Hub : Genes

TEX29

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.143	0.0455	1.6e-03	0.000	NA	0.009	NA	0.012	3.4e-01	NA	5.9e-02	NA	3.9e-02
2	GTEx	Brain Cerebellum	0.251	0.0970	7.4e-03	0.083	NA	0.064	NA	0.079	1.9e-03	NA	5.9e-03	NA	2.5e-03
3	GTEx	Brain Frontal Cortex BA9	0.452	0.1200	8.5e-04	0.095	NA	0.196	NA	0.243	1.7e-03	NA	6.6e-06	NA	4.2e-07
4	GTEx	Skin Not Sun Exposed Suprapubic	0.143	0.0550	5.8e-03	0.060	NA	0.056	NA	0.078	3.3e-04	NA	4.8e-04	NA	4.3e-05
5	GTEx	Testis	0.372	0.0700	4.6e-09	0.244	NA	0.324	NA	0.329	3.4e-11	NA	5.4e-15	NA	2.9e-15

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.5	0.8	1.8	0.6	-0.6	1.0	-0.8	-1.4
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	0.0	-0.1	-0.7	-0.2	-0.7
Depressed Affect (Nagel 2018)	0.2	0.4	0.9	-0.4	1.0	-0.6	0.9	0.0
Depression (Nagel 2018)	3.8	5.8	14.4	1.1	0.8	-3.8	2.4	2.6
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.8	-0.8	-0.6	0.5	-0.9	0.1
Neuroticism (Nagel 2018)	0.4	0.9	2.6	-0.2	1.6	-0.6	1.3	-0.5
Schizophrenia (2018)	0.3	0.7	3.0	-0.5	0.3	-1.7	0.4	0.2
Schizophrenia vs Biploar Disorder	2.1	2.7	5.7	-0.3	1.4	-2.4	1.7	1.7
Worry (Nagel 2018)	0.2	0.5	2.2	0.2	1.5	-0.3	0.4	0.1
Alzheimer’s Disease (in mother)	0.8	0.9	3.1	0.5	-1.8	0.4	-1.0	-0.5
Alzheimer’s Disease (in father)	0.7	0.8	2.7	0.8	-0.4	-1.6	0.2	0.5
Alzheimer’s Disease (including proxy)	0.7	1.0	2.3	1.5	-1.4	-0.9	-0.0	-0.1
Crohns Disease (2017)	0.5	1.0	2.1	1.3	-0.3	-1.4	1.0	0.5
Irritable Bowel Disease (IBD)	0.4	0.9	1.8	1.2	-1.1	-1.3	0.4	0.3
Ulcerative Colitis (UC)	0.3	0.5	2.1	0.5	-1.4	-0.3	-0.5	-0.2
Major Depression (MDD)	1.6	2.0	5.6	0.3	0.7	-2.4	1.5	1.3
Reaction Time	3.0	5.6	14.0	-0.1	-0.4	3.7	-2.5	-2.7
Verbal and Numeric Reasoning (VNR)	0.2	0.6	2.2	-1.5	0.4	-0.6	-0.0	0.1
Breast Cancer	0.4	0.9	2.8	0.0	0.1	-1.3	1.7	0.4
Ovarian Cancer	0.1	0.2	0.9	1.0	-0.1	0.0	-0.0	0.2
Prostate Cancer	0.3	0.4	1.0	0.3	0.7	-0.4	1.0	0.2
Age at First Birth	0.9	1.3	3.2	-0.3	-1.8	0.2	-1.8	-0.1
Bipolar Disorder (2011)	1.2	1.2	4.4	0.5	-0.6	0.7	-0.6	-2.1
Body Mass Index (BMI) (2010)	1.4	1.9	4.0	0.1	1.1	-2.0	1.4	1.5
Coronary Artery Disease (CAD)	2.0	2.4	5.7	-0.3	-1.0	-2.4	-0.4	2.2
Crohns Disease (2012)	0.5	0.7	1.4	0.7	0.4	-1.2	1.0	-0.9
Mean Putamen Volume	1.9	2.2	4.1	0.4	0.8	-1.6	2.0	1.9
Fasting Glucose	2.1	2.5	7.8	0.6	1.0	-1.9	2.8	0.1
HbA1C	1.8	2.0	4.5	2.0	-0.0	-1.1	0.4	2.1
HDL Cholesterol	0.8	1.3	3.4	1.3	-1.8	0.8	-0.8	-0.4
LDL Cholesterol	0.2	0.3	0.8	-0.7	0.9	0.2	0.0	0.3
Lupus	0.2	0.3	0.8	-0.5	0.3	0.7	-0.2	-0.9
Neuroticism (2016)	0.6	0.9	1.9	-1.3	1.4	-0.4	0.4	-0.5
Primary Biliary Cirrhosis	1.0	1.5	3.8	-1.5	-0.8	-0.2	-1.9	0.9
Rheumatoid Arthritis	0.9	1.2	1.8	1.2	-0.3	-1.3	0.9	1.4
Schizophrenia (2014)	0.4	0.8	3.7	0.1	0.1	-1.9	0.5	0.1
Triglycerides	0.1	0.2	0.4	-0.3	0.4	0.2	0.2	0.6
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.1	1.4	1.0	-1.0	1.1	0.6
