Hub : Genes

RGS6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0740 0.0280 0.00450 0.016 0.006 0.000 0.01 0.000 3.7e-03 5.5e-02 2.7e-01 0.02 3.1e-01
2 TCGA Bladder Urothelial Carcinoma 0.2190 0.0640 0.00011 0.073 0.051 0.129 NA 0.127 8.6e-07 3.5e-05 4.9e-11 NA 6.8e-11
3 TCGA Head and Neck Squamous Cell Carcinoma 0.0691 0.0306 0.00570 0.037 0.015 0.040 NA 0.047 4.3e-05 6.8e-03 2.6e-05 NA 4.5e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 2.2 3.5 7.5 -1.4 1.1 2.7
Bipolar Disorder or Schizophrenia 1.2 2.8 5.2 -2.3 -0.0 1.8
Depressed Affect (Nagel 2018) 0.8 1.6 3.0 1.3 -0.0 1.7
Depression (Nagel 2018) 2.0 3.0 7.6 0.4 1.1 2.8
Intelligence (Savage-Jansen 2018) 0.7 2.2 4.2 -1.2 -0.9 -2.0
Neuroticism (Nagel 2018) 0.7 1.7 4.1 0.9 -0.5 2.0
Schizophrenia (2018) 0.7 1.4 3.3 -1.8 -0.9 0.1
Schizophrenia vs Biploar Disorder 0.4 0.5 1.1 -0.5 -0.6 -1.0
Worry (Nagel 2018) 0.7 1.5 2.5 1.3 -0.7 1.6
Alzheimer’s Disease (in mother) 0.8 0.9 1.4 -1.2 1.0 0.5
Alzheimer’s Disease (in father) 0.2 0.2 0.4 0.3 -0.6 -0.5
Alzheimer’s Disease (including proxy) 0.5 0.7 2.1 -1.5 0.2 0.3
Crohns Disease (2017) 1.0 2.3 3.9 0.5 -1.6 -2.0
Irritable Bowel Disease (IBD) 0.0 0.0 0.1 0.1 0.2 -0.0
Ulcerative Colitis (UC) 0.4 0.7 1.2 -0.1 1.1 1.0
Major Depression (MDD) 1.5 1.8 4.2 2.0 -1.0 0.3
Reaction Time 4.4 8.3 13.0 0.4 -3.4 -3.6
Verbal and Numeric Reasoning (VNR) 0.2 0.5 0.7 -0.8 -0.7 -0.6
Breast Cancer 0.1 0.3 0.5 0.7 -0.3 -0.6
Ovarian Cancer 0.5 0.7 1.2 -0.2 1.1 0.9
Prostate Cancer 2.1 2.9 4.2 -0.8 2.0 2.0
Age at First Birth 2.1 3.0 8.8 -3.0 0.2 0.3
Bipolar Disorder (2011) 0.9 0.8 2.2 0.0 -1.5 -0.5
Body Mass Index (BMI) (2010) 4.6 6.3 9.5 3.1 -2.0 -2.3
Coronary Artery Disease (CAD) 2.3 2.7 5.1 0.5 2.3 1.6
Crohns Disease (2012) 0.4 0.7 1.1 -0.3 -0.9 -1.1
Mean Putamen Volume 2.6 3.0 4.3 1.1 2.1 1.9
Fasting Glucose 2.0 2.4 3.8 0.8 -2.0 -1.7
HbA1C 0.9 1.0 2.0 1.4 0.8 0.6
HDL Cholesterol 0.3 0.4 0.8 0.7 -0.2 0.9
LDL Cholesterol 0.5 0.8 0.9 -1.0 0.9 0.7
Lupus 0.0 0.1 0.2 -0.2 0.4 0.1
Neuroticism (2016) 0.3 0.4 0.9 0.0 0.6 1.0
Primary Biliary Cirrhosis 0.4 0.6 1.0 0.3 0.8 1.0
Rheumatoid Arthritis 1.6 2.2 3.1 -0.7 1.7 1.8
Schizophrenia (2014) 0.5 1.2 2.9 -0.8 -1.7 -0.1
Triglycerides 0.1 0.1 0.2 -0.4 0.1 -0.5
Type 2 Diabetes (T2D) (2012) 0.7 0.8 1.3 -0.2 -1.2 -1.1
Ulcerative Colitis 0.5 0.7 1.4 0.3 0.7 1.2
Blood Eosinophil Count 0.2 1.6 3.4 -0.4 -1.1 -1.9
Blood Platelet Count 0.0 0.5 0.9 0.9 0.1 0.7
