TWAS hub - RGS6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0740	0.0280	0.00450	0.016	0.006	0.000	0.01	0.000	3.7e-03	5.5e-02	2.7e-01	0.02	3.1e-01
2	TCGA	Bladder Urothelial Carcinoma	0.2190	0.0640	0.00011	0.073	0.051	0.129	NA	0.127	8.6e-07	3.5e-05	4.9e-11	NA	6.8e-11
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0691	0.0306	0.00570	0.037	0.015	0.040	NA	0.047	4.3e-05	6.8e-03	2.6e-05	NA	4.5e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Medication: Blood pressure	7.4	13.1	14.7	3.8	-3.3	-3.7
Length of working week for main job	5.7	6.3	10.5	3.2	-2.4	-1.6
Medication for hormone replacement therapy	5.4	6.0	9.4	1.6	-2.5	-3.1
Number of self-reported non-cancer illnesses	5.2	8.9	16.8	4.1	-2.2	-2.3
Mean time to correctly identify matches	5.1	9.8	15.2	0.2	-3.9	-3.8
Body Mass Index (BMI) (2010)	4.6	6.3	9.5	3.1	-2.0	-2.3
Overall health rating	4.5	9.8	25.6	5.1	-1.5	-1.1
Reaction Time	4.4	8.3	13.0	0.4	-3.4	-3.6
Medication for cholesterol, blood pressure or diabetes	4.3	7.1	8.6	-2.7	2.3	2.9
Cardiovascular Disease	3.7	12.2	17.1	3.0	-3.2	-4.1
Number of treatments/medications taken	3.7	6.7	11.4	3.4	-1.8	-2.4
Wears glasses or contact lenses	3.7	4.3	6.0	1.6	-2.4	-2.1
Heart disease (mother)	3.6	4.4	4.9	2.1	-2.2	-2.0
Medication: Paracetamol	3.6	5.6	6.5	2.4	-2.1	-2.6
Wheeze or whistling in the chest in last year	3.5	6.2	9.1	3.0	-2.3	-2.1
Chest pain or discomfort	3.5	5.1	14.9	3.9	-0.4	-0.5
Back pain experienced in last month	3.5	5.1	11.3	3.4	-1.7	-1.1
Body mass index (BMI)	3.4	14.6	32.0	5.7	-2.2	-2.6
Illnesses of mother	3.4	4.2	6.6	-1.5	2.6	1.9
BMI	3.3	19.4	45.0	6.7	-2.3	-2.8
Long-standing illness, disability or infirmity	3.3	5.0	13.2	3.6	-1.1	-0.7
Systolic blood pressure, automated reading	3.2	9.4	15.1	1.3	-3.9	-3.4
Impedance of arm (right)	3.1	14.7	24.1	-4.9	2.6	3.6
Qualifications: College or University degree	3.1	9.8	29.5	-5.4	0.1	-0.1
Hypertension (Self-reported)	3.1	8.6	9.5	2.9	-3.1	-2.9
Breastfed as a baby	3.0	3.7	5.5	-1.4	-2.3	-1.9
Exposure to tobacco smoke outside home	3.0	3.9	9.4	3.1	-0.6	-1.4
Age at first live birth	3.0	5.4	14.1	-3.8	0.6	1.3
Systolic Blood Pressure	2.9	14.4	21.2	1.2	-4.6	-4.5
Impedance of leg (left)	2.9	13.9	20.9	-4.6	3.1	3.4
High blood pressure	2.8	7.8	8.1	2.8	-2.8	-2.7
Alcohol intake versus 10 years previously	2.8	4.2	11.8	3.4	0.9	-0.3
Qualifications: O levels/GCSEs or equivalent	2.8	4.5	9.2	-3.0	1.2	1.7
Diastolic blood pressure, automated reading	2.8	8.8	15.7	0.9	-4.0	-3.1
Medication: Co-codamol	2.7	3.1	8.5	2.9	0.6	-0.7
Impedance of leg (right)	2.7	13.3	22.2	-4.7	3.0	3.0
Qualifications: None of the above	2.7	5.8	17.2	4.1	-0.6	0.2
Chronic bronchitis/emphysema (mother)	2.7	3.2	5.8	-0.1	-2.4	-1.9
Vascular/heart problems diagnosed by doctor	2.7	7.3	7.7	-2.7	2.7	2.8