Ulcerative Colitis	0.2	0.3	1.0	0.3	-0.5	-1.0	0.2	0.0
Blood Eosinophil Count	0.3	2.4	6.2	-0.9	-1.8	0.6	-2.5	1.2
Blood Platelet Count	0.0	0.1	0.6	-0.3	-0.2	-0.7	-0.2	-0.0
Blood Red Count	0.3	3.0	6.2	2.5	-1.2	-2.1	1.4	0.9
Blood White Count	0.1	1.0	2.2	-0.4	-1.5	-0.7	-1.0	1.0
Heel T-Score	0.2	1.2	2.4	1.4	-0.6	1.5	-0.2	-1.2
BMI	3.9	22.4	56.0	0.7	2.8	-7.5	5.2	4.5
Height	0.1	1.4	3.4	0.1	-1.1	1.8	-1.6	0.0
Waist Hip Ratio (WHR)	0.2	0.7	1.5	0.3	-0.8	1.2	-0.3	-1.0
Systolic Blood Pressure	0.5	2.7	6.1	0.9	2.1	-1.4	2.5	0.0
Smoking Status	1.7	4.0	11.2	-2.8	3.3	0.7	1.0	0.2
Allergy or Eczema	0.5	1.3	3.5	1.0	-1.0	-1.9	0.1	1.0
Cardiovascular Disease	1.5	4.9	12.5	1.9	1.6	-2.3	3.5	0.6
Hypothyroidism (self reported)	0.3	0.6	1.6	0.7	-0.6	-1.3	0.6	-0.4
Respiratory disease	0.5	1.2	2.0	0.4	-1.4	-1.3	-0.6	1.3
Type 2 Diabetes (T2D) (2018)	1.2	2.2	4.4	0.4	1.8	-1.5	2.1	1.0
Lung FEV1/FVC ratio	0.4	2.2	7.9	-0.2	2.8	-0.4	1.7	-0.3
Lung FVC	0.6	3.0	5.2	0.2	2.3	0.7	2.1	-2.1
Neuroticism	0.1	0.3	1.0	-0.8	1.0	-0.3	-0.1	0.2
Chronotype (morning person)	0.5	1.1	2.9	-1.3	0.5	-1.7	0.7	0.1
Hair Pigment	0.0	0.7	1.4	-0.3	1.2	-0.5	1.2	-0.4
Tanning	0.2	2.1	7.5	0.4	0.5	-2.7	1.2	1.1
Hand grip strength (left)	0.0	0.1	0.1	0.4	0.2	0.4	-0.2	-0.2
Number of treatments/medications taken	2.7	4.8	12.3	1.9	1.1	-3.5	2.5	0.7
Average weekly spirits intake	1.6	2.0	4.7	-2.2	2.0	-0.7	0.7	-0.7
Sensitivity / hurt feelings	0.3	0.5	1.1	0.5	0.1	-0.9	1.0	-0.5
Frequency of depressed mood in last 2 weeks	3.4	4.8	11.5	0.9	0.2	-3.4	1.7	2.9
Hearing difficulty/problems: Yes	0.3	0.5	1.3	1.2	0.7	-0.1	0.7	0.5
Relative age of first facial hair	0.3	0.7	1.9	-0.0	1.4	0.3	1.2	-0.2
Other serious medical condition/disability diagnosed by doctor	2.5	3.3	9.7	1.6	-0.5	-3.1	1.8	0.7
Ever used hormone-replacement therapy (HRT)	1.5	1.9	3.4	-1.6	-0.2	-1.7	-0.7	1.9
Ever had hysterectomy (womb removed)	0.8	0.9	2.5	1.3	0.3	-0.5	1.6	0.0
Systolic blood pressure, automated reading	0.8	2.4	4.3	0.7	1.8	-1.8	2.1	0.8
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	5.1	0.5	-0.4	-0.6	0.4	2.2
Angina	3.4	4.5	7.8	2.5	-1.8	-2.8	1.8	1.4
Medication for hormone replacement therapy	1.2	1.3	3.5	-1.1	0.4	1.9	-1.1	-0.8
Vitamin and mineral supplements	1.1	1.5	3.3	-0.5	-1.3	1.1	-1.1	1.8
Supplements: Zinc	0.5	0.6	1.1	0.4	0.3	-0.9	1.0	-0.8
Medication: Co-codamol	0.6	0.6	1.7	0.3	1.0	1.3	0.6	-0.2
Medication: Metformin	1.4	2.0	2.8	1.2	1.3	-1.5	1.7	1.3
Diabetes (father)	0.5	0.7	1.3	0.3	-1.1	1.1	-0.4	0.6
Diabetes (mother)	1.4	1.8	5.2	1.1	-0.7	-1.2	0.9	2.3
Severe depression (siblings)	0.5	0.5	1.9	0.7	-0.2	-1.4	-0.5	0.3
Pack years adult smoking proportion	0.7	1.1	2.9	-0.1	1.1	-1.7	1.0	-0.5
Impedance of leg (right)	0.7	3.5	6.3	1.0	-2.4	2.0	-2.5	-0.5
Leg fat-free mass (left)	1.7	8.8	19.6	-0.8	2.2	-4.4	2.9	3.3
Trunk fat percentage	2.4	9.5	27.1	0.8	1.5	-5.2	3.0	2.9