Blood Red Count 0.1 1.0 1.4 1.2 -0.5 -1.1
Blood White Count 0.5 3.5 5.0 0.9 -2.2 -2.2
Heel T-Score 0.6 4.6 9.8 0.8 -1.8 -3.1
BMI 3.3 19.4 45.0 6.7 -2.3 -2.8
Height 0.3 5.4 8.6 -1.9 2.9 2.1
Waist Hip Ratio (WHR) 0.1 0.5 0.7 0.8 0.5 0.6
Systolic Blood Pressure 2.9 14.4 21.2 1.2 -4.6 -4.5
Smoking Status 0.8 1.9 2.6 1.4 -1.1 -1.6
Allergy or Eczema 0.9 2.4 3.3 -1.1 1.6 1.8
Cardiovascular Disease 3.7 12.2 17.1 3.0 -3.2 -4.1
Hypothyroidism (self reported) 0.4 1.0 1.3 0.7 -1.1 -1.1
Respiratory disease 0.3 0.8 1.5 0.3 -0.9 -1.2
Type 2 Diabetes (T2D) (2018) 0.7 1.4 2.3 1.5 -0.7 -1.1
Lung FEV1/FVC ratio 0.5 2.3 5.1 2.3 -0.8 -1.1
Lung FVC 0.3 1.4 4.0 -2.0 0.4 -0.2
Neuroticism 1.0 2.4 3.2 1.8 -1.2 1.6
Chronotype (morning person) 0.0 0.1 0.3 0.0 -0.6 -0.0
Hair Pigment 0.0 0.4 1.0 -1.0 0.1 -0.1
Tanning 0.0 0.5 1.0 -1.0 0.7 -0.2
Hand grip strength (left) 1.1 2.9 5.5 -2.4 -1.4 -1.2
Number of treatments/medications taken 3.7 6.7 11.4 3.4 -1.8 -2.4
Average weekly spirits intake 0.6 0.7 1.1 0.7 -0.7 -1.1
Sensitivity / hurt feelings 0.8 1.4 2.4 1.3 -1.6 0.1
Frequency of depressed mood in last 2 weeks 1.2 1.7 3.8 0.8 0.9 1.9
Hearing difficulty/problems: Yes 0.4 0.6 1.2 0.1 0.8 1.1
Relative age of first facial hair 1.1 2.4 5.1 -0.8 -2.3 -1.1
Other serious medical condition/disability diagnosed by doctor 2.2 2.9 4.2 2.1 -1.8 -1.2
Ever used hormone-replacement therapy (HRT) 1.2 1.5 2.3 0.5 -1.4 -1.5
Ever had hysterectomy (womb removed) 1.7 1.9 2.8 -1.4 -1.7 -1.0
Systolic blood pressure, automated reading 3.2 9.4 15.1 1.3 -3.9 -3.4
Eye problems/disorders: Diabetes related eye disease 1.3 1.5 2.3 1.3 1.5 -0.7
Angina 1.1 1.4 2.4 1.1 -0.7 -1.5
Medication for hormone replacement therapy 5.4 6.0 9.4 1.6 -2.5 -3.1
Vitamin and mineral supplements 0.2 0.3 0.9 0.9 -0.1 -0.1
Supplements: Zinc 0.3 0.3 0.8 0.9 -0.4 -0.3
Medication: Co-codamol 2.7 3.1 8.5 2.9 0.6 -0.7
Medication: Metformin 1.3 1.9 4.0 2.0 0.7 1.1
Diabetes (father) 2.1 2.6 5.1 -0.7 -2.3 -1.5
Diabetes (mother) 0.2 0.2 0.6 0.8 -0.3 0.2
Severe depression (siblings) 0.9 1.0 1.7 0.7 0.9 1.3
Pack years adult smoking proportion 0.7 1.1 2.4 0.8 -0.6 -1.6
Impedance of leg (right) 2.7 13.3 22.2 -4.7 3.0 3.0
Leg fat-free mass (left) 0.9 4.6 8.9 3.0 -1.4 -1.7
Trunk fat percentage 1.5 5.8 16.3 4.0 -0.8 -0.7
Hand grip strength (right) 0.2 0.4 0.7 -0.8 -0.8 -0.1
Townsend deprivation index at recruitment 1.6 2.3 2.8 1.5 -1.4 -1.7
