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chr14:71,712,035-74,627,634

Best TWAS P=8.38e-14 · Best GWAS P=4.11e-10 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RGS6	0.07	0.02	bslmm	888	0.01	2.0e-02	-1.84	6.7	2.0e-11	-0.03	0.14	0.03	TRUE
2	GTEx	Adipose Subcutaneous	DCAF4	0.20	0.05	lasso	7	0.18	1.1e-14	4.80	6.0	1.7e-09	-0.36	0.32	0.68	FALSE
3	GTEx	Adipose Visceral Omentum	DCAF4	0.23	0.07	enet	30	0.13	4.3e-07	4.49	6.8	1.2e-11	-0.31	0.48	0.45	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-109N23.6	0.14	0.11	enet	15	0.13	2.2e-07	-6.16	6.9	4.4e-12	-0.29	0.02	0.98	FALSE
5	GTEx	Artery Aorta	DCAF4	0.22	0.06	lasso	9	0.24	3.9e-13	2.06	5.4	6.1e-08	-0.35	0.33	0.57	TRUE
6	GTEx	Artery Tibial	DCAF4	0.23	0.10	lasso	9	0.24	5.1e-19	2.06	5.6	2.6e-08	-0.42	0.14	0.86	FALSE
7	GTEx	Breast Mammary Tissue	DCAF4	0.24	0.10	lasso	6	0.18	1.2e-09	4.80	7.0	2.8e-12	-0.51	0.31	0.66	FALSE
8	GTEx	Breast Mammary Tissue	RP11-109N23.6	0.11	0.01	enet	26	0.05	1.7e-03	1.99	5.6	2.6e-08	-0.52	0.14	0.79	FALSE
9	GTEx	Breast Mammary Tissue (Female)	DCAF4	0.16	0.07	lasso	4	0.03	4.4e-02	-5.94	6.4	2.0e-10	-0.84	0.03	0.72	FALSE
10	GTEx	Breast Mammary Tissue (Female)	RP11-109N23.6	0.18	-0.01	lasso	7	0.00	3.9e-01	-4.73	6.6	4.3e-11	-0.33	0.07	0.49	TRUE
11	GTEx	Cells EBV-transformed lymphocytes	DCAF4	0.23	0.03	enet	18	0.05	7.4e-03	3.64	5.5	3.2e-08	-0.48	0.05	0.39	TRUE
12	GTEx	Cells Transformed fibroblasts	DPF3	0.39	0.40	lasso	4	0.39	9.6e-31	5.23	5.4	6.2e-08	-0.05	0.50	0.50	FALSE
13	GTEx	Colon Sigmoid	DCAF4	0.30	0.10	lasso	9	0.11	1.3e-04	5.02	6.0	2.1e-09	-0.32	0.13	0.25	FALSE
14	GTEx	Colon Transverse	DCAF4	0.26	0.27	lasso	10	0.27	2.7e-13	4.80	5.7	1.4e-08	-0.27	0.87	0.13	FALSE
15	GTEx	Colon Transverse	RP11-109N23.6	0.16	0.01	enet	19	0.02	5.6e-02	2.01	5.8	6.0e-09	-0.29	0.16	0.66	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	DCAF4	0.18	0.01	enet	10	0.06	3.0e-03	5.02	7.5	8.4e-14	-0.37	0.09	0.36	TRUE
17	GTEx	Esophagus Gastroesophageal Junction	RP11-109N23.6	0.17	0.01	lasso	12	0.00	2.6e-01	-3.34	6.3	2.2e-10	-0.30	0.07	0.38	FALSE
18	GTEx	Esophagus Mucosa	DCAF4	0.30	0.19	enet	35	0.23	1.3e-15	5.02	6.6	3.7e-11	-0.46	0.72	0.28	FALSE
19	GTEx	Esophagus Mucosa	ZFYVE1	0.10	0.00	lasso	7	0.00	2.0e-01	5.02	7.3	2.8e-13	-0.51	0.08	0.72	FALSE
20	GTEx	Heart Atrial Appendage	DCAF4	0.18	0.00	enet	22	0.01	9.1e-02	5.47	5.2	2.4e-07	-0.28	0.08	0.12	FALSE
21	GTEx	Lung	DCAF4	0.32	0.15	lasso	8	0.25	5.6e-19	5.02	5.4	6.4e-08	-0.31	0.78	0.22	FALSE
22	GTEx	Pancreas	DCAF4	0.20	0.15	lasso	4	0.14	2.4e-06	5.02	5.3	9.2e-08	-0.29	0.44	0.18	TRUE
23	GTEx	Skin Sun Exposed Lower leg	DCAF4	0.29	0.12	enet	32	0.25	1.9e-20	5.02	5.9	3.3e-09	-0.31	0.76	0.24	FALSE
24	GTEx	Spleen	DCAF4	0.47	0.12	enet	10	0.19	1.5e-05	4.80	7.0	2.1e-12	-0.54	0.09	0.87	FALSE
25	GTEx	Spleen	NUMB	0.46	-0.01	enet	28	0.09	3.2e-03	0.72	5.8	5.5e-09	-0.31	0.08	0.25	FALSE
26	GTEx	Stomach	DCAF4	0.22	0.07	enet	27	0.14	4.7e-07	5.02	6.0	1.8e-09	-0.31	0.42	0.17	FALSE
27	GTEx	Stomach	RP11-109N23.6	0.09	0.00	enet	15	0.00	6.7e-01	-4.71	5.3	1.1e-07	-0.33	0.09	0.55	FALSE
28	GTEx	Whole Blood	DCAF4	0.08	0.04	enet	12	0.06	5.0e-06	5.02	5.5	3.2e-08	-0.32	0.57	0.17	FALSE
29	METSIM	Adipose	DCAF4	0.21	0.15	bslmm	452	0.21	3.0e-30	4.80	5.9	3.1e-09	-0.35	0.89	0.11	FALSE
30	NTR	Blood	DCAF4	0.04	0.03	lasso	6	0.03	6.5e-09	5.02	5.5	3.4e-08	-0.25	0.74	0.26	FALSE
31	YFS	Blood	NUMB	0.04	0.02	blup	461	0.03	3.9e-09	-4.18	6.5	6.0e-11	-0.29	0.97	0.03	TRUE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DCAF4	0.04	0.02	blup	83	0.03	1.2e-04	4.34	6.1	1.2e-09	-0.36	0.25	0.48	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DCAF4	0.32	0.11	enet	25	0.12	1.1e-13	5.06	5.3	1.3e-07	-0.27	0.47	0.53	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	DCAF4	0.26	0.09	enet	13	0.13	2.1e-14	4.80	5.9	3.9e-09	-0.28	0.67	0.33	FALSE
35	The Cancer Genome Atlas	Stomach Adenocarcinoma	DCAF4	0.07	0.02	blup	84	0.04	8.9e-04	4.26	5.3	9.9e-08	-0.28	0.10	0.12	FALSE
36	The Cancer Genome Atlas	Thyroid Carcinoma	DPF3	0.10	0.02	blup	210	0.07	1.9e-07	-5.04	-7.1	1.2e-12	0.56	0.12	0.88	FALSE