Hand grip strength (right)	0.1	0.4	0.8	0.9	0.4	-0.7	0.7	0.2
Townsend deprivation index at recruitment	0.6	0.8	2.0	-0.8	-0.2	-1.4	0.2	1.1
Current tobacco smoking	1.8	2.9	3.9	-1.7	1.9	-1.9	0.8	2.0
Average weekly fortified wine intake	0.2	0.2	0.9	-0.9	-0.0	0.4	-0.2	-0.3
Maternal smoking around birth	0.1	0.2	0.3	-0.6	0.6	-0.2	0.2	0.3
Fed-up feelings	0.3	0.5	1.2	-0.2	0.4	-1.1	0.9	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	2.7	3.6	7.5	1.6	-0.9	-2.4	1.2	2.7
Relative age voice broke	0.8	1.2	3.1	-1.5	1.8	-0.1	0.4	0.6
Taking other prescription medications	3.8	5.9	15.4	-0.5	1.2	-3.9	1.7	3.1
Age when periods started (menarche)	0.2	0.6	2.2	-1.5	0.3	-0.2	0.3	-0.6
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	3.3	1.8	-0.7	-0.2	0.6	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.5	1.6	-0.3	-0.8	0.4	-1.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.5	0.4	0.6	0.4	-0.4	-0.7
Qualifications: CSEs or equivalent	0.2	0.3	1.0	0.3	-0.2	0.5	-0.4	-1.0
Serious illness, injury or assault to yourself	0.8	1.0	2.8	0.2	-0.6	-1.7	0.9	0.8
High blood pressure	0.5	1.3	4.6	0.8	1.0	-0.2	2.2	-0.1
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.6	1.1	-1.6	-1.1	-0.4	0.6
Multivitamins +/- minerals	1.6	2.0	3.8	0.4	1.9	-1.7	1.3	-1.2
Stomach or abdominal pain in last month	1.6	2.0	7.5	-0.2	-0.4	-1.5	-0.2	2.7
Supplements: Glucosamine	0.6	0.8	2.2	0.7	0.6	0.7	0.8	-1.5
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.1	0.4	-0.8	-1.4	0.4	0.6
Medication: Atenolol	0.2	0.2	0.6	0.1	0.8	-0.5	0.4	-0.1
Medication: Levothyroxine sodium	0.3	0.5	1.1	0.5	-0.2	-1.0	0.9	0.3
Sitting height	0.2	1.2	4.3	-0.1	-0.6	-1.1	0.4	2.1
Chronic bronchitis/emphysema (father)	1.1	1.3	2.9	0.6	0.8	-1.4	1.7	-0.7
High blood pressure (mother)	1.9	2.7	5.5	-0.8	2.3	1.2	0.8	-2.3
Body mass index (BMI)	3.4	14.5	40.0	0.8	2.1	-6.3	4.2	3.1
Impedance of leg (left)	0.8	4.0	7.3	0.9	-2.5	2.3	-2.7	-0.7
Leg predicted mass (left)	1.7	8.7	20.4	-0.7	2.1	-4.5	2.8	3.2
Trunk fat mass	2.7	11.6	32.6	0.6	1.9	-5.7	3.4	3.2
Waist circumference	2.6	9.5	25.8	0.6	1.7	-5.1	3.4	2.6
Number of incorrect matches in round	0.3	0.5	0.9	0.9	-0.7	-0.9	-0.3	0.4
Past tobacco smoking	1.5	2.8	6.2	2.3	-2.5	-1.1	-0.7	0.8
Alcohol usually taken with meals	0.6	1.0	2.3	-1.5	-0.5	0.5	-1.5	0.1
Nervous feelings	0.8	1.5	3.1	0.1	-0.8	1.7	-1.8	-0.8
Frequency of tenseness / restlessness in last 2 weeks	3.6	5.6	13.3	0.4	1.4	-3.7	2.4	2.5
Hearing difficulty/problems with background noise	0.6	1.0	2.5	1.0	-1.6	-0.7	-0.8	0.3
Hair/balding pattern: Pattern 2	0.2	0.3	0.6	0.8	0.3	-0.3	0.6	-0.6
Had menopause	0.6	0.7	1.9	-1.1	0.5	-0.5	0.1	1.4
Had other major operations	0.4	0.5	0.6	-0.7	-0.5	-0.7	-0.8	0.7
Forced vital capacity (FVC)	0.7	2.6	6.6	0.0	2.5	-0.2	2.6	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.3	3.2	1.8	-0.2	-1.1	0.9	-1.0