Current tobacco smoking 1.0 1.6 3.5 0.2 -1.1 -1.9
Average weekly fortified wine intake 0.3 0.4 1.0 -0.4 -0.1 1.0
Maternal smoking around birth 1.3 1.8 3.6 0.4 -1.3 -1.9
Fed-up feelings 1.5 2.8 5.2 2.3 0.3 1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.4 3.6 0.3 0.7 1.9
Relative age voice broke 0.1 0.2 0.3 -0.4 -0.6 0.1
Taking other prescription medications 1.9 2.9 6.0 2.4 -1.0 -1.3
Age when periods started (menarche) 2.1 4.9 7.5 -1.1 -2.5 -2.7
Bilateral oophorectomy (both ovaries removed) 0.6 0.6 1.0 0.6 -0.8 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 1.7 -1.3 0.2 -0.8
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.3 -0.4 -0.2 -0.6
Qualifications: CSEs or equivalent 0.8 1.0 2.2 1.5 0.4 0.8
Serious illness, injury or assault to yourself 0.4 0.5 1.4 0.3 1.2 0.1
High blood pressure 2.8 7.8 8.1 2.8 -2.8 -2.7
Hayfever, allergic rhinitis or eczema 0.7 1.6 2.0 -1.0 1.4 1.4
Multivitamins +/- minerals 0.4 0.5 0.7 -0.5 -0.8 -0.8
Stomach or abdominal pain in last month 1.9 2.4 5.7 2.4 -0.9 -0.7
Supplements: Glucosamine 0.3 0.4 0.6 -0.6 -0.5 -0.8
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 2.5 1.6 -0.7 -1.1
Medication: Atenolol 2.0 2.5 3.9 0.8 -2.0 -1.7
Medication: Levothyroxine sodium 0.8 1.4 2.0 1.4 -1.1 -1.0
Sitting height 0.4 3.1 6.4 -2.5 -0.4 -1.6
Chronic bronchitis/emphysema (father) 0.5 0.6 1.8 -1.4 0.1 0.1
High blood pressure (mother) 2.3 3.2 5.4 1.0 -2.3 -1.8
Body mass index (BMI) 3.4 14.6 32.0 5.7 -2.2 -2.6
Impedance of leg (left) 2.9 13.9 20.9 -4.6 3.1 3.4
Leg predicted mass (left) 0.9 4.5 8.8 3.0 -1.4 -1.7
Trunk fat mass 1.7 7.3 19.1 4.4 -1.2 -1.2
Waist circumference 2.5 9.1 20.6 4.5 -1.7 -1.9
Number of incorrect matches in round 0.4 0.6 1.1 1.1 -0.0 0.8
Past tobacco smoking 0.6 1.1 1.7 -1.3 0.4 1.2
Alcohol usually taken with meals 1.1 1.8 3.9 0.2 -2.0 -1.2
Nervous feelings 0.4 0.8 1.3 0.8 -1.1 0.6
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.4 0.1 -0.5 0.6
Hearing difficulty/problems with background noise 0.2 0.3 0.9 0.1 -0.9 -0.3
Hair/balding pattern: Pattern 2 0.7 0.9 1.4 0.9 1.2 0.5
Had menopause 1.0 1.3 3.3 -1.8 -0.5 -0.7
Had other major operations 0.3 0.4 1.0 1.0 -0.2 -0.3
Forced vital capacity (FVC) 1.4 5.5 9.2 -2.2 3.0 1.6
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 1.6 -1.3 0.2 -1.1
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.9 0.1 -1.4 0.1
Qualifications: None of the above 2.7 5.8 17.2 4.1 -0.6 0.2