Mean Putamen Volume	2.6	3.0	4.3	1.1	2.1	1.9
Pain type(s) experienced in last month: Hip pain	2.6	3.2	8.1	2.8	-1.2	0.3
Alcohol drinker status: Never	2.6	3.1	3.9	1.7	-1.6	-2.0
Waist circumference	2.5	9.1	20.6	4.5	-1.7	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	2.5	3.3	5.4	2.3	-2.0	-0.7
Financial difficulties in last 2 years	2.4	3.2	9.3	3.0	-0.1	0.5
Depression (self-reported)	2.4	2.9	8.3	2.9	0.4	0.4
High blood pressure (siblings)	2.4	3.4	5.2	0.4	-2.3	-2.2
Impedance of whole body	2.4	12.4	19.5	-4.4	2.5	3.3
Coronary Artery Disease (CAD)	2.3	2.7	5.1	0.5	2.3	1.6
High blood pressure (mother)	2.3	3.2	5.4	1.0	-2.3	-1.8
Arm fat percentage (left)	2.3	9.3	24.0	4.9	-1.5	-1.3
Arm fat mass (left)	2.3	9.6	22.3	4.7	-1.7	-1.9
Pain experienced in last month	2.3	3.8	11.2	-3.3	0.3	0.3
Bipolar Disorder (2018)	2.2	3.5	7.5	-1.4	1.1	2.7
Other serious medical condition/disability diagnosed by doctor	2.2	2.9	4.2	2.1	-1.8	-1.2
Noisy workplace	2.2	2.7	4.6	2.2	-1.1	-1.5
Prostate Cancer	2.1	2.9	4.2	-0.8	2.0	2.0
Age at First Birth	2.1	3.0	8.8	-3.0	0.2	0.3
Diabetes (father)	2.1	2.6	5.1	-0.7	-2.3	-1.5
Age when periods started (menarche)	2.1	4.9	7.5	-1.1	-2.5	-2.7
Pulse rate, automated reading	2.1	6.9	10.6	2.2	2.3	3.3
Alcohol intake frequency.	2.1	4.8	14.0	3.7	0.4	0.6
Qualifications: NVQ or HND or HNC or equivalent	2.1	2.5	3.3	1.8	-1.2	-1.7
Depression (Nagel 2018)	2.0	3.0	7.6	0.4	1.1	2.8
Fasting Glucose	2.0	2.4	3.8	0.8	-2.0	-1.7
Medication: Atenolol	2.0	2.5	3.9	0.8	-2.0	-1.7
Medication: Simvastatin	2.0	3.0	7.4	2.7	-0.9	-0.8
Impedance of arm (left)	2.0	9.1	16.7	-4.1	1.8	2.7
Arm fat mass (right)	2.0	8.4	21.0	4.6	-1.3	-1.5
Medication: Paracetamol	2.0	3.4	4.6	2.1	-1.6	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	3.0	-1.3	1.5	1.7
Neck or shoulder pain in last month	2.0	2.8	4.6	2.1	-1.3	-1.5
Leg fat mass (right)	2.0	7.7	20.4	4.5	-1.1	-1.3
Leg fat percentage (left)	2.0	7.1	19.7	4.4	-0.9	-0.8
Heart attack/myocardial infarction (self-reported)	2.0	2.6	3.2	1.8	-1.4	-1.7
Leg fat mass (left)	2.0	7.8	20.1	4.5	-1.2	-1.3
Taking other prescription medications	1.9	2.9	6.0	2.4	-1.0	-1.3
Stomach or abdominal pain in last month	1.9	2.4	5.7	2.4	-0.9	-0.7
Arm fat percentage (right)	1.9	7.5	20.1	4.5	-1.2	-1.0
Exposure to tobacco smoke at home	1.9	2.1	3.3	-0.3	1.7	1.8
Heart attack	1.8	2.4	3.4	1.8	-1.3	-1.5
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.1	4.8	-0.0	-1.2	-2.2
Headache pain in last month	1.8	3.1	4.3	2.1	-2.0	-1.0
Medication: Amlodipine	1.8	2.5	5.0	0.1	-1.6	-2.2
Leg fat percentage (right)	1.8	6.5	18.4	4.3	-0.7	-0.8
Medication for pain relief, constipation, heartburn	1.8	3.1	5.6	-2.4	1.3	1.4
Whole body fat mass	1.8	7.4	20.1	4.5	-1.0	-1.0
Friendships satisfaction	1.8	2.2	5.4	-2.3	0.8	0.7
Ever had hysterectomy (womb removed)	1.7	1.9	2.8	-1.4	-1.7	-1.0