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.7	1.2	0.9	-1.6	1.3	0.4
Qualifications: None of the above	0.4	0.9	2.3	-0.7	1.5	0.3	0.1	-1.3
Financial difficulties in last 2 years	2.3	3.0	10.4	-1.7	0.1	-1.3	-0.1	3.2
Mouth/teeth dental problems	0.7	1.0	2.5	-0.8	0.4	-1.2	1.6	-0.5
Heart attack	1.6	2.0	4.8	-0.3	-2.2	-0.3	-1.8	1.4
Allergy	1.0	2.4	6.3	-0.6	2.5	1.2	1.4	-1.3
Pain all over the body in last month	0.2	0.2	0.6	0.3	-0.5	-0.8	0.4	0.0
Diabetes (self-reported)	0.7	1.1	3.3	1.8	0.9	-0.1	1.1	0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.5	0.4	-0.3	-0.5	0.1	0.7
Medication: Ramipril	0.4	0.6	1.5	1.0	-1.2	-0.1	-0.1	-0.6
Medication: Simvastatin	1.5	2.2	6.2	0.7	0.8	-2.5	1.6	1.2
Fluid intelligence score	0.3	0.6	1.9	-1.4	-0.1	-0.5	-0.7	0.3
Illnesses of siblings	1.2	1.6	4.0	-0.6	-0.4	2.0	-1.6	-1.0
Neuroticism score	0.0	0.0	0.1	-0.2	0.3	-0.1	-0.1	-0.2
Weight	2.7	13.4	36.3	0.7	1.9	-6.0	3.7	3.6
Impedance of arm (right)	1.3	6.1	15.2	-0.6	-1.6	3.9	-3.2	-1.6
Arm fat percentage (right)	2.3	9.1	24.2	0.3	2.1	-4.9	3.2	2.6
Trunk fat-free mass	0.8	4.5	11.2	0.2	1.3	-3.3	2.4	2.0
Hip circumference	3.0	12.8	35.6	1.1	1.5	-6.0	3.8	3.3
Time employed in main current job	5.4	6.2	10.6	0.7	3.3	1.9	2.4	-3.3
Alcohol intake versus 10 years previously	0.8	1.1	2.1	-0.5	1.1	-1.4	1.1	1.0
Father’s age at death	2.5	3.3	10.3	-3.2	2.3	0.6	0.5	-0.6
Worrier / anxious feelings	0.5	0.9	2.4	-0.4	1.6	-0.9	1.1	0.3
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	9.8	1.0	-0.3	-3.1	0.9	2.0
Falls in the last year	2.4	3.2	6.9	-0.6	1.1	-2.6	0.8	2.6
Hair/balding pattern: Pattern 3	0.7	1.1	2.1	-1.5	1.4	0.1	1.0	-0.7
Number of live births	0.8	1.2	4.4	2.1	-0.9	0.6	0.4	-0.1
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	9.4	0.3	3.1	-0.4	2.9	-0.2
Pulse rate	0.6	1.1	4.2	-0.9	0.4	-0.5	0.0	2.0
Happiness	0.4	0.5	1.5	1.2	-0.3	-0.8	0.6	-0.1
Noisy workplace	0.3	0.4	1.5	-0.1	-0.3	0.0	-0.3	1.2
Qualifications: A levels/AS levels or equivalent	0.9	2.0	6.2	-0.1	-2.5	-0.5	-1.7	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	0.8	-0.9	0.9	0.4	0.5	0.9
Mouth/teeth dental problems: Dentures	0.5	0.9	1.4	1.0	-1.1	0.8	-1.2	0.4
Asthma	1.3	2.6	6.1	-0.3	-2.5	0.5	-2.3	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.6	1.3	-0.1	-1.1	0.9	0.4
Medication: Cholesterol lowering	0.4	0.7	3.2	-0.1	0.2	-1.8	0.3	-0.1
Depression (self-reported)	0.7	0.8	2.6	0.0	0.3	-1.6	0.1	1.2
Medication: Lansoprazole	1.2	1.3	2.7	0.0	-0.3	-1.7	1.4	1.4
Prospective memory result	0.9	1.1	4.0	-0.4	-0.6	1.1	-2.0	0.1
Lung cancer (father)	0.7	0.8	2.9	1.7	-0.4	-0.2	0.4	0.8
Illnesses of mother	0.3	0.4	0.7	0.8	-0.8	0.2	-0.2	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	6.5	1.7	1.8	0.2	2.5	-0.6
Pulse wave Arterial Stiffness index	2.0	2.3	5.9	1.4	1.7	-0.5	2.4	0.8
Impedance of arm (left)	0.9	4.3	12.5	-0.9	-0.7	3.5	-2.5	-1.2