Financial difficulties in last 2 years 2.4 3.2 9.3 3.0 -0.1 0.5
Mouth/teeth dental problems 0.9 1.4 2.8 -1.7 0.9 0.7
Heart attack 1.8 2.4 3.4 1.8 -1.3 -1.5
Allergy 0.0 0.1 0.2 0.0 -0.4 -0.3
Pain all over the body in last month 0.0 0.0 0.1 0.2 0.1 0.3
Diabetes (self-reported) 0.1 0.2 0.4 0.6 0.5 -0.0
Hayfever/allergic rhinitis (self-reported) 0.9 1.3 1.9 0.8 1.1 1.4
Medication: Ramipril 0.4 0.5 1.1 1.0 -0.6 -0.4
Medication: Simvastatin 2.0 3.0 7.4 2.7 -0.9 -0.8
Fluid intelligence score 0.5 1.0 2.0 -0.3 -1.4 -1.0
Illnesses of siblings 0.7 1.0 1.8 -0.6 1.4 1.0
Neuroticism score 0.9 1.9 3.4 1.9 -0.9 1.2
Weight 1.6 7.8 16.2 4.0 -1.6 -2.1
Impedance of arm (right) 3.1 14.7 24.1 -4.9 2.6 3.6
Arm fat percentage (right) 1.9 7.5 20.1 4.5 -1.2 -1.0
Trunk fat-free mass 0.3 1.9 3.0 1.3 -1.1 -1.7
Hip circumference 1.3 5.4 13.9 3.7 -0.9 -1.2
Time employed in main current job 0.3 0.3 0.8 -0.9 -0.3 0.1
Alcohol intake versus 10 years previously 2.8 4.2 11.8 3.4 0.9 -0.3
Father’s age at death 0.3 0.4 0.8 -0.9 0.1 0.7
Worrier / anxious feelings 0.6 1.1 1.7 1.3 -0.4 1.3
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 1.3 0.8 -1.2 0.0
Falls in the last year 0.7 0.9 1.9 1.4 0.8 0.4
Hair/balding pattern: Pattern 3 0.1 0.2 0.5 0.7 -0.2 0.3
Number of live births 0.4 0.5 1.1 -0.7 -1.0 -0.1
Forced expiratory volume in 1-second (FEV1) 0.9 3.1 6.2 -1.3 2.5 1.2
Pulse rate 1.7 2.8 4.8 2.2 0.9 1.7
Happiness 1.2 1.5 3.3 -1.8 0.4 1.0
Noisy workplace 2.2 2.7 4.6 2.2 -1.1 -1.5
Qualifications: A levels/AS levels or equivalent 1.2 2.6 7.2 -2.7 0.7 0.6
Serious illness, injury or assault of a close relative in last 2 years 1.8 2.1 4.8 -0.0 -1.2 -2.2
Mouth/teeth dental problems: Dentures 0.1 0.1 0.2 0.3 -0.5 0.2
Asthma 0.7 1.5 1.8 1.3 -1.1 -1.1
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.0 4.5 2.1 -0.7 -1.0
Medication: Cholesterol lowering 1.4 2.2 2.6 1.2 -1.6 -1.6
Depression (self-reported) 2.4 2.9 8.3 2.9 0.4 0.4
Medication: Lansoprazole 0.8 0.9 1.5 -0.0 -1.1 -1.2
Prospective memory result 0.4 0.5 1.1 0.5 0.4 1.1
Lung cancer (father) 0.6 0.7 1.8 1.4 0.0 0.3
Illnesses of mother 3.4 4.2 6.6 -1.5 2.6 1.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.6 4.4 -1.6 2.1 0.8
Pulse wave Arterial Stiffness index 0.1 0.1 0.2 0.1 0.1 -0.4
Impedance of arm (left) 2.0 9.1 16.7 -4.1 1.8 2.7
Arm fat mass (right) 2.0 8.4 21.0 4.6 -1.3 -1.5
Trunk predicted mass 0.3 2.0 3.2 1.3 -1.1 -1.8