Trunk fat mass	1.7	7.3	19.1	4.4	-1.2	-1.2
Pulse rate	1.7	2.8	4.8	2.2	0.9	1.7
Body fat percentage	1.7	6.7	19.3	4.4	-0.7	-0.6
Medication for cholesterol	1.7	2.6	4.7	-2.2	1.1	1.3
Illnesses of father: None of the above (group 1)	1.7	2.2	2.7	1.3	1.4	1.6
Rheumatoid Arthritis	1.6	2.2	3.1	-0.7	1.7	1.8
Townsend deprivation index at recruitment	1.6	2.3	2.8	1.5	-1.4	-1.7
Weight	1.6	7.8	16.2	4.0	-1.6	-2.1
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	4.5	2.1	-0.7	-1.0
Loud music exposure frequency	1.6	1.7	4.9	-2.2	-0.3	0.3
Osteoarthritis (self-reported)	1.6	2.1	2.7	1.3	-1.4	-1.7
Major Depression (MDD)	1.5	1.8	4.2	2.0	-1.0	0.3
Trunk fat percentage	1.5	5.8	16.3	4.0	-0.8	-0.7
Fed-up feelings	1.5	2.8	5.2	2.3	0.3	1.7
Medication: Gliclazide	1.5	1.7	2.3	-1.5	1.1	1.2
Irritability	1.5	2.6	4.8	2.2	0.6	1.6
Forced vital capacity (FVC)	1.4	5.5	9.2	-2.2	3.0	1.6
Medication: Cholesterol lowering	1.4	2.2	2.6	1.2	-1.6	-1.6
Medication: Ibuprofen	1.4	1.6	4.0	2.0	-0.3	-0.9
Age at last live birth	1.4	2.1	6.0	-2.4	-0.1	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	5.4	-0.5	2.3	1.8
Eye problems/disorders: Diabetes related eye disease	1.3	1.5	2.3	1.3	1.5	-0.7
Medication: Metformin	1.3	1.9	4.0	2.0	0.7	1.1
Maternal smoking around birth	1.3	1.8	3.6	0.4	-1.3	-1.9
Hip circumference	1.3	5.4	13.9	3.7	-0.9	-1.2
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	5.1	2.3	-0.3	0.1
Family relationship satisfaction	1.3	1.6	4.6	-2.1	0.5	0.0
Leg pain on walking	1.3	1.6	4.3	2.1	0.0	0.7
Average weekly red wine intake	1.3	1.9	5.1	-2.3	0.7	-0.2
Ever taken oral contraceptive pill	1.3	1.5	1.8	1.0	-1.4	-1.3
Medication: Lisinopril	1.3	1.6	4.3	2.1	-0.3	0.8
Illnesses of father: High blood pressure	1.3	1.7	3.9	-0.7	-2.0	-0.8
Bipolar Disorder or Schizophrenia	1.2	2.8	5.2	-2.3	-0.0	1.8
Frequency of depressed mood in last 2 weeks	1.2	1.7	3.8	0.8	0.9	1.9
Ever used hormone-replacement therapy (HRT)	1.2	1.5	2.3	0.5	-1.4	-1.5
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	2.5	1.6	-0.7	-1.1
Happiness	1.2	1.5	3.3	-1.8	0.4	1.0
Qualifications: A levels/AS levels or equivalent	1.2	2.6	7.2	-2.7	0.7	0.6
Pulse wave reflection index	1.2	1.4	3.8	-1.9	0.0	-0.8
Emphysema/chronic bronchitis	1.2	1.3	3.3	0.1	-1.8	-0.8
Mood swings	1.2	2.3	5.0	2.2	-0.1	1.3
Ever had bowel cancer screening	1.2	1.4	2.0	-1.2	-1.4	-1.0
Hand grip strength (left)	1.1	2.9	5.5	-2.4	-1.4	-1.2
Relative age of first facial hair	1.1	2.4	5.1	-0.8	-2.3	-1.1
Angina	1.1	1.4	2.4	1.1	-0.7	-1.5
Alcohol usually taken with meals	1.1	1.8	3.9	0.2	-2.0	-1.2
Forced vital capacity (FVC), Best measure	1.1	3.9	6.4	-2.5	2.2	0.6
Migraine (self-reported)	1.1	1.4	3.0	1.7	-1.0	-0.5
Supplements: Calcium	1.1	1.2	2.5	-1.6	0.1	1.0
Crohns Disease (2017)	1.0	2.3	3.9	0.5	-1.6	-2.0