Arm fat mass (right)	2.9	12.0	34.0	0.2	1.9	-5.8	3.3	3.4
Trunk predicted mass	0.8	4.6	11.1	0.2	1.3	-3.3	2.4	2.1
Standing height	0.0	0.4	1.6	-0.1	-0.5	0.2	-0.5	1.3
Length of working week for main job	3.6	4.0	9.7	-0.3	3.1	-2.0	2.4	0.6
Exposure to tobacco smoke at home	1.1	1.2	2.7	-0.3	-0.8	1.6	-1.6	-0.2
Breastfed as a baby	0.4	0.5	1.1	0.7	-1.1	0.5	0.6	-0.5
Tense / ‘highly strung’	0.3	0.4	1.1	0.4	-0.0	0.4	-0.8	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.9	0.4	0.4	-1.5	1.0	2.0
Hair/balding pattern: Pattern 4	0.3	0.8	2.3	1.5	-0.9	-1.0	-0.1	0.3
Birth weight of first child	0.7	1.2	2.3	-0.4	1.4	1.5	-0.6	-1.1
Peak expiratory flow (PEF)	0.9	2.1	4.4	0.6	2.1	-0.2	1.9	-1.5
Pulse wave reflection index	2.3	2.9	8.2	1.6	1.7	-0.7	2.9	-0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.5	-0.2	0.4	-0.1	-0.7	-0.3
Loud music exposure frequency	1.4	1.5	4.8	-0.9	2.2	-0.3	1.3	-0.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.8	-0.6	-1.4	-0.6	-0.8	0.9
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.3	-0.0	-0.4	0.3	-1.1	-0.1
Blood clot in the leg (DVT)	1.6	2.1	4.9	0.9	0.6	-2.1	2.2	-0.2
Medication: Paracetamol	2.0	3.2	5.0	1.8	1.7	-0.5	2.2	-2.2
Headache pain in last month	1.2	2.0	5.3	2.3	-0.2	-1.5	0.9	1.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.6	-0.7	0.8	0.7	0.1	0.7
Glaucoma (self-reported)	1.5	1.8	3.0	-1.7	-0.5	1.0	-1.6	1.4
Gout (self-reported)	0.8	1.1	3.2	-1.8	1.0	-0.4	-0.4	1.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.0	0.6	0.4	-1.0	1.0	-0.3
Medication: Amlodipine	0.3	0.5	1.1	-0.3	0.8	1.0	0.7	-0.2
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.8	-1.5	-0.1	0.3	-0.2	1.7
Birth weight	0.8	1.7	5.2	-0.2	1.2	-1.1	2.3	0.6
Chronic bronchitis/emphysema (mother)	0.5	0.5	2.1	-0.2	0.3	0.6	-0.3	-1.4
High blood pressure (siblings)	0.5	0.7	1.9	1.3	-0.1	-0.2	1.4	0.1
Forced vital capacity (FVC), Best measure	0.4	1.5	4.0	1.0	1.3	0.4	2.0	-0.7
Body fat percentage	2.8	11.1	31.3	1.1	1.7	-5.6	3.5	2.8
Leg fat percentage (right)	3.6	13.0	36.2	1.7	1.5	-6.0	3.8	3.1
Arm fat-free mass (right)	1.7	8.7	22.9	0.3	1.5	-4.8	3.0	3.1
Exposure to tobacco smoke outside home	0.8	1.0	1.9	1.4	0.3	-1.0	0.9	1.1
Comparative body size at age 10	0.6	1.6	4.1	-0.4	0.9	-2.0	1.7	0.1
Number of full brothers	0.6	0.8	2.0	0.8	-1.4	-0.9	0.4	-0.6
Worry too long after embarrassment	0.2	0.4	0.8	0.5	-0.7	0.6	-0.9	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.3	0.1	-0.2	-1.5	0.4	1.3
Wheeze or whistling in the chest in last year	2.3	4.2	8.3	-1.5	1.3	-2.9	1.5	2.6
Number of children fathered	2.0	2.2	5.1	0.2	2.2	1.6	0.9	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.7	-0.6	0.6	0.8	-0.6	-0.2
Age at first live birth	1.0	1.7	3.9	-0.8	-1.1	1.6	-2.0	0.2
Pulse wave peak to peak time	2.0	2.3	6.0	-1.2	-1.8	0.5	-2.5	-0.6