Standing height 0.3 3.4 9.1 -3.0 1.0 0.5
Length of working week for main job 5.7 6.3 10.5 3.2 -2.4 -1.6
Exposure to tobacco smoke at home 1.9 2.1 3.3 -0.3 1.7 1.8
Breastfed as a baby 3.0 3.7 5.5 -1.4 -2.3 -1.9
Tense / ‘highly strung’ 0.2 0.3 0.4 0.5 -0.5 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 0.9 0.9 -0.7 0.1
Hair/balding pattern: Pattern 4 0.5 1.2 2.2 -0.8 -0.9 -1.5
Birth weight of first child 0.8 1.5 2.0 -1.0 -1.3 -1.4
Peak expiratory flow (PEF) 0.6 1.3 3.2 0.4 1.8 0.8
Pulse wave reflection index 1.2 1.4 3.8 -1.9 0.0 -0.8
Ever highly irritable/argumentative for 2 days 0.9 1.1 2.5 1.6 -0.8 0.4
Loud music exposure frequency 1.6 1.7 4.9 -2.2 -0.3 0.3
Qualifications: O levels/GCSEs or equivalent 2.8 4.5 9.2 -3.0 1.2 1.7
Mouth/teeth dental problems: Bleeding gums 1.3 1.7 5.1 2.3 -0.3 0.1
Blood clot in the leg (DVT) 0.0 0.0 0.0 0.2 -0.1 0.2
Medication: Paracetamol 2.0 3.4 4.6 2.1 -1.6 -1.8
Headache pain in last month 1.8 3.1 4.3 2.1 -2.0 -1.0
Medication for cholesterol, blood pressure or diabetes 4.3 7.1 8.6 -2.7 2.3 2.9
Glaucoma (self-reported) 0.1 0.2 0.2 -0.3 0.4 0.4
Gout (self-reported) 0.2 0.2 0.6 0.8 -0.1 -0.2
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.1 1.1 -0.5 -0.7
Medication: Amlodipine 1.8 2.5 5.0 0.1 -1.6 -2.2
Medication: Ventolin 100micrograms inhaler 0.7 1.0 2.8 1.7 0.2 0.2
Birth weight 0.6 1.4 3.3 1.8 0.3 0.9
Chronic bronchitis/emphysema (mother) 2.7 3.2 5.8 -0.1 -2.4 -1.9
High blood pressure (siblings) 2.4 3.4 5.2 0.4 -2.3 -2.2
Forced vital capacity (FVC), Best measure 1.1 3.9 6.4 -2.5 2.2 0.6
Body fat percentage 1.7 6.7 19.3 4.4 -0.7 -0.6
Leg fat percentage (right) 1.8 6.5 18.4 4.3 -0.7 -0.8
Arm fat-free mass (right) 0.8 4.0 7.3 2.7 -1.2 -1.9
Exposure to tobacco smoke outside home 3.0 3.9 9.4 3.1 -0.6 -1.4
Comparative body size at age 10 0.3 1.0 2.8 1.7 0.3 -0.0
Number of full brothers 0.7 0.9 1.6 -0.2 -1.1 -1.3
Worry too long after embarrassment 0.9 1.5 1.8 -1.4 -1.0 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 2.5 3.3 5.4 2.3 -2.0 -0.7
Wheeze or whistling in the chest in last year 3.5 6.2 9.1 3.0 -2.3 -2.1
Number of children fathered 0.1 0.1 0.2 -0.2 0.3 0.4
Reason for reducing amount of alcohol drunk: Health precaution 2.0 2.3 3.0 -1.3 1.5 1.7
Age at first live birth 3.0 5.4 14.1 -3.8 0.6 1.3
Pulse wave peak to peak time 0.1 0.1 0.3 -0.3 0.1 0.6
Health satisfaction 0.8 1.0 2.2 1.5 -0.9 -0.2
Shortness of breath walking on level ground 0.6 0.7 2.0 1.4 -0.3 0.1