Neuroticism	1.0	2.4	3.2	1.8	-1.2	1.6
Current tobacco smoking	1.0	1.6	3.5	0.2	-1.1	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	3.6	0.3	0.7	1.9
Had menopause	1.0	1.3	3.3	-1.8	-0.5	-0.7
Illnesses of father: Heart disease	1.0	1.4	2.7	0.6	-1.1	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	2.1	1.5	-0.9	-0.7
Bipolar Disorder (2011)	0.9	0.8	2.2	0.0	-1.5	-0.5
HbA1C	0.9	1.0	2.0	1.4	0.8	0.6
Allergy or Eczema	0.9	2.4	3.3	-1.1	1.6	1.8
Severe depression (siblings)	0.9	1.0	1.7	0.7	0.9	1.3
Leg fat-free mass (left)	0.9	4.6	8.9	3.0	-1.4	-1.7
Leg predicted mass (left)	0.9	4.5	8.8	3.0	-1.4	-1.7
Mouth/teeth dental problems	0.9	1.4	2.8	-1.7	0.9	0.7
Hayfever/allergic rhinitis (self-reported)	0.9	1.3	1.9	0.8	1.1	1.4
Neuroticism score	0.9	1.9	3.4	1.9	-0.9	1.2
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	6.2	-1.3	2.5	1.2
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.5	1.6	-0.8	0.4
Worry too long after embarrassment	0.9	1.5	1.8	-1.4	-1.0	1.3
Angina (self-reported)	0.9	1.2	1.8	1.3	-0.5	-1.4
Suffer from ‘nerves’	0.9	1.5	3.4	1.8	0.2	1.0
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.5	-1.0	-0.7	-1.2
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	1.6	-1.1	0.7	1.3
Knee pain experienced in last month	0.9	1.4	3.5	1.9	-0.2	-0.7
Guilty feelings	0.9	1.4	3.3	0.8	-1.8	-0.5
Pack years of smoking	0.9	1.3	2.7	0.9	-0.6	-1.6
Depressed Affect (Nagel 2018)	0.8	1.6	3.0	1.3	-0.0	1.7
Alzheimer’s Disease (in mother)	0.8	0.9	1.4	-1.2	1.0	0.5
Smoking Status	0.8	1.9	2.6	1.4	-1.1	-1.6
Sensitivity / hurt feelings	0.8	1.4	2.4	1.3	-1.6	0.1
Qualifications: CSEs or equivalent	0.8	1.0	2.2	1.5	0.4	0.8
Medication: Levothyroxine sodium	0.8	1.4	2.0	1.4	-1.1	-1.0
Medication: Lansoprazole	0.8	0.9	1.5	-0.0	-1.1	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	4.4	-1.6	2.1	0.8
Birth weight of first child	0.8	1.5	2.0	-1.0	-1.3	-1.4
Arm fat-free mass (right)	0.8	4.0	7.3	2.7	-1.2	-1.9
Health satisfaction	0.8	1.0	2.2	1.5	-0.9	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.6	-0.6	0.9	1.3
Arm predicted mass (right)	0.8	4.1	8.1	2.8	-1.0	-1.8
Leg fat-free mass (right)	0.8	4.2	8.2	2.9	-1.4	-1.6
Qualifications: nursing, teaching	0.8	1.3	3.5	-1.9	-0.3	-0.5
Commuting to job workplace: Walk	0.8	0.9	2.1	-0.7	-1.4	-0.3
Leg predicted mass (right)	0.8	4.2	8.2	2.9	-1.3	-1.6
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.8	-0.3	-1.0	-1.3
Age started oral contraceptive pill	0.8	1.0	1.4	-0.8	-1.2	-1.0
Arm predicted mass (left)	0.8	4.1	8.2	2.9	-0.8	-1.9
Intelligence (Savage-Jansen 2018)	0.7	2.2	4.2	-1.2	-0.9	-2.0
Neuroticism (Nagel 2018)	0.7	1.7	4.1	0.9	-0.5	2.0
Schizophrenia (2018)	0.7	1.4	3.3	-1.8	-0.9	0.1
Worry (Nagel 2018)	0.7	1.5	2.5	1.3	-0.7	1.6
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.3	-0.2	-1.2	-1.1