Health satisfaction	2.4	3.1	7.2	1.6	1.2	-2.7	2.0	0.6
Shortness of breath walking on level ground	0.9	1.1	3.4	-0.9	1.8	1.0	0.3	0.2
Qualifications: College or University degree	0.3	1.0	3.5	0.4	-1.9	0.1	-1.1	0.1
Eye problems/disorders: None of the above	0.4	0.5	1.0	-1.0	-0.3	0.6	-0.6	-0.8
Mouth/teeth dental problems: Loose teeth	0.8	0.9	1.8	-1.4	0.5	0.2	-1.2	1.0
Emphysema/chronic bronchitis	2.7	3.0	6.6	-0.0	1.2	-2.5	2.6	0.8
Medication for pain relief, constipation, heartburn	1.8	3.1	6.7	-2.6	-0.7	1.1	-1.7	2.0
Neck or shoulder pain in last month	1.3	1.9	3.1	1.1	1.3	-1.8	1.7	0.7
Medication: Blood pressure	0.2	0.4	0.8	0.9	-0.8	0.5	0.2	-0.6
Angina (self-reported)	3.6	4.7	7.5	2.6	-1.8	-2.7	1.9	1.5
Migraine (self-reported)	0.8	0.9	3.4	0.6	0.8	-0.2	1.8	0.5
Medication: Ibuprofen	0.6	0.7	1.6	1.3	0.1	-0.9	1.1	0.3
Medication: Allopurinol	0.3	0.4	1.1	-1.1	0.7	0.0	-0.5	0.2
Medication: Omeprazole	0.5	0.6	1.4	0.5	0.9	-0.7	1.2	-0.1
Medication: Seretide 50 evohaler	0.3	0.4	1.3	-0.4	-1.1	-0.1	-0.4	0.5
Mean time to correctly identify matches	3.9	7.4	17.4	0.6	-0.1	4.2	-1.9	-4.0
Heart disease (mother)	3.9	4.7	14.0	2.4	-3.7	-0.7	-1.8	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.7	0.3	0.1	-0.5	0.9	-0.5
Whole body fat mass	3.4	14.1	39.0	0.8	2.0	-6.2	3.8	3.5
Leg fat mass (right)	4.1	15.9	43.7	0.9	2.1	-6.6	4.0	3.8
Arm predicted mass (right)	1.7	8.9	22.8	0.3	1.5	-4.8	3.1	3.1
Pulse rate, automated reading	1.5	4.9	12.1	-1.2	1.5	-3.5	1.8	2.4
Alcohol intake frequency.	1.0	2.4	5.2	2.3	-0.6	-2.1	1.5	0.1
Comparative height size at age 10	0.2	1.1	2.3	0.5	-1.2	-0.0	-1.2	1.5
Number of full sisters	0.1	0.2	0.5	-0.2	0.0	0.2	-0.5	-0.7
Suffer from ‘nerves’	0.1	0.2	0.8	0.9	0.1	0.4	-0.2	-0.1
Overall health rating	2.2	4.8	10.5	0.9	1.2	-3.2	2.1	2.7
Chest pain or discomfort	0.9	1.2	2.1	-0.5	0.5	-1.4	1.3	1.3
Had major operations	0.9	1.1	3.8	1.2	0.2	-2.0	0.5	-0.2
Age at last live birth	0.9	1.3	2.4	1.2	-1.6	0.7	-0.9	1.3
Family relationship satisfaction	0.3	0.4	0.8	-0.9	0.8	-0.4	-0.3	0.2
Leg pain on walking	1.8	2.2	5.6	2.4	-0.3	-1.6	1.5	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.6	-0.9	0.9	-1.3	0.8	1.1
Commuting to job workplace: Car/motor vehicle	2.7	3.1	6.4	0.7	1.5	-2.5	2.3	0.9
Illness, injury, bereavement, stress in last 2 years	2.7	3.3	12.3	0.9	-0.1	1.8	-0.3	-3.5
Medication: Aspirin	1.1	1.5	5.9	2.4	-0.9	-0.0	0.0	-0.9
Supplements: Vitamin C	0.8	1.0	2.2	-0.2	1.1	-0.7	1.5	-0.8
Knee pain experienced in last month	2.6	4.0	12.1	0.7	1.0	-3.5	0.8	2.4
Hypertension (Self-reported)	0.6	1.7	5.5	1.4	0.8	-0.7	2.3	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	3.6	-0.2	0.2	-1.9	0.8	1.6
Illnesses of father: Heart disease	1.9	2.6	4.5	1.6	-1.3	-2.1	-0.3	2.1
Illnesses of siblings: Diabetes	0.9	1.1	2.2	-1.5	0.4	-1.1	0.0	1.4
Smoking status: Previous	1.4	2.0	3.6	-1.3	1.8	1.9	0.5	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	1.9	1.4	-1.1	-0.9	0.6	1.2