Qualifications: College or University degree 3.1 9.8 29.5 -5.4 0.1 -0.1
Eye problems/disorders: None of the above 0.4 0.4 0.7 -0.2 0.7 0.9
Mouth/teeth dental problems: Loose teeth 0.0 0.0 0.1 0.3 0.1 -0.2
Emphysema/chronic bronchitis 1.2 1.3 3.3 0.1 -1.8 -0.8
Medication for pain relief, constipation, heartburn 1.8 3.1 5.6 -2.4 1.3 1.4
Neck or shoulder pain in last month 2.0 2.8 4.6 2.1 -1.3 -1.5
Medication: Blood pressure 7.4 13.1 14.7 3.8 -3.3 -3.7
Angina (self-reported) 0.9 1.2 1.8 1.3 -0.5 -1.4
Migraine (self-reported) 1.1 1.4 3.0 1.7 -1.0 -0.5
Medication: Ibuprofen 1.4 1.6 4.0 2.0 -0.3 -0.9
Medication: Allopurinol 0.7 0.9 1.4 1.2 0.8 0.8
Medication: Omeprazole 0.3 0.3 0.8 0.5 0.1 0.9
Medication: Seretide 50 evohaler 0.3 0.3 0.5 0.7 -0.7 0.2
Mean time to correctly identify matches 5.1 9.8 15.2 0.2 -3.9 -3.8
Heart disease (mother) 3.6 4.4 4.9 2.1 -2.2 -2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 1.6 -0.6 0.9 1.3
Whole body fat mass 1.8 7.4 20.1 4.5 -1.0 -1.0
Leg fat mass (right) 2.0 7.7 20.4 4.5 -1.1 -1.3
Arm predicted mass (right) 0.8 4.1 8.1 2.8 -1.0 -1.8
Pulse rate, automated reading 2.1 6.9 10.6 2.2 2.3 3.3
Alcohol intake frequency. 2.1 4.8 14.0 3.7 0.4 0.6
Comparative height size at age 10 0.2 1.0 2.6 -1.6 0.5 0.3
Number of full sisters 0.3 0.4 0.8 -0.9 -0.2 -0.4
Suffer from ‘nerves’ 0.9 1.5 3.4 1.8 0.2 1.0
Overall health rating 4.5 9.8 25.6 5.1 -1.5 -1.1
Chest pain or discomfort 3.5 5.1 14.9 3.9 -0.4 -0.5
Had major operations 0.2 0.2 0.4 0.1 0.4 0.6
Age at last live birth 1.4 2.1 6.0 -2.4 -0.1 0.5
Family relationship satisfaction 1.3 1.6 4.6 -2.1 0.5 0.0
Leg pain on walking 1.3 1.6 4.3 2.1 0.0 0.7
Qualifications: NVQ or HND or HNC or equivalent 2.1 2.5 3.3 1.8 -1.2 -1.7
Commuting to job workplace: Car/motor vehicle 0.9 1.0 1.5 -1.0 -0.7 -1.2
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 1.6 -1.1 0.7 1.3
Medication: Aspirin 0.3 0.4 1.0 0.3 1.0 -0.4
Supplements: Vitamin C 0.3 0.3 0.7 -0.0 0.9 0.5
Knee pain experienced in last month 0.9 1.4 3.5 1.9 -0.2 -0.7
Hypertension (Self-reported) 3.1 8.6 9.5 2.9 -3.1 -2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.4 -0.2 -0.6 0.4
Illnesses of father: Heart disease 1.0 1.4 2.7 0.6 -1.1 -1.6
Illnesses of siblings: Diabetes 0.1 0.1 0.3 0.6 0.2 0.0
Smoking status: Previous 0.6 0.9 2.5 1.6 -0.4 -0.0
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.3 0.7 0.3 -0.8 -0.4