Type 2 Diabetes (T2D) (2018)	0.7	1.4	2.3	1.5	-0.7	-1.1
Pack years adult smoking proportion	0.7	1.1	2.4	0.8	-0.6	-1.6
Hayfever, allergic rhinitis or eczema	0.7	1.6	2.0	-1.0	1.4	1.4
Hair/balding pattern: Pattern 2	0.7	0.9	1.4	0.9	1.2	0.5
Illnesses of siblings	0.7	1.0	1.8	-0.6	1.4	1.0
Falls in the last year	0.7	0.9	1.9	1.4	0.8	0.4
Asthma	0.7	1.5	1.8	1.3	-1.1	-1.1
Medication: Ventolin 100micrograms inhaler	0.7	1.0	2.8	1.7	0.2	0.2
Number of full brothers	0.7	0.9	1.6	-0.2	-1.1	-1.3
Medication: Allopurinol	0.7	0.9	1.4	1.2	0.8	0.8
Financial situation satisfaction	0.7	0.9	2.5	1.6	-0.2	-0.3
Medication: Blood pressure	0.7	1.2	2.1	1.0	-1.4	-0.9
High cholesterol (Self-reported)	0.7	1.3	2.2	1.5	-0.9	-1.0
Basal metabolic rate	0.7	3.9	7.2	2.7	-1.1	-1.8
Heart disease (siblings)	0.7	0.9	2.1	-0.3	0.7	1.4
Heel T-Score	0.6	4.6	9.8	0.8	-1.8	-3.1
Average weekly spirits intake	0.6	0.7	1.1	0.7	-0.7	-1.1
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	1.0	0.6	-0.8	-1.0
Past tobacco smoking	0.6	1.1	1.7	-1.3	0.4	1.2
Worrier / anxious feelings	0.6	1.1	1.7	1.3	-0.4	1.3
Lung cancer (father)	0.6	0.7	1.8	1.4	0.0	0.3
Peak expiratory flow (PEF)	0.6	1.3	3.2	0.4	1.8	0.8
Birth weight	0.6	1.4	3.3	1.8	0.3	0.9
Shortness of breath walking on level ground	0.6	0.7	2.0	1.4	-0.3	0.1
Smoking status: Previous	0.6	0.9	2.5	1.6	-0.4	-0.0
Whole body fat-free mass	0.6	3.2	4.6	2.1	-1.2	-1.9
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.5	-1.2	1.2	0.4
Breast cancer (self-reported)	0.6	0.7	1.1	-1.1	-0.8	-0.6
Asthma (self-reported)	0.6	1.2	1.5	1.2	-1.0	-1.1
Smoking status: Current	0.6	0.9	2.3	-0.2	-0.5	-1.5
Medication: Bendroflumethiazide	0.6	1.0	1.3	0.6	-1.1	-1.2
Arm fat-free mass (left)	0.6	3.0	6.4	2.5	-0.5	-1.5
Number of operations (self-reported)	0.6	0.8	1.9	1.4	0.5	0.6
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.1	-0.4	-0.9	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	2.1	0.4	0.3	1.5
Alzheimer’s Disease (including proxy)	0.5	0.7	2.1	-1.5	0.2	0.3
Ovarian Cancer	0.5	0.7	1.2	-0.2	1.1	0.9
LDL Cholesterol	0.5	0.8	0.9	-1.0	0.9	0.7
Schizophrenia (2014)	0.5	1.2	2.9	-0.8	-1.7	-0.1
Ulcerative Colitis	0.5	0.7	1.4	0.3	0.7	1.2
Blood White Count	0.5	3.5	5.0	0.9	-2.2	-2.2
Lung FEV1/FVC ratio	0.5	2.3	5.1	2.3	-0.8	-1.1
Chronic bronchitis/emphysema (father)	0.5	0.6	1.8	-1.4	0.1	0.1
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.9	0.1	-1.4	0.1
Fluid intelligence score	0.5	1.0	2.0	-0.3	-1.4	-1.0
Hair/balding pattern: Pattern 4	0.5	1.2	2.2	-0.8	-0.9	-1.5
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.8	-0.9	-0.4	-0.8
Whole body water mass	0.5	3.0	4.9	2.2	-1.1	-1.8
Eye problems/disorders: Glaucoma	0.5	0.6	0.7	0.7	-0.7	-0.8
Medication: Atorvastatin	0.5	0.6	0.9	0.2	-0.9	-0.9
Commuting to job workplace: Cycle	0.5	0.6	1.5	-1.2	0.3	0.4