Whole body fat-free mass	1.2	6.8	16.1	-0.2	1.7	-4.0	2.8	2.7
Leg fat-free mass (right)	1.4	7.3	15.3	-0.8	2.1	-3.9	2.7	3.0
Arm fat percentage (left)	2.7	10.7	27.7	0.1	2.4	-5.3	3.4	2.9
Average weekly red wine intake	0.7	1.1	4.0	-0.1	-2.0	0.8	-0.9	0.0
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.2	-0.3	0.3	0.6	-0.1	-1.1
Mood swings	0.3	0.5	1.4	0.3	0.7	-0.7	1.2	0.0
Loneliness, isolation	0.6	0.8	2.9	-0.4	-0.1	-1.7	0.7	0.8
Long-standing illness, disability or infirmity	4.6	7.0	23.0	0.9	0.5	-4.8	2.5	2.2
Ever had bowel cancer screening	2.5	2.9	8.8	0.8	1.8	-1.4	3.0	-0.1
Diabetes diagnosed by doctor	1.0	1.6	1.8	1.2	1.3	-1.2	1.3	1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.0	-0.1	0.5	-1.4	1.2	1.7
Friendships satisfaction	0.4	0.5	0.8	0.9	-0.7	-0.5	-0.3	-0.9
Qualifications: nursing, teaching	0.2	0.3	0.8	0.3	-0.4	-0.7	0.9	0.4
Commuting to job workplace: Walk	1.7	1.8	4.8	0.1	-2.2	1.3	-1.6	0.3
Eye problems/disorders: Cataract	1.1	1.3	3.2	1.8	-1.0	-0.7	0.4	1.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.6	0.4	0.4	0.4	0.8	0.2
Medication for cholesterol	0.7	1.0	2.3	0.1	-1.5	0.9	-1.4	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.2	-0.0	1.0	-1.5	0.6	0.7
Back pain experienced in last month	1.7	2.5	6.5	-0.3	1.2	-1.8	1.0	2.6
Mineral and other dietary supplements	1.4	1.9	7.0	-0.5	-1.0	-0.1	-1.1	2.6
Breast cancer (self-reported)	0.2	0.2	0.6	0.8	-0.2	-0.5	0.0	-0.5
Asthma (self-reported)	1.2	2.4	6.3	-0.1	-2.5	0.3	-2.1	1.1
Osteoporosis (self-reported)	0.5	0.6	1.1	0.6	0.9	0.2	0.7	-1.1
Osteoarthritis (self-reported)	0.5	0.6	2.3	0.5	0.0	-1.5	0.7	0.5
Medication: Aspirin	0.9	1.2	5.2	2.3	-0.7	-0.3	0.1	-0.5
Medication: Gliclazide	1.5	1.7	3.2	1.6	0.1	-1.8	1.0	1.2
Illnesses of father: None of the above (group 1)	0.2	0.2	0.5	-0.7	-0.1	0.6	-0.3	0.1
Smoking status: Current	1.8	2.9	3.8	-1.6	1.9	-1.9	0.9	1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	4.0	9.8	2.0	2.1	-0.4	3.1	-1.1
Whole body water mass	1.2	6.9	16.5	-0.3	1.7	-4.1	2.7	2.7
Leg predicted mass (right)	1.3	7.2	15.0	-0.9	2.1	-3.9	2.6	3.0
Arm fat mass (left)	3.5	14.2	38.9	0.5	2.1	-6.2	3.8	3.6
Number of self-reported non-cancer illnesses	2.9	5.1	13.5	1.3	0.8	-3.7	2.7	1.4
Average weekly champagne plus white wine intake	0.7	1.0	2.6	-1.6	0.8	1.2	-0.3	-0.5
Miserableness	0.5	0.8	1.4	-1.0	0.3	1.2	-0.6	-1.1
Guilty feelings	0.6	1.0	1.8	-0.6	0.8	-1.4	1.2	0.6
Wears glasses or contact lenses	0.3	0.4	1.2	0.1	-0.2	-1.1	0.8	-0.0
Ever taken oral contraceptive pill	1.5	1.6	3.2	0.9	0.4	-1.7	1.8	1.0
Hearing aid user	0.4	0.4	1.0	0.6	-0.6	1.0	-0.5	-0.3
Mother’s age at death	0.1	0.1	0.3	-0.1	0.1	-0.6	0.1	0.5
Financial situation satisfaction	0.7	0.8	1.6	-0.7	1.2	-0.6	0.5	1.3
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.9	0.9	-1.7	0.1	-1.1	0.7