Whole body fat-free mass 0.6 3.2 4.6 2.1 -1.2 -1.9
Leg fat-free mass (right) 0.8 4.2 8.2 2.9 -1.4 -1.6
Arm fat percentage (left) 2.3 9.3 24.0 4.9 -1.5 -1.3
Average weekly red wine intake 1.3 1.9 5.1 -2.3 0.7 -0.2
Handedness (chirality/laterality): Left-handed 0.5 0.6 0.8 -0.9 -0.4 -0.8
Mood swings 1.2 2.3 5.0 2.2 -0.1 1.3
Loneliness, isolation 0.3 0.5 1.3 0.1 -0.1 1.2
Long-standing illness, disability or infirmity 3.3 5.0 13.2 3.6 -1.1 -0.7
Ever had bowel cancer screening 1.2 1.4 2.0 -1.2 -1.4 -1.0
Diabetes diagnosed by doctor 0.4 0.6 1.6 1.3 0.3 0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.4 -0.1 0.4 0.7
Friendships satisfaction 1.8 2.2 5.4 -2.3 0.8 0.7
Qualifications: nursing, teaching 0.8 1.3 3.5 -1.9 -0.3 -0.5
Commuting to job workplace: Walk 0.8 0.9 2.1 -0.7 -1.4 -0.3
Eye problems/disorders: Cataract 0.2 0.2 0.5 0.4 -0.2 -0.7
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 1.5 -1.2 1.2 0.4
Medication for cholesterol 1.7 2.6 4.7 -2.2 1.1 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.1 2.1 1.5 -0.9 -0.7
Back pain experienced in last month 3.5 5.1 11.3 3.4 -1.7 -1.1
Mineral and other dietary supplements 0.1 0.1 0.2 0.5 -0.0 -0.4
Breast cancer (self-reported) 0.6 0.7 1.1 -1.1 -0.8 -0.6
Asthma (self-reported) 0.6 1.2 1.5 1.2 -1.0 -1.1
Osteoporosis (self-reported) 0.3 0.3 0.9 -0.9 -0.2 -0.0
Osteoarthritis (self-reported) 1.6 2.1 2.7 1.3 -1.4 -1.7
Medication: Aspirin 0.4 0.5 1.1 -0.0 1.1 -0.6
Medication: Gliclazide 1.5 1.7 2.3 -1.5 1.1 1.2
Illnesses of father: None of the above (group 1) 1.7 2.2 2.7 1.3 1.4 1.6
Smoking status: Current 0.6 0.9 2.3 -0.2 -0.5 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.4 3.0 5.4 -0.5 2.3 1.8
Whole body water mass 0.5 3.0 4.9 2.2 -1.1 -1.8
Leg predicted mass (right) 0.8 4.2 8.2 2.9 -1.3 -1.6
Arm fat mass (left) 2.3 9.6 22.3 4.7 -1.7 -1.9
Number of self-reported non-cancer illnesses 5.2 8.9 16.8 4.1 -2.2 -2.3
Average weekly champagne plus white wine intake 0.1 0.2 0.4 -0.1 0.6 0.5
Miserableness 0.1 0.2 0.2 -0.0 -0.5 0.5
Guilty feelings 0.9 1.4 3.3 0.8 -1.8 -0.5
Wears glasses or contact lenses 3.7 4.3 6.0 1.6 -2.4 -2.1
Ever taken oral contraceptive pill 1.3 1.5 1.8 1.0 -1.4 -1.3
Hearing aid user 0.4 0.4 1.0 0.5 0.0 -1.0
Mother’s age at death 0.4 0.5 0.9 -0.9 0.4 0.7
Financial situation satisfaction 0.7 0.9 2.5 1.6 -0.2 -0.3
Tinnitus: Yes, now most or all of the time 0.8 0.9 1.8 -0.3 -1.0 -1.3