Myopia	0.5	0.7	1.5	-1.2	0.1	0.8
Schizophrenia vs Biploar Disorder	0.4	0.5	1.1	-0.5	-0.6	-1.0
Ulcerative Colitis (UC)	0.4	0.7	1.2	-0.1	1.1	1.0
Crohns Disease (2012)	0.4	0.7	1.1	-0.3	-0.9	-1.1
Primary Biliary Cirrhosis	0.4	0.6	1.0	0.3	0.8	1.0
Hypothyroidism (self reported)	0.4	1.0	1.3	0.7	-1.1	-1.1
Hearing difficulty/problems: Yes	0.4	0.6	1.2	0.1	0.8	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.7	-1.3	0.2	-0.8
Serious illness, injury or assault to yourself	0.4	0.5	1.4	0.3	1.2	0.1
Multivitamins +/- minerals	0.4	0.5	0.7	-0.5	-0.8	-0.8
Sitting height	0.4	3.1	6.4	-2.5	-0.4	-1.6
Number of incorrect matches in round	0.4	0.6	1.1	1.1	-0.0	0.8
Nervous feelings	0.4	0.8	1.3	0.8	-1.1	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	1.6	-1.3	0.2	-1.1
Medication: Ramipril	0.4	0.5	1.1	1.0	-0.6	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.3	0.8	-1.2	0.0
Number of live births	0.4	0.5	1.1	-0.7	-1.0	-0.1
Prospective memory result	0.4	0.5	1.1	0.5	0.4	1.1
Eye problems/disorders: None of the above	0.4	0.4	0.7	-0.2	0.7	0.9
Diabetes diagnosed by doctor	0.4	0.6	1.6	1.3	0.3	0.3
Medication: Aspirin	0.4	0.5	1.1	-0.0	1.1	-0.6
Hearing aid user	0.4	0.4	1.0	0.5	0.0	-1.0
Mother’s age at death	0.4	0.5	0.9	-0.9	0.4	0.7
Ever depressed for a whole week	0.4	0.6	1.3	0.4	-0.4	1.2
Alcohol drinker status: Previous	0.4	0.4	0.8	0.4	-0.6	-0.9
HDL Cholesterol	0.3	0.4	0.8	0.7	-0.2	0.9
Neuroticism (2016)	0.3	0.4	0.9	0.0	0.6	1.0
Height	0.3	5.4	8.6	-1.9	2.9	2.1
Respiratory disease	0.3	0.8	1.5	0.3	-0.9	-1.2
Lung FVC	0.3	1.4	4.0	-2.0	0.4	-0.2
Supplements: Zinc	0.3	0.3	0.8	0.9	-0.4	-0.3
Average weekly fortified wine intake	0.3	0.4	1.0	-0.4	-0.1	1.0
Supplements: Glucosamine	0.3	0.4	0.6	-0.6	-0.5	-0.8
Had other major operations	0.3	0.4	1.0	1.0	-0.2	-0.3
Trunk fat-free mass	0.3	1.9	3.0	1.3	-1.1	-1.7
Time employed in main current job	0.3	0.3	0.8	-0.9	-0.3	0.1
Father’s age at death	0.3	0.4	0.8	-0.9	0.1	0.7
Trunk predicted mass	0.3	2.0	3.2	1.3	-1.1	-1.8
Standing height	0.3	3.4	9.1	-3.0	1.0	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.9	0.9	-0.7	0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.1	1.1	-0.5	-0.7
Comparative body size at age 10	0.3	1.0	2.8	1.7	0.3	-0.0
Medication: Omeprazole	0.3	0.3	0.8	0.5	0.1	0.9
Medication: Seretide 50 evohaler	0.3	0.3	0.5	0.7	-0.7	0.2
Number of full sisters	0.3	0.4	0.8	-0.9	-0.2	-0.4
Medication: Aspirin	0.3	0.4	1.0	0.3	1.0	-0.4
Supplements: Vitamin C	0.3	0.3	0.7	-0.0	0.9	0.5
Loneliness, isolation	0.3	0.5	1.3	0.1	-0.1	1.2
Osteoporosis (self-reported)	0.3	0.3	0.9	-0.9	-0.2	-0.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.0	-1.0	-0.5	-0.2
Risk taking	0.3	0.4	0.9	-0.9	-0.2	-0.6
Basal cell carcinoma (self-reported)	0.3	0.3	0.4	-0.7	0.3	-0.6