Commuting to job workplace: Public transport	0.2	0.2	0.4	0.4	-0.6	-0.3	-0.4	-0.4
Eye problems/disorders: Glaucoma	1.0	1.2	2.3	-1.4	0.5	1.5	-1.0	0.6
Medication: Blood pressure	1.0	2.0	5.5	1.0	1.6	-0.9	2.3	0.3
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.8	-0.9	0.6	-1.3	-0.0	0.4
Supplements: Fish oil (including cod liver oil)	0.6	0.7	3.3	0.5	0.1	-0.1	0.2	-1.8
High cholesterol (Self-reported)	0.9	1.6	4.5	0.3	1.4	-1.2	2.1	-0.2
Medication: Bendroflumethiazide	0.9	1.4	2.6	0.5	0.4	-1.5	1.6	1.3
Medication: Paracetamol	1.1	1.6	5.3	1.3	0.8	0.2	0.6	-2.3
Medication: Lisinopril	1.0	1.3	2.5	0.3	-1.0	1.5	-1.6	-0.6
Medication: Atorvastatin	0.4	0.5	1.3	0.4	-1.2	0.8	-0.4	-0.6
Illnesses of father: High blood pressure	0.7	0.9	1.7	-1.1	1.1	1.3	-0.2	-0.5
Alcohol drinker status: Never	0.4	0.5	2.1	0.4	-1.5	-0.2	-0.0	0.4
Ever smoked	1.0	1.7	4.9	-2.2	1.7	0.8	-0.1	-0.2
Basal metabolic rate	1.7	9.2	22.9	-0.1	1.9	-4.8	3.1	3.2
Leg fat percentage (left)	3.3	12.0	32.4	1.7	1.7	-5.7	3.9	2.6
Arm fat-free mass (left)	1.7	8.6	23.1	0.6	1.0	-4.8	2.9	3.1
Number of operations (self-reported)	0.6	0.9	2.8	0.9	0.1	-1.7	0.7	0.3
Average weekly beer plus cider intake	1.7	2.5	8.6	-0.6	0.9	2.9	-0.8	-1.4
Irritability	0.1	0.2	0.6	0.1	0.2	0.2	0.5	-0.8
Risk taking	0.8	1.2	2.5	-1.2	-0.5	-1.2	-0.5	1.6
Ever had prostate specific antigen (PSA) test	1.7	2.0	5.2	0.0	1.1	-1.3	2.3	-1.3
Fractured/broken bones in last 5 years	0.8	1.0	2.5	-0.5	0.3	-1.6	0.2	1.5
Age started oral contraceptive pill	0.5	0.6	1.9	0.6	-1.4	0.2	-0.1	-1.0
Diastolic blood pressure, automated reading	1.5	4.5	8.5	-0.3	2.9	-2.7	2.4	1.1
Ever depressed for a whole week	1.0	1.2	1.7	1.3	1.1	-1.2	1.3	0.1
Unable to work because of sickness or disability	1.4	1.8	5.4	-1.3	0.2	-1.3	-0.7	2.3
Commuting to job workplace: Cycle	2.0	2.5	7.8	-0.9	-1.7	0.8	-2.8	0.6
Myopia	1.7	2.5	8.0	-0.1	1.7	-1.2	2.8	-0.0
Vascular/heart problems diagnosed by doctor	0.5	1.4	4.5	-1.2	-0.8	0.7	-2.1	-0.1
Cholesterol lowering medication	0.8	1.1	2.7	0.2	0.2	-1.2	1.2	1.6
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	0.1	0.8	-1.0	0.9	0.0
Pain experienced in last month	2.5	4.1	8.2	-1.4	-0.4	2.9	-1.4	-2.9
Supplements: Calcium	0.1	0.1	0.4	-0.2	-0.0	-0.6	0.2	0.5
Basal cell carcinoma (self-reported)	0.2	0.3	1.0	-1.0	0.3	0.2	-0.5	-0.2
Heart attack/myocardial infarction (self-reported)	1.6	2.1	5.4	-0.1	-2.3	-0.0	-2.0	1.1
Deep venous thrombosis (DVT) (self-reported)	1.8	2.4	5.8	1.5	0.2	-1.9	2.4	-0.3
Heart disease (siblings)	1.3	1.6	4.0	1.2	-0.9	-2.0	0.9	0.8
Alcohol drinker status: Previous	0.3	0.4	0.7	0.9	0.6	0.5	0.3	-0.7
Pack years of smoking	0.6	0.8	1.5	-0.1	1.0	-1.2	0.7	-1.1
Impedance of whole body	1.0	5.2	9.8	0.4	-2.3	3.1	-3.1	-1.0
Leg fat mass (left)	3.9	15.2	41.3	0.9	2.2	-6.4	4.1	3.5
Arm predicted mass (left)	1.6	8.3	23.0	0.5	1.1	-4.8	2.9	2.9