Commuting to job workplace: Public transport 0.0 0.0 0.0 0.2 0.1 0.0
Eye problems/disorders: Glaucoma 0.5 0.6 0.7 0.7 -0.7 -0.8
Medication: Blood pressure 0.7 1.2 2.1 1.0 -1.4 -0.9
Pain type(s) experienced in last month: Hip pain 2.6 3.2 8.1 2.8 -1.2 0.3
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.0 -1.0 -0.5 -0.2
High cholesterol (Self-reported) 0.7 1.3 2.2 1.5 -0.9 -1.0
Medication: Bendroflumethiazide 0.6 1.0 1.3 0.6 -1.1 -1.2
Medication: Paracetamol 3.6 5.6 6.5 2.4 -2.1 -2.6
Medication: Lisinopril 1.3 1.6 4.3 2.1 -0.3 0.8
Medication: Atorvastatin 0.5 0.6 0.9 0.2 -0.9 -0.9
Illnesses of father: High blood pressure 1.3 1.7 3.9 -0.7 -2.0 -0.8
Alcohol drinker status: Never 2.6 3.1 3.9 1.7 -1.6 -2.0
Ever smoked 0.1 0.2 0.6 -0.3 0.0 -0.7
Basal metabolic rate 0.7 3.9 7.2 2.7 -1.1 -1.8
Leg fat percentage (left) 2.0 7.1 19.7 4.4 -0.9 -0.8
Arm fat-free mass (left) 0.6 3.0 6.4 2.5 -0.5 -1.5
Number of operations (self-reported) 0.6 0.8 1.9 1.4 0.5 0.6
Average weekly beer plus cider intake 0.1 0.1 0.1 -0.3 0.3 -0.0
Irritability 1.5 2.6 4.8 2.2 0.6 1.6
Risk taking 0.3 0.4 0.9 -0.9 -0.2 -0.6
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.1 -0.4 -0.9 -1.1
Fractured/broken bones in last 5 years 0.1 0.1 0.2 -0.4 0.2 0.4
Age started oral contraceptive pill 0.8 1.0 1.4 -0.8 -1.2 -1.0
Diastolic blood pressure, automated reading 2.8 8.8 15.7 0.9 -4.0 -3.1
Ever depressed for a whole week 0.4 0.6 1.3 0.4 -0.4 1.2
Unable to work because of sickness or disability 0.2 0.3 0.8 0.9 -0.3 -0.2
Commuting to job workplace: Cycle 0.5 0.6 1.5 -1.2 0.3 0.4
Myopia 0.5 0.7 1.5 -1.2 0.1 0.8
Vascular/heart problems diagnosed by doctor 2.7 7.3 7.7 -2.7 2.7 2.8
Cholesterol lowering medication 0.2 0.3 0.6 0.8 0.6 0.1
Medication: Omeprazole (e.g. Zanprol) 0.6 0.8 2.1 0.4 0.3 1.5
Pain experienced in last month 2.3 3.8 11.2 -3.3 0.3 0.3
Supplements: Calcium 1.1 1.2 2.5 -1.6 0.1 1.0
Basal cell carcinoma (self-reported) 0.3 0.3 0.4 -0.7 0.3 -0.6
Heart attack/myocardial infarction (self-reported) 2.0 2.6 3.2 1.8 -1.4 -1.7
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.2 -0.5 -0.4 -0.1
Heart disease (siblings) 0.7 0.9 2.1 -0.3 0.7 1.4
Alcohol drinker status: Previous 0.4 0.4 0.8 0.4 -0.6 -0.9
Pack years of smoking 0.9 1.3 2.7 0.9 -0.6 -1.6
Impedance of whole body 2.4 12.4 19.5 -4.4 2.5 3.3
Leg fat mass (left) 2.0 7.8 20.1 4.5 -1.2 -1.3
Arm predicted mass (left) 0.8 4.1 8.2 2.9 -0.8 -1.9