Alzheimer’s Disease (in father)	0.2	0.2	0.4	0.3	-0.6	-0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.7	-0.8	-0.7	-0.6
Blood Eosinophil Count	0.2	1.6	3.4	-0.4	-1.1	-1.9
Vitamin and mineral supplements	0.2	0.3	0.9	0.9	-0.1	-0.1
Diabetes (mother)	0.2	0.2	0.6	0.8	-0.3	0.2
Hand grip strength (right)	0.2	0.4	0.7	-0.8	-0.8	-0.1
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	-0.4	-0.2	-0.6
Hearing difficulty/problems with background noise	0.2	0.3	0.9	0.1	-0.9	-0.3
Tense / ‘highly strung’	0.2	0.3	0.4	0.5	-0.5	0.6
Gout (self-reported)	0.2	0.2	0.6	0.8	-0.1	-0.2
Comparative height size at age 10	0.2	1.0	2.6	-1.6	0.5	0.3
Had major operations	0.2	0.2	0.4	0.1	0.4	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	-0.2	-0.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.7	0.3	-0.8	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	-0.1	0.4	0.7
Eye problems/disorders: Cataract	0.2	0.2	0.5	0.4	-0.2	-0.7
Unable to work because of sickness or disability	0.2	0.3	0.8	0.9	-0.3	-0.2
Cholesterol lowering medication	0.2	0.3	0.6	0.8	0.6	0.1
Breast Cancer	0.1	0.3	0.5	0.7	-0.3	-0.6
Triglycerides	0.1	0.1	0.2	-0.4	0.1	-0.5
Blood Red Count	0.1	1.0	1.4	1.2	-0.5	-1.1
Waist Hip Ratio (WHR)	0.1	0.5	0.7	0.8	0.5	0.6
Relative age voice broke	0.1	0.2	0.3	-0.4	-0.6	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	0.1	-0.5	0.6
Diabetes (self-reported)	0.1	0.2	0.4	0.6	0.5	-0.0
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	0.7	-0.2	0.3
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	0.3	-0.5	0.2
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	0.1	0.1	-0.4
Glaucoma (self-reported)	0.1	0.2	0.2	-0.3	0.4	0.4
Number of children fathered	0.1	0.1	0.2	-0.2	0.3	0.4
Pulse wave peak to peak time	0.1	0.1	0.3	-0.3	0.1	0.6
Illnesses of siblings: Diabetes	0.1	0.1	0.3	0.6	0.2	0.0
Mineral and other dietary supplements	0.1	0.1	0.2	0.5	-0.0	-0.4
Average weekly champagne plus white wine intake	0.1	0.2	0.4	-0.1	0.6	0.5
Miserableness	0.1	0.2	0.2	-0.0	-0.5	0.5
Ever smoked	0.1	0.2	0.6	-0.3	0.0	-0.7
Average weekly beer plus cider intake	0.1	0.1	0.1	-0.3	0.3	-0.0
Fractured/broken bones in last 5 years	0.1	0.1	0.2	-0.4	0.2	0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	-0.5	-0.4	-0.1
Irritable Bowel Disease (IBD)	0.0	0.0	0.1	0.1	0.2	-0.0
Lupus	0.0	0.1	0.2	-0.2	0.4	0.1
Blood Platelet Count	0.0	0.5	0.9	0.9	0.1	0.7
Chronotype (morning person)	0.0	0.1	0.3	0.0	-0.6	-0.0
Hair Pigment	0.0	0.4	1.0	-1.0	0.1	-0.1
Tanning	0.0	0.5	1.0	-1.0	0.7	-0.2
Allergy	0.0	0.1	0.2	0.0	-0.4	-0.3
Pain all over the body in last month	0.0	0.0	0.1	0.2	0.1	0.3
Blood clot in the leg (DVT)	0.0	0.0	0.0	0.2	-0.1	0.2
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	0.3	0.1	-0.2
Commuting to job workplace: Public transport	0.0	0.0	0.0	0.2	0.1	0.0

Hub : Genes

RGS6

Models

Trait associations