5.3 1.3 0.8 0.2 0.6 -2.3
Medication: Lisinopril 1.0 1.3 2.5 0.3 -1.0 1.5 -1.6 -0.6
Medication: Atorvastatin 0.4 0.5 1.3 0.4 -1.2 0.8 -0.4 -0.6
Illnesses of father: High blood pressure 0.7 0.9 1.7 -1.1 1.1 1.3 -0.2 -0.5
Alcohol drinker status: Never 0.4 0.5 2.1 0.4 -1.5 -0.2 -0.0 0.4
Ever smoked 1.0 1.7 4.9 -2.2 1.7 0.8 -0.1 -0.2
Basal metabolic rate 1.7 9.2 22.9 -0.1 1.9 -4.8 3.1 3.2
Leg fat percentage (left) 3.3 12.0 32.4 1.7 1.7 -5.7 3.9 2.6
Arm fat-free mass (left) 1.7 8.6 23.1 0.6 1.0 -4.8 2.9 3.1
Number of operations (self-reported) 0.6 0.9 2.8 0.9 0.1 -1.7 0.7 0.3
Average weekly beer plus cider intake 1.7 2.5 8.6 -0.6 0.9 2.9 -0.8 -1.4
Irritability 0.1 0.2 0.6 0.1 0.2 0.2 0.5 -0.8
Risk taking 0.8 1.2 2.5 -1.2 -0.5 -1.2 -0.5 1.6
Ever had prostate specific antigen (PSA) test 1.7 2.0 5.2 0.0 1.1 -1.3 2.3 -1.3
Fractured/broken bones in last 5 years 0.8 1.0 2.5 -0.5 0.3 -1.6 0.2 1.5
Age started oral contraceptive pill 0.5 0.6 1.9 0.6 -1.4 0.2 -0.1 -1.0
Diastolic blood pressure, automated reading 1.5 4.5 8.5 -0.3 2.9 -2.7 2.4 1.1
Ever depressed for a whole week 1.0 1.2 1.7 1.3 1.1 -1.2 1.3 0.1
Unable to work because of sickness or disability 1.4 1.8 5.4 -1.3 0.2 -1.3 -0.7 2.3
Commuting to job workplace: Cycle 2.0 2.5 7.8 -0.9 -1.7 0.8 -2.8 0.6
Myopia 1.7 2.5 8.0 -0.1 1.7 -1.2 2.8 -0.0
Vascular/heart problems diagnosed by doctor 0.5 1.4 4.5 -1.2 -0.8 0.7 -2.1 -0.1
Cholesterol lowering medication 0.8 1.1 2.7 0.2 0.2 -1.2 1.2 1.6
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 0.9 0.1 0.8 -1.0 0.9 0.0
Pain experienced in last month 2.5 4.1 8.2 -1.4 -0.4 2.9 -1.4 -2.9
Supplements: Calcium 0.1 0.1 0.4 -0.2 -0.0 -0.6 0.2 0.5
Basal cell carcinoma (self-reported) 0.2 0.3 1.0 -1.0 0.3 0.2 -0.5 -0.2
Heart attack/myocardial infarction (self-reported) 1.6 2.1 5.4 -0.1 -2.3 -0.0 -2.0 1.1
Deep venous thrombosis (DVT) (self-reported) 1.8 2.4 5.8 1.5 0.2 -1.9 2.4 -0.3
Heart disease (siblings) 1.3 1.6 4.0 1.2 -0.9 -2.0 0.9 0.8
Alcohol drinker status: Previous 0.3 0.4 0.7 0.9 0.6 0.5 0.3 -0.7
Pack years of smoking 0.6 0.8 1.5 -0.1 1.0 -1.2 0.7 -1.1
Impedance of whole body 1.0 5.2 9.8 0.4 -2.3 3.1 -3.1 -1.0
Leg fat mass (left) 3.9 15.2 41.3 0.9 2.2 -6.4 4.1 3.5
Arm predicted mass (left) 1.6 8.3 23.0 0.5 1.1 -4.8 2.9 